AAC -- Table of Contents (April 1 2008, 52 [4])

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Contents: April 2008, Volume 52, Issue 4

       Minireviews

       Susceptibility

       Mechanisms of Resistance

       Clinical Therapeutics

       Mechanisms of Action

       Antiviral Agents

       Experimental Therapeutics

       Pharmacology

       Analytical Procedures

       Biologic Response Modifiers

       Letters

Other Issues

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Minireviews:

A Practical Guide to Measuring Mutation Rates in Antibiotic Resistance
Cassie F. Pope, Denise M. O'Sullivan, Timothy D. McHugh, and Stephen H. Gillespie
Antimicrob. Agents Chemother. April 2008 52: 1209-1214; published ahead of print February 4, 2008, doi:10.1128/AAC.01152-07
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Susceptibility:

New Active Drugs against Liver Stages of Plasmodium Predicted by Molecular Topology
Nassira Mahmoudi, Ramon Garcia-Domenech, Jorge Galvez, Khemais Farhati, Jean-François Franetich, Robert Sauerwein, Laurent Hannoun, Francis Derouin, Martin Danis, and Dominique Mazier
Antimicrob. Agents Chemother. April 2008 52: 1215-1220; published ahead of print January 22, 2008, doi:10.1128/AAC.01043-07
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Aspergillus Section Fumigati: Antifungal Susceptibility Patterns and Sequence-Based Identification
Laura Alcazar-Fuoli, Emilia Mellado, Ana Alastruey-Izquierdo, Manuel Cuenca-Estrella, and Juan L. Rodriguez-Tudela
Antimicrob. Agents Chemother. April 2008 52: 1244-1251; published ahead of print January 22, 2008, doi:10.1128/AAC.00942-07
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In Vitro Susceptibility of Various Genotypic Strains of Toxoplasma gondii to Pyrimethamine, Sulfadiazine, and Atovaquone
Pascale Meneceur, Marie-Anne Bouldouyre, Dominique Aubert, Isabelle Villena, Jean Menotti, Virginie Sauvage, Jean-François Garin, and Francis Derouin
Antimicrob. Agents Chemother. April 2008 52: 1269-1277; published ahead of print January 22, 2008, doi:10.1128/AAC.01203-07
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Effects on Gram-Negative and Gram-Positive Bacteria Mediated by 5-Aminolevulinic Acid and 5-Aminolevulinic Acid Derivatives
Nicolas Fotinos, Maruska Convert, Jean-Claude Piffaretti, Robert Gurny, and Norbert Lange
Antimicrob. Agents Chemother. April 2008 52: 1366-1373; published ahead of print January 14, 2008, doi:10.1128/AAC.01372-07
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In Vitro Antifungal Activities of Isavuconazole (BAL4815), Voriconazole, and Fluconazole against 1,007 Isolates of Zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium Species
Jesús Guinea, Teresa Peláez, Sandra Recio, Marta Torres-Narbona, and Emilio Bouza
Antimicrob. Agents Chemother. April 2008 52: 1396-1400; published ahead of print January 22, 2008, doi:10.1128/AAC.01512-07
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Antimicrobial-Resistant Pathogens in Intensive Care Units in Canada: Results of the Canadian National Intensive Care Unit (CAN-ICU) Study, 2005-2006
George G. Zhanel, Mel DeCorby, Nancy Laing, Barb Weshnoweski, Ravi Vashisht, Franil Tailor, Kim A. Nichol, Aleksandra Wierzbowski, Patricia J. Baudry, James A. Karlowsky, Philippe Lagacé-Wiens, Andrew Walkty, Melissa McCracken, Michael R. Mulvey, Jack Johnson, The Canadian Antimicrobial Resistance Alliance (CARA), and Daryl J. Hoban
Antimicrob. Agents Chemother. April 2008 52: 1430-1437; published ahead of print February 19, 2008, doi:10.1128/AAC.01538-07
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Potent Antimalarial Activity of Histone Deacetylase Inhibitor Analogues
K. T. Andrews, T. N. Tran, A. J. Lucke, P. Kahnberg, G. T. Le, G. M. Boyle, D. L. Gardiner, T. S. Skinner-Adams, and D. P. Fairlie
Antimicrob. Agents Chemother. April 2008 52: 1454-1461; published ahead of print January 22, 2008, doi:10.1128/AAC.00757-07
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Activity of Tigecycline against Coryneform Bacteria of Clinical Interest and Listeria monocytogenes
Carlos Salas, Jorge Calvo, and Luis Martínez-Martínez
Antimicrob. Agents Chemother. April 2008 52: 1503-1505; published ahead of print January 28, 2008, doi:10.1128/AAC.01129-07
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Prevalence and Susceptibility Profile of Candida metapsilosis and Candida orthopsilosis: Results from Population-Based Surveillance of Candidemia in Spain
A. Gomez-Lopez, A. Alastruey-Izquierdo, D. Rodriguez, B. Almirante, A. Pahissa, J. L. Rodriguez-Tudela, M. Cuenca-Estrella and the Barcelona Candidemia Project Study Group
Antimicrob. Agents Chemother. April 2008 52: 1506-1509; published ahead of print February 19, 2008, doi:10.1128/AAC.01595-07
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In Vitro Interactions of Micafungin with Amphotericin B against Clinical Isolates of Candida spp.
Carolina Serena, Marçal Mariné, Guillermo Quindós, Alfonso J. Carrillo, J. F. Cano, F. Javier Pastor, and Josep Guarro
Antimicrob. Agents Chemother. April 2008 52: 1529-1532; published ahead of print January 28, 2008, doi:10.1128/AAC.01097-07
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Attenuated Vancomycin Bactericidal Activity against Staphylococcus aureus hemB Mutants Expressing the Small-Colony-Variant Phenotype
Brian T. Tsuji, Christof von Eiff, Pamela A. Kelchlin, Alan Forrest, and Patrick F. Smith
Antimicrob. Agents Chemother. April 2008 52: 1533-1537; published ahead of print February 19, 2008, doi:10.1128/AAC.01254-07
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Antibiotic Susceptibility of Invasive Haemophilus influenzae Strains in Canada
Michelle L. Sill and Raymond S. W. Tsang
Antimicrob. Agents Chemother. April 2008 52: 1551-1552; published ahead of print January 28, 2008, doi:10.1128/AAC.01580-07
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Killing of Neisseria gonorrhoeae, Streptococcus agalactiae (Group B Streptococcus), Haemophilus ducreyi, and Vaginal Lactobacillus by 3-O-Octyl-sn-Glycerol
B. J. Moncla, K. Pryke, and Charles E. Isaacs
Antimicrob. Agents Chemother. April 2008 52: 1577-1579; published ahead of print January 28, 2008, doi:10.1128/AAC.01023-07
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In Vitro Activity of the New Azole Isavuconazole (BAL4815) Compared with Six Other Antifungal Agents against 162 Cryptococcus neoformans Isolates from Cuba
Maria-Teresa Illnait-Zaragozi, Gerardo F. Martínez, Ilse Curfs-Breuker, Carlos M. Fernández, Teun Boekhout, and Jacques F. Meis
Antimicrob. Agents Chemother. April 2008 52: 1580-1582; published ahead of print January 22, 2008, doi:10.1128/AAC.01384-07
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Mechanisms of Resistance:

Spontaneous Deletion of the Methicillin Resistance Determinant, mecA, Partially Compensates for the Fitness Cost Associated with High-Level Vancomycin Resistance in Staphylococcus aureus
Michael J. Noto, Paige M. Fox, and Gordon L. Archer
Antimicrob. Agents Chemother. April 2008 52: 1221-1229; published ahead of print January 22, 2008, doi:10.1128/AAC.01164-07
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In Vitro Model of Colonization Resistance by the Enteric Microbiota: Effects of Antimicrobial Agents Used in Food-Producing Animals
R. Doug Wagner, Shemedia J. Johnson, and Carl E. Cerniglia
Antimicrob. Agents Chemother. April 2008 52: 1230-1237; published ahead of print January 28, 2008, doi:10.1128/AAC.00852-07
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Diversity of Extended-Spectrum β-Lactamases and Class C β-Lactamases among Cloacal Escherichia coli Isolates in Belgian Broiler Farms
Annemieke Smet, An Martel, Davy Persoons, Jeroen Dewulf, Marc Heyndrickx, Boudewijn Catry, Lieve Herman, Freddy Haesebrouck, and Patrick Butaye
Antimicrob. Agents Chemother. April 2008 52: 1238-1243; published ahead of print January 28, 2008, doi:10.1128/AAC.01285-07
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Acinetobacter radioresistens as a Silent Source of Carbapenem Resistance for Acinetobacter spp.
Laurent Poirel, Samy Figueiredo, Vincent Cattoir, Alessandra Carattoli, and Patrice Nordmann
Antimicrob. Agents Chemother. April 2008 52: 1252-1256; published ahead of print January 14, 2008, doi:10.1128/AAC.01304-07
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Genetic Structures at the Origin of Acquisition of the β-Lactamase bla_KPC Gene
Thierry Naas, Gaelle Cuzon, Maria-Virginia Villegas, Marie-Frédérique Lartigue, John P. Quinn, and Patrice Nordmann
Antimicrob. Agents Chemother. April 2008 52: 1257-1263; published ahead of print January 28, 2008, doi:10.1128/AAC.01451-07
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Genetic and Biochemical Characterization of OXA-63, a New Class D β-Lactamase from Brachyspira pilosicoli BM4442
Djalal Meziane-Cherif, Thierry Lambert, Marine Dupêchez, Patrice Courvalin, and Marc Galimand
Antimicrob. Agents Chemother. April 2008 52: 1264-1268; published ahead of print January 22, 2008, doi:10.1128/AAC.00684-07
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erm(B)-Carrying Elements in Tetracycline-Resistant Pneumococci and Correspondence between Tn1545 and Tn6003
Ileana Cochetti, Emily Tili, Marina Mingoia, Pietro E. Varaldo, and Maria Pia Montanari
Antimicrob. Agents Chemother. April 2008 52: 1285-1290; published ahead of print February 19, 2008, doi:10.1128/AAC.01457-07
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Convergent In Vivo and In Vitro Selection of Ceftazidime Resistance Mutations at Position 167 of CTX-M-3 β-Lactamase in Hypermutable Escherichia coli Strains
Marina N. Stepanova, Maxim Pimkin, Anatoly A. Nikulin, Varvara K. Kozyreva, Elena D. Agapova, and Mikhail V. Edelstein
Antimicrob. Agents Chemother. April 2008 52: 1297-1301; published ahead of print January 22, 2008, doi:10.1128/AAC.01060-07
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Genomewide Screening for Genes Associated with Gliotoxin Resistance and Sensitivity in Saccharomyces cerevisiae
Georgios Chamilos, Russell E. Lewis, Gregory A. Lamaris, Nathaniel D. Albert, and Dimitrios P. Kontoyiannis
Antimicrob. Agents Chemother. April 2008 52: 1325-1329; published ahead of print January 22, 2008, doi:10.1128/AAC.01393-07
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Roles of Trypanothione S-Transferase and Tryparedoxin Peroxidase in Resistance to Antimonials
Susan Wyllie, Tim J. Vickers, and Alan H. Fairlamb
Antimicrob. Agents Chemother. April 2008 52: 1359-1365; published ahead of print February 4, 2008, doi:10.1128/AAC.01563-07
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DNA Gyrase from the Albicidin Producer Xanthomonas albilineans Has Multiple-Antibiotic-Resistance and Unusual Enzymatic Properties
Saeed M. Hashimi, Guozhong Huang, Anthony Maxwell, and Robert G. Birch
Antimicrob. Agents Chemother. April 2008 52: 1382-1390; published ahead of print February 11, 2008, doi:10.1128/AAC.01551-07
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Drug-Regulated Expression of Plasmodium falciparum P-Glycoprotein Homologue 1: a Putative Role for Nuclear Receptors
David J. Johnson, Andrew Owen, Nick Plant, Patrick G. Bray, and Stephen A. Ward
Antimicrob. Agents Chemother. April 2008 52: 1438-1445; published ahead of print January 14, 2008, doi:10.1128/AAC.01392-07
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Different Pathways to Acquiring Resistance Genes Illustrated by the Recent Evolution of IncW Plasmids
Carlos Revilla, M. Pilar Garcillán-Barcia, Raúl Fernández-López, Nicholas R. Thomson, Mandy Sanders, Martin Cheung, Christopher M. Thomas, and Fernando de la Cruz
Antimicrob. Agents Chemother. April 2008 52: 1472-1480; published ahead of print February 11, 2008, doi:10.1128/AAC.00982-07
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Transcriptional Activation and Increased mRNA Stability Contribute to Overexpression of CDR1 in Azole-Resistant Candida albicans
Raman Manoharlal, Naseem Akhtar Gaur, Sneh Lata Panwar, Joachim Morschhäuser, and Rajendra Prasad
Antimicrob. Agents Chemother. April 2008 52: 1481-1492; published ahead of print February 11, 2008, doi:10.1128/AAC.01106-07
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Structure-Function Correlations of Two Highly Conserved Motifs in Saccharomyces cerevisiae Squalene Epoxidase
Christoph Ruckenstuhl, Andrea Poschenel, Reinhard Possert, Pravas Kumar Baral, Karl Gruber, and Friederike Turnowsky
Antimicrob. Agents Chemother. April 2008 52: 1496-1499; published ahead of print January 22, 2008, doi:10.1128/AAC.01282-07
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Induction of L1 and L2 β-Lactamase Production in Stenotrophomonas maltophilia Is Dependent on an AmpR-Type Regulator
Aki Okazaki and Matthew B. Avison
Antimicrob. Agents Chemother. April 2008 52: 1525-1528; published ahead of print January 22, 2008, doi:10.1128/AAC.01485-07
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Potential Basis for Amphotericin B Resistance in Aspergillus terreus
Gerhard Blum, Susanne Perkhofer, Hubertus Haas, Markus Schrettl, Reinhard Würzner, Manfred P. Dierich, and Cornelia Lass-Flörl
Antimicrob. Agents Chemother. April 2008 52: 1553-1555; published ahead of print February 11, 2008, doi:10.1128/AAC.01280-07
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Role of the AheABC Efflux Pump in Aeromonas hydrophila Intrinsic Multidrug Resistance
Mathieu Hernould, Séverine Gagné, Michel Fournier, Claudine Quentin, and Corinne Arpin
Antimicrob. Agents Chemother. April 2008 52: 1559-1563; published ahead of print February 11, 2008, doi:10.1128/AAC.01052-07
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Plasmid-Mediated qepA Gene among Escherichia coli Clinical Isolates from Japan
Kunikazu Yamane, Jun-ichi Wachino, Satowa Suzuki, and Yoshichika Arakawa
Antimicrob. Agents Chemother. April 2008 52: 1564-1566; published ahead of print February 19, 2008, doi:10.1128/AAC.01137-07
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Prevalence of the erm(T) Gene in Clinical Isolates of Erythromycin-Resistant Group D Streptococcus and Enterococcus
Linda P. DiPersio, Joseph R. DiPersio, Kevin C. Frey, and Jacqueline A. Beach
Antimicrob. Agents Chemother. April 2008 52: 1567-1569; published ahead of print February 19, 2008, doi:10.1128/AAC.01325-07
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Linezolid Resistance in Staphylococcus aureus: Gene Dosage Effect, Stability, Fitness Costs, and Cross-Resistances
Silke Besier, Albrecht Ludwig, Johannes Zander, Volker Brade, and Thomas A. Wichelhaus
Antimicrob. Agents Chemother. April 2008 52: 1570-1572; published ahead of print January 22, 2008, doi:10.1128/AAC.01098-07
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Clinical Therapeutics:

Clinical Response and Outcome of Infection with Salmonella enterica Serotype Typhi with Decreased Susceptibility to Fluoroquinolones: a United States FoodNet Multicenter Retrospective Cohort Study
John A. Crump, Katrina Kretsinger, Kathryn Gay, R. Michael Hoekstra, Duc J. Vugia, Sharon Hurd, Susan D. Segler, Melanie Megginson, L. Jeffrey Luedeman, Beletshachew Shiferaw, Samir S. Hanna, Kevin W. Joyce, Eric D. Mintz, Frederick J. Angulo and the Emerging Infections Program FoodNet and NARMS Working Groups
Antimicrob. Agents Chemother. April 2008 52: 1278-1284; published ahead of print January 22, 2008, doi:10.1128/AAC.01509-07
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Larger Vancomycin Doses (at Least Four Grams per Day) Are Associated with an Increased Incidence of Nephrotoxicity
Thomas P. Lodise, Ben Lomaestro, Jeffrey Graves, and G. L. Drusano
Antimicrob. Agents Chemother. April 2008 52: 1330-1336; published ahead of print January 28, 2008, doi:10.1128/AAC.01602-07
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Isolation of Imipenem-Resistant Enterobacter Species: Emergence of KPC-2 Carbapenemase, Molecular Characterization, Epidemiology, and Outcomes
Dror Marchaim, Shiri Navon-Venezia, Mitchell J. Schwaber, and Yehuda Carmeli
Antimicrob. Agents Chemother. April 2008 52: 1413-1418; published ahead of print January 28, 2008, doi:10.1128/AAC.01103-07
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Malaria Treatment with Atovaquone-Proguanil in Malaria-Immune Adults: Implications for Malaria Intervention Trials and for Pre-Exposure Prophylaxis of Malaria
Mark E. Polhemus, Shon Remich, Bernhards Ogutu, John Waitumbi, Marc Lievens, W. Ripley Ballou, and D. Gray Heppner, Jr.
Antimicrob. Agents Chemother. April 2008 52: 1493-1495; published ahead of print February 11, 2008, doi:10.1128/AAC.01367-07
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Mechanisms of Action:

Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials
Darren J. Creek, William N. Charman, Francis C. K. Chiu, Richard J. Prankerd, Yuxiang Dong, Jonathan L. Vennerstrom, and Susan A. Charman
Antimicrob. Agents Chemother. April 2008 52: 1291-1296; published ahead of print February 11, 2008, doi:10.1128/AAC.01033-07
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Drosomycin-Like Defensin, a Human Homologue of Drosophila melanogaster Drosomycin with Antifungal Activity
Anna Simon, Bart Jan Kullberg, Brian Tripet, Otto C. Boerman, Patrick Zeeuwen, Johanna van der Ven-Jongekrijg, Paul Verweij, Joost Schalkwijk, Robert Hodges, Jos W. M. van der Meer, and Mihai G. Netea
Antimicrob. Agents Chemother. April 2008 52: 1407-1412; published ahead of print January 22, 2008, doi:10.1128/AAC.00155-07
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Comparison of the Antimicrobial Effects of Chlorine, Silver Ion, and Tobramycin on Biofilm
Jaeeun Kim, Betsey Pitts, Philip S. Stewart, Anne Camper, and Jeyong Yoon
Antimicrob. Agents Chemother. April 2008 52: 1446-1453; published ahead of print January 14, 2008, doi:10.1128/AAC.00054-07
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Affinity of Doripenem and Comparators to Penicillin-Binding Proteins in Escherichia coli and Pseudomonas aeruginosa
Todd A. Davies, Wenchi Shang, Karen Bush, and Robert K. Flamm
Antimicrob. Agents Chemother. April 2008 52: 1510-1512; published ahead of print February 4, 2008, doi:10.1128/AAC.01529-07
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Antiviral Agents:

Inhibition of Human Immunodeficiency Virus Type 1 Replication in Human Cells by Debio-025, a Novel Cyclophilin Binding Agent
Roger G. Ptak, Philippe A. Gallay, Dirk Jochmans, Andrew P. Halestrap, Urs T. Ruegg, Luke A. Pallansch, Michael D. Bobardt, Marie-Pierre de Béthune, Johan Neyts, Erik De Clercq, Jean-Maurice Dumont, Pietro Scalfaro, Kamel Besseghir, Roland M. Wenger, and Brigitte Rosenwirth
Antimicrob. Agents Chemother. April 2008 52: 1302-1317; published ahead of print January 22, 2008, doi:10.1128/AAC.01324-07
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Characterization of a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, A-790742
Tatyana Dekhtyar, Teresa I. Ng, Liangjun Lu, Sherie Masse, David A. DeGoey, William J. Flosi, David J. Grampovnik, Larry L. Klein, Dale J. Kempf, and Akhteruzzaman Molla
Antimicrob. Agents Chemother. April 2008 52: 1337-1344; published ahead of print January 22, 2008, doi:10.1128/AAC.01132-07
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Mutations Associated with Failure of Raltegravir Treatment Affect Integrase Sensitivity to the Inhibitor In Vitro
Isabelle Malet, Olivier Delelis, Marc-Antoine Valantin, Brigitte Montes, Cathia Soulie, Marc Wirden, Luba Tchertanov, Gilles Peytavin, Jacques Reynes, Jean-François Mouscadet, Christine Katlama, Vincent Calvez, and Anne-Geneviève Marcelin
Antimicrob. Agents Chemother. April 2008 52: 1351-1358; published ahead of print January 28, 2008, doi:10.1128/AAC.01228-07
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Sulfated K5 Escherichia coli Polysaccharide Derivatives as Wide-Range Inhibitors of Genital Types of Human Papillomavirus
David Lembo, Manuela Donalisio, Marco Rusnati, Antonella Bugatti, Maura Cornaglia, Paola Cappello, Mirella Giovarelli, Pasqua Oreste, and Santo Landolfo
Antimicrob. Agents Chemother. April 2008 52: 1374-1381; published ahead of print February 4, 2008, doi:10.1128/AAC.01467-07
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Discovery and Characterization of Substituted Diphenyl Heterocyclic Compounds as Potent and Selective Inhibitors of Hepatitis C Virus Replication
Peiyong Huang, Dane A. Goff, Qi Huang, Anthony Martinez, Xiang Xu, Scott Crowder, Sarkiz D. Issakani, Emily Anderson, Ning Sheng, Philip Achacoso, Ann Yen, Todd Kinsella, Ihab S. Darwish, Rao Kolluri, Hui Hong, Kunbin Qu, Emily Stauffer, Eileen Goldstein, Rajinder Singh, Donald G. Payan, and H. Henry Lu
Antimicrob. Agents Chemother. April 2008 52: 1419-1429; published ahead of print January 28, 2008, doi:10.1128/AAC.00525-07
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Recovery of Humoral Immunity Is Critical for Successful Antiviral Therapy in Disseminated Mouse Adenovirus Type 1 Infection
L. Lenaerts, H. Kelchtermans, L. Geboes, P. Matthys, E. Verbeken, E. De Clercq, and L. Naesens
Antimicrob. Agents Chemother. April 2008 52: 1462-1471; published ahead of print February 11, 2008, doi:10.1128/AAC.01311-07
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Anti-BK Virus Activity of Nucleoside Analogs
Parmjeet Randhawa, Jiri Zemlicka, Andreas Sauerbrei, Chris Meier, Karl Y. Hostetler, James R. Beadle, Noush Afarin Farasati, Yuchen Huang, and Matthews Bradley
Antimicrob. Agents Chemother. April 2008 52: 1519-1521; published ahead of print February 19, 2008, doi:10.1128/AAC.01241-07
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Antiretroviral Therapy with a Twice-Daily Regimen Containing 400 Milligrams of Indinavir and 100 Milligrams of Ritonavir in Human Immunodeficiency Virus Type 1-Infected Women during Pregnancy
Jade Ghosn, Ines De Montgolfier, Chantal Cornélie, Stéphanie Dominguez, Claire Pérot, Gilles Peytavin, Anne-Geneviève Marcelin, Michèle Pauchard, Zineb Ouagari, Manuela Bonmarchand, Rachid Agher, Vincent Calvez, François Bricaire, Marc Dommergues, Christine Katlama, and Roland Tubiana
Antimicrob. Agents Chemother. April 2008 52: 1542-1544; published ahead of print February 4, 2008, doi:10.1128/AAC.01301-07
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In Vitro Phenotypic Susceptibility of Human Immunodeficiency Virus Type 2 Clinical Isolates to Protease Inhibitors
Delphine Desbois, Bénédicte Roquebert, Gilles Peytavin, Florence Damond, Gilles Collin, Antoine Bénard, Pauline Campa, Sophie Matheron, Geneviève Chêne, Françoise Brun-Vézinet, Diane Descamps for the French ANRS HIV-2 Cohort (ANRS CO 05 VIH-2)
Antimicrob. Agents Chemother. April 2008 52: 1545-1548; published ahead of print January 28, 2008, doi:10.1128/AAC.01284-07
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Experimental Therapeutics:

In Vitro and In Vivo Antifungal Activities of T-2307, a Novel Arylamidine
Junichi Mitsuyama, Nobuhiko Nomura, Kyoko Hashimoto, Eio Yamada, Hiroshi Nishikawa, Makoto Kaeriyama, Akiko Kimura, Yozo Todo, and Hirokazu Narita
Antimicrob. Agents Chemother. April 2008 52: 1318-1324; published ahead of print January 28, 2008, doi:10.1128/AAC.01159-07
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Caspofungin Prolongs Survival of Transiently Neutropenic Rats with Advanced-Stage Invasive Pulmonary Aspergillosis
Wendy W. J. van de Sande, Wim van Vianen, Marian T. ten Kate, Jolanda Vissers, John Laurijsens, Mehri Tavakol, Bart J. A. Rijnders, Ron A. A. Mathot, and Irma A. J. M. Bakker-Woudenberg
Antimicrob. Agents Chemother. April 2008 52: 1345-1350; published ahead of print January 14, 2008, doi:10.1128/AAC.00536-07
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Pharmacodynamics of the Antibacterial Effect and Emergence of Resistance to Tomopenem, Formerly RO4908463/CS-023, in an In Vitro Pharmacokinetic Model of Staphylococcus aureus Infection
Alasdair P. MacGowan, Karen E. Bowker, and Alan R. Noel
Antimicrob. Agents Chemother. April 2008 52: 1401-1406; published ahead of print January 28, 2008, doi:10.1128/AAC.01153-07
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Evaluation of a 2-Pyridone, KRQ-10018, against Mycobacterium tuberculosis In Vitro and In Vivo
Anne J. Lenaerts, Casey Bitting, Lisa Woolhiser, Veronica Gruppo, Karen S. Marietta, Christine M. Johnson, and Ian M. Orme
Antimicrob. Agents Chemother. April 2008 52: 1513-1515; published ahead of print February 11, 2008, doi:10.1128/AAC.00897-07
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Microdialysis Study of Imipenem Distribution in the Peritoneal Fluid of Rats with Experimental Acute Pancreatitis
Sandrine Lefeuvre, Sandrine Marchand, Claudine Pariat, Isabelle Lamarche, and William Couet
Antimicrob. Agents Chemother. April 2008 52: 1516-1518; published ahead of print January 14, 2008, doi:10.1128/AAC.01474-07
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Powerful Bactericidal and Sterilizing Activity of a Regimen Containing PA-824, Moxifloxacin, and Pyrazinamide in a Murine Model of Tuberculosis
Eric Nuermberger, Sandeep Tyagi, Rokeya Tasneen, Kathy N. Williams, Deepak Almeida, Ian Rosenthal, and Jacques H. Grosset
Antimicrob. Agents Chemother. April 2008 52: 1522-1524; published ahead of print February 19, 2008, doi:10.1128/AAC.00074-08
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In Vivo Therapeutic Effect of Gatifloxacin on BALB/c Mice Infected with Nocardia brasiliensis
Alejandra Daw-Garza, Oliverio Welsh, Salvador Said-Fernández, Hector Gerardo Lozano-Garza, Noemi Waksman de Torres, Norma Cavazos Rocha, Jorge Ocampo-Candiani, and Lucio Vera-Cabrera
Antimicrob. Agents Chemother. April 2008 52: 1549-1550; published ahead of print February 19, 2008, doi:10.1128/AAC.00148-08
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Combination Echinocandin-Polyene Treatment of Murine Mucormycosis
Ashraf S. Ibrahim, Teclegiorgis Gebremariam, Yue Fu, John E. Edwards, Jr., and Brad Spellberg
Antimicrob. Agents Chemother. April 2008 52: 1556-1558; published ahead of print January 22, 2008, doi:10.1128/AAC.01458-07
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Comparison of Lipid Amphotericin B Preparations in Treating Murine Zygomycosis
Ashraf S. Ibrahim, Teclegiorgis Gebremariam, Mohamed I. Husseiny, David A. Stevens, Yue Fu, John E. Edwards, Jr., and Brad Spellberg
Antimicrob. Agents Chemother. April 2008 52: 1573-1576; published ahead of print January 28, 2008, doi:10.1128/AAC.01488-07
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Pharmacology:

Safety, Tolerance, and Pharmacokinetic Studies of OPT-80 in Healthy Volunteers following Single and Multiple Oral Doses
Y. K. Shue, P. S. Sears, S. Shangle, R. B. Walsh, C. Lee, S. L. Gorbach, F. Okumu, and R. A. Preston
Antimicrob. Agents Chemother. April 2008 52: 1391-1395; published ahead of print February 11, 2008, doi:10.1128/AAC.01045-07
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Analytical Procedures:

Multilaboratory Testing of Antifungal Combinations against a Quality Control Isolate of Candida krusei
Vishnu Chaturvedi, Rama Ramani, Mahmoud A. Ghannoum, Scott B. Killian, Nicole Holliday, Cindy Knapp, Luis Ostrosky-Zeichner, Shawn A. Messer, Michael A. Pfaller, Naureen J. Iqbal, Beth A. Arthington-Skaggs, Jose A. Vazquez, Tin Sein, John H. Rex, and Thomas J. Walsh
Antimicrob. Agents Chemother. April 2008 52: 1500-1502; published ahead of print January 28, 2008, doi:10.1128/AAC.00574-07
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Biologic Response Modifiers:

Effect of 14-Membered-Ring Macrolides on Production of Interleukin-8 Mediated by Protease-Activated Receptor 2 in Human Keratinocytes
Tatsuya Tsuda, Chika Ishikawa, Hiroe Konishi, Yoshiaki Hayashi, Noboru Nakagawa, Masato Matsuki, Hitoshi Mizutani, and Kiyofumi Yamanishi
Antimicrob. Agents Chemother. April 2008 52: 1538-1541; published ahead of print January 22, 2008, doi:10.1128/AAC.00140-07
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Letters:

Simvastatin Treatment Shows No Effect on the Incidence of Cerebral Malaria or Parasitemia during Experimental Malaria
Robin Kobbe, Nadine Schreiber, Jürgen May, and Thomas Jacobs
Antimicrob. Agents Chemother. April 2008 52: 1583-1584; published ahead of print February 11, 2008, doi:10.1128/AAC.01428-07
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Failure of Deferasirox, an Iron Chelator Agent, Combined with Antifungals in a Case of Severe Zygomycosis
Alexis Soummer, Armelle Mathonnet, Olivier Scatton, Pierre Philippe Massault, André Paugam, Virginie Lemiale, Jean Paul Mira, Eric Dannaoui, Alain Cariou, and Olivier Lortholary
Antimicrob. Agents Chemother. April 2008 52: 1585-1586; published ahead of print January 22, 2008, doi:10.1128/AAC.01611-07
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RmtD 16S RNA Methylase in Epidemiologically Unrelated SPM-1-Producing Pseudomonas aeruginosa Isolates from Brazil
Mariana Castanheira, Thomas R. Fritsche, Hélio S. Sader, Ronald N. Jones, Yohei Doi, Doroti de Oliveira Garcia, and David L. Paterson
Antimicrob. Agents Chemother. April 2008 52: 1587-1588;
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