Other Issues

Contents: October 2009, Volume 53, Issue 10        Minireviews        Experimental Therapeutics        Clinical Therapeutics        Pharmacology        Mechanisms of Resistance        Antiviral Agents        Susceptibility        Mechanisms of Action        Analytical Procedures        Letters

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Molecular Basis and Phenotype of Methicillin Resistance in Staphylococcus aureus and Insights into New β-Lactams That Meet the Challenge Leticia I. Llarrull, Jed F. Fisher, and Shahriar Mobashery Antimicrob. Agents Chemother. October 2009 53: 4051-4063; published ahead of print May 26, 2009, doi:10.1128/AAC.00084-09 [Full Text] [PDF] [Author Bios] [Reprints and Permissions]

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Experimental Therapeutics:

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The Electricidal Effect Is Active in an Experimental Model of Staphylococcus epidermidis Chronic Foreign Body Osteomyelitis Jose L. Del Pozo, Mark S. Rouse, Gorane Euba, Cheol-In Kang, Jayawant N. Mandrekar, James M. Steckelberg, and Robin Patel Antimicrob. Agents Chemother. October 2009 53: 4064-4068; published ahead of print August 3, 2009, doi:10.1128/AAC.00432-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Proteasome Inhibitor Epoxomicin Has Potent Plasmodium falciparum Gametocytocidal Activity Beata Czesny, Samrawit Goshu, James L. Cook, and Kim C. Williamson Antimicrob. Agents Chemother. October 2009 53: 4080-4085; published ahead of print August 3, 2009, doi:10.1128/AAC.00088-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Addition of Gentamicin or Rifampin Does Not Enhance the Effectiveness of Daptomycin in Treatment of Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus J. M. Miró, C. García-de-la-Mària, Y. Armero, D. Soy, A. Moreno, A. del Río, M. Almela, M. Sarasa, C. A. Mestres, J. M. Gatell, M. T. Jiménez de Anta, F. Marco and the Hospital Clinic Experimental Endocarditis Study Group Antimicrob. Agents Chemother. October 2009 53: 4172-4177; published ahead of print July 20, 2009, doi:10.1128/AAC.00051-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Paradoxical Effect of Isoniazid on the Activity of Rifampin-Pyrazinamide Combination in a Mouse Model of Tuberculosis Deepak Almeida, Eric Nuermberger, Rokeya Tasneen, Ian Rosenthal, Sandeep Tyagi, Kathy Williams, Charles Peloquin, and Jacques Grosset Antimicrob. Agents Chemother. October 2009 53: 4178-4184; published ahead of print July 20, 2009, doi:10.1128/AAC.00830-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Treatment Option for Second-Stage African Sleeping Sickness: In Vitro and In Vivo Efficacy of Aza Analogs of DB289 Tanja Wenzler, David W. Boykin, Mohamed A. Ismail, James Edwin Hall, Richard R. Tidwell, and Reto Brun Antimicrob. Agents Chemother. October 2009 53: 4185-4192; published ahead of print July 20, 2009, doi:10.1128/AAC.00225-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of High Doses of Daptomycin versus Alternative Therapies against Experimental Foreign-Body Infection by Methicillin-Resistant Staphylococcus aureus O. Murillo, C. Garrigós, M. E. Pachón, G. Euba, R. Verdaguer, C. Cabellos, J. Cabo, F. Gudiol, and J. Ariza Antimicrob. Agents Chemother. October 2009 53: 4252-4257; published ahead of print July 27, 2009, doi:10.1128/AAC.00208-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Silica-Antibiotic Hybrid Nanoparticles for Targeting Intracellular Pathogens Mohamed N. Seleem, Prabhakaran Munusamy, Ashish Ranjan, Hamzeh Alqublan, Gary Pickrell, and Nammalwar Sriranganathan Antimicrob. Agents Chemother. October 2009 53: 4270-4274; published ahead of print August 10, 2009, doi:10.1128/AAC.00815-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Imidocarb Dipropionate Clears Persistent Babesia caballi Infection with Elimination of Transmission Potential O. Nicolas Schwint, Massaro W. Ueti, Guy H. Palmer, Lowell S. Kappmeyer, Melissa T. Hines, R. Timothy Cordes, Donald P. Knowles, and Glen A. Scoles Antimicrob. Agents Chemother. October 2009 53: 4327-4332; published ahead of print July 20, 2009, doi:10.1128/AAC.00404-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Efficacy of 1- and 2-Gram Human Simulated Prolonged Infusions of Doripenem against Pseudomonas aeruginosa Jared L. Crandon, Catharine C. Bulik, and David P. Nicolau Antimicrob. Agents Chemother. October 2009 53: 4352-4356; published ahead of print October 1, 2009, doi:10.1128/AAC.00282-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Aryl Rhodanines Specifically Inhibit Staphylococcal and Enterococcal Biofilm Formation Timothy J. Opperman, Steven M. Kwasny, John D. Williams, Atiyya R. Khan, Norton P. Peet, Donald T. Moir, and Terry L. Bowlin Antimicrob. Agents Chemother. October 2009 53: 4357-4367; published ahead of print August 3, 2009, doi:10.1128/AAC.00077-09 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Antimalarial Activity of Simalikalactone E, a New Quassinoid from Quassia amara L. (Simaroubaceae) N. Cachet, F. Hoakwie, S. Bertani, G. Bourdy, E. Deharo, D. Stien, E. Houel, H. Gornitzka, J. Fillaux, S. Chevalley, A. Valentin, and V. Jullian Antimicrob. Agents Chemother. October 2009 53: 4393-4398; published ahead of print August 10, 2009, doi:10.1128/AAC.00951-09 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Artemisone and Artemiside Control Acute and Reactivated Toxoplasmosis in a Murine Model Ildiko R. Dunay, Wing Chi Chan, Richard K. Haynes, and L. David Sibley Antimicrob. Agents Chemother. October 2009 53: 4450-4456; published ahead of print July 27, 2009, doi:10.1128/AAC.00502-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2Rnull Mice Engrafted with Human Erythrocytes María Belén Jiménez-Díaz, Teresa Mulet, Sara Viera, Vanessa Gómez, Helen Garuti, Javier Ibáñez, Angela Alvarez-Doval, Leonard D. Shultz, Antonio Martínez, Domingo Gargallo-Viola, and Iñigo Angulo-Barturen Antimicrob. Agents Chemother. October 2009 53: 4533-4536; published ahead of print July 13, 2009, doi:10.1128/AAC.00519-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Albaconazole against Candida albicans in a Vaginitis Model Gloria M. González, Efrén Robledo, Elvira Garza-González, Mariana Elizondo, and J. Gerardo González Antimicrob. Agents Chemother. October 2009 53: 4540-4541; published ahead of print July 27, 2009, doi:10.1128/AAC.00565-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evaluating Aztreonam and Ceftazidime Pharmacodynamics with Escherichia coli in Combination with Daptomycin, Linezolid, or Vancomycin in an In Vitro Pharmacodynamic Model Kerry L. LaPlante and George Sakoulas Antimicrob. Agents Chemother. October 2009 53: 4549-4555; published ahead of print July 20, 2009, doi:10.1128/AAC.00180-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Comparative Efficacy and Safety of Vancomycin versus Teicoplanin: Systematic Review and Meta-Analysis Shuli Svetitsky, Leonard Leibovici, and Mical Paul Antimicrob. Agents Chemother. October 2009 53: 4069-4079; published ahead of print July 13, 2009, doi:10.1128/AAC.00341-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prospective Randomized Trial of Six-Month versus Nine-Month Therapy for Intestinal Tuberculosis Sang Hyoung Park, Suk-Kyun Yang, Dong-Hoon Yang, Kyung Jo Kim, Soon Man Yoon, Jae Won Choe, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, and Jin-Ho Kim Antimicrob. Agents Chemother. October 2009 53: 4167-4171; published ahead of print August 10, 2009, doi:10.1128/AAC.00874-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pilot Study of Ampicillin-Ceftriaxone Combination for Treatment of Orthopedic Infections Due to Enterococcus faecalis G. Euba, J. Lora-Tamayo, O. Murillo, S. Pedrero, J. Cabo, R. Verdaguer, and J. Ariza Antimicrob. Agents Chemother. October 2009 53: 4305-4310; published ahead of print August 10, 2009, doi:10.1128/AAC.00444-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Antiretroviral Tissue Kinetics: In Vivo Imaging Using Positron Emission Tomography Michele Di Mascio, Sharat Srinivasula, Abesh Bhattacharjee, Lily Cheng, Lucia Martiniova, Peter Herscovitch, Juan Lertora, and Dale Kiesewetter Antimicrob. Agents Chemother. October 2009 53: 4086-4095; published ahead of print August 10, 2009, doi:10.1128/AAC.00419-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dosing Regimens of Cotrimoxazole (Trimethoprim-Sulfamethoxazole) for Melioidosis Allen C. Cheng, Emma S. McBryde, Vanaporn Wuthiekanun, Wirongrong Chierakul, Premjit Amornchai, Nicholas P. J. Day, Nicholas J. White, and Sharon J. Peacock Antimicrob. Agents Chemother. October 2009 53: 4193-4199; published ahead of print July 20, 2009, doi:10.1128/AAC.01301-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Brain Penetration of Colistin in Mice Assessed by a Novel High-Performance Liquid Chromatographic Technique Liang Jin, Jian Li, Roger L. Nation, and Joseph A. Nicolazzo Antimicrob. Agents Chemother. October 2009 53: 4247-4251; published ahead of print August 10, 2009, doi:10.1128/AAC.00485-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of Low-Level Resistance to Fluoroquinolones Due to qnrA1 and qnrS1 Genes or a gyrA Mutation on Ciprofloxacin Bactericidal Activity in a Murine Model of Escherichia coli Urinary Tract Infection Nicolas Allou, Emmanuelle Cambau, Laurent Massias, Françoise Chau, and Bruno Fantin Antimicrob. Agents Chemother. October 2009 53: 4292-4297; published ahead of print July 27, 2009, doi:10.1128/AAC.01664-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity and In Vivo Efficacy of Clavulanic Acid against Acinetobacter baumannii Alejandro Beceiro, Rafael López-Rojas, Juan Domínguez-Herrera, Fernando Docobo-Pérez, Germán Bou, Jerónimo Pachón the Spanish Network for Research in Infectious Diseases (REIPI) Antimicrob. Agents Chemother. October 2009 53: 4298-4304; published ahead of print July 27, 2009, doi:10.1128/AAC.00320-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetic Properties of Sulfadoxine-Pyrimethamine in Pregnant Women Harin A. Karunajeewa, Sam Salman, Ivo Mueller, Francisca Baiwog, Servina Gomorrai, Irwin Law, Madhu Page-Sharp, Stephen Rogerson, Peter Siba, Kenneth F. Ilett, and Timothy M. E. Davis Antimicrob. Agents Chemother. October 2009 53: 4368-4376; published ahead of print July 20, 2009, doi:10.1128/AAC.00335-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differential Effects of Tipranavir plus Ritonavir on Atorvastatin or Rosuvastatin Pharmacokinetics in Healthy Volunteers P. A. Pham, C. J. L. la Porte, L. S. Lee, R. van Heeswijk, J. P. Sabo, M. M. Elgadi, P. J. Piliero, P. Barditch-Crovo, E. Fuchs, C. Flexner, and D. W. Cameron Antimicrob. Agents Chemother. October 2009 53: 4385-4392; published ahead of print August 10, 2009, doi:10.1128/AAC.00449-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Didanosine Population Pharmacokinetics in West African Human Immunodeficiency Virus-Infected Children Administered Once-Daily Tablets in Relation to Efficacy after One Year of Treatment Déborah Hirt, Christophe Bardin, Serge Diagbouga, Boubacar Nacro, Hervé Hien, Emmanuelle Zoure, François Rouet, Adama Ouiminga, Saik Urien, Vincent Foulongne, Philippe Van De Perre, Jean-Marc Tréluyer, and Philippe Msellati Antimicrob. Agents Chemother. October 2009 53: 4399-4406; published ahead of print July 6, 2009, doi:10.1128/AAC.01187-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Is the Recommended Dose of Efavirenz Optimal in Young West African Human Immunodeficiency Virus-Infected Children? Déborah Hirt, Saik Urien, Mathieu Olivier, Hélène Peyrière, Boubacar Nacro, Serge Diagbouga, Emmanuelle Zoure, François Rouet, Hervé Hien, Philippe Msellati, Philippe Van De Perre, and Jean-Marc Tréluyer Antimicrob. Agents Chemother. October 2009 53: 4407-4413; published ahead of print July 27, 2009, doi:10.1128/AAC.01594-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Experimental Chemotherapy against Trypanosoma cruzi Infection Using Ruthenium Nitric Oxide Donors Jean Jerley N. Silva, Wander R. Pavanelli, José Clayston M. Pereira, João S. Silva, and Douglas W. Franco Antimicrob. Agents Chemother. October 2009 53: 4414-4421; published ahead of print July 6, 2009, doi:10.1128/AAC.00104-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Oritavancin Population Pharmacokinetics in Healthy Subjects and Patients with Complicated Skin and Skin Structure Infections or Bacteremia Christopher M. Rubino, Scott A. Van Wart, Sujata M. Bhavnani, Paul G. Ambrose, Jill S. McCollam, and Alan Forrest Antimicrob. Agents Chemother. October 2009 53: 4422-4428; published ahead of print July 27, 2009, doi:10.1128/AAC.00231-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetics of Ceftazidime in Intensive Care Unit Patients: Influence of Glomerular Filtration Rate, Mechanical Ventilation, and Reason for Admission Bernard Georges, Jean-Marie Conil, Thierry Seguin, Stéphanie Ruiz, Vincent Minville, Pierre Cougot, Jean-François Decun, Hélène Gonzalez, Georges Houin, Olivier Fourcade, and Sylvie Saivin Antimicrob. Agents Chemother. October 2009 53: 4483-4489; published ahead of print July 27, 2009, doi:10.1128/AAC.00430-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Antibacterial Activity of Vertilmicin, a New Aminoglycoside Antibiotic Xue-Fu You, Cong-Ran Li, Xin-Yi Yang, Min Yuan, Wei-Xin Zhang, Ren-Hui Lou, Yue-Ming Wang, Guo-Qing Li, Hui-Zhen Chen, Dan-Qing Song, Cheng-Hang Sun, Shan Cen, Li-Yan Yu, Li-Xun Zhao, and Jian-Dong Jiang Antimicrob. Agents Chemother. October 2009 53: 4525-4528; published ahead of print July 27, 2009, doi:10.1128/AAC.00223-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Impact of sarA on Daptomycin Susceptibility of Staphylococcus aureus Biofilms In Vivo Elizabeth C. Weiss, Agnieszka Zielinska, Karen E. Beenken, Horace J. Spencer, Sonja J. Daily, and Mark S. Smeltzer Antimicrob. Agents Chemother. October 2009 53: 4096-4102; published ahead of print August 3, 2009, doi:10.1128/AAC.00484-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Simple, Rapid, and Inexpensive Detection of Neisseria gonorrhoeae Resistance Mechanisms Using Heat-Denatured Isolates and SYBR Green-Based Real-Time PCR Gayle Kugelman, John W. Tapsall, Namraj Goire, Melanie W. Syrmis, Athena Limnios, Stephen B. Lambert, Michael D. Nissen, Theo P. Sloots, and David M. Whiley Antimicrob. Agents Chemother. October 2009 53: 4211-4216; published ahead of print June 15, 2009, doi:10.1128/AAC.00385-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Telavancin against Staphylococci and Enterococci Determined by MIC and Resistance Selection Studies Klaudia Kosowska-Shick, Catherine Clark, Glenn A. Pankuch, Pamela McGhee, Bonifacio Dewasse, Linda Beachel, and Peter C. Appelbaum Antimicrob. Agents Chemother. October 2009 53: 4217-4224; published ahead of print July 20, 2009, doi:10.1128/AAC.00742-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cotransfer of Antibiotic Resistance Genes and a hylEfm-Containing Virulence Plasmid in Enterococcus faecium Cesar A. Arias, Diana Panesso, Kavindra V. Singh, Louis B. Rice, and Barbara E. Murray Antimicrob. Agents Chemother. October 2009 53: 4240-4246; published ahead of print August 10, 2009, doi:10.1128/AAC.00242-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibiotic Usage and Risk of Colonization and Infection with Antibiotic-Resistant Bacteria: a Hospital Population-Based Study Evelina Tacconelli, Giulia De Angelis, Maria Adriana Cataldo, Elisabetta Mantengoli, Teresa Spanu, Angelo Pan, Giampaolo Corti, Anna Radice, Lucia Stolzuoli, Spinello Antinori, Franco Paradisi, Giampiero Carosi, Roberto Bernabei, Massimo Antonelli, Giovanni Fadda, Gian Maria Rossolini, and Roberto Cauda Antimicrob. Agents Chemother. October 2009 53: 4264-4269; published ahead of print August 10, 2009, doi:10.1128/AAC.00431-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

IND-6, a Highly Divergent IND-Type Metallo-β-Lactamase from Chryseobacterium indologenes Strain 597 Isolated in Burkina Faso Boukaré Zeba, Filomena De Luca, Alain Dubus, Michael Delmarcelle, Jacques Simporé, Odile G. Nacoulma, Gian Maria Rossolini, Jean-Marie Frère, and Jean-Denis Docquier Antimicrob. Agents Chemother. October 2009 53: 4320-4326; published ahead of print August 3, 2009, doi:10.1128/AAC.01607-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Genetic Environment of the Carbapenem-Hydrolyzing β-Lactamase KPC-2 among Enterobacteriaceae in China Ping Shen, Zeqing Wei, Yan Jiang, Xiaoxing Du, Shujuan Ji, Yunsong Yu, and Lanjuan Li Antimicrob. Agents Chemother. October 2009 53: 4333-4338; published ahead of print July 20, 2009, doi:10.1128/AAC.00260-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Involvement of pmrAB and phoPQ in Polymyxin B Adaptation and Inducible Resistance in Non-Cystic Fibrosis Clinical Isolates of Pseudomonas aeruginosa Kristen N. Schurek, Jorge L. M. Sampaio, Carlos R. V. Kiffer, Sumiko Sinto, Caio M. F. Mendes, and Robert E. W. Hancock Antimicrob. Agents Chemother. October 2009 53: 4345-4351; published ahead of print July 27, 2009, doi:10.1128/AAC.01267-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biofilm Formation and Effect of Caspofungin on Biofilm Structure of Candida Species Bloodstream Isolates J. A. G. Ferreira, J. H. Carr, C. E. F. Starling, M. A. de Resende, and R. M. Donlan Antimicrob. Agents Chemother. October 2009 53: 4377-4384; published ahead of print June 22, 2009, doi:10.1128/AAC.00316-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Structure of the Dizinc Subclass B2 Metallo-β-Lactamase CphA Reveals that the Second Inhibitory Zinc Ion Binds in the Histidine Site Carine Bebrone, Heinrich Delbrück, Michaël B. Kupper, Philipp Schlömer, Charlotte Willmann, Jean-Marie Frère, Rainer Fischer, Moreno Galleni, and Kurt M. V. Hoffmann Antimicrob. Agents Chemother. October 2009 53: 4464-4471; published ahead of print August 3, 2009, doi:10.1128/AAC.00288-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Complete Nucleotide Sequences of Plasmids pEK204, pEK499, and pEK516, Encoding CTX-M Enzymes in Three Major Escherichia coli Lineages from the United Kingdom, All Belonging to the International O25:H4-ST131 Clone Neil Woodford, Alessandra Carattoli, Edi Karisik, Anthony Underwood, Matthew J. Ellington, and David M. Livermore Antimicrob. Agents Chemother. October 2009 53: 4472-4482; published ahead of print August 17, 2009, doi:10.1128/AAC.00688-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Borrelia burgdorferi Resistance to a Major Skin Antimicrobial Peptide Is Independent of Outer Surface Lipoprotein Content Amit Sarkar, Kit Tilly, Philip Stewart, Aaron Bestor, James M. Battisti, and Patricia A. Rosa Antimicrob. Agents Chemother. October 2009 53: 4490-4494; published ahead of print August 3, 2009, doi:10.1128/AAC.00558-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fluoroquinolone Resistance in Mycobacterium tuberculosis and Mutations in gyrA and gyrB Andrea Von Groll, Anandi Martin, Pontus Jureen, Sven Hoffner, Peter Vandamme, Françoise Portaels, Juan Carlos Palomino, and Pedro Almeida da Silva Antimicrob. Agents Chemother. October 2009 53: 4498-4500; published ahead of print August 17, 2009, doi:10.1128/AAC.00287-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Regional Dissemination of KPC-Producing Klebsiella pneumoniae Brandon Kitchel, Daniel R. Sundin, and Jean B. Patel Antimicrob. Agents Chemother. October 2009 53: 4511-4513; published ahead of print August 17, 2009, doi:10.1128/AAC.00784-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Variant of CTX-M-Type Extended-Spectrum β-Lactamases, CTX-M-71, with a Gly238Cys Substitution in a Klebsiella pneumoniae Isolate from Bulgaria Ines Schneider, Anne Marie Queenan, Rumyana Markovska, Boyka Markova, Emma Keuleyan, and Adolf Bauernfeind Antimicrob. Agents Chemother. October 2009 53: 4518-4521; published ahead of print July 20, 2009, doi:10.1128/AAC.00461-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differential Expression of ccrA in Methicillin-Resistant Staphylococcus aureus Strains Carrying Staphylococcal Cassette Chromosome mec Type II and IVa Elements Paul G. Higgins, Adriana E. Rosato, Harald Seifert, Gordon L. Archer, and Hilmar Wisplinghoff Antimicrob. Agents Chemother. October 2009 53: 4556-4558; published ahead of print July 13, 2009, doi:10.1128/AAC.00395-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Identification of Inhibitors of Yellow Fever Virus Replication Using a Replicon-Based High-Throughput Assay Chinmay G. Patkar, Martha Larsen, Michael Owston, Janet L. Smith, and Richard J. Kuhn Antimicrob. Agents Chemother. October 2009 53: 4103-4114; published ahead of print August 3, 2009, doi:10.1128/AAC.00074-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Triple Combination of Oseltamivir, Amantadine, and Ribavirin Displays Synergistic Activity against Multiple Influenza Virus Strains In Vitro Jack T. Nguyen, Justin D. Hoopes, Donald F. Smee, Mark N. Prichard, Elizabeth M. Driebe, David M. Engelthaler, Minh H. Le, Paul S. Keim, R. Paul Spence, and Gregory T. Went Antimicrob. Agents Chemother. October 2009 53: 4115-4126; published ahead of print July 20, 2009, doi:10.1128/AAC.00476-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetic Assessment of Nevirapine and Metabolites in Human Immunodeficiency Virus Type 1-Infected Patients with Hepatic Fibrosis Anna Maria Cammett, Thomas R. MacGregor, Jan M. Wruck, Franco Felizarta, Patrick Miailhes, Josep Mallolas, and Peter J. Piliero Antimicrob. Agents Chemother. October 2009 53: 4147-4152; published ahead of print July 20, 2009, doi:10.1128/AAC.00460-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Use of Different Inhibitory Quotients To Predict Early Virological Response to Tipranavir in Antiretroviral-Experienced Human Immunodeficiency Virus-Infected Patients Judit Morello, Carmen De Mendoza, Vincent Soriano, Lourdes Anta, Gema González-Pardo, Angélica Corral, Francisco Blanco, Inmaculada Jiménez-Nácher, Juan González-Lahoz, and Sonia Rodríguez-Novoa Antimicrob. Agents Chemother. October 2009 53: 4153-4158; published ahead of print July 13, 2009, doi:10.1128/AAC.00041-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Natural Polymorphisms of Human Immunodeficiency Virus Type 1 Integrase and Inherent Susceptibilities to a Panel of Integrase Inhibitors Andrea Low, Nicole Prada, Michael Topper, Florin Vaida, Delivette Castor, Hiroshi Mohri, Daria Hazuda, Mark Muesing, and Martin Markowitz Antimicrob. Agents Chemother. October 2009 53: 4275-4282; published ahead of print August 3, 2009, doi:10.1128/AAC.00397-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Development of a Cell-Based Hepatitis C Virus Infection Fluorescent Resonance Energy Transfer Assay for High-Throughput Antiviral Compound Screening Xuemei Yu, Bruno Sainz, Jr., and Susan L. Uprichard Antimicrob. Agents Chemother. October 2009 53: 4311-4319; published ahead of print July 20, 2009, doi:10.1128/AAC.00495-09 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

In Vitro Generation of Neuraminidase Inhibitor Resistance in A(H5N1) Influenza Viruses Aeron C. Hurt, Jessica K. Holien, and Ian G. Barr Antimicrob. Agents Chemother. October 2009 53: 4433-4440; published ahead of print August 3, 2009, doi:10.1128/AAC.00334-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Large-Scale Sequence Analysis of M Gene of Influenza A Viruses from Different Species: Mechanisms for Emergence and Spread of Amantadine Resistance Yuki Furuse, Akira Suzuki, and Hitoshi Oshitani Antimicrob. Agents Chemother. October 2009 53: 4457-4463; published ahead of print August 3, 2009, doi:10.1128/AAC.00650-09 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

In Vitro Antiviral Activity of V-073 against Polioviruses M. Steven Oberste, Deborah Moore, Barbara Anderson, Mark A. Pallansch, Daniel C. Pevear, and Marc S. Collett Antimicrob. Agents Chemother. October 2009 53: 4501-4503; published ahead of print July 27, 2009, doi:10.1128/AAC.00671-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Longitudinal Analysis of Raltegravir Susceptibility and Integrase Replication Capacity of Human Immunodeficiency Virus Type 1 during Virologic Failure Signe Fransen, Marina Karmochkine, Wei Huang, Laurence Weiss, Christos J. Petropoulos, and Charlotte Charpentier Antimicrob. Agents Chemother. October 2009 53: 4522-4524; published ahead of print August 10, 2009, doi:10.1128/AAC.00651-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Body Weight Cutoff for Daily Dosage of Efavirenz and 60-Week Efficacy of Efavirenz-Based Regimen in Human Immunodeficiency Virus and Tuberculosis Coinfected Patients Receiving Rifampin Weerawat Manosuthi, Somnuek Sungkanuparph, Preecha Tantanathip, Wiroj Mankatitham, Aroon Lueangniyomkul, Supeda Thongyen, Boonchuay Eampokarap, Sumonmal Uttayamakul, Pawita Suwanvattana, Samroui Kaewsaard, Kiat Ruxrungtham for the N2R Study Team Antimicrob. Agents Chemother. October 2009 53: 4545-4548; published ahead of print August 10, 2009, doi:10.1128/AAC.00492-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Evaluation of Vancomycin and Daptomycin Potency Trends (MIC Creep) against Methicillin-Resistant Staphylococcus aureus Isolates Collected in Nine U.S. Medical Centers from 2002 to 2006 Helio S. Sader, Paul D. Fey, Douglas N. Fish, Ajit P. Limaye, George Pankey, James Rahal, Michael J. Rybak, David R. Snydman, Lisa L. Steed, Ken Waites, and Ronald N. Jones Antimicrob. Agents Chemother. October 2009 53: 4127-4132; published ahead of print July 27, 2009, doi:10.1128/AAC.00616-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Activities of Piperacillin-Tazobactam against Haemophilus influenzae Isolates, Including β-Lactamase-Negative Ampicillin-Resistant and β-Lactamase-Positive Amoxicillin- Clavulanate-Resistant Isolates, and Mutations in Their Quinolone Resistance-Determining Regions Yoichi Hirakata, Kaori Ohmori, Miwako Mikuriya, Takeshi Saika, Kaoru Matsuzaki, Miyuki Hasegawa, Masumitsu Hatta, Natsuo Yamamoto, Hiroyuki Kunishima, Hisakazu Yano, Miho Kitagawa, Kazuaki Arai, Kazuyoshi Kawakami, Intetsu Kobayashi, Ronald N. Jones, Shigeru Kohno, Keizo Yamaguchi, and Mitsuo Kaku Antimicrob. Agents Chemother. October 2009 53: 4225-4230; published ahead of print August 3, 2009, doi:10.1128/AAC.00192-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antibacterial Activity of Acyl-Lysyl Oligomers against Helicobacter pylori Morris O. Makobongo, Tchelet Kovachi, Hanan Gancz, Amram Mor, and D. Scott Merrell Antimicrob. Agents Chemother. October 2009 53: 4231-4239; published ahead of print July 20, 2009, doi:10.1128/AAC.00510-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Broad-Spectrum Bis-(Imidazolinylindole) Derivatives with Potent Antibacterial Activities against Antibiotic-Resistant Strains Rekha G. Panchal, Ricky L. Ulrich, Douglas Lane, Michelle M. Butler, Chad Houseweart, Timothy Opperman, John D. Williams, Norton P. Peet, Donald T. Moir, Tam Nguyen, Rick Gussio, Terry Bowlin, and Sina Bavari Antimicrob. Agents Chemother. October 2009 53: 4283-4291; published ahead of print July 27, 2009, doi:10.1128/AAC.01709-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

New Selectable Marker for Manipulating the Simple Genomes of Mycoplasma Species Mikkel A. Algire, Carole Lartigue, David W. Thomas, Nacyra Assad-Garcia, John I. Glass, and Chuck Merryman Antimicrob. Agents Chemother. October 2009 53: 4429-4432; published ahead of print August 17, 2009, doi:10.1128/AAC.00388-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro 24-Hour Time-Kill Studies of Vancomycin and Linezolid in Combination versus Methicillin-Resistant Staphylococcus aureus Shveta Rani Singh, Alfred E. Bacon, III, David C. Young, and Kimberly A. Couch Antimicrob. Agents Chemother. October 2009 53: 4495-4497; published ahead of print July 27, 2009, doi:10.1128/AAC.00237-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

ACHN-490, a Neoglycoside with Potent In Vitro Activity against Multidrug-Resistant Klebsiella pneumoniae Isolates Andrea Endimiani, Kristine M. Hujer, Andrea M. Hujer, Eliana S. Armstrong, Yuvraj Choudhary, James B. Aggen, and Robert A. Bonomo Antimicrob. Agents Chemother. October 2009 53: 4504-4507; published ahead of print October 1, 2009, doi:10.1128/AAC.00556-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility of Urinary Tract Bacteria to Fosfomycin Sofia Maraki, George Samonis, Petros I. Rafailidis, Evridiki K. Vouloumanou, Emmanuel Mavromanolakis, and Matthew E. Falagas Antimicrob. Agents Chemother. October 2009 53: 4508-4510; published ahead of print August 17, 2009, doi:10.1128/AAC.00721-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Species Identification and Antifungal Susceptibility Patterns of Species Belonging to Aspergillus Section Nigri Laura Alcazar-Fuoli, Emilia Mellado, Ana Alastruey-Izquierdo, Manuel Cuenca-Estrella, and Juan L. Rodriguez-Tudela Antimicrob. Agents Chemother. October 2009 53: 4514-4517; published ahead of print July 27, 2009, doi:10.1128/AAC.00585-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Panduratin A against Clinical Staphylococcus Strains Yaya Rukayadi, Kwanghyung Lee, Sunghwa Han, Dongeun Yong, and Jae-Kwan Hwang Antimicrob. Agents Chemother. October 2009 53: 4529-4532; published ahead of print August 3, 2009, doi:10.1128/AAC.00624-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Postantibiotic Effect of Ceftaroline against Gram-Positive Organisms G. A. Pankuch and P. C. Appelbaum Antimicrob. Agents Chemother. October 2009 53: 4537-4539; published ahead of print October 1, 2009, doi:10.1128/AAC.00785-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antifungal Activity of Micafungin in Serum Jun Ishikawa, Tetsuo Maeda, Itaru Matsumura, Masato Yasumi, Hidetoshi Ujiie, Hiroaki Masaie, Tsuyoshi Nakazawa, Nobuo Mochizuki, Satoshi Kishino, and Yuzuru Kanakura Antimicrob. Agents Chemother. October 2009 53: 4559-4562; published ahead of print August 17, 2009, doi:10.1128/AAC.01404-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Examination of Potential Mechanisms To Explain the Association between Proton Pump Inhibitors and Clostridium difficile Infection Michelle M. Nerandzic, Michael J. Pultz, and Curtis J. Donskey Antimicrob. Agents Chemother. October 2009 53: 4133-4137; published ahead of print August 10, 2009, doi:10.1128/AAC.00252-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Arabinosyltransferase EmbC Is Inhibited by Ethambutol in Mycobacterium tuberculosis R. Goude, A. G. Amin, D. Chatterjee, and T. Parish Antimicrob. Agents Chemother. October 2009 53: 4138-4146; published ahead of print July 13, 2009, doi:10.1128/AAC.00162-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Furanone at Subinhibitory Concentrations Enhances Staphylococcal Biofilm Formation by luxS Repression Richard Kuehl, Sameer Al-Bataineh, Oliver Gordon, Reto Luginbuehl, Michael Otto, Marcus Textor, and Regine Landmann Antimicrob. Agents Chemother. October 2009 53: 4159-4166; published ahead of print July 20, 2009, doi:10.1128/AAC.01704-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Staphylococcus aureus Mutant Screen Reveals Interaction of the Human Antimicrobial Peptide Dermcidin with Membrane Phospholipids Min Li, Kevin Rigby, Yuping Lai, Vinod Nair, Andreas Peschel, Birgit Schittek, and Michael Otto Antimicrob. Agents Chemother. October 2009 53: 4200-4210; published ahead of print July 13, 2009, doi:10.1128/AAC.00428-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

AI-2/LuxS Is Involved in Increased Biofilm Formation by Streptococcus intermedius in the Presence of Antibiotics Nibras A. Ahmed, Fernanda C. Petersen, and Anne A. Scheie Antimicrob. Agents Chemother. October 2009 53: 4258-4263; published ahead of print July 13, 2009, doi:10.1128/AAC.00546-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Antimalarial Aminoquinolines: Heme Binding and Effects on Normal or Plasmodium falciparum-Parasitized Human Erythrocytes Fausta Omodeo-Salè, Lucia Cortelezzi, Nicoletta Basilico, Manolo Casagrande, Anna Sparatore, and Donatella Taramelli Antimicrob. Agents Chemother. October 2009 53: 4339-4344; published ahead of print August 3, 2009, doi:10.1128/AAC.00536-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Bactericidal Activity of Iclaprim in Human Plasma Heike Laue, Tiziana Valensise, Aurélie Seguin, Sergio Lociuro, Khalid Islam, and Stephen Hawser Antimicrob. Agents Chemother. October 2009 53: 4542-4544; published ahead of print August 3, 2009, doi:10.1128/AAC.00766-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Analytical Procedures:

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High-Throughput Screening Identifies Three Inhibitor Classes of the Telomere Resolvase from the Lyme Disease Spirochete Georgia Lefas and George Chaconas Antimicrob. Agents Chemother. October 2009 53: 4441-4449; published ahead of print July 13, 2009, doi:10.1128/AAC.00529-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Identification of the Aminoglycoside Resistance Determinants armA and rmtC among Non-Typhi Salmonella Isolates from Humans in the United States Jason P. Folster, Regan Rickert, Ezra J. Barzilay, and Jean M. Whichard Antimicrob. Agents Chemother. October 2009 53: 4563-4564; published ahead of print July 13, 2009, doi:10.1128/AAC.00656-09 [Full Text] [PDF] [Reprints and Permissions]

Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland Anna Baraniak, Radoslaw Izdebski, Malgorzata Herda, Janusz Fiett, Waleria Hryniewicz, Marek Gniadkowski, Izabela Kern-Zdanowicz, Krzysztof Filczak, and Urszula Lopaciuk Antimicrob. Agents Chemother. October 2009 53: 4565-4567; published ahead of print July 20, 2009, doi:10.1128/AAC.00436-09 [Full Text] [PDF] [Reprints and Permissions]

Serum Concentrations of Aerosolized Tobramycin in Medical, Surgical, and Trauma Patients Steven D. Burdette, Ashley J. Limkemann, Jonathan B. Slaughter, William B. Beam, and Ronald J. Markert Antimicrob. Agents Chemother. October 2009 53: 4568 published ahead of print August 17, 2009, doi:10.1128/AAC.00490-09 [Full Text] [PDF] [Reprints and Permissions]

Culture Medium Composition Affects the Lethality of Cunninghamella bertholletiae in a Fly Model of Mucormycosis Georgios N. Pongas, Ronen Ben-Ami, Russell E. Lewis, Thomas J. Walsh, and Dimitrios P. Kontoyiannis Antimicrob. Agents Chemother. October 2009 53: 4569 published ahead of print July 27, 2009, doi:10.1128/AAC.00994-09 [Full Text] [PDF] [Reprints and Permissions]

New PfATP6 Mutations Found in Plasmodium falciparum Isolates from Vietnam Lionel Bertaux, Le Hong Quang, Véronique Sinou, Nguyen Xuan Thanh, and Daniel Parzy Antimicrob. Agents Chemother. October 2009 53: 4570-4571; published ahead of print August 17, 2009, doi:10.1128/AAC.00684-09 [Full Text] [PDF] [Reprints and Permissions]

Is Vancomycin Ototoxicity a Significant Risk? Ryan K. Shields, Jay L. Martello, Brian A. Potoski, George Sakoulas, and Pamela A. Moise Antimicrob. Agents Chemother. October 2009 53: 4572-4573; [Full Text] [PDF] [Reprints and Permissions]

Relationship between Antibiotic Consumption and Clostridium difficile-Associated Diarrhea: an Epidemiological Note Klaus Kaier and Uwe Frank Antimicrob. Agents Chemother. October 2009 53: 4574-4575; [Full Text] [PDF] [Reprints and Permissions]

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