Contents: September 2008, Volume 52, Issue 9        Mechanisms of Resistance        Pharmacology        Clinical Therapeutics        Antiviral Agents        Mechanisms of Action        Chemistry; Biosynthesis        Experimental Therapeutics        Susceptibility        Biologic Response Modifiers        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

---

Mechanisms of Resistance:

---

Correlation of Antimicrobial Resistance with β-Lactamases, the OmpA-Like Porin, and Efflux Pumps in Clinical Isolates of Acinetobacter baumannii Endemic to New York City Simona Bratu, David Landman, Don Antonio Martin, Claudiu Georgescu, and John Quale Antimicrob. Agents Chemother. September 2008 52: 2999-3005; published ahead of print June 30, 2008, doi:10.1128/AAC.01684-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inducible Resistance of Fish Bacterial Pathogens to the Antimicrobial Peptide Cecropin B Ulysses W. Sallum and Thomas T. Chen Antimicrob. Agents Chemother. September 2008 52: 3006-3012; published ahead of print May 12, 2008, doi:10.1128/AAC.00023-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Extended-Spectrum β-Lactamase Production Is Associated with an Increase in Cell Invasion and Expression of Fimbrial Adhesins in Klebsiella pneumoniae H. Sahly, S. Navon-Venezia, L. Roesler, A. Hay, Y. Carmeli, R. Podschun, C. Hennequin, C. Forestier, and I. Ofek Antimicrob. Agents Chemother. September 2008 52: 3029-3034; published ahead of print June 23, 2008, doi:10.1128/AAC.00010-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Functional Cloning and Characterization of the Multidrug Efflux Pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli Feng Long, Corinne Rouquette-Loughlin, William M. Shafer, and Edward W. Yu Antimicrob. Agents Chemother. September 2008 52: 3052-3060; published ahead of print June 30, 2008, doi:10.1128/AAC.00475-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Mutations in the fks1 Gene in Candida albicans, C. tropicalis, and C. krusei Correlate with Elevated Caspofungin MICs Uncovered in AM3 Medium Using the Method of the European Committee on Antibiotic Susceptibility Testing Marie Desnos-Ollivier, Stéphane Bretagne, Dorothée Raoux, Damien Hoinard, Françoise Dromer, and Eric Dannaoui Antimicrob. Agents Chemother. September 2008 52: 3092-3098; published ahead of print June 30, 2008, doi:10.1128/AAC.00088-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Complete Sequence of p07-406, a 24,179-Base-Pair Plasmid Harboring the blaVIM-7 Metallo-β-Lactamase Gene in a Pseudomonas aeruginosa Isolate from the United States Hongyang Li, Mark A. Toleman, Peter M. Bennett, Ronald N. Jones, and Timothy R. Walsh Antimicrob. Agents Chemother. September 2008 52: 3099-3105; published ahead of print June 30, 2008, doi:10.1128/AAC.01093-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of Porins for Uptake of Antibiotics by Mycobacterium smegmatis Olga Danilchanka, Mikhail Pavlenok, and Michael Niederweis Antimicrob. Agents Chemother. September 2008 52: 3127-3134; published ahead of print June 16, 2008, doi:10.1128/AAC.00239-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Genotyping as a Tool for Antibiotic Resistance Surveillance of Neisseria gonorrhoeae in New Caledonia: Evidence of a Novel Genotype Associated with Reduced Penicillin Susceptibility Frédérique Vernel-Pauillac, Sobhan Nandi, Robert A. Nicholas, and Cyrille Goarant Antimicrob. Agents Chemother. September 2008 52: 3293-3300; published ahead of print June 30, 2008, doi:10.1128/AAC.00020-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Convergent Evolutionary Analysis Identifies Significant Mutations in Drug Resistance Targets of Mycobacterium tuberculosis Manzour Hernando Hazbón, Alifiya S. Motiwala, Magali Cavatore, Michael Brimacombe, Thomas S. Whittam, and David Alland Antimicrob. Agents Chemother. September 2008 52: 3369-3376; published ahead of print June 30, 2008, doi:10.1128/AAC.00309-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Recombination and Selection Can Remove blaTEM Alleles from Bacterial Populations Joanna E. Mroczkowska and Miriam Barlow Antimicrob. Agents Chemother. September 2008 52: 3408-3410; published ahead of print July 14, 2008, doi:10.1128/AAC.00501-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The KQ Element, a Complex Genetic Region Conferring Transferable Resistance to Carbapenems, Aminoglycosides, and Fluoroquinolones in Klebsiella pneumoniae Louis B. Rice, Lenore L. Carias, Rebecca A. Hutton, Susan D. Rudin, Andrea Endimiani, and Robert A. Bonomo Antimicrob. Agents Chemother. September 2008 52: 3427-3429; published ahead of print June 23, 2008, doi:10.1128/AAC.00493-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Real-Time PCR and Statistical Analyses of acrAB and ramA Expression in Clinical Isolates of Klebsiella pneumoniae Alexey Ruzin, Frederick W. Immermann, and Patricia A. Bradford Antimicrob. Agents Chemother. September 2008 52: 3430-3432; published ahead of print July 14, 2008, doi:10.1128/AAC.00591-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Pharmacology:

---

Pharmacokinetics and Tolerability of Oseltamivir Combined with Probenecid Mark Holodniy, Scott R. Penzak, Timothy M. Straight, Richard T. Davey, Kelvin K. Lee, Matthew Bidwell Goetz, Dennis W. Raisch, Francesca Cunningham, Emil T. Lin, Noemi Olivo, and Lawrence R. Deyton Antimicrob. Agents Chemother. September 2008 52: 3013-3021; published ahead of print June 16, 2008, doi:10.1128/AAC.00047-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evaluation of Daptomycin Pharmacodynamics and Resistance at Various Dosage Regimens against Staphylococcus aureus Isolates with Reduced Susceptibilities to Daptomycin in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations Warren E. Rose, Steven N. Leonard, and Michael J. Rybak Antimicrob. Agents Chemother. September 2008 52: 3061-3067; published ahead of print June 30, 2008, doi:10.1128/AAC.00102-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lung Microdialysis Study of Levofloxacin in Rats following Intravenous Infusion at Steady State Sandrine Marchand, Denis Frasca, Claire Dahyot-Fizelier, Céline Breheret, Olivier Mimoz, and William Couet Antimicrob. Agents Chemother. September 2008 52: 3074-3077; published ahead of print June 30, 2008, doi:10.1128/AAC.00242-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

First Assessment in Humans of the Safety, Tolerability, Pharmacokinetics, and Ex Vivo Pharmacodynamic Antimalarial Activity of the New Artemisinin Derivative Artemisone Johannes Nagelschmitz, Barbara Voith, Georg Wensing, Axel Roemer, Burkhard Fugmann, Richard K. Haynes, Barbara M. Kotecka, Karl H. Rieckmann, and Michael D. Edstein Antimicrob. Agents Chemother. September 2008 52: 3085-3091; published ahead of print June 16, 2008, doi:10.1128/AAC.01585-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Clinical Therapeutics:

---

Association of Fluconazole Pharmacodynamics with Mortality in Patients with Candidemia John W. Baddley, Mukesh Patel, Sujata M. Bhavnani, Stephen A. Moser, and David R. Andes Antimicrob. Agents Chemother. September 2008 52: 3022-3028; published ahead of print June 30, 2008, doi:10.1128/AAC.00116-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Powerful Bactericidal Activity of Moxifloxacin in Human Leprosy Fe Eleanor F. Pardillo, Jasmin Burgos, Tranquilino T. Fajardo, Eduardo Dela Cruz, Rodolfo M. Abalos, Rose Maria D. Paredes, Cora Evelyn S. Andaya, and Robert H. Gelber Antimicrob. Agents Chemother. September 2008 52: 3113-3117; published ahead of print June 23, 2008, doi:10.1128/AAC.01162-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clostridium difficile Infections in a Canadian Tertiary Care Hospital before and during a Regional Epidemic Associated with the BI/NAP1/027 Strain Annie-Claude Labbé, Louise Poirier, Duncan MacCannell, Thomas Louie, Michel Savoie, Claire Béliveau, Michel Laverdière, and Jacques Pépin Antimicrob. Agents Chemother. September 2008 52: 3180-3187; published ahead of print June 23, 2008, doi:10.1128/AAC.00146-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Delay of Active Antimicrobial Therapy and Mortality among Patients with Bacteremia: Impact of Severe Neutropenia Michael Y. Lin, Robert A. Weinstein, and Bala Hota Antimicrob. Agents Chemother. September 2008 52: 3188-3194; published ahead of print July 14, 2008, doi:10.1128/AAC.01553-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bloodstream Infections Caused by Extended-Spectrum-β-Lactamase- Producing Escherichia coli: Risk Factors for Inadequate Initial Antimicrobial Therapy Mario Tumbarello, Michela Sali, Enrico Maria Trecarichi, Fiammetta Leone, Marianna Rossi, Barbara Fiori, Gennaro De Pascale, Tiziana D'Inzeo, Maurizio Sanguinetti, Giovanni Fadda, Roberto Cauda, and Teresa Spanu Antimicrob. Agents Chemother. September 2008 52: 3244-3252; published ahead of print June 30, 2008, doi:10.1128/AAC.00063-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of High-Dose Lopinavir-Ritonavir with and without Saquinavir or Nonnucleoside Reverse Transcriptase Inhibitors in Human Immunodeficiency Virus-Infected Pediatric and Adolescent Patients Previously Treated with Protease Inhibitors Brian L. Robbins, Edmund V. Capparelli, Ellen G. Chadwick, Ram Yogev, Leslie Serchuck, Carol Worrell, Mary Elizabeth Smith, Carmelita Alvero, Terence Fenton, Barbara Heckman, Stephen I. Pelton, Grace Aldrovandi, William Borkowsky, John Rodman, Peter L. Havens for the PACTG 1038 Team Antimicrob. Agents Chemother. September 2008 52: 3276-3283; published ahead of print July 14, 2008, doi:10.1128/AAC.00224-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Relationship between Vancomycin MIC and Failure among Patients with Methicillin-Resistant Staphylococcus aureus Bacteremia Treated with Vancomycin T. P. Lodise, J. Graves, A. Evans, E. Graffunder, M. Helmecke, B. M. Lomaestro, and K. Stellrecht Antimicrob. Agents Chemother. September 2008 52: 3315-3320; published ahead of print June 30, 2008, doi:10.1128/AAC.00113-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Microbiological and Genotypic Analysis of Methicillin-Resistant Staphylococcus aureus Bacteremia Carlo McCalla, Davida S. Smyth, D. Ashley Robinson, Judith Steenbergen, Steven A. Luperchio, Pamela A. Moise, Vance G. Fowler, Jr., and George Sakoulas Antimicrob. Agents Chemother. September 2008 52: 3441-3443; published ahead of print July 7, 2008, doi:10.1128/AAC.00357-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Antiviral Agents:

---

Effects of Minocycline and Valproic Acid Coadministration on Atazanavir Plasma Concentrations in Human Immunodeficiency Virus-Infected Adults Receiving Atazanavir-Ritonavir Robert DiCenzo, Derick R. Peterson, Kim Cruttenden, Peter Mariuz, Naser L. Rezk, Jill Hochreiter, Harris Gelbard, and Giovanni Schifitto Antimicrob. Agents Chemother. September 2008 52: 3035-3039; published ahead of print June 23, 2008, doi:10.1128/AAC.00194-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rolling Circle Amplification, a Powerful Tool for Genetic and Functional Studies of Complete Hepatitis B Virus Genomes from Low-Level Infections and for Directly Probing Covalently Closed Circular DNA Séverine Margeridon, Sandra Carrouée-Durantel, Isabelle Chemin, Luc Barraud, Fabien Zoulim, Christian Trépo, and Alan Kay Antimicrob. Agents Chemother. September 2008 52: 3068-3073; published ahead of print July 7, 2008, doi:10.1128/AAC.01318-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Herpes Simplex Virus Types 1 and 2 In Vitro Infection by Sulfated Derivatives of Escherichia coli K5 Polysaccharide Debora Pinna, Pasqua Oreste, Tiziana Coradin, Anna Kajaste-Rudnitski, Silvia Ghezzi, Giorgio Zoppetti, Antonella Rotola, Rafaela Argnani, Guido Poli, Roberto Manservigi, and Elisa Vicenzi Antimicrob. Agents Chemother. September 2008 52: 3078-3084; published ahead of print June 23, 2008, doi:10.1128/AAC.00359-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chronic Administration of Tenofovir to Rhesus Macaques from Infancy through Adulthood and Pregnancy: Summary of Pharmacokinetics and Biological and Virological Effects Koen K. A. Van Rompay, Lucie Durand-Gasselin, Laurie L. Brignolo, Adrian S. Ray, Kristina Abel, Tomas Cihlar, Abigail Spinner, Christopher Jerome, Joseph Moore, Brian P. Kearney, Marta L. Marthas, Hans Reiser, and Norbert Bischofberger Antimicrob. Agents Chemother. September 2008 52: 3144-3160; published ahead of print June 23, 2008, doi:10.1128/AAC.00350-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Heterocyclic Compounds That Inhibit Rev-RRE Function and Human Immunodeficiency Virus Type 1 Replication Deidra Shuck-Lee, Fei Fei Chen, Ryan Willard, Sharmila Raman, Roger Ptak, Marie-Louise Hammarskjold, and David Rekosh Antimicrob. Agents Chemother. September 2008 52: 3169-3179; published ahead of print July 14, 2008, doi:10.1128/AAC.00274-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tipranavir-Ritonavir Genotypic Resistance Score in Protease Inhibitor-Experienced Patients Anne-Genevieve Marcelin, Bernard Masquelier, Diane Descamps, Jacques Izopet, Charlotte Charpentier, Chakib Alloui, Magali Bouvier-Alias, Anne Signori-Schmuck, Brigitte Montes, Marie-Laure Chaix, Corinne Amiel, Georges Dos Santos, Annick Ruffault, Francis Barin, Gilles Peytavin, Marc Lavignon, Philippe Flandre, and Vincent Calvez Antimicrob. Agents Chemother. September 2008 52: 3237-3243; published ahead of print July 14, 2008, doi:10.1128/AAC.00133-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lack of a Significant Drug Interaction between Raltegravir and Tenofovir Larissa A. Wenning, Evan J. Friedman, James T. Kost, Sheila A. Breidinger, Jon E. Stek, Kenneth C. Lasseter, Keith M. Gottesdiener, Joshua Chen, Hedy Teppler, John A. Wagner, Julie A. Stone, and Marian Iwamoto Antimicrob. Agents Chemother. September 2008 52: 3253-3258; published ahead of print July 14, 2008, doi:10.1128/AAC.00005-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Combinations of Cyclophilin Inhibitor NIM811 with Hepatitis C Virus NS3-4A Protease or NS5B Polymerase Inhibitors Enhance Antiviral Activity and Suppress the Emergence of Resistance Joanna E. Mathy, Sue Ma, Teresa Compton, and Kai Lin Antimicrob. Agents Chemother. September 2008 52: 3267-3275; published ahead of print June 30, 2008, doi:10.1128/AAC.00498-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Surveillance for Neuraminidase Inhibitor Resistance among Human Influenza A and B Viruses Circulating Worldwide from 2004 to 2008 Tiffany G. Sheu, Varough M. Deyde, Margaret Okomo-Adhiambo, Rebecca J. Garten, Xiyan Xu, Rick A. Bright, Eboneé N. Butler, Teresa R. Wallis, Alexander I. Klimov, and Larisa V. Gubareva Antimicrob. Agents Chemother. September 2008 52: 3284-3292; published ahead of print July 14, 2008, doi:10.1128/AAC.00555-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Mechanism of Hepatitis C Virus Replicon Variants with Reduced Susceptibility to a Benzofuran Inhibitor, HCV-796 Anita Y. M. Howe, Huiming Cheng, Stephen Johann, Stanley Mullen, Srinivas K. Chunduru, Dorothy C. Young, Joel Bard, Rajiv Chopra, Girija Krishnamurthy, Tarek Mansour, and John O'Connell Antimicrob. Agents Chemother. September 2008 52: 3327-3338; published ahead of print June 16, 2008, doi:10.1128/AAC.00238-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Human Immunodeficiency Virus Type 1 Concerted Integration Related to Strand Transfer Inhibition and Drug Resistance Jacob A. Zahm, Sibes Bera, Krishan K. Pandey, Ajaykumar Vora, Kara Stillmock, Daria Hazuda, and Duane P. Grandgenett Antimicrob. Agents Chemother. September 2008 52: 3358-3368; published ahead of print June 30, 2008, doi:10.1128/AAC.00271-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cytokine Expression in the Colonic Mucosa of Human Immunodeficiency Virus-Infected Individuals before and during 9 Months of Antiretroviral Therapy Hubert Schulbin, Hagen Bode, Hartmut Stocker, Wolfgang Schmidt, Thomas Zippel, Christoph Loddenkemper, Elisabeth Engelmann, Hans-Jörg Epple, Keikawus Arastéh, Martin Zeitz and Reiner Ullrich for the Kompetenznetz HIV/AIDS Germany Antimicrob. Agents Chemother. September 2008 52: 3377-3384; published ahead of print June 23, 2008, doi:10.1128/AAC.00250-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification and Biochemical Characterization of Small-Molecule Inhibitors of West Nile Virus Serine Protease by a High-Throughput Screen Niklaus H. Mueller, Nagarajan Pattabiraman, Camilo Ansarah-Sobrinho, Prasanth Viswanathan, Theodore C. Pierson, and R. Padmanabhan Antimicrob. Agents Chemother. September 2008 52: 3385-3393; published ahead of print July 7, 2008, doi:10.1128/AAC.01508-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors Jan Paeshuyse, Inge Vliegen, Lotte Coelmont, Pieter Leyssen, Oriana Tabarrini, Piet Herdewijn, Harald Mittendorfer, Johnny Easmon, Violetta Cecchetti, Ralf Bartenschlager, Gerhard Puerstinger, and Johan Neyts Antimicrob. Agents Chemother. September 2008 52: 3433-3437; published ahead of print July 14, 2008, doi:10.1128/AAC.01534-07 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Anti-Human Immunodeficiency Virus Type 1 Activities of Antimicrobial Peptides Derived from Human and Bovine Cathelicidins Guangshun Wang, Karen M. Watson, and Robert W. Buckheit, Jr. Antimicrob. Agents Chemother. September 2008 52: 3438-3440; published ahead of print June 30, 2008, doi:10.1128/AAC.00452-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Mechanisms of Action:

---

Cooperation between Prokaryotic (Lde) and Eukaryotic (MRP) Efflux Transporters in J774 Macrophages Infected with Listeria monocytogenes: Studies with Ciprofloxacin and Moxifloxacin Ann Lismond, Paul M. Tulkens, Marie-Paule Mingeot-Leclercq, Patrice Courvalin, and Françoise Van Bambeke Antimicrob. Agents Chemother. September 2008 52: 3040-3046; published ahead of print June 23, 2008, doi:10.1128/AAC.00105-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Inhibition of OXA-1 β-Lactamase by Penems Christopher R. Bethel, Anne M. Distler, Mark W. Ruszczycky, Marianne P. Carey, Paul R. Carey, Andrea M. Hujer, Magda Taracila, Marion S. Helfand, Jodi M. Thomson, Matthew Kalp, Vernon E. Anderson, David A. Leonard, Kristine M. Hujer, Takao Abe, Aranapakam M. Venkatesan, Tarek S. Mansour, and Robert A. Bonomo Antimicrob. Agents Chemother. September 2008 52: 3135-3143; published ahead of print June 16, 2008, doi:10.1128/AAC.01677-07 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Inhibitors of Bacterial Multidrug Efflux Pumps Potentiate Antimicrobial Photoinactivation George P. Tegos, Kayo Masago, Fatima Aziz, Andrew Higginbotham, Frank R. Stermitz, and Michael R. Hamblin Antimicrob. Agents Chemother. September 2008 52: 3202-3209; published ahead of print May 12, 2008, doi:10.1128/AAC.00006-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chemical Target Validation Studies of Aminopeptidase in Malaria Parasites Using -Aminoalkylphosphonate and Phosphonopeptide Inhibitors Eithne Cunningham, Marcin Drag, Pawel Kafarski, and Angus Bell Antimicrob. Agents Chemother. September 2008 52: 3221-3228; published ahead of print May 5, 2008, doi:10.1128/AAC.01327-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Polymyxin Derivatives Carrying Only Three Positive Charges Are Effective Antibacterial Agents Martti Vaara, John Fox, Günther Loidl, Osmo Siikanen, Juha Apajalahti, Frank Hansen, Niels Frimodt-Møller, Junya Nagai, Mikihisa Takano, and Timo Vaara Antimicrob. Agents Chemother. September 2008 52: 3229-3236; published ahead of print June 30, 2008, doi:10.1128/AAC.00405-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Action of the Antibiotic NXL101, a Novel Nonfluoroquinolone Inhibitor of Bacterial Type II Topoisomerases Michael T. Black, Thérèse Stachyra, Denis Platel, Anne-Marie Girard, Monique Claudon, Jean-Michel Bruneau, and Christine Miossec Antimicrob. Agents Chemother. September 2008 52: 3339-3349; published ahead of print July 14, 2008, doi:10.1128/AAC.00496-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Subinhibitory Concentrations of Antibiotics on SOS and DNA Repair Gene Expression in Staphylococcus aureus Lili Rosana Mesak, Vivian Miao, and Julian Davies Antimicrob. Agents Chemother. September 2008 52: 3394-3397; published ahead of print June 30, 2008, doi:10.1128/AAC.01599-07 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

---

Chemistry; Biosynthesis:

---

Stability of Colistin Methanesulfonate in Pharmaceutical Products and Solutions for Administration to Patients Stephanie J. Wallace, Jian Li, Craig. R. Rayner, Kingsley Coulthard, and Roger L. Nation Antimicrob. Agents Chemother. September 2008 52: 3047-3051; published ahead of print July 7, 2008, doi:10.1128/AAC.00103-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Experimental Therapeutics:

---

Efficacy of Pyrvinium Pamoate against Cryptosporidium parvum Infection In Vitro and in a Neonatal Mouse Model Autumn S. Downey, Curtis R. Chong, Thaddeus K. Graczyk, and David J. Sullivan Antimicrob. Agents Chemother. September 2008 52: 3106-3112; published ahead of print June 30, 2008, doi:10.1128/AAC.00207-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficient Clearance of Aspergillus fumigatus in Murine Lungs by an Ultrashort Antimicrobial Lipopeptide, Palmitoyl-Lys-Ala-DAla-Lys Alexandra Vallon-Eberhard, Arik Makovitzki, Anne Beauvais, Jean-Paul Latgé, Steffen Jung, and Yechiel Shai Antimicrob. Agents Chemother. September 2008 52: 3118-3126; published ahead of print July 7, 2008, doi:10.1128/AAC.00526-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intracellular Time Course, Pharmacokinetics, and Biodistribution of Isoniazid and Rifabutin following Pulmonary Delivery of Inhalable Microparticles to Mice Rahul Kumar Verma, Jatinder Kaur, Kaushlendra Kumar, Awadh Bihari Yadav, and Amit Misra Antimicrob. Agents Chemother. September 2008 52: 3195-3201; published ahead of print June 30, 2008, doi:10.1128/AAC.00153-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapid Eradication of Listeria monocytogenes by Moxifloxacin in a Murine Model of Central Nervous System Listeriosis Solène Grayo, Marie-Catherine Lott-Desroches, Olivier Dussurget, Renaud Respaud, Arnaud Fontanet, Olivier Join-Lambert, Eric Singlas, and Alban Le Monnier Antimicrob. Agents Chemother. September 2008 52: 3210-3215; published ahead of print June 23, 2008, doi:10.1128/AAC.00177-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Studies of the Trypanocidal Activity of a Diarylthiophene Diamidine against Trypanosoma cruzi Cristiane França da Silva, Marcos Meuser Batista, Denise da Gama Jaen Batista, Elen Mello de Souza, Patrícia Bernardino da Silva, Gabriel Melo de Oliveira, Andrea Souza Meuser, Abdur-Rafay Shareef, David W. Boykin, and Maria de Nazaré C. Soeiro Antimicrob. Agents Chemother. September 2008 52: 3307-3314; published ahead of print July 14, 2008, doi:10.1128/AAC.00038-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Efficacy of Quinoxaline-2-Carboxylate 1,4-Di-N-Oxide Derivatives in Experimental Tuberculosis Esther Vicente, Raquel Villar, Asunción Burguete, Beatriz Solano, Silvia Pérez-Silanes, Ignacio Aldana, Joseph A. Maddry, Anne J. Lenaerts, Scott G. Franzblau, Sang-hyun Cho, Antonio Monge, and Robert C. Goldman Antimicrob. Agents Chemother. September 2008 52: 3321-3326; published ahead of print July 14, 2008, doi:10.1128/AAC.00379-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Oritavancin in a Murine Model of Bacillus anthracis Spore Inhalation Anthrax H. S. Heine, J. Bassett, L. Miller, A. Bassett, B. E. Ivins, D. Lehoux, F. F. Arhin, T. R. Parr, Jr., and G. Moeck Antimicrob. Agents Chemother. September 2008 52: 3350-3357; published ahead of print July 7, 2008, doi:10.1128/AAC.00360-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Treatments of Echinococcus Protoscoleces and Metacestodes with Artemisinin and Artemisinin Derivatives Martin Spicher, Carole Roethlisberger, Catharina Lany, Britta Stadelmann, Jennifer Keiser, Luis M. Ortega-Mora, Bruno Gottstein, and Andrew Hemphill Antimicrob. Agents Chemother. September 2008 52: 3447-3450; published ahead of print July 14, 2008, doi:10.1128/AAC.00553-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimalarial Activity of a New Stilbene Glycoside from Parthenocissus tricuspidata in Mice Won-Hwan Park, Sung-Jae Lee, and Hyung-In Moon Antimicrob. Agents Chemother. September 2008 52: 3451-3453; published ahead of print July 14, 2008, doi:10.1128/AAC.00562-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of Plasma Proteins in Pharmacokinetics of Micafungin, an Antifungal Antibiotic, in Analbuminemic Rats Fumie Abe, Jun Ueyama, Noriyo Kawasumi, Masayuki Nadai, Tamon Hayashi, Miki Kato, Masafumi Ohnishi, Hiroko Saito, Naoshi Takeyama, and Takaaki Hasegawa Antimicrob. Agents Chemother. September 2008 52: 3454-3456; published ahead of print June 30, 2008, doi:10.1128/AAC.00396-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence and Acquisition of Fluoroquinolone-Resistant Gram-Negative Bacilli in the Intestinal Tracts of Mice Treated with Fluoroquinolone Antimicrobial Agents Michael J. Pultz, Michelle M. Nerandzic, Usha Stiefel, and Curtis J. Donskey Antimicrob. Agents Chemother. September 2008 52: 3457-3460; published ahead of print July 7, 2008, doi:10.1128/AAC.00117-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Susceptibility:

---

Increasing Trends in Antimicrobial Resistance among Clinically Important Anaerobes and Bacteroides fragilis Isolates Causing Nosocomial Infections: Emerging Resistance to Carbapenems Chia-Ying Liu, Yu-Tsung Huang, Chun-Hsing Liao, Li-Ching Yen, Hsiu-Ying Lin, and Po-Ren Hsueh Antimicrob. Agents Chemother. September 2008 52: 3161-3168; published ahead of print July 14, 2008, doi:10.1128/AAC.00355-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Temporal and Spatial Distribution of Clonal Complexes of Streptococcus pneumoniae Isolates Resistant to Multiple Classes of Antibiotics in Belgium, 1997 to 2004 Heather Amrine-Madsen, Johan Van Eldere, Robertino M. Mera, Linda A. Miller, James A. Poupard, Elizabeth S. Thomas, Wendy S. Halsey, Julie A. Becker, and F. Patrick O'Hara Antimicrob. Agents Chemother. September 2008 52: 3216-3220; published ahead of print June 23, 2008, doi:10.1128/AAC.00358-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cell Density and Cell Aging as Factors Modulating Antifungal Resistance of Candida albicans Biofilms C. J. Seneviratne, L. J. Jin, Y. H. Samaranayake, and L. P. Samaranayake Antimicrob. Agents Chemother. September 2008 52: 3259-3266; published ahead of print July 14, 2008, doi:10.1128/AAC.00541-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Profiling of Ceftaroline against a Collection of Recent Bacterial Clinical Isolates from across the United States Yigong Ge, Donald Biek, George H. Talbot, and Daniel F. Sahm Antimicrob. Agents Chemother. September 2008 52: 3398-3407; published ahead of print July 14, 2008, doi:10.1128/AAC.00149-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Reduced Biocide Susceptibility in Candida albicans Biofilms Jeniel E. Nett, Kristie M. Guite, Alex Ringeisen, Kathleen A. Holoyda, and David R. Andes Antimicrob. Agents Chemother. September 2008 52: 3411-3413; published ahead of print June 23, 2008, doi:10.1128/AAC.01656-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cell-Penetrating Peptide TP10 Shows Broad-Spectrum Activity against both Plasmodium falciparum and Trypanosoma brucei brucei Romanico B. G. Arrighi, Charles Ebikeme, Yang Jiang, Lisa Ranford-Cartwright, Michael P. Barrett, Ülo Langel, and Ingrid Faye Antimicrob. Agents Chemother. September 2008 52: 3414-3417; published ahead of print June 2, 2008, doi:10.1128/AAC.01450-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Ceftobiprole against Pathogens from Two Phase 3 Clinical Trials of Complicated Skin and Skin Structure Infections Karen M. Amsler, Todd A. Davies, Wenchi Shang, Michael R. Jacobs, and Karen Bush Antimicrob. Agents Chemother. September 2008 52: 3418-3423; published ahead of print June 30, 2008, doi:10.1128/AAC.00336-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antifungal Resistance of Candida glabrata Vaginal Isolates and Development of a Quantitative Reverse Transcription-PCR-Based Azole Susceptibility Assay Scott E. Gygax, John-Paul Vermitsky, Sean G. Chadwick, Matthew J. Self, Jessica A. Zimmerman, Eli Mordechai, Martin E. Adelson, and Jason P. Trama Antimicrob. Agents Chemother. September 2008 52: 3424-3426; published ahead of print June 30, 2008, doi:10.1128/AAC.00462-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Isolates of Aspergillus Species Remain Fully Susceptible to Voriconazole in the Post-Voriconazole Era Jesús Guinea, Sandra Recio, Teresa Peláez, Marta Torres-Narbona, and Emilio Bouza Antimicrob. Agents Chemother. September 2008 52: 3444-3446; published ahead of print July 7, 2008, doi:10.1128/AAC.00629-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Biologic Response Modifiers:

---

Immunomodulatory Effects of Voriconazole on Monocytes Challenged with Aspergillus fumigatus: Differential Role of Toll-Like Receptors Maria Simitsopoulou, Emmanuel Roilides, Fotini Paliogianni, Christodoulos Likartsis, John Ioannidis, Kalliopi Kanellou, and Thomas J. Walsh Antimicrob. Agents Chemother. September 2008 52: 3301-3306; published ahead of print July 14, 2008, doi:10.1128/AAC.01018-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Letters:

---

Expanded-Spectrum β-Lactamase PER-1 in an Environmental Aeromonas media Isolate from Switzerland Renata Cristina Picão, Laurent Poirel, Antonella Demarta, Orlando Petrini, Anna Rita Corvaglia, and Patrice Nordmann Antimicrob. Agents Chemother. September 2008 52: 3461-3462; published ahead of print July 21, 2008, doi:10.1128/AAC.00770-08 [Full Text] [PDF] [Reprints and Permissions]

Plasmid-Encoded Carbapenem-Hydrolyzing β-Lactamase OXA-48 in an Imipenem-Susceptible Klebsiella pneumoniae Strain from Belgium Gaelle Cuzon, Thierry Naas, Pierre Bogaerts, Youri Glupczynski, Te-Din Huang, and Patrice Nordmann Antimicrob. Agents Chemother. September 2008 52: 3463-3464; published ahead of print July 21, 2008, doi:10.1128/AAC.00543-08 [Full Text] [PDF] [Reprints and Permissions]

Novel Mutation in 23S rRNA That Confers Low-Level Resistance to Clarithromycin in Helicobacter pylori Emiko Rimbara, Norihisa Noguchi, Takashi Kawai, and Masanori Sasatsu Antimicrob. Agents Chemother. September 2008 52: 3465-3466; published ahead of print July 7, 2008, doi:10.1128/AAC.00445-08 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.