AAC -- Table of Contents (June 1 2008, 52 [6])

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Contents: June 2008, Volume 52, Issue 6

       Antiviral Agents

       Experimental Therapeutics

       Susceptibility

       Pharmacology

       Mechanisms of Resistance

       Clinical Therapeutics

       Chemistry; Biosynthesis

       Mechanisms of Action

       Letters

       Errata

Other Issues

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Antiviral Agents:

Effects of Mutagenic and Chain-Terminating Nucleotide Analogs on Enzymes Isolated from Hepatitis C Virus Strains of Various Genotypes
Julie A. Heck, Angela M. I. Lam, Nirupama Narayanan, and David N. Frick
Antimicrob. Agents Chemother. June 2008 52: 1901-1911; published ahead of print April 7, 2008, doi:10.1128/AAC.01496-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Morpholino Oligomer Targeting Highly Conserved Internal Ribosome Entry Site Sequence Is Able To Inhibit Multiple Species of Picornavirus
Jeffrey K. Stone, Rene Rijnbrand, David A. Stein, Yinghong Ma, Yan Yang, Patrick L. Iversen, and Raul Andino
Antimicrob. Agents Chemother. June 2008 52: 1970-1981; published ahead of print March 17, 2008, doi:10.1128/AAC.00011-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by a Stavudine Analogue, 4'-Ethynyl Stavudine Triphosphate
Guangwei Yang, Jimin Wang, Yao Cheng, Ginger E. Dutschman, Hiromichi Tanaka, Masanori Baba, and Yung-Chi Cheng
Antimicrob. Agents Chemother. June 2008 52: 2035-2042; published ahead of print April 7, 2008, doi:10.1128/AAC.00083-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Selection of Replicon Variants Resistant to ACH-806, a Novel Hepatitis C Virus Inhibitor with No Cross-Resistance to NS3 Protease and NS5B Polymerase Inhibitors
Wengang Yang, Yongsen Zhao, Joanne Fabrycki, Xiaohong Hou, Xingtie Nie, Amy Sanchez, Avinash Phadke, Milind Deshpande, Atul Agarwal, and Mingjun Huang
Antimicrob. Agents Chemother. June 2008 52: 2043-2052; published ahead of print April 14, 2008, doi:10.1128/AAC.01548-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations in Human Immunodeficiency Virus Type 1 Integrase Confer Resistance to the Naphthyridine L-870,810 and Cross-Resistance to the Clinical Trial Drug GS-9137
Anneleen Hombrouck, Arnout Voet, Barbara Van Remoortel, Christel Desadeleer, Marc De Maeyer, Zeger Debyser, and Myriam Witvrouw
Antimicrob. Agents Chemother. June 2008 52: 2069-2078; published ahead of print March 31, 2008, doi:10.1128/AAC.00911-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multivalent Presentation of Antihantavirus Peptides on Nanoparticles Enhances Infection Blockade
Pamela R. Hall, Brian Hjelle, David C. Brown, Chunyan Ye, Virginie Bondu-Hawkins, Kathleen A. Kilpatrick, and Richard S. Larson
Antimicrob. Agents Chemother. June 2008 52: 2079-2088; published ahead of print April 7, 2008, doi:10.1128/AAC.01415-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Hepatitis C Virus (HCV) RNA Polymerase by DNA Aptamers: Mechanism of Inhibition of In Vitro RNA Synthesis and Effect on HCV-Infected Cells
Pantxika Bellecave, Christian Cazenave, Julie Rumi, Cathy Staedel, Ophélie Cosnefroy, Marie-Line Andreola, Michel Ventura, Laura Tarrago-Litvak, and Thérèse Astier-Gin
Antimicrob. Agents Chemother. June 2008 52: 2097-2110; published ahead of print March 17, 2008, doi:10.1128/AAC.01227-07
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Potent Synergistic Anti-Human Immunodeficiency Virus (HIV) Effects Using Combinations of the CCR5 Inhibitor Aplaviroc with Other Anti-HIV Drugs
Hirotomo Nakata, Seth M. Steinberg, Yasuhiro Koh, Kenji Maeda, Yoshikazu Takaoka, Hirokazu Tamamura, Nobutaka Fujii, and Hiroaki Mitsuya
Antimicrob. Agents Chemother. June 2008 52: 2111-2119; published ahead of print March 31, 2008, doi:10.1128/AAC.01299-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Herpes Simplex Virus Type 1 Infection by Cationic β-Peptides
Radeekorn Akkarawongsa, Terra B. Potocky, Emily P. English, Samuel H. Gellman, and Curtis R. Brandt
Antimicrob. Agents Chemother. June 2008 52: 2120-2129; published ahead of print April 7, 2008, doi:10.1128/AAC.01424-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Experimental Therapeutics:

Bactericidal and Sterilizing Activities of Several Orally Administered Combined Regimens against Mycobacterium ulcerans in Mice
Baohong Ji, Aurélie Chauffour, Jérome Robert, and Vincent Jarlier
Antimicrob. Agents Chemother. June 2008 52: 1912-1916; published ahead of print April 7, 2008, doi:10.1128/AAC.00193-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Enrichment of Fluoroquinolone-Resistant Staphylococcus aureus: Oscillating Ciprofloxacin Concentrations Simulated at the Upper and Lower Portions of the Mutant Selection Window
Alexander A. Firsov, Irene Y. Lubenko, Maria V. Smirnova, Elena N. Strukova, and Stephen H. Zinner
Antimicrob. Agents Chemother. June 2008 52: 1924-1928; published ahead of print March 31, 2008, doi:10.1128/AAC.01371-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Posaconazole against Candida glabrata Isolates with Various Susceptibilities to Fluconazole
Elisabetta Spreghini, Carmelo Massimo Maida, Serena Tomassetti, Fiorenza Orlando, Daniele Giannini, Maria Eleonora Milici, Giorgio Scalise, and Francesco Barchiesi
Antimicrob. Agents Chemother. June 2008 52: 1929-1933; published ahead of print April 7, 2008, doi:10.1128/AAC.00130-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Anti-Infective Coatings of Medical Implants
F. D. Matl, A. Obermeier, S. Repmann, W. Friess, A. Stemberger, and K.-D. Kuehn
Antimicrob. Agents Chemother. June 2008 52: 1957-1963; published ahead of print March 24, 2008, doi:10.1128/AAC.01438-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Clindamycin, Daptomycin, Doxycycline, Linezolid, Trimethoprim-Sulfamethoxazole, and Vancomycin against Community-Associated Methicillin-Resistant Staphylococcus aureus with Inducible Clindamycin Resistance in Murine Thigh Infection and In Vitro Pharmacodynamic Models
Kerry L. LaPlante, Steven N. Leonard, David R. Andes, William A. Craig, and Michael J. Rybak
Antimicrob. Agents Chemother. June 2008 52: 2156-2162; published ahead of print April 14, 2008, doi:10.1128/AAC.01046-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potency of SMP-601, a Novel Carbapenem, in Hematogenous Murine Bronchopneumonia Caused by Methicillin-Resistant and Vancomycin-Intermediate Staphylococcus aureus
Rie Kihara, Katsunori Yanagihara, Yoshitomo Morinaga, Nobuko Araki, Shigeki Nakamura, Masafumi Seki, Koichi Izumikawa, Hiroshi Kakeya, Yoshihiro Yamamoto, Kazuhiro Tsukamoto, Shimeru Kamihira, and Shigeru Kohno
Antimicrob. Agents Chemother. June 2008 52: 2163-2168; published ahead of print April 7, 2008, doi:10.1128/AAC.01532-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Gamma Interferon and Specific Antibody for Treatment of Microsporidiosis Caused by Encephalitozoon cuniculi in SCID Mice
Jirí Salát, Jirí Jelínek, Jindrich Chmelar, and Jan Kopecky
Antimicrob. Agents Chemother. June 2008 52: 2169-2174; published ahead of print March 17, 2008, doi:10.1128/AAC.01506-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tolevamer, an Anionic Polymer, Neutralizes Toxins Produced by the BI/027 Strains of Clostridium difficile
Paul L. Hinkson, Carol Dinardo, Daniel DeCiero, Jeffrey D. Klinger, and Robert H. Barker, Jr.
Antimicrob. Agents Chemother. June 2008 52: 2190-2195; published ahead of print April 7, 2008, doi:10.1128/AAC.00041-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

RNAIII-Inhibiting Peptide Enhances Healing of Wounds Infected with Methicillin-Resistant Staphylococcus aureus
Oriana Simonetti, Oscar Cirioni, Roberto Ghiselli, Gaia Goteri, Alessandro Scalise, Fiorenza Orlando, Carmela Silvestri, Alessandra Riva, Vittorio Saba, Kiran D. Madanahally, Annamaria Offidani, Naomi Balaban, Giorgio Scalise, and Andrea Giacometti
Antimicrob. Agents Chemother. June 2008 52: 2205-2211; published ahead of print April 7, 2008, doi:10.1128/AAC.01340-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Efficacy of β-Cyclodextrin Derivatives against Anthrax Lethal Toxin
Mahtab Moayeri, Tanisha M. Robinson, Stephen H. Leppla, and Vladimir A. Karginov
Antimicrob. Agents Chemother. June 2008 52: 2239-2241; published ahead of print March 31, 2008, doi:10.1128/AAC.00009-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility:

Production of Enterocins L50A, L50B, and IT, a New Enterocin, by Enterococcus faecium IT62, a Strain Isolated from Italian Ryegrass in Japan
Esther Izquierdo, Audrey Bednarczyk, Christine Schaeffer, Yimin Cai, Eric Marchioni, Alain Van Dorsselaer, and Saïd Ennahar
Antimicrob. Agents Chemother. June 2008 52: 1917-1923; published ahead of print April 7, 2008, doi:10.1128/AAC.01409-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differential Antibiotic Susceptibility of Mycobacterium abscessus Variants in Biofilms and Macrophages Compared to That of Planktonic Bacteria
Rebecca Greendyke and Thomas F. Byrd
Antimicrob. Agents Chemother. June 2008 52: 2019-2026; published ahead of print March 31, 2008, doi:10.1128/AAC.00986-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiparasitic Activities and Toxicities of Individual Enantiomers of the 8-Aminoquinoline 8-[(4-Amino-1-Methylbutyl)Amino]-6-Methoxy-4-Methyl-5-[3,4-Dichlorophenoxy]Quinoline Succinate
N. P. Dhammika Nanayakkara, Arba L. Ager, Jr., Marilyn S. Bartlett, Vanessa Yardley, Simon L. Croft, Ikhlas A. Khan, James D. McChesney, and Larry A. Walker
Antimicrob. Agents Chemother. June 2008 52: 2130-2137; published ahead of print March 31, 2008, doi:10.1128/AAC.00645-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Pradofloxacin against Porphyromonas and Prevotella spp. Implicated in Periodontal Disease in Dogs: Susceptibility Test Data from a European Multicenter Study
Bernd Stephan, Heinrich A. Greife, Andrew Pridmore, and Peter Silley
Antimicrob. Agents Chemother. June 2008 52: 2149-2155; published ahead of print April 14, 2008, doi:10.1128/AAC.00019-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Isobolographic Analysis of Pharmacodynamic Interactions between Antifungal Agents and Ciprofloxacin against Candida albicans and Aspergillus fumigatus
Theodouli Stergiopoulou, Joseph Meletiadis, Tin Sein, Paraskevi Papaioannidou, Ioannis Tsiouris, Emmanuel Roilides, and Thomas J. Walsh
Antimicrob. Agents Chemother. June 2008 52: 2196-2204; published ahead of print February 25, 2008, doi:10.1128/AAC.00735-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Linezolid against Clinical Isolates of Mycobacterium tuberculosis Complex Isolated in Taiwan over 10 Years
Tsi-Shu Huang, Yung-Ching Liu, Cheng-Len Sy, Yao-Shen Chen, Hui-Zin Tu, and Bao-Chen Chen
Antimicrob. Agents Chemother. June 2008 52: 2226-2227; published ahead of print April 7, 2008, doi:10.1128/AAC.00414-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antifungal Susceptibility and Molecular Characterization of Clinical Isolates of Fusarium verticillioides (F. moniliforme) and Fusarium thapsinum
Mónica Azor, Josepa Gené, Josep Cano, Deanna A. Sutton, Annette W. Fothergill, Michael G. Rinaldi, and Josep Guarro
Antimicrob. Agents Chemother. June 2008 52: 2228-2231; published ahead of print April 7, 2008, doi:10.1128/AAC.00176-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Radiofungicidal Effects of External Gamma Radiation and Antibody-Targeted Beta and Alpha Radiation on Cryptococcus neoformans
Ruth A. Bryan, Xianchun Huang, Alfred Morgenstern, Frank Bruchertseifer, Arturo Casadevall, and Ekaterina Dadachova
Antimicrob. Agents Chemother. June 2008 52: 2232-2235; published ahead of print March 31, 2008, doi:10.1128/AAC.01245-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Anidulafungin against Candida albicans Biofilms
Melissa J. Jacobson, Kerryl E. Piper, Gary Nguyen, James M. Steckelberg, and Robin Patel
Antimicrob. Agents Chemother. June 2008 52: 2242-2243; published ahead of print April 7, 2008, doi:10.1128/AAC.00211-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interactions of DB75, a Novel Antimalarial Agent, with Other Antimalarial Drugs In Vitro
Anne E. Purfield, Richard R. Tidwell, and Steven R. Meshnick
Antimicrob. Agents Chemother. June 2008 52: 2253-2255; published ahead of print March 24, 2008, doi:10.1128/AAC.01536-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clonal Spread of Highly β-Lactam-Resistant Streptococcus pneumoniae Isolates in Taiwan
Yu-Chia Hsieh, Kuang-Yi Chang, Yi-Chuan Huang, Hsiao-Chuan Lin, Yu-Huai Ho, Li-Min Huang, and Po-Ren Hsueh
Antimicrob. Agents Chemother. June 2008 52: 2266-2269; published ahead of print April 14, 2008, doi:10.1128/AAC.00046-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibility of Isolates of Francisella tularensis Types A and B from North America
Sandra K. Urich and Jeannine M. Petersen
Antimicrob. Agents Chemother. June 2008 52: 2276-2278; published ahead of print April 14, 2008, doi:10.1128/AAC.01584-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antistreptococcal Activity of AR-709 Compared to That of Other Agents
Kathy Smith, Lois M. Ednie, Peter C. Appelbaum, Stephen Hawser, and Sergio Lociuro
Antimicrob. Agents Chemother. June 2008 52: 2279-2282; published ahead of print March 24, 2008, doi:10.1128/AAC.01620-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacology:

Cerebrospinal Fluid Compartmental Pharmacokinetics of Amikacin in Neonates
K. Allegaert, I. Scheers, E. Adams, G. Brajanoski, V. Cossey, and B. J. Anderson
Antimicrob. Agents Chemother. June 2008 52: 1934-1939; published ahead of print March 31, 2008, doi:10.1128/AAC.01099-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Apoptosis Induced by Aminoglycosides in LLC-PK1 Cells: Comparative Study of Neomycin, Gentamicin, Amikacin, and Isepamicin Using Electroporation
Sophie Denamur, Françoise Van Bambeke, Marie-Paule Mingeot-Leclercq, and Paul M. Tulkens
Antimicrob. Agents Chemother. June 2008 52: 2236-2238; published ahead of print April 7, 2008, doi:10.1128/AAC.01680-07
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Mechanisms of Resistance:

Delayed Development of Linezolid Resistance in Staphylococcus aureus following Exposure to Low Levels of Antimicrobial Agents
Keith Miller, Alexander J. O'Neill, Mark H. Wilcox, Eileen Ingham, and Ian Chopra
Antimicrob. Agents Chemother. June 2008 52: 1940-1944; published ahead of print March 31, 2008, doi:10.1128/AAC.01302-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of a Naturally Occurring Class D β-Lactamase from Achromobacter xylosoxidans
Yohei Doi, Laurent Poirel, David L. Paterson, and Patrice Nordmann
Antimicrob. Agents Chemother. June 2008 52: 1952-1956; published ahead of print March 24, 2008, doi:10.1128/AAC.01463-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Polyclonal Population Structure of Streptococcus pneumoniae Isolates in Spain Carrying mef and mef plus erm(B)
Elia Gómez G. de la Pedrosa, María-Isabel Morosini, Mark van der Linden, Patricia Ruiz-Garbajosa, Juan Carlos Galán, Fernando Baquero, Ralf René Reinert, and Rafael Cantón
Antimicrob. Agents Chemother. June 2008 52: 1964-1969; published ahead of print March 24, 2008, doi:10.1128/AAC.01487-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates Possessing the Plasmid-Mediated Carbapenem-Hydrolyzing β-Lactamase KPC-2 in Intensive Care Units of a Chinese Hospital
Jia Chang Cai, Hong Wei Zhou, Rong Zhang, and Gong-Xiang Chen
Antimicrob. Agents Chemother. June 2008 52: 2014-2018; published ahead of print March 10, 2008, doi:10.1128/AAC.01539-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Transfer of embB Codon 306 Mutations into Clinical Mycobacterium tuberculosis Strains Alters Susceptibility to Ethambutol, Isoniazid, and Rifampin
Hassan Safi, Brendan Sayers, Manzour H. Hazbón, and David Alland
Antimicrob. Agents Chemother. June 2008 52: 2027-2034; published ahead of print March 31, 2008, doi:10.1128/AAC.01486-07
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Methicillin-Resistant Staphylococcus saprophyticus Isolates Carrying Staphylococcal Cassette Chromosome mec Have Emerged in Urogenital Tract Infections
Masato Higashide, Makoto Kuroda, Carlos Takashi Neves Omura, Miyuki Kumano, Saburo Ohkawa, Sadahiro Ichimura, and Toshiko Ohta
Antimicrob. Agents Chemother. June 2008 52: 2061-2068; published ahead of print March 24, 2008, doi:10.1128/AAC.01150-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Selection and Characterization of Ceftobiprole-Resistant Methicillin-Resistant Staphylococcus aureus
Ritu Banerjee, Michael Gretes, Li Basuino, Natalie Strynadka, and Henry F. Chambers
Antimicrob. Agents Chemother. June 2008 52: 2089-2096; published ahead of print March 31, 2008, doi:10.1128/AAC.01403-07
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Relation between Genetic Markers of Drug Resistance and Susceptibility Profile of Clinical Neisseria gonorrhoeae Strains
Elena N. Ilina, Vladimir A. Vereshchagin, Alexandra D. Borovskaya, Maja V. Malakhova, Sergei V. Sidorenko, Nazar C. Al-Khafaji, Anna A. Kubanova, and Vadim M. Govorun
Antimicrob. Agents Chemother. June 2008 52: 2175-2182; published ahead of print March 31, 2008, doi:10.1128/AAC.01420-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Thymidine-Dependent Small-Colony-Variant Phenotype Is Associated with Hypermutability and Antibiotic Resistance in Clinical Staphylococcus aureus Isolates
Silke Besier, Johannes Zander, Barbara C. Kahl, Peter Kraiczy, Volker Brade, and Thomas A. Wichelhaus
Antimicrob. Agents Chemother. June 2008 52: 2183-2189; published ahead of print March 31, 2008, doi:10.1128/AAC.01395-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Discordant Patterns of Genetic Variation at Two Chloroquine Resistance Loci in Worldwide Populations of the Malaria Parasite Plasmodium falciparum
Rajeev K. Mehlotra, Gabriel Mattera, Moses J. Bockarie, Jason D. Maguire, J. Kevin Baird, Yagya D. Sharma, Michael Alifrangis, Grant Dorsey, Philip J. Rosenthal, David J. Fryauff, James W. Kazura, Mark Stoneking, and Peter A. Zimmerman
Antimicrob. Agents Chemother. June 2008 52: 2212-2222; published ahead of print April 14, 2008, doi:10.1128/AAC.00089-08
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

First Report of cfr-Mediated Resistance to Linezolid in Human Staphylococcal Clinical Isolates Recovered in the United States
Rodrigo E. Mendes, Lalitagauri M. Deshpande, Mariana Castanheira, Joseph DiPersio, Michael A. Saubolle, and Ronald N. Jones
Antimicrob. Agents Chemother. June 2008 52: 2244-2246; published ahead of print April 7, 2008, doi:10.1128/AAC.00231-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biochemical Characterization of Metallo-β-Lactamase VIM-11 from a Pseudomonas aeruginosa Clinical Strain
Patricia Marchiaro, Pablo E. Tomatis, María A. Mussi, Fernando Pasteran, Alejandro M. Viale, Adriana S. Limansky, and Alejandro J. Vila
Antimicrob. Agents Chemother. June 2008 52: 2250-2252; published ahead of print March 24, 2008, doi:10.1128/AAC.01025-07
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Increasing Incidence of Linezolid-Intermediate or -Resistant, Vancomycin-Resistant Enterococcus faecium Strains Parallels Increasing Linezolid Consumption
Marc H. Scheetz, Stephanie A. Knechtel, Michael Malczynski, Michael J. Postelnick, and Chao Qi
Antimicrob. Agents Chemother. June 2008 52: 2256-2259; published ahead of print April 7, 2008, doi:10.1128/AAC.00070-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Macrolide Resistance among Streptococcus pneumoniae Isolates from Russia
Ralf R. Reinert, Olga Y. Filimonova, Adnan Al-Lahham, Svetlana A. Grudinina, Elena N. Ilina, Linda M. Weigel, and Sergey V. Sidorenko
Antimicrob. Agents Chemother. June 2008 52: 2260-2262; published ahead of print March 31, 2008, doi:10.1128/AAC.01270-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Reduced Candida glabrata Susceptibility Secondary to an FKS1 Mutation Developed during Candidemia Treatment
John D. Cleary, Guillermo Garcia-Effron, Stanley W. Chapman, and David S. Perlin
Antimicrob. Agents Chemother. June 2008 52: 2263-2265; published ahead of print March 31, 2008, doi:10.1128/AAC.01568-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Environment of 16S rRNA Methylase Gene rmtD
Yohei Doi, Jennifer M. Adams-Haduch, and David L. Paterson
Antimicrob. Agents Chemother. June 2008 52: 2270-2272; published ahead of print April 7, 2008, doi:10.1128/AAC.00037-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Therapeutics:

Use of Population Pharmacokinetic Modeling and Monte Carlo Simulation To Describe the Pharmacodynamic Profile of Cefditoren in Plasma and Epithelial Lining Fluid
Thomas P. Lodise, Martina Kinzig-Schippers, George L. Drusano, Ulrich Loos, Friedrich Vogel, Jürgen Bulitta, Markus Hinder, and Fritz Sörgel
Antimicrob. Agents Chemother. June 2008 52: 1945-1951; published ahead of print May 7, 2007, doi:10.1128/AAC.00736-06
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetics of Rifampin in Pulmonary Tuberculosis Patients, Including a Semimechanistic Model To Describe Variable Absorption
Justin J. Wilkins, Radojka M. Savic, Mats O. Karlsson, Grant Langdon, Helen McIlleron, Goonaseelan Pillai, Peter J. Smith, and Ulrika S. H. Simonsson
Antimicrob. Agents Chemother. June 2008 52: 2138-2148; published ahead of print April 7, 2008, doi:10.1128/AAC.00461-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Decrease of Atazanavir and Lopinavir Plasma Concentrations in a Boosted Double Human Immunodeficiency Virus Protease Inhibitor Salvage Regimen
Nils von Hentig, Pavel Kaykhin, Christoph Stephan, Errol Babacan, Martin Stürmer, Schlomo Staszewski, and Jörn Lötsch
Antimicrob. Agents Chemother. June 2008 52: 2273-2275; published ahead of print April 14, 2008, doi:10.1128/AAC.01565-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chemistry; Biosynthesis:

Biological Activities of Novel Gyrase Inhibitors of the Aminocoumarin Class
Christine Anderle, Martin Stieger, Matthew Burrell, Stefan Reinelt, Anthony Maxwell, Malcolm Page, and Lutz Heide
Antimicrob. Agents Chemother. June 2008 52: 1982-1990; published ahead of print March 17, 2008, doi:10.1128/AAC.01235-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Action:

Chlamydia pneumoniae Growth Inhibition in Cells by the Steroid Receptor Antagonist RU486 (Mifepristone)
Hiroyuki Yamaguchi, Shigeru Kamiya, Tomonori Uruma, Takako Osaki, Haruhiko Taguchi, Tomoko Hanawa, Minoru Fukuda, Hayato Kawakami, Hajime Goto, Herman Friedman, and Yoshimasa Yamamoto
Antimicrob. Agents Chemother. June 2008 52: 1991-1998; published ahead of print March 17, 2008, doi:10.1128/AAC.01416-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Host Cells Participate in the In Vitro Effects of Novel Diamidine Analogues against Tachyzoites of the Intracellular Apicomplexan Parasites Neospora caninum and Toxoplasma gondii
Angela Leepin, Angela Stüdli, Reto Brun, Chad E. Stephens, David W. Boykin, and Andrew Hemphill
Antimicrob. Agents Chemother. June 2008 52: 1999-2008; published ahead of print March 24, 2008, doi:10.1128/AAC.01236-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of the Essential Cellular Functions of the Two murA Genes of Bacillus anthracis
G. C. Kedar, Vickie Brown-Driver, Daniel R. Reyes, Mark T. Hilgers, Mark A. Stidham, Karen Joy Shaw, John Finn, and Robert J. Haselbeck
Antimicrob. Agents Chemother. June 2008 52: 2009-2013; published ahead of print March 31, 2008, doi:10.1128/AAC.01594-07
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Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae
Mototsugu Yamada, Takashi Watanabe, Nobuyoshi Baba, Yasuo Takeuchi, Fukuichi Ohsawa, and Shuichi Gomi
Antimicrob. Agents Chemother. June 2008 52: 2053-2060; published ahead of print April 7, 2008, doi:10.1128/AAC.01456-07
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Daptomycin Exerts Bactericidal Activity without Lysis of Staphylococcus aureus
Nicole Cotroneo, Robert Harris, Nancy Perlmutter, Terry Beveridge, and Jared A. Silverman
Antimicrob. Agents Chemother. June 2008 52: 2223-2225; published ahead of print March 31, 2008, doi:10.1128/AAC.01410-07
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Bovicin HC5, a Lantibiotic Produced by Streptococcus bovis HC5, Catalyzes the Efflux of Intracellular Potassium but Not ATP
Hilário C. Mantovani and James B. Russell
Antimicrob. Agents Chemother. June 2008 52: 2247-2249; published ahead of print March 17, 2008, doi:10.1128/AAC.00109-08
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Letters:

First Case of Emergence of Atovaquone-Proguanil Resistance in Plasmodium falciparum during Treatment in a Traveler in Comoros
Helene Savini, Hervé Bogreau, Lionel Bertaux, Housem Bouchiba, Philippe Kraemer, Daniel Parzy, Eric Garnotel, Christophe Rogier, Fabrice Simon, and Bruno Pradines
Antimicrob. Agents Chemother. June 2008 52: 2283-2284; published ahead of print April 14, 2008, doi:10.1128/AAC.00282-08
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Chronic Respiratory Infections by Mucoid Carbapenemase-Producing Pseudomonas aeruginosa Strains, a New Potential Public Health Problem
Carlos Juan, Olivia Gutiérrez, Feliu Renom, Margarita Garau, Carmen Gallegos, Sebastián Albertí, José Luis Pérez, and Antonio Oliver
Antimicrob. Agents Chemother. June 2008 52: 2285-2286; published ahead of print April 7, 2008, doi:10.1128/AAC.00076-08
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Nomenclature of Plasmid-Mediated 16S rRNA Methylases Responsible for Panaminoglycoside Resistance
Yohei Doi, Jun-ichi Wachino, and Yoshichika Arakawa
Antimicrob. Agents Chemother. June 2008 52: 2287-2288; published ahead of print March 31, 2008, doi:10.1128/AAC.00022-08
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IMP-15-Producing Pseudomonas aeruginosa Strain Isolated in a U.S. Medical Center: a Recent Arrival from Mexico
Craig A. Martin, Kazumi Morita, Julie A. Ribes, Lalitagauri M. Deshpande, Helio S. Sader, and Mariana Castanheira
Antimicrob. Agents Chemother. June 2008 52: 2289-2290; published ahead of print March 24, 2008, doi:10.1128/AAC.00299-08
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Evaluation of the VITEK 2 Advanced Expert System for Reporting Piperacillin Susceptibility in Klebsiella spp.
So-Young Lee, Jin Kyung Yu, Sang Yoon Lee, Sang Hyun Shin, Hae-Il Park, Eun-Jee Oh, and Yeon-Joon Park
Antimicrob. Agents Chemother. June 2008 52: 2291-2292; published ahead of print April 7, 2008, doi:10.1128/AAC.01610-07
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Plasma and Cerebrospinal Fluid Pharmacokinetics of Moxifloxacin in a Patient with Tuberculous Meningitis
J. W. C. Alffenaar, P. M. de Vries, G. J. Luijckx, D. van Soolingen, T. S. van der Werf, and R. van Altena
Antimicrob. Agents Chemother. June 2008 52: 2293-2295; published ahead of print March 24, 2008, doi:10.1128/AAC.01637-07
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Errata:

Transcriptional Response of Candida parapsilosis following Exposure to Farnesol
Tristan Rossignol, Mary E. Logue, Kieran Reynolds, Muriel Grenon, Noel F. Lowndes, and Geraldine Butler
Antimicrob. Agents Chemother. June 2008 52: 2296
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