AAC -- Table of Contents (February 1 2009, 53 [2])

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Contents: February 2009, Volume 53, Issue 2

       Minireviews

       Mechanisms of Resistance

       Susceptibility

       Mechanisms of Action

       Experimental Therapeutics

       Antiviral Agents

       Pharmacology

       Clinical Therapeutics

       Analytical Procedures

       Letters

       Errata

Other Issues

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Table of Contents

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Minireviews:

Genetic Elements Responsible for Erythromycin Resistance in Streptococci
Pietro E. Varaldo, Maria Pia Montanari, and Eleonora Giovanetti
Antimicrob. Agents Chemother. February 2009 53: 343-353; published ahead of print November 10, 2008, doi:10.1128/AAC.00781-08
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Mechanisms of Resistance:

Abc1p Is a Multidrug Efflux Transporter That Tips the Balance in Favor of Innate Azole Resistance in Candida krusei
Erwin Lamping, Amrita Ranchod, Kenjirou Nakamura, Joel D. A. Tyndall, Kyoko Niimi, Ann R. Holmes, Masakazu Niimi, and Richard D. Cannon
Antimicrob. Agents Chemother. February 2009 53: 354-369; published ahead of print November 17, 2008, doi:10.1128/AAC.01095-08
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Reconstruction of the Phenotypes of Methicillin-Resistant Staphylococcus aureus by Replacement of the Staphylococcal Cassette Chromosome mec with a Plasmid-Borne Copy of Staphylococcus sciuri pbpD Gene
Aude Antignac and Alexander Tomasz
Antimicrob. Agents Chemother. February 2009 53: 435-441; published ahead of print November 17, 2008, doi:10.1128/AAC.01099-08
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Diversity of Staphylococcal Cassette Chromosome mec Structures in Methicillin-Resistant Staphylococcus epidermidis and Staphylococcus haemolyticus Strains among Outpatients from Four Countries
Etienne Ruppé, François Barbier, Yasmine Mesli, Aminata Maiga, Radu Cojocaru, Mokhtar Benkhalfat, Samia Benchouk, Hafida Hassaine, Ibrahim Maiga, Amadou Diallo, Abdel Karim Koumaré, Kalilou Ouattara, Sambou Soumaré, Jean-Baptiste Dufourcq, Chhor Nareth, Jean-Louis Sarthou, Antoine Andremont, and Raymond Ruimy
Antimicrob. Agents Chemother. February 2009 53: 442-449; published ahead of print November 10, 2008, doi:10.1128/AAC.00724-08
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Characterization and Sequence Analysis of Extended-Spectrum-β-Lactamase-Encoding Genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis Isolates Collected during Tigecycline Phase 3 Clinical Trials
C. Hal Jones, Margareta Tuckman, David Keeney, Alexey Ruzin, and Patricia A. Bradford
Antimicrob. Agents Chemother. February 2009 53: 465-475; published ahead of print November 17, 2008, doi:10.1128/AAC.00883-08
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Differential Effects of Inhibiting Chitin and 1,3-β-D-Glucan Synthesis in Ras and Calcineurin Mutants of Aspergillus fumigatus
Jarrod R. Fortwendel, Praveen Rao Juvvadi, Nadthanan Pinchai, B. Zachary Perfect, J. Andrew Alspaugh, John R. Perfect, and William J. Steinbach
Antimicrob. Agents Chemother. February 2009 53: 476-482; published ahead of print November 17, 2008, doi:10.1128/AAC.01154-08
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Molecular Evidence for Spread of Two Major Methicillin-Resistant Staphylococcus aureus Clones with a Unique Geographic Distribution in Chinese Hospitals
Yudong Liu, Hui Wang, Na Du, Enhua Shen, Hongbin Chen, Junqi Niu, Huifen Ye, and Minjun Chen
Antimicrob. Agents Chemother. February 2009 53: 512-518; published ahead of print November 24, 2008, doi:10.1128/AAC.00804-08
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High Prevalence of Plasmid-Mediated Quinolone Resistance Determinants qnr, aac(6')-Ib-cr, and qepA among Ceftiofur-Resistant Enterobacteriaceae Isolates from Companion and Food-Producing Animals
Junying Ma, Zhenling Zeng, Zhangliu Chen, Xiaogang Xu, Xiaoying Wang, Yuting Deng, Dianhong Lü, Liangzong Huang, Yunyuan Zhang, Jianhua Liu, and Minggui Wang
Antimicrob. Agents Chemother. February 2009 53: 519-524; published ahead of print October 20, 2008, doi:10.1128/AAC.00886-08
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Novel Staphylococcal Cassette Chromosome mec Type, Tentatively Designated Type VIII, Harboring Class A mec and Type 4 ccr Gene Complexes in a Canadian Epidemic Strain of Methicillin-Resistant Staphylococcus aureus
Kunyan Zhang, Jo-Ann McClure, Sameer Elsayed, and John M. Conly
Antimicrob. Agents Chemother. February 2009 53: 531-540; published ahead of print December 8, 2008, doi:10.1128/AAC.01118-08
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Phenotypic and Enzymatic Comparative Analysis of the Novel KPC Variant KPC-5 and Its Evolutionary Variants, KPC-2 and KPC-4
Daniel J. Wolter, Philip M. Kurpiel, Neil Woodford, Marie-France I. Palepou, Richard V. Goering, and Nancy D. Hanson
Antimicrob. Agents Chemother. February 2009 53: 557-562; published ahead of print November 17, 2008, doi:10.1128/AAC.00734-08
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qnrD, a Novel Gene Conferring Transferable Quinolone Resistance in Salmonella enterica Serovar Kentucky and Bovismorbificans Strains of Human Origin
L. M. Cavaco, H. Hasman, S. Xia, and F. M. Aarestrup
Antimicrob. Agents Chemother. February 2009 53: 603-608; published ahead of print November 24, 2008, doi:10.1128/AAC.00997-08
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Prevalence of Plasmid-Mediated Quinolone Resistance Determinants over a 9-Year Period
Hong Bin Kim, Chi Hye Park, Chung Jong Kim, Eui-Chong Kim, George A. Jacoby, and David C. Hooper
Antimicrob. Agents Chemother. February 2009 53: 639-645; published ahead of print December 8, 2008, doi:10.1128/AAC.01051-08
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Immunity to the Bacteriocin Sublancin 168 Is Determined by the SunI (YolF) Protein of Bacillus subtilis
Jean-Yves F. Dubois, Thijs R. H. M. Kouwen, Anna K. C. Schurich, Carlos R. Reis, Hendrik T. Ensing, Erik N. Trip, Jessica C. Zweers, and Jan Maarten van Dijl
Antimicrob. Agents Chemother. February 2009 53: 651-661; published ahead of print December 1, 2008, doi:10.1128/AAC.01189-08
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Prevalence of Sulfonamide Resistance Genes in Bacterial Isolates from Manured Agricultural Soils and Pig Slurry in the United Kingdom
K. G. Byrne-Bailey, W. H. Gaze, P. Kay, A. B. A. Boxall, P. M. Hawkey, and E. M. H. Wellington
Antimicrob. Agents Chemother. February 2009 53: 696-702; published ahead of print December 8, 2008, doi:10.1128/AAC.00652-07
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Variation in Salmonella enterica Serovar Typhi IncHI1 Plasmids during the Global Spread of Resistant Typhoid Fever
Minh-Duy Phan, Claire Kidgell, Satheesh Nair, Kathryn E. Holt, Arthur K. Turner, Jason Hinds, Philip Butcher, Fiona J. Cooke, Nicholas R. Thomson, Richard Titball, Zulfiqar A. Bhutta, Rumina Hasan, Gordon Dougan, and John Wain
Antimicrob. Agents Chemother. February 2009 53: 716-727; published ahead of print November 17, 2008, doi:10.1128/AAC.00645-08
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Isolation of VanB-Type Enterococcus faecalis Strains from Nosocomial Infections: First Report of the Isolation and Identification of the Pheromone-Responsive Plasmids pMG2200, Encoding VanB-Type Vancomycin Resistance and a Bac41-Type Bacteriocin, and pMG2201, Encoding Erythromycin Resistance and Cytolysin (Hly/Bac)
Bo Zheng, Haruyoshi Tomita, Takako Inoue, and Yasuyoshi Ike
Antimicrob. Agents Chemother. February 2009 53: 735-747; published ahead of print November 24, 2008, doi:10.1128/AAC.00754-08
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Identification of a Novel Trimethoprim Resistance Gene, dfrK, in a Methicillin-Resistant Staphylococcus aureus ST398 Strain and Its Physical Linkage to the Tetracycline Resistance Gene tet(L)
Kristina Kadlec and Stefan Schwarz
Antimicrob. Agents Chemother. February 2009 53: 776-778; published ahead of print November 17, 2008, doi:10.1128/AAC.01128-08
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Methicillin-Resistant and -Susceptible Staphylococcus aureus Strains of Clonal Lineages ST398 and ST9 from Swine Carry the Multidrug Resistance Gene cfr
Corinna Kehrenberg, Christiane Cuny, Birgit Strommenger, Stefan Schwarz, and Wolfgang Witte
Antimicrob. Agents Chemother. February 2009 53: 779-781; published ahead of print December 1, 2008, doi:10.1128/AAC.01376-08
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First Report on a Hyperepidemic Clone of KPC-3-Producing Klebsiella pneumoniae in Israel Genetically Related to a Strain Causing Outbreaks in the United States
Shiri Navon-Venezia, Azita Leavitt, Mitchell J. Schwaber, J. Kamile Rasheed, Arjun Srinivasan, Jean B. Patel, Yehuda Carmeli and the Israeli KPC Kpn Study Group
Antimicrob. Agents Chemother. February 2009 53: 818-820; published ahead of print November 24, 2008, doi:10.1128/AAC.00987-08
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SOS Regulation of qnrB Expression
Minghua Wang, George A. Jacoby, Debra M. Mills, and David C. Hooper
Antimicrob. Agents Chemother. February 2009 53: 821-823; published ahead of print November 24, 2008, doi:10.1128/AAC.00132-08
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Truncated tni Module Adjacent to the Complex Integron of Salmonella Genomic Island 1 in Salmonella enterica Serovar Virchow
Benoît Doublet, Chishih Chu, Cheng-Hsun Chiu, Yi-Chin Fan, and Axel Cloeckaert
Antimicrob. Agents Chemother. February 2009 53: 824-827; published ahead of print November 17, 2008, doi:10.1128/AAC.01015-08
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CTX-M Expression and Selection of Ertapenem Resistance in Klebsiella pneumoniae and Escherichia coli
Delphine Girlich, Laurent Poirel, and Patrice Nordmann
Antimicrob. Agents Chemother. February 2009 53: 832-834; published ahead of print November 24, 2008, doi:10.1128/AAC.01007-08
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Susceptibility:

Establishment of In Vitro Susceptibility Testing Methodologies and Comparative Activities of Piperacillin in Combination with the Penem β-Lactamase Inhibitor BLI-489
Peter J. Petersen, C. Hal Jones, Aranapakam M. Venkatesan, Tarek S. Mansour, Steven J. Projan, and Patricia A. Bradford
Antimicrob. Agents Chemother. February 2009 53: 370-384; published ahead of print November 10, 2008, doi:10.1128/AAC.01047-08
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In Vitro Activity of LK-157, a Novel Tricyclic Carbapenem As Broad-Spectrum β-Lactamase Inhibitor
Susanne Paukner, Lars Hesse, Andrej Prezelj, Tomaz Solmajer, and Uros Urleb
Antimicrob. Agents Chemother. February 2009 53: 505-511; published ahead of print December 15, 2008, doi:10.1128/AAC.00085-08
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In Vitro Evaluation of the Antimicrobial Activity of Ceftaroline against Cephalosporin-Resistant Isolates of Streptococcus pneumoniae
Lesley McGee, Donald Biek, Yigong Ge, Magderie Klugman, Mignon du Plessis, Anthony M. Smith, Bernard Beall, Cynthia G. Whitney, and Keith P. Klugman
Antimicrob. Agents Chemother. February 2009 53: 552-556; published ahead of print November 17, 2008, doi:10.1128/AAC.01324-08
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Multinormal In Vitro Distribution Model Suitable for the Distribution of Plasmodium falciparum Chemosusceptibility to Doxycycline
Sébastien Briolant, Meili Baragatti, Philippe Parola, Fabrice Simon, Adama Tall, Cheikh Sokhna, Philippe Hovette, Modeste Mabika Mamfoumbi, Jean-Louis Koeck, Jean Delmont, André Spiegel, Jacky Castello, Jean Pierre Gardair, Jean Francois Trape, Maryvonne Kombila, Philippe Minodier, Thierry Fusai, Christophe Rogier, and Bruno Pradines
Antimicrob. Agents Chemother. February 2009 53: 688-695; published ahead of print December 1, 2008, doi:10.1128/AAC.00546-08
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Antifungal Activity of Caspofungin in Combination with Amphotericin B against Candida glabrata: Comparison of Disk Diffusion, Etest, and Time-Kill Methods
Nuri Kiraz, Ilknur Dag, Mustafa Yamac, Abdurrahman Kiremitci, Nilgun Kasifoglu, and Yurdanur Akgun
Antimicrob. Agents Chemother. February 2009 53: 788-790; published ahead of print November 24, 2008, doi:10.1128/AAC.01131-08
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In Vitro Activities of Various Antifungal Drugs against Aspergillus terreus: Global Assessment Using the Methodology of the European Committee on Antimicrobial Susceptibility Testing
Cornelia Lass-Flörl, Ana Alastruey-Izquierdo, Manuel Cuenca-Estrella, Susanne Perkhofer, and Juan Luis Rodriguez-Tudela
Antimicrob. Agents Chemother. February 2009 53: 794-795; published ahead of print December 8, 2008, doi:10.1128/AAC.00335-08
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Nalidixic Acid Disk for Laboratory Detection of Ciprofloxacin Resistance in Neisseria meningitidis
Rocío Enríquez, Raquel Abad, Celia Salcedo, and Julio A. Vázquez
Antimicrob. Agents Chemother. February 2009 53: 796-797; published ahead of print November 17, 2008, doi:10.1128/AAC.00531-08
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In Vitro Activity of the Quinolone WCK 771 against Recent U.S. Hospital and Community-Acquired Staphylococcus aureus Pathogens with Various Resistance Types
Sachin S. Bhagwat, Pamela McGhee, Klaudia Kosowska-Shick, Mahesh V. Patel, and Peter C. Appelbaum
Antimicrob. Agents Chemother. February 2009 53: 811-813; published ahead of print November 24, 2008, doi:10.1128/AAC.01150-08
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Activity of Levofloxacin Alone and in Combination with a DnaK Inhibitor against Gram-Negative Rods, Including Levofloxacin-Resistant Strains
Kim Credito, Gengrong Lin, Laura Koeth, Michael A. Sturgess, and Peter C. Appelbaum
Antimicrob. Agents Chemother. February 2009 53: 814-817; published ahead of print November 17, 2008, doi:10.1128/AAC.01132-08
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In Vitro Susceptibility of Field Isolates of Leishmania donovani to Miltefosine and Amphotericin B: Correlation with Sodium Antimony Gluconate Susceptibility and Implications for Treatment in Areas of Endemicity
Dhiraj Kumar, Arpita Kulshrestha, Ruchi Singh, and Poonam Salotra
Antimicrob. Agents Chemother. February 2009 53: 835-838; published ahead of print November 17, 2008, doi:10.1128/AAC.01233-08
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Mechanisms of Action:

Targeting Type III Secretion in Yersinia pestis
Ning J. Pan, Michael J. Brady, John M. Leong, and Jon D. Goguen
Antimicrob. Agents Chemother. February 2009 53: 385-392; published ahead of print November 17, 2008, doi:10.1128/AAC.00670-08
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Giardia, Entamoeba, and Trichomonas Enzymes Activate Metronidazole (Nitroreductases) and Inactivate Metronidazole (Nitroimidazole Reductases)
Dibyarupa Pal, Sulagna Banerjee, Jike Cui, Aaron Schwartz, Sudip K. Ghosh, and John Samuelson
Antimicrob. Agents Chemother. February 2009 53: 458-464; published ahead of print November 17, 2008, doi:10.1128/AAC.00909-08
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Inhibition of Inositol Phosphorylceramide Synthase by the Cyclic Peptide Aureobasidin A
Paul A. Aeed, Casey L. Young, Marek M. Nagiec, and Åke P. Elhammer
Antimicrob. Agents Chemother. February 2009 53: 496-504; published ahead of print December 1, 2008, doi:10.1128/AAC.00633-08
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Variations in Amino Acid Composition of Antisense Peptide-Phosphorodiamidate Morpholino Oligomer Affect Potency against Escherichia coli In Vitro and In Vivo
Brett L. Mellbye, Susan E. Puckett, Luke D. Tilley, Patrick L. Iversen, and Bruce L. Geller
Antimicrob. Agents Chemother. February 2009 53: 525-530; published ahead of print November 17, 2008, doi:10.1128/AAC.00917-08
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Erythromycin- and Chloramphenicol-Induced Ribosomal Assembly Defects Are Secondary Effects of Protein Synthesis Inhibition
Triinu Siibak, Lauri Peil, Liqun Xiong, Alexander Mankin, Jaanus Remme, and Tanel Tenson
Antimicrob. Agents Chemother. February 2009 53: 563-571; published ahead of print November 24, 2008, doi:10.1128/AAC.00870-08
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Ambuic Acid Inhibits the Biosynthesis of Cyclic Peptide Quormones in Gram-Positive Bacteria
Jiro Nakayama, Yumi Uemura, Kenzo Nishiguchi, Norito Yoshimura, Yasuhiro Igarashi, and Kenji Sonomoto
Antimicrob. Agents Chemother. February 2009 53: 580-586; published ahead of print November 17, 2008, doi:10.1128/AAC.00995-08
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Evaluation of Strategies for Improving Proteolytic Resistance of Antimicrobial Peptides by Using Variants of EFK17, an Internal Segment of LL-37
Adam A. Strömstedt, Mukesh Pasupuleti, Artur Schmidtchen, and Martin Malmsten
Antimicrob. Agents Chemother. February 2009 53: 593-602; published ahead of print November 24, 2008, doi:10.1128/AAC.00477-08
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Discovery of a Small-Molecule Inhibitor of β-1,6-Glucan Synthesis
Akihiro Kitamura, Kazuhiko Someya, Masato Hata, Ryohei Nakajima, and Makoto Takemura
Antimicrob. Agents Chemother. February 2009 53: 670-677; published ahead of print November 17, 2008, doi:10.1128/AAC.00844-08
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A Small-Molecule Screen Identifies the Antipsychotic Drug Pimozide as an Inhibitor of Listeria monocytogenes Infection
Linda A. Lieberman and Darren E. Higgins
Antimicrob. Agents Chemother. February 2009 53: 756-764; published ahead of print November 17, 2008, doi:10.1128/AAC.00607-08
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Postantibiotic Effect of Tigecycline against 14 Gram-Positive Organisms
G. A. Pankuch and P. C. Appelbaum
Antimicrob. Agents Chemother. February 2009 53: 782-784; published ahead of print December 8, 2008, doi:10.1128/AAC.01122-08
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Ultrastructural Effects of Oritavancin on Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus
Adam Belley, Robert Harris, Terry Beveridge, Tom Parr, Jr., and Gregory Moeck
Antimicrob. Agents Chemother. February 2009 53: 800-804; published ahead of print November 24, 2008, doi:10.1128/AAC.00603-08
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Impact of Inoculum Size and Heterogeneous Vancomycin-Intermediate Staphylococcus aureus (hVISA) on Vancomycin Activity and Emergence of VISA in an In Vitro Pharmacodynamic Model
Warren E. Rose, Steven N. Leonard, Kerri L. Rossi, Glenn W. Kaatz, and Michael J. Rybak
Antimicrob. Agents Chemother. February 2009 53: 805-807; published ahead of print November 17, 2008, doi:10.1128/AAC.01009-08
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Experimental Therapeutics:

Chitosan Acetate Bandage as a Topical Antimicrobial Dressing for Infected Burns
Tianhong Dai, George P. Tegos, Marina Burkatovskaya, Ana P. Castano, and Michael R. Hamblin
Antimicrob. Agents Chemother. February 2009 53: 393-400; published ahead of print November 17, 2008, doi:10.1128/AAC.00760-08
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Effects of Exposure of Clostridium difficile PCR Ribotypes 027 and 001 to Fluoroquinolones in a Human Gut Model
Katie Saxton, Simon D. Baines, Jane Freeman, Rachael O'Connor, and Mark H. Wilcox
Antimicrob. Agents Chemother. February 2009 53: 412-420; published ahead of print August 18, 2008, doi:10.1128/AAC.00306-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Statistical Model To Evaluate In Vivo Activities of Antimalarial Drugs in a Plasmodium cynomolgi-Macaque Model for Plasmodium vivax Malaria
Clemens H. M. Kocken, Edmond J. Remarque, Martin A. Dubbeld, Sharon Wein, Annemarie van der Wel, R. Joyce Verburgh, Henri J. Vial, and Alan W. Thomas
Antimicrob. Agents Chemother. February 2009 53: 421-427; published ahead of print November 17, 2008, doi:10.1128/AAC.00576-08
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Compounds Structurally Related to Ellagic Acid Show Improved Antiplasmodial Activity
Nicole Sturm, Ying Hu, Herbert Zimmermann, Karin Fritz-Wolf, Sergio Wittlin, Stefan Rahlfs, and Katja Becker
Antimicrob. Agents Chemother. February 2009 53: 622-630; published ahead of print November 17, 2008, doi:10.1128/AAC.00544-08
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Posaconazole Mono- or Combination Therapy for Treatment of Murine Zygomycosis
Ashraf S. Ibrahim, Teclegiorgis Gebremariam, Julie A. Schwartz, John E. Edwards, Jr., and Brad Spellberg
Antimicrob. Agents Chemother. February 2009 53: 772-775; published ahead of print October 20, 2008, doi:10.1128/AAC.01124-08
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Antileishmanial Activity of 1,3,4-Thiadiazolium-2-Aminide in Mice Infected with Leishmania amazonensis
Raquel F. Rodrigues, Karen S. Charret, Edson F. da Silva, Áurea Echevarria, Verônica F. Amaral, Leonor L. Leon, and Marilene M. Canto-Cavalheiro
Antimicrob. Agents Chemother. February 2009 53: 839-842; published ahead of print November 17, 2008, doi:10.1128/AAC.00062-08
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Antiviral Agents:

Selection and Characterization of Hepatitis C Virus Replicons Dually Resistant to the Polymerase and Protease Inhibitors HCV-796 and Boceprevir (SCH 503034)
Mike Flint, Stanley Mullen, Anne M. Deatly, Wei Chen, Lynn Z. Miller, Robert Ralston, Colin Broom, Emilio A. Emini, and Anita Y. M. Howe
Antimicrob. Agents Chemother. February 2009 53: 401-411; published ahead of print October 20, 2008, doi:10.1128/AAC.01081-08
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Safety, Pharmacokinetics, and Antiretroviral Activity of Multiple Doses of Ibalizumab (formerly TNX-355), an Anti-CD4 Monoclonal Antibody, in Human Immunodeficiency Virus Type 1-Infected Adults
Jeffrey M. Jacobson, Daniel R. Kuritzkes, Eliot Godofsky, Edwin DeJesus, Jeffrey A. Larson, Steven P. Weinheimer, and Stanley T. Lewis
Antimicrob. Agents Chemother. February 2009 53: 450-457; published ahead of print November 17, 2008, doi:10.1128/AAC.00942-08
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Inhibition of Human Immunodeficiency Virus Type 1 Infection by the Candidate Microbicide Dapivirine, a Nonnucleoside Reverse Transcriptase Inhibitor
P. Fletcher, S. Harman, H. Azijn, N. Armanasco, P. Manlow, D. Perumal, M.-P. de Bethune, J. Nuttall, J. Romano, and R. Shattock
Antimicrob. Agents Chemother. February 2009 53: 487-495; published ahead of print November 24, 2008, doi:10.1128/AAC.01156-08
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Activities of Certain 5-Substituted 4'-Thiopyrimidine Nucleosides against Orthopoxvirus Infections
Earl R. Kern, Mark N. Prichard, Debra C. Quenelle, Kathy A. Keith, Kamal N. Tiwari, Joseph A. Maddry, and John A. Secrist, III
Antimicrob. Agents Chemother. February 2009 53: 572-579; published ahead of print November 24, 2008, doi:10.1128/AAC.01257-08
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Polymorphism in the Human Major Histocompatibility Complex and Early Viral Decline during Treatment of Chronic Hepatitis C
Leland J. Yee, KyungAh Im, Abdus S. Wahed, Teodorica Bugawan, Jia Li, Shannon L. Rhodes, Henry Erlich, Hugo R. Rosen, T. Jake Liang, Huiying Yang for the Virahep-C Study
Antimicrob. Agents Chemother. February 2009 53: 615-621; published ahead of print October 13, 2008, doi:10.1128/AAC.00947-08
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Specific Interactions between the Viral Coreceptor CXCR4 and the Biguanide-Based Compound NB325 Mediate Inhibition of Human Immunodeficiency Virus Type 1 Infection
Nina Thakkar, Vanessa Pirrone, Shendra Passic, Wei Zhu, Vladyslav Kholodovych, William Welsh, Robert F. Rando, Mohamed E. Labib, Brian Wigdahl, and Fred C. Krebs
Antimicrob. Agents Chemother. February 2009 53: 631-638; published ahead of print December 1, 2008, doi:10.1128/AAC.00866-08
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Candidate Polyanionic Microbicides Inhibit Human T-Cell Lymphotropic Virus Type 1 Receptor Interactions, Cell-Free Infection, and Cell-Cell Spread
Daniela Romer, David W. Brighty, Cynthia L. Robson, and Quentin J. Sattentau
Antimicrob. Agents Chemother. February 2009 53: 678-687; published ahead of print December 1, 2008, doi:10.1128/AAC.01550-07
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Nucleoside and Nucleotide Analogs Select in Culture for Different Patterns of Drug Resistance in Human Immunodeficiency Virus Types 1 and 2
Michel L. Ntemgwa, Thomas d'Aquin Toni, Bluma G. Brenner, Maureen Oliveira, Eugene L. Asahchop, Daniela Moisi, and Mark A. Wainberg
Antimicrob. Agents Chemother. February 2009 53: 708-715; published ahead of print December 8, 2008, doi:10.1128/AAC.01109-08
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Fluorescence Resonance Energy Transfer-Based Assay for Characterization of Hepatitis C Virus NS3-4A Protease Activity in Live Cells
Rosario Sabariegos, Fernando Picazo, Beatriz Domingo, Sandra Franco, Miguel-Angel Martinez, and Juan Llopis
Antimicrob. Agents Chemother. February 2009 53: 728-734; published ahead of print December 8, 2008, doi:10.1128/AAC.01029-08
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Real-Time Monitoring of Human Enterovirus (HEV)-Infected Cells and Anti-HEV 3C Protease Potency by Fluorescence Resonance Energy Transfer
Meng-Tian Tsai, Yun-Hsiang Cheng, Yu-Ning Liu, Nien-Chien Liao, Wen-Wen Lu, and Szu-Hao Kung
Antimicrob. Agents Chemother. February 2009 53: 748-755; published ahead of print November 17, 2008, doi:10.1128/AAC.00841-08
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Variety of Antiprion Compounds Discovered through an In Silico Screen Based on Cellular-Form Prion Protein Structure: Correlation between Antiprion Activity and Binding Affinity
Junji Hosokawa-Muto, Yuji O. Kamatari, Hironori K. Nakamura, and Kazuo Kuwata
Antimicrob. Agents Chemother. February 2009 53: 765-771; published ahead of print November 17, 2008, doi:10.1128/AAC.01112-08
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Activity of the Oral Neuraminidase Inhibitor A-322278 against the Oseltamivir-Resistant H274Y (A/H1N1) Influenza Virus Mutant in Mice
Mariana Baz, Yacine Abed, Benjamin Nehmé, and Guy Boivin
Antimicrob. Agents Chemother. February 2009 53: 791-793; published ahead of print November 17, 2008, doi:10.1128/AAC.01276-08
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Pharmacology:

Daptomycin Pharmacokinetics in Adult Oncology Patients with Neutropenic Fever
Joseph S. Bubalo, Myrna Y. Munar, Ganesh Cherala, Brandon Hayes-Lattin, and Richard Maziarz
Antimicrob. Agents Chemother. February 2009 53: 428-434; published ahead of print November 17, 2008, doi:10.1128/AAC.00943-08
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Voriconazole Increases while Itraconazole Decreases Plasma Meloxicam Concentrations
V. V. Hynninen, K. T. Olkkola, L. Bertilsson, K. J. Kurkinen, T. Korhonen, P. J. Neuvonen, and K. Laine
Antimicrob. Agents Chemother. February 2009 53: 587-592; published ahead of print November 17, 2008, doi:10.1128/AAC.00530-08
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Drug-Drug Interaction Study of Ketoconazole and Ritonavir-Boosted Saquinavir
Benoite Kaeser, Hagen Zandt, Fabrice Bour, Elke Zwanziger, Christophe Schmitt, and Xiaoping Zhang
Antimicrob. Agents Chemother. February 2009 53: 609-614; published ahead of print November 17, 2008, doi:10.1128/AAC.00769-08
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Effect of a Single Dose of Ritonavir on the Pharmacokinetic Behavior of Elvucitabine, a Nucleoside Reverse Transcriptase Inhibitor, Administered in Healthy Volunteers
Philippe Colucci, John C. Pottage, Heather Robison, Jacques Turgeon, and Murray P. Ducharme
Antimicrob. Agents Chemother. February 2009 53: 646-650; published ahead of print November 17, 2008, doi:10.1128/AAC.00905-08
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Multiple-Dose Pharmacokinetic Behavior of Elvucitabine, a Nucleoside Reverse Transcriptase Inhibitor, Administered over 21 Days with Lopinavir-Ritonavir in Human Immunodeficiency Virus Type 1-Infected Subjects
Philippe Colucci, John C. Pottage, Heather Robison, Jacques Turgeon, Dirk Schürmann, I. M. Hoepelman, and Murray P. Ducharme
Antimicrob. Agents Chemother. February 2009 53: 662-669; published ahead of print November 17, 2008, doi:10.1128/AAC.00907-08
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Intrapulmonary Pharmacokinetics and Pharmacodynamics of Posaconazole at Steady State in Healthy Subjects
John E. Conte, Jr., Jeffrey A. Golden, Gopal Krishna, Marina McIver, Emily Little, and Elisabeth Zurlinden
Antimicrob. Agents Chemother. February 2009 53: 703-707; published ahead of print November 24, 2008, doi:10.1128/AAC.00663-08
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Reassessment of Recommended Imipenem Doses in Febrile Neutropenic Patients with Hematological Malignancies
F. Lamoth, T. Buclin, C. Csajka, A. Pascual, T. Calandra, and O. Marchetti
Antimicrob. Agents Chemother. February 2009 53: 785-787; published ahead of print December 1, 2008, doi:10.1128/AAC.00891-08
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Preparation and Stability of Voriconazole Eye Drop Solution
Antoine Dupuis, Nicolas Tournier, Gwenaël Le Moal, and Nicolas Venisse
Antimicrob. Agents Chemother. February 2009 53: 798-799; published ahead of print November 10, 2008, doi:10.1128/AAC.01126-08
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Pharmacokinetics and Bioequivalence Evaluation of Two Fixed-Dose Tablet Formulations of Dihydroartemisinin and Piperaquine in Vietnamese Subjects
Nguyen Trong Chinh, Nguyen Ngoc Quang, Nguyen Xuan Thanh, Bui Dai, Jason P. Geue, Russell S. Addison, Thomas Travers, and Michael D. Edstein
Antimicrob. Agents Chemother. February 2009 53: 828-831; published ahead of print December 1, 2008, doi:10.1128/AAC.00927-08
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Clinical Therapeutics:

Vancomycin Ototoxicity: a Reevaluation in an Era of Increasing Doses
Avisheh Forouzesh, Pamela A. Moise, and George Sakoulas
Antimicrob. Agents Chemother. February 2009 53: 483-486; published ahead of print November 10, 2008, doi:10.1128/AAC.01088-08
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Comprehensive In Vitro Analysis of Voriconazole Inhibition of Eight Cytochrome P450 (CYP) Enzymes: Major Effect on CYPs 2B6, 2C9, 2C19, and 3A
Seongwook Jeong, Phuong D. Nguyen, and Zeruesenay Desta
Antimicrob. Agents Chemother. February 2009 53: 541-551; published ahead of print November 24, 2008, doi:10.1128/AAC.01123-08
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Analytical Procedures:

Comparison of the Performances of Two In-House Rapid Methods for Antitubercular Drug Susceptibility Testing
Agustina I. de la Iglesia, Emma J. Stella, and Héctor R. Morbidoni
Antimicrob. Agents Chemother. February 2009 53: 808-810; published ahead of print November 17, 2008, doi:10.1128/AAC.00960-08
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Letters:

Codetection of bla_OXA-23-Like Gene (bla_OXA-133) and bla_OXA-58 in Acinetobacter radioresistens: Report from the SENTRY Antimicrobial Surveillance Program
Rodrigo E. Mendes, Jan M. Bell, John D. Turnidge, Mariana Castanheira, Lalitagauri M. Deshpande, and Ronald N. Jones
Antimicrob. Agents Chemother. February 2009 53: 843-844; published ahead of print November 17, 2008, doi:10.1128/AAC.00999-08
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IncA/C Plasmid-Mediated Florfenicol Resistance in the Catfish Pathogen Edwardsiella ictaluri
Timothy J. Welch, Jason Evenhuis, David G. White, Patrick F. McDermott, Heather Harbottle, Ron A. Miller, Matt Griffin, and David Wise
Antimicrob. Agents Chemother. February 2009 53: 845-846; published ahead of print November 24, 2008, doi:10.1128/AAC.01312-08
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Errata:

High Prevalence of Plasmid-Mediated Quinolone Resistance Genes qnr and aac(6')-Ib-cr in Clinical Isolates of Enterobacteriaceae from Nine Teaching Hospitals in China
Hong Yang, Hongbin Chen, Qiwen Yang, Minjun Chen, and Hui Wang
Antimicrob. Agents Chemother. February 2009 53: 847
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Secretion of E,E-Farnesol and Biofilm Formation in Eight Different Candida Species
K. Weber, R. Sohr, B. Schulz, M. Fleischhacker, and M. Ruhnke
Antimicrob. Agents Chemother. February 2009 53: 848
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