AAC -- Table of Contents (July 1 2008, 52 [7])

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Contents: July 2008, Volume 52, Issue 7

       Guest Commentary

       Pharmacology

       Mechanisms of Resistance

       Mechanisms of Action

       Susceptibility

       Experimental Therapeutics

       Antiviral Agents

       Clinical Therapeutics

       Biologic Response Modifiers

       Letters

       Errata

Other Issues

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Guest Commentary:

qnr Gene Nomenclature
George Jacoby, Vincent Cattoir, David Hooper, Luis Martínez-Martínez, Patrice Nordmann, Alvaro Pascual, Laurent Poirel, and Minggui Wang
Antimicrob. Agents Chemother. July 2008 52: 2297-2299; published ahead of print April 21, 2008, doi:10.1128/AAC.00147-08
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Pharmacology:

Telavancin Penetration into Human Epithelial Lining Fluid Determined by Population Pharmacokinetic Modeling and Monte Carlo Simulation
Thomas P. Lodise, Jr., Mark Gotfried, Steven Barriere, and George L. Drusano
Antimicrob. Agents Chemother. July 2008 52: 2300-2304; published ahead of print April 21, 2008, doi:10.1128/AAC.01110-07
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Effect of Impaired Renal Function on the Pharmacokinetics of Tomopenem (RO4908463/CS-023), a Novel Carbapenem
Navita L. Mallalieu, Siân Lennon, Mei Liu, Christopher Kirkpatrick, Richard Robson, Eric Luedin, and Brian E. Davies
Antimicrob. Agents Chemother. July 2008 52: 2360-2366; published ahead of print April 28, 2008, doi:10.1128/AAC.01249-07
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In Vivo Pharmacodynamic Profiling of Doripenem against Pseudomonas aeruginosa by Simulating Human Exposures
Aryun Kim, Mary Anne Banevicius, and David P. Nicolau
Antimicrob. Agents Chemother. July 2008 52: 2497-2502; published ahead of print May 5, 2008, doi:10.1128/AAC.01252-07
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Pharmacokinetics and Tissue Distribution of Anidulafungin in Rats
Bharat Damle, Martin Stogniew, and James Dowell
Antimicrob. Agents Chemother. July 2008 52: 2673-2676; published ahead of print April 28, 2008, doi:10.1128/AAC.01596-07
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Mechanisms of Resistance:

A Naturally Occurring Proline-to-Alanine Amino Acid Change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis Accounts for Reduced Echinocandin Susceptibility
Guillermo Garcia-Effron, Santosh K. Katiyar, Steven Park, Thomas D. Edlind, and David S. Perlin
Antimicrob. Agents Chemother. July 2008 52: 2305-2312; published ahead of print April 28, 2008, doi:10.1128/AAC.00262-08
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Fitness Trade-Offs in bla_TEM Evolution
Joanna E. Mroczkowska and Miriam Barlow
Antimicrob. Agents Chemother. July 2008 52: 2340-2345; published ahead of print April 28, 2008, doi:10.1128/AAC.00018-08
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Changes in the Plasmodial Surface Anion Channel Reduce Leupeptin Uptake and Can Confer Drug Resistance in Plasmodium falciparum-Infected Erythrocytes
Godfrey Lisk, Margaret Pain, Ilya Y. Gluzman, Shivkumar Kambhampati, Tetsuya Furuya, Xin-zhuan Su, Michael P. Fay, Daniel E. Goldberg, and Sanjay A. Desai
Antimicrob. Agents Chemother. July 2008 52: 2346-2354; published ahead of print April 28, 2008, doi:10.1128/AAC.00057-08
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Mutational Events in Cefotaximase Extended-Spectrum β-Lactamases of the CTX-M-1 Cluster Involved in Ceftazidime Resistance
Ângela Novais, Rafael Cantón, Teresa M. Coque, Andrés Moya, Fernando Baquero, and Juan Carlos Galán
Antimicrob. Agents Chemother. July 2008 52: 2377-2382; published ahead of print April 28, 2008, doi:10.1128/AAC.01658-07
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ramR Mutations Involved in Efflux-Mediated Multidrug Resistance in Salmonella enterica Serovar Typhimurium
Yousef M. Abouzeed, Sylvie Baucheron, and Axel Cloeckaert
Antimicrob. Agents Chemother. July 2008 52: 2428-2434; published ahead of print April 28, 2008, doi:10.1128/AAC.00084-08
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Molecular Survey of β-Lactamases Conferring Resistance to Newer β-Lactams in Enterobacteriaceae Isolates from Polish Hospitals
Joanna Empel, Anna Baraniak, Elzbieta Literacka, Agnieszka Mrówka, Janusz Fiett, Ewa Sadowy, Waleria Hryniewicz, Marek Gniadkowski and the Beta-PL Study Group
Antimicrob. Agents Chemother. July 2008 52: 2449-2454; published ahead of print May 5, 2008, doi:10.1128/AAC.00043-08
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Resistance and Virulence of Pseudomonas aeruginosa Clinical Strains Overproducing the MexCD-OprJ Efflux Pump
Katy Jeannot, Sylvie Elsen, Thilo Köhler, Ina Attree, Christian van Delden, and Patrick Plésiat
Antimicrob. Agents Chemother. July 2008 52: 2455-2462; published ahead of print May 12, 2008, doi:10.1128/AAC.01107-07
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Functional Diversity among Metallo-β-Lactamases: Characterization of the CAR-1 Enzyme of Erwinia carotovora
Magdalena Stoczko, Jean-Marie Frère, Gian Maria Rossolini, and Jean-Denis Docquier
Antimicrob. Agents Chemother. July 2008 52: 2473-2479; published ahead of print April 28, 2008, doi:10.1128/AAC.01062-07
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Identification of a Novel Multidrug Efflux Pump of Mycobacterium tuberculosis
Olga Danilchanka, Claudia Mailaender, and Michael Niederweis
Antimicrob. Agents Chemother. July 2008 52: 2503-2511; published ahead of print May 5, 2008, doi:10.1128/AAC.00298-08
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SGI2, a Relative of Salmonella Genomic Island SGI1 with an Independent Origin
Renee S. Levings, Steven P. Djordjevic, and Ruth M. Hall
Antimicrob. Agents Chemother. July 2008 52: 2529-2537; published ahead of print April 28, 2008, doi:10.1128/AAC.00189-08
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Acquisition of a Plasmid-Borne bla_OXA-58 Gene with an Upstream IS1008 Insertion Conferring a High Level of Carbapenem Resistance to Acinetobacter baumannii
Te-Li Chen, Roy Chen-Chih Wu, Men-Fang Shaio, Chang-Phone Fung, and Wen-Long Cho
Antimicrob. Agents Chemother. July 2008 52: 2573-2580; published ahead of print April 28, 2008, doi:10.1128/AAC.00393-08
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Sequence of Conjugative Plasmid pIP1206 Mediating Resistance to Aminoglycosides by 16S rRNA Methylation and to Hydrophilic Fluoroquinolones by Efflux
Bruno Périchon, Pierre Bogaerts, Thierry Lambert, Lionel Frangeul, Patrice Courvalin, and Marc Galimand
Antimicrob. Agents Chemother. July 2008 52: 2581-2592; published ahead of print May 5, 2008, doi:10.1128/AAC.01540-07
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Whole-Genome Pyrosequencing of an Epidemic Multidrug-Resistant Acinetobacter baumannii Strain Belonging to the European Clone II Group
Michele Iacono, Laura Villa, Daniela Fortini, Roberta Bordoni, Francesco Imperi, Raoul J. P. Bonnal, Thomas Sicheritz-Ponten, Gianluca De Bellis, Paolo Visca, Antonio Cassone, and Alessandra Carattoli
Antimicrob. Agents Chemother. July 2008 52: 2616-2625; published ahead of print April 14, 2008, doi:10.1128/AAC.01643-07
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Typing of SHV Extended-Spectrum β-Lactamases by Pyrosequencing in Klebsiella pneumoniae Strains with Chromosomal SHV β-Lactamase
Marjo Haanperä, Sofia D. Forssten, Pentti Huovinen, and Jari Jalava
Antimicrob. Agents Chemother. July 2008 52: 2632-2635; published ahead of print May 5, 2008, doi:10.1128/AAC.01259-07
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Gene Amplification of the Multidrug Resistance 1 Gene of Plasmodium vivax Isolates from Thailand, Laos, and Myanmar
Mallika Imwong, Sasithon Pukrittayakamee, Wirichada Pongtavornpinyo, Supatchara Nakeesathit, Shalini Nair, Paul Newton, Francois Nosten, Timothy J. C. Anderson, Arjen Dondorp, Nicholas P. J. Day, and Nicholas J. White
Antimicrob. Agents Chemother. July 2008 52: 2657-2659; published ahead of print April 28, 2008, doi:10.1128/AAC.01459-07
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Molecular Characterization of Enterococcus faecalis N06-0364 with Low-Level Vancomycin Resistance Harboring a Novel D-Ala-D-Ser Gene Cluster, vanL
David A. Boyd, Barbara M. Willey, Darlene Fawcett, Nazira Gillani, and Michael R. Mulvey
Antimicrob. Agents Chemother. July 2008 52: 2667-2672; published ahead of print May 5, 2008, doi:10.1128/AAC.01516-07
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Presence of Plasmid-Mediated Quinolone Resistance in Klebsiella pneumoniae Isolates Possessing bla_KPC in the United States
Andrea Endimiani, Lenore L. Carias, Andrea M. Hujer, Christopher R. Bethel, Kristine M. Hujer, Federico Perez, Rebecca A. Hutton, William R. Fox, Geraldine S. Hall, Michael R. Jacobs, David L. Paterson, Louis B. Rice, Stephen G. Jenkins, Fred C. Tenover, and Robert A. Bonomo
Antimicrob. Agents Chemother. July 2008 52: 2680-2682; published ahead of print April 21, 2008, doi:10.1128/AAC.00158-08
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Accumulation of ^99mTc-Ciprofloxacin in Staphylococcus aureus and Pseudomonas aeruginosa
J. M. Sierra, D. Rodriguez-Puig, A. Soriano, J. Mensa, C. Piera, and J. Vila
Antimicrob. Agents Chemother. July 2008 52: 2691-2692; published ahead of print May 12, 2008, doi:10.1128/AAC.00217-08
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Mechanisms of Action:

In Vitro Evaluation of CBR-2092, a Novel Rifamycin-Quinolone Hybrid Antibiotic: Studies of the Mode of Action in Staphylococcus aureus
Gregory T. Robertson, Eric J. Bonventre, Timothy B. Doyle, Qun Du, Leonard Duncan, Timothy W. Morris, Eric D. Roche, Dalai Yan, and A. Simon Lynch
Antimicrob. Agents Chemother. July 2008 52: 2313-2323; published ahead of print April 28, 2008, doi:10.1128/AAC.01649-07
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The Human CXC Chemokine Granulocyte Chemotactic Protein 2 (GCP-2)/CXCL6 Possesses Membrane-Disrupting Properties and Is Antibacterial
Helena M. Linge, Mattias Collin, Pontus Nordenfelt, Matthias Mörgelin, Martin Malmsten, and Arne Egesten
Antimicrob. Agents Chemother. July 2008 52: 2599-2607; published ahead of print April 28, 2008, doi:10.1128/AAC.00028-08
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Susceptibility:

In Vitro Evaluation of CBR-2092, a Novel Rifamycin-Quinolone Hybrid Antibiotic: Microbiology Profiling Studies with Staphylococci and Streptococci
Gregory T. Robertson, Eric J. Bonventre, Timothy B. Doyle, Qun Du, Leonard Duncan, Timothy W. Morris, Eric D. Roche, Dalai Yan, and A. Simon Lynch
Antimicrob. Agents Chemother. July 2008 52: 2324-2334; published ahead of print April 28, 2008, doi:10.1128/AAC.01651-07
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Surveillance Study of Telavancin Activity against Recently Collected Gram-Positive Clinical Isolates from across the United States
Deborah C. Draghi, Bret M. Benton, Kevin M. Krause, Clyde Thornsberry, Chris Pillar, and Daniel F. Sahm
Antimicrob. Agents Chemother. July 2008 52: 2383-2388; published ahead of print April 28, 2008, doi:10.1128/AAC.01641-07
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Low β-Lactamase-Negative Ampicillin-Resistant Haemophilus influenzae Strains Are Best Detected by Testing Amoxicillin Susceptibility by the Broth Microdilution Method
Silvia García-Cobos, José Campos, Federico Román, Cristina Carrera, María Pérez-Vázquez, Belén Aracil, and Jesús Oteo
Antimicrob. Agents Chemother. July 2008 52: 2407-2414; published ahead of print April 28, 2008, doi:10.1128/AAC.00214-08
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Trypanocidal and Leishmanicidal Activities of Sesquiterpene Lactones from Ambrosia tenuifolia Sprengel (Asteraceae)
Valeria P. Sülsen, Fernanda M. Frank, Silvia I. Cazorla, Claudia A. Anesini, Emilio L. Malchiodi, Blanca Freixa, Roser Vila, Liliana V. Muschietti, and Virginia S. Martino
Antimicrob. Agents Chemother. July 2008 52: 2415-2419; published ahead of print April 28, 2008, doi:10.1128/AAC.01630-07
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Stronger Activity of Human Immunodeficiency Virus Type 1 Protease Inhibitors against Clinical Isolates of Plasmodium vivax than against Those of P. falciparum
U. Lek-Uthai, R. Suwanarusk, R. Ruengweerayut, T. S. Skinner-Adams, F. Nosten, D. L. Gardiner, P. Boonma, K. A. Piera, K. T. Andrews, B. MacHunter, J. S. McCarthy, N. M. Anstey, R. N. Price, and B. Russell
Antimicrob. Agents Chemother. July 2008 52: 2435-2441; published ahead of print April 28, 2008, doi:10.1128/AAC.00169-08
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Potent In Vitro Antifungal Activities of Naturally Occurring Acetylenic Acids
Xing-Cong Li, Melissa R. Jacob, Shabana I. Khan, M. Khalid Ashfaq, K. Suresh Babu, Ameeta K. Agarwal, Hala N. ElSohly, Susan P. Manly, and Alice M. Clark
Antimicrob. Agents Chemother. July 2008 52: 2442-2448; published ahead of print May 5, 2008, doi:10.1128/AAC.01297-07
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Epidemiological Cutoffs and Cross-Resistance to Azole Drugs in Aspergillus fumigatus
Juan Luis Rodriguez-Tudela, Laura Alcazar-Fuoli, Emilia Mellado, Ana Alastruey-Izquierdo, Araceli Monzon, and Manuel Cuenca-Estrella
Antimicrob. Agents Chemother. July 2008 52: 2468-2472; published ahead of print May 12, 2008, doi:10.1128/AAC.00156-08
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Connection between Trimethoprim-Sulfamethoxazole Use and Resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis
Pauliina Kärpänoja, Solja T. Nyberg, Miika Bergman, Tinna Voipio, Pirkko Paakkari, Pentti Huovinen, Hannu Sarkkinen and the Finnish Study Group for Antimicrobial Resistance (FiRe Network)
Antimicrob. Agents Chemother. July 2008 52: 2480-2485; published ahead of print April 28, 2008, doi:10.1128/AAC.01118-07
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Use of an In Vitro Pharmacodynamic Model To Derive a Linezolid Regimen That Optimizes Bacterial Kill and Prevents Emergence of Resistance in Bacillus anthracis
A. Louie, H. S. Heine, K. Kim, D. L. Brown, B. VanScoy, W. Liu, M. Kinzig-Schippers, F. Sörgel, and G. L. Drusano
Antimicrob. Agents Chemother. July 2008 52: 2486-2496; published ahead of print May 5, 2008, doi:10.1128/AAC.01439-07
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Genetic and Physiological Effects of Noncoherent Visible Light Combined with Hydrogen Peroxide on Streptococcus mutans in Biofilm
Doron Steinberg, Daniel Moreinos, John Featherstone, Moshe Shemesh, and Osnat Feuerstein
Antimicrob. Agents Chemother. July 2008 52: 2626-2631; published ahead of print March 3, 2008, doi:10.1128/AAC.01666-07
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Posaconazole Enhances the Activity of Amphotericin B against Hyphae of Zygomycetes In Vitro
Susanne Perkhofer, Maria Locher, Manuel Cuenca-Estrella, Reinhard Rüchel, Reinhard Würzner, Manfred P. Dierich, and Cornelia Lass-Flörl
Antimicrob. Agents Chemother. July 2008 52: 2636-2638; published ahead of print May 5, 2008, doi:10.1128/AAC.00492-08
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Prevalence of Serotype 19A Streptococcus pneumoniae among Isolates from U.S. Children in 2005-2006 and Activity of Faropenem
Ian A. Critchley, Michael R. Jacobs, Steven D. Brown, Maria M. Traczewski, Glenn S. Tillotson, and Nebojsa Janjic
Antimicrob. Agents Chemother. July 2008 52: 2639-2643; published ahead of print April 28, 2008, doi:10.1128/AAC.00310-08
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In Vitro Activity of Telavancin against Resistant Gram-Positive Bacteria
Kevin M. Krause, Marika Renelli, Stacey Difuntorum, Terry X. Wu, Dmitri V. Debabov, and Bret M. Benton
Antimicrob. Agents Chemother. July 2008 52: 2647-2652; published ahead of print April 28, 2008, doi:10.1128/AAC.01398-07
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Synergy of Human Immunodeficiency Virus Protease Inhibitors with Chloroquine against Plasmodium falciparum In Vitro and Plasmodium chabaudi In Vivo
Zhengxiang He, Li Qin, Lili Chen, Nanzheng Peng, Jianlan You, and Xiaoping Chen
Antimicrob. Agents Chemother. July 2008 52: 2653-2656; published ahead of print April 28, 2008, doi:10.1128/AAC.01329-07
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Susceptibility of Chlamydia trachomatis to the Excipient Hydroxyethyl Cellulose: pH and Concentration Dependence of Antimicrobial Activity
Ali A. Abdul Sater, David M. Ojcius, and Matthew P. Meyer
Antimicrob. Agents Chemother. July 2008 52: 2660-2662; published ahead of print April 14, 2008, doi:10.1128/AAC.00785-07
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In Vitro Antibacterial Activity of CE-156811, a Novel Analog Derived from Hygromycin A
Gregory G. Stone, Dennis Girard, Steve Finegan, Joan Duignan, John Schafer, Meghan Maloney, Richard P. Zaniewski, Steven J. Brickner, Sarah K. Wade, Phuong T. Le, and Michael D. Huband
Antimicrob. Agents Chemother. July 2008 52: 2663-2666; published ahead of print April 21, 2008, doi:10.1128/AAC.01326-07
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In Vitro Activities of Tigecycline against Clinical Isolates of Aeromonas, Vibrio, and Salmonella Species in Taiwan
Chia-Ying Liu, Yu-Tsung Huang, Chun-Hsing Liao, and Po-Ren Hsueh
Antimicrob. Agents Chemother. July 2008 52: 2677-2679; published ahead of print May 12, 2008, doi:10.1128/AAC.00002-08
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Species Distribution and In Vitro Antifungal Susceptibility Patterns of 75 Clinical Isolates of Fusarium spp. from Northern Italy
Anna Maria Tortorano, Anna Prigitano, Giovanna Dho, Maria Carmela Esposto, Claudia Gianni, Anna Grancini, Cristina Ossi, and Maria Anna Viviani
Antimicrob. Agents Chemother. July 2008 52: 2683-2685; published ahead of print April 28, 2008, doi:10.1128/AAC.00272-08
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Resistance Trends of the Bacteroides fragilis Group over a 10-Year Period, 1997 to 2006, in Madrid, Spain
Carmen Betriu, Esther Culebras, María Gómez, Fátima López, Iciar Rodríguez-Avial, and Juan J. Picazo
Antimicrob. Agents Chemother. July 2008 52: 2686-2690; published ahead of print May 12, 2008, doi:10.1128/AAC.00081-08
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Experimental Therapeutics:

Local Treatment of Experimental Pseudomonas aeruginosa Osteomyelitis with a Biodegradable Dilactide Polymer Releasing Ciprofloxacin
Kyriaki Kanellakopoulou, George C. Thivaios, Maria Kolia, Ismini Dontas, Lydia Nakopoulou, Eleftherios Dounis, Evangelos J. Giamarellos-Bourboulis, Andreas Andreopoulos, Panayotis Karagiannakos, and Helen Giamarellou
Antimicrob. Agents Chemother. July 2008 52: 2335-2339; published ahead of print April 14, 2008, doi:10.1128/AAC.01360-07
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Activities and Ultrastructural Effects of Antifungal Combinations against Simulated Candida Endocardial Vegetations
Manjunath P. Pai, Marie L. Samples, Renee-Claude Mercier, and Michael N. Spilde
Antimicrob. Agents Chemother. July 2008 52: 2367-2376; published ahead of print April 21, 2008, doi:10.1128/AAC.01557-07
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Pharmacodynamic Characterization of Ceftobiprole in Experimental Pneumonia Caused by Phenotypically Diverse Staphylococcus aureus Strains
Somvadee Laohavaleeson, Pamela R. Tessier, and David P. Nicolau
Antimicrob. Agents Chemother. July 2008 52: 2389-2394; published ahead of print April 14, 2008, doi:10.1128/AAC.01422-07
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Daptomycin Is Effective in Treatment of Experimental Endocarditis Due to Methicillin-Resistant and Glycopeptide-Intermediate Staphylococcus aureus
Francesc Marco, Cristina García de la Mària, Yolanda Armero, Eurídice Amat, Dolors Soy, Asunción Moreno, Ana del Río, Manel Almela, Carlos A. Mestres, José M. Gatell, María Teresa Jiménez de Anta, José M. Miró for the Hospital Clinic Experimental Endocarditis Study Group
Antimicrob. Agents Chemother. July 2008 52: 2538-2543; published ahead of print April 21, 2008, doi:10.1128/AAC.00510-07
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Assessment of Aspergillus fumigatus Burden in Pulmonary Tissue of Guinea Pigs by Quantitative PCR, Galactomannan Enzyme Immunoassay, and Quantitative Culture
Ana C. Vallor, William R. Kirkpatrick, Laura K. Najvar, Rosie Bocanegra, Marsha C. Kinney, Annette W. Fothergill, Monica L. Herrera, Brian L. Wickes, John R. Graybill, and Thomas F. Patterson
Antimicrob. Agents Chemother. July 2008 52: 2593-2598; published ahead of print May 12, 2008, doi:10.1128/AAC.00276-08
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Antiviral Agents:

Long-Term Suppression of Hepatitis B Virus Replication by Short Hairpin RNA Expression Using the Scaffold/Matrix Attachment Region-Based Replicating Vector System pEPI-1
Andreas C. W. Jenke, Andreas D. Wilhelm, Valerie Orth, Hans Joachim Lipps, Ulrike Protzer, and Stefan Wirth
Antimicrob. Agents Chemother. July 2008 52: 2355-2359; published ahead of print May 12, 2008, doi:10.1128/AAC.00067-08
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Establishment of a Cell-Based Assay for Screening of Compounds Inhibiting Very Early Events in the Cytomegalovirus Replication Cycle and Characterization of a Compound Identified Using the Assay
Yoshiko Fukui, Keiko Shindoh, Yumiko Yamamoto, Shin Koyano, Isao Kosugi, Toyofumi Yamaguchi, Ichiro Kurane, and Naoki Inoue
Antimicrob. Agents Chemother. July 2008 52: 2420-2427; published ahead of print May 5, 2008, doi:10.1128/AAC.00134-08
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Nonclinical Safety Profile of Telbivudine, a Novel Potent Antiviral Agent for Treatment of Hepatitis B
Edward G. Bridges, Jules R. Selden, and Shouqi Luo
Antimicrob. Agents Chemother. July 2008 52: 2521-2528; published ahead of print May 12, 2008, doi:10.1128/AAC.00029-08
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Human Immunodeficiency Virus Type 1 (HIV-1) Integration: a Potential Target for Microbicides To Prevent Cell-Free or Cell-Associated HIV-1 Infection
Katty Terrazas-Aranda, Yven Van Herrewege, Daria Hazuda, Paul Lewi, Roberta Costi, Roberto Di Santo, Andrea Cara, and Guido Vanham
Antimicrob. Agents Chemother. July 2008 52: 2544-2554; published ahead of print May 12, 2008, doi:10.1128/AAC.01627-07
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High Levels of Zidovudine (AZT) and Its Intracellular Phosphate Metabolites in AZT- and AZT-Lamivudine-Treated Newborns of Human Immunodeficiency Virus-Infected Mothers
Lucie Durand-Gasselin, Alain Pruvost, Axelle Dehée, Genevieve Vaudre, Marie-Dominique Tabone, Jacques Grassi, Guy Leverger, Antoine Garbarg-Chenon, Henri Bénech, and Catherine Dollfus
Antimicrob. Agents Chemother. July 2008 52: 2555-2563; published ahead of print April 21, 2008, doi:10.1128/AAC.01130-07
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Suppression of Dualtropic Human Immunodeficiency Virus Type 1 by the CXCR4 Antagonist AMD3100 Is Associated with Efficiency of CXCR4 Use and Baseline Virus Composition
Signe Fransen, Gary Bridger, Jeannette M. Whitcomb, Jonathan Toma, Eric Stawiski, Neil Parkin, Christos J. Petropoulos, and Wei Huang
Antimicrob. Agents Chemother. July 2008 52: 2608-2615; published ahead of print April 28, 2008, doi:10.1128/AAC.01226-07
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Clinical Therapeutics:

Systemic Expression of Cytokine Production in Patients with Severe Pneumococcal Pneumonia: Effects of Treatment with a β-Lactam versus a Fluoroquinolone
Esther Calbo, Montserrat Alsina, Mónica Rodríguez-Carballeira, Josep Lite, and Javier Garau
Antimicrob. Agents Chemother. July 2008 52: 2395-2402; published ahead of print April 21, 2008, doi:10.1128/AAC.00658-07
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Both Oral Metronidazole and Oral Vancomycin Promote Persistent Overgrowth of Vancomycin-Resistant Enterococci during Treatment of Clostridium difficile-Associated Disease
Wafa N. Al-Nassir, Ajay K. Sethi, Yuejin Li, Michael J. Pultz, Michelle M. Riggs, and Curtis J. Donskey
Antimicrob. Agents Chemother. July 2008 52: 2403-2406; published ahead of print April 28, 2008, doi:10.1128/AAC.00090-08
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Addition of Rifampin to Standard Therapy for Treatment of Native Valve Infective Endocarditis Caused by Staphylococcus aureus
David J. Riedel, Elizabeth Weekes, and Graeme N. Forrest
Antimicrob. Agents Chemother. July 2008 52: 2463-2467; published ahead of print May 12, 2008, doi:10.1128/AAC.00300-08
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Pharmacodynamic Analysis and Clinical Trial of Amoxicillin Sprinkle Administered Once Daily for 7 Days Compared to Penicillin V Potassium Administered Four Times Daily for 10 Days in the Treatment of Tonsillopharyngitis Due to Streptococcus pyogenes in Children
M. E. Pichichero, J. R. Casey, S. L. Block, R. Guttendorf, H. Flanner, D. Markowitz, and S. Clausen
Antimicrob. Agents Chemother. July 2008 52: 2512-2520; published ahead of print March 10, 2008, doi:10.1128/AAC.00132-07
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Reduced Tissue Parasitic Load and Infectivity to Sand Flies in Dogs Naturally Infected by Leishmania (Leishmania) chagasi following Treatment with a Liposome Formulation of Meglumine Antimoniate
Raul R. Ribeiro, Eliane P. Moura, Vitor M. Pimentel, Weverton M. Sampaio, Sydnei M. Silva, Dante A. Schettini, Cintia F. Alves, Ferdinan A. Melo, Wagner L. Tafuri, Cynthia Demicheli, Maria N. Melo, Frédéric Frézard, and Marilene S. M. Michalick
Antimicrob. Agents Chemother. July 2008 52: 2564-2572; published ahead of print May 5, 2008, doi:10.1128/AAC.00223-08
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Biologic Response Modifiers:

Impact of Mycophenolic Acid on the Functionality of Human Polymorphonuclear Neutrophils and Dendritic Cells during Interaction with Aspergillus fumigatus
Markus Mezger, Iwona Wozniok, Christian Blockhaus, Oliver Kurzai, Holger Hebart, Hermann Einsele, and Juergen Loeffler
Antimicrob. Agents Chemother. July 2008 52: 2644-2646; published ahead of print April 21, 2008, doi:10.1128/AAC.01618-07
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Letters:

Diversity of Penicillin Binding Proteins among Clinical Streptococcus pneumoniae Strains from Portugal
Ricardo Dias, David Félix, and Manuela Caniça
Antimicrob. Agents Chemother. July 2008 52: 2693-2695; published ahead of print May 27, 2008, doi:10.1128/AAC.01655-07
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Genome Size and Antibiotic Resistance
Stuart B. Levy
Antimicrob. Agents Chemother. July 2008 52: 2696
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Errata:

In Vitro Model of Colonization Resistance by the Enteric Microbiota: Effects of Antimicrobial Agents Used in Food-Producing Animals
R. Doug Wagner, Shemedia J. Johnson, and Carl E. Cerniglia
Antimicrob. Agents Chemother. July 2008 52: 2697
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