Contents: March 2009, Volume 53, Issue 3        Minireviews        Pharmacology        Mechanisms of Resistance        Clinical Therapeutics        Antiviral Agents        Susceptibility        Mechanisms of Action        Experimental Therapeutics        Chemistry; Biosynthesis        Letters        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

---

Minireviews:

---

New Drugs against Tuberculosis: Problems, Progress, and Evaluation of Agents in Clinical Development Jossy van den Boogaard, Gibson S. Kibiki, Elton R. Kisanga, Martin J. Boeree, and Rob E. Aarnoutse Antimicrob. Agents Chemother. March 2009 53: 849-862; published ahead of print December 15, 2008, doi:10.1128/AAC.00749-08 [Full Text] [PDF] [Reprints and Permissions]

---

Pharmacology:

---

CYP2B6 G516T Polymorphism but Not Rifampin Coadministration Influences Steady-State Pharmacokinetics of Efavirenz in Human Immunodeficiency Virus-Infected Patients in South India Geetha Ramachandran, A. K. Hemanth Kumar, Sikhamani Rajasekaran, P. Kumar, K. Ramesh, S. Anitha, G. Narendran, Pradeep Menon, C. Gomathi, and Soumya Swaminathan Antimicrob. Agents Chemother. March 2009 53: 863-868; published ahead of print January 5, 2009, doi:10.1128/AAC.00899-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Safety of Caspofungin in Neonates and Infants Less than 3 Months of Age Xavier Sáez-Llorens, Mercedes Macias, Padmanabha Maiya, Juan Pineros, Hasan S. Jafri, Archana Chatterjee, Gloria Ruiz, Janaki Raghavan, Susan K. Bradshaw, Nicholas A. Kartsonis, Peng Sun, Kim M. Strohmaier, Marissa Fallon, Sheng Bi, Julie A. Stone, and Joseph W. Chow Antimicrob. Agents Chemother. March 2009 53: 869-875; published ahead of print December 15, 2008, doi:10.1128/AAC.00868-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetic Analysis of Voriconazole Plasma Concentration Data from Pediatric Studies Mats O. Karlsson, Irja Lutsar, and Peter A. Milligan Antimicrob. Agents Chemother. March 2009 53: 935-944; published ahead of print December 15, 2008, doi:10.1128/AAC.00751-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of High-Dose Oseltamivir in Healthy Volunteers Y. Wattanagoon, K. Stepniewska, N. Lindegårdh, S. Pukrittayakamee, U. Silachamroon, W. Piyaphanee, T. Singtoroj, W. Hanpithakpong, G. Davies, J. Tarning, W. Pongtavornpinyo, C. Fukuda, P. Singhasivanon, N. P. J. Day, and N. J. White Antimicrob. Agents Chemother. March 2009 53: 945-952; published ahead of print December 22, 2008, doi:10.1128/AAC.00588-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Absorption of Posaconazole Oral Suspension under Various Gastric Conditions in Healthy Volunteers Gopal Krishna, Allen Moton, Lei Ma, Matthew M. Medlock, and James McLeod Antimicrob. Agents Chemother. March 2009 53: 958-966; published ahead of print December 15, 2008, doi:10.1128/AAC.01034-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetics of Emtricitabine in Human Immunodeficiency Virus Type 1-Infected Pregnant Women and Their Neonates Déborah Hirt, Saik Urien, Elisabeth Rey, Elise Arrivé, Didier K. Ekouévi, Patrick Coffié, Sim Kruy Leang, Sarita Lalsab, Divine Avit, Eric Nerrienet, James McIntyre, Stéphane Blanche, François Dabis, and Jean-Marc Tréluyer Antimicrob. Agents Chemother. March 2009 53: 1067-1073; published ahead of print December 22, 2008, doi:10.1128/AAC.00860-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Studies To Characterize the Clearance Mechanism and Potential Cytochrome P450 Interactions of Anidulafungin Bharat D. Damle, James A. Dowell, Robert L. Walsky, Gregory L. Weber, Martin Stogniew, and Philip B. Inskeep Antimicrob. Agents Chemother. March 2009 53: 1149-1156; published ahead of print November 24, 2008, doi:10.1128/AAC.01279-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiretroviral Concentrations in Breast-Feeding Infants of Mothers Receiving Highly Active Antiretroviral Therapy Mark Mirochnick, Timothy Thomas, Edmund Capparelli, Clement Zeh, Diane Holland, Rose Masaba, Prisca Odhiambo, Mary Glenn Fowler, Paul J. Weidle, and Michael C. Thigpen Antimicrob. Agents Chemother. March 2009 53: 1170-1176; published ahead of print December 29, 2008, doi:10.1128/AAC.01117-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bronchopulmonary Disposition of Micafungin in Healthy Adult Volunteers Anthony M. Nicasio, Pamela R. Tessier, David P. Nicolau, R. Fredrick Knauft, John Russomanno, Eric Shore, and Joseph L. Kuti Antimicrob. Agents Chemother. March 2009 53: 1218-1220; published ahead of print December 29, 2008, doi:10.1128/AAC.01386-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetic Analysis of Ceftobiprole for Treatment of Complicated Skin and Skin Structure Infections Holly Kimko, Bindu Murthy, Xu Xu, Partha Nandy, Richard Strauss, and Gary J. Noel Antimicrob. Agents Chemother. March 2009 53: 1228-1230; published ahead of print December 15, 2008, doi:10.1128/AAC.00632-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Mechanisms of Resistance:

---

Naturally Occurring Class A ß-Lactamases from the Burkholderia cepacia Complex Laurent Poirel, José-Manuel Rodriguez-Martinez, Patrick Plésiat, and Patrice Nordmann Antimicrob. Agents Chemother. March 2009 53: 876-882; published ahead of print December 15, 2008, doi:10.1128/AAC.00946-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Selection of Plasmodium falciparum Multidrug Resistance Gene 1 Alleles in Asexual Stages and Gametocytes by Artemether-Lumefantrine in Nigerian Children with Uncomplicated Falciparum Malaria C. T. Happi, G. O. Gbotosho, O. A. Folarin, A. Sowunmi, T. Hudson, M. O'Neil, W. Milhous, D. F. Wirth, and A. M. J. Oduola Antimicrob. Agents Chemother. March 2009 53: 888-895; published ahead of print December 15, 2008, doi:10.1128/AAC.00968-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification by Genomic and Genetic Analysis of Two New Genes Playing a Key Role in Intermediate Glycopeptide Resistance in Staphylococcus aureus Adriana Renzoni, William L. Kelley, Christine Barras, Antoinette Monod, Elzbieta Huggler, Patrice François, Jacques Schrenzel, René Studer, Pierre Vaudaux, and Daniel P. Lew Antimicrob. Agents Chemother. March 2009 53: 903-911; published ahead of print December 22, 2008, doi:10.1128/AAC.01287-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pyrosequencing Using the Single-Nucleotide Polymorphism Protocol for Rapid Determination of TEM- and SHV-Type Extended-Spectrum β-Lactamases in Clinical Isolates and Identification of the Novel β-Lactamase Genes blaSHV-48, blaSHV-105, and blaTEM-155 C. Hal Jones, Alexey Ruzin, Margareta Tuckman, Melissa A. Visalli, Peter J. Petersen, and Patricia A. Bradford Antimicrob. Agents Chemother. March 2009 53: 977-986; published ahead of print December 15, 2008, doi:10.1128/AAC.01155-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations at embB Codon 306 Are an Important Molecular Indicator of Ethambutol Resistance in Mycobacterium tuberculosis Angela M. Starks, Aysel Gumusboga, Bonnie B. Plikaytis, Thomas M. Shinnick, and James E. Posey Antimicrob. Agents Chemother. March 2009 53: 1061-1066; published ahead of print December 22, 2008, doi:10.1128/AAC.01357-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multiple Regulatory Pathways Associated with High-Level Ciprofloxacin and Multidrug Resistance in Salmonella enterica Serovar Enteritidis: Involvement of ramA and Other Global Regulators Edel O'Regan, Teresa Quinn, Jean-Marie Pagès, Matthew McCusker, Laura Piddock, and Séamus Fanning Antimicrob. Agents Chemother. March 2009 53: 1080-1087; published ahead of print December 22, 2008, doi:10.1128/AAC.01005-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasmids Imparting Sulfonamide Resistance in Escherichia coli: Implications for Persistence David C. Bean, David M. Livermore, and Lucinda M. C. Hall Antimicrob. Agents Chemother. March 2009 53: 1088-1093; published ahead of print December 15, 2008, doi:10.1128/AAC.00800-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

An Important Site in PBP2x of Penicillin-Resistant Clinical Isolates of Streptococcus pneumoniae: Mutational Analysis of Thr338 Ilka Zerfaß, Regine Hakenbeck, and Dalia Denapaite Antimicrob. Agents Chemother. March 2009 53: 1107-1115; published ahead of print December 15, 2008, doi:10.1128/AAC.01107-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Variability among ampC Genes from Acinetobacter Genomic Species 3 Alejandro Beceiro, Astrid Pérez, Felipe Fernández-Cuenca, Luis Martínez-Martínez, Alvaro Pascual, Jordi Vila, Jesús Rodríguez-Baño, Jose Miguel Cisneros, Jerónimo Pachón, Germán Bou and the Spanish Group for Nosocomial Infection (GEIH) Antimicrob. Agents Chemother. March 2009 53: 1177-1184; published ahead of print November 24, 2008, doi:10.1128/AAC.00485-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Carbapenem Resistance among Pseudomonas aeruginosa Strains from India: Evidence for Nationwide Endemicity of Multiple Metallo-β-Lactamase Clones (VIM-2, -5, -6, and -11 and the Newly Characterized VIM-18) Mariana Castanheira, Jan M. Bell, John D. Turnidge, Dillip Mathai, and Ronald N. Jones Antimicrob. Agents Chemother. March 2009 53: 1225-1227; published ahead of print December 29, 2008, doi:10.1128/AAC.01011-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Contribution of vraSR and graSR Point Mutations to Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus Longzhu Cui, Hui-min Neoh, Mitsutaka Shoji, and Keiichi Hiramatsu Antimicrob. Agents Chemother. March 2009 53: 1231-1234; published ahead of print January 5, 2009, doi:10.1128/AAC.01173-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mobilization of qnrB2 and ISCR1 in Plasmids Ying-Tsong Chen, Tsai-Lien Liao, Yen-Ming Liu, Tsai-Ling Lauderdale, Jing-Jou Yan, and Shih-Feng Tsai Antimicrob. Agents Chemother. March 2009 53: 1235-1237; published ahead of print December 15, 2008, doi:10.1128/AAC.00970-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Analysis of the Sequences Surrounding blaOXA-45 Reveals Acquisition of This Gene by Pseudomonas aeruginosa via a Novel ISCR Element, ISCR5 Hongyang Li, Timothy R. Walsh, and Mark A. Toleman Antimicrob. Agents Chemother. March 2009 53: 1248-1251; published ahead of print December 8, 2008, doi:10.1128/AAC.00480-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

CMY-31 and CMY-36 Cephalosporinases Encoded by ColE1-Like Plasmids A. Zioga, J. M. Whichard, S. D. Kotsakis, L. S. Tzouvelekis, E. Tzelepi, and V. Miriagou Antimicrob. Agents Chemother. March 2009 53: 1256-1259; published ahead of print December 22, 2008, doi:10.1128/AAC.01284-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Quinolone Resistance in Neisseria gonorrhoeae: Rapid Genotyping of Quinolone Resistance-Determining Regions in gyrA and parC Genes by Melting Curve Analysis Predicts Susceptibility Frédérique Vernel-Pauillac, Tiffany R. Hogan, John W. Tapsall, and Cyrille Goarant Antimicrob. Agents Chemother. March 2009 53: 1264-1267; published ahead of print January 5, 2009, doi:10.1128/AAC.01104-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Changes in aac(6')-Ib-cr Prevalence and Fluoroquinolone Resistance in Nosocomial Isolates of Escherichia coli Collected from 1991 through 2005 Gabriela Warburg, Maya Korem, Ari Robicsek, Dalia Engelstein, Allon E. Moses, Colin Block, and Jacob Strahilevitz Antimicrob. Agents Chemother. March 2009 53: 1268-1270; published ahead of print December 22, 2008, doi:10.1128/AAC.01300-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Clinical Therapeutics:

---

Continuous Cefazolin Infusion To Treat Bone and Joint Infections: Clinical Efficacy, Feasibility, Safety, and Serum and Bone Concentrations Valérie Zeller, Frédérick Durand, Marie-Dominique Kitzis, Luc Lhotellier, Jean-Marc Ziza, Patrick Mamoudy, and Nicole Desplaces Antimicrob. Agents Chemother. March 2009 53: 883-887; published ahead of print December 15, 2008, doi:10.1128/AAC.00389-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antifungal Therapy of Aspergillus Invasive Otitis Externa: Efficacy of Voriconazole and Review Perrine Parize, Marie-Olivia Chandesris, Fanny Lanternier, Sylvain Poirée, Jean-Paul Viard, Boris Bienvenu, Michaël Mimoun, Frédéric Méchai, Marie-France Mamzer, Philippe Herman, Marie-Elisabeth Bougnoux, Marc Lecuit, and Olivier Lortholary Antimicrob. Agents Chemother. March 2009 53: 1048-1053; published ahead of print December 22, 2008, doi:10.1128/AAC.01220-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Differences in MIC Values on Clinical Outcomes in Patients with Bloodstream Infections Caused by Gram-Negative Organisms Treated with Levofloxacin Robyn DeFife, Marc H. Scheetz, Joe M. Feinglass, Michael J. Postelnick, and Kimberly K. Scarsi Antimicrob. Agents Chemother. March 2009 53: 1074-1079; published ahead of print December 15, 2008, doi:10.1128/AAC.00580-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo and In Vitro Efficacy of Amodiaquine Monotherapy for Treatment of Infection by Chloroquine-Resistant Plasmodium vivax A. R. Hasugian, E. Tjitra, A. Ratcliff, H. Siswantoro, E. Kenangalem, R. M. Wuwung, H. L. E. Purba, K. A. Piera, F. Chalfien, J. Marfurt, P. M. Penttinen, B. Russell, N. M. Anstey, and R. N. Price Antimicrob. Agents Chemother. March 2009 53: 1094-1099; published ahead of print December 22, 2008, doi:10.1128/AAC.01511-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevalence and Risk Factors for Selection of Quinolone-Resistant Escherichia coli Strains in Fecal Flora of Patients Receiving Quinolone Therapy D. Yagci, F. Yoruk, A. Azap, and O. Memikoglu Antimicrob. Agents Chemother. March 2009 53: 1287-1289; published ahead of print December 8, 2008, doi:10.1128/AAC.01228-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Antiviral Agents:

---

Combination of Tenofovir and Emtricitabine plus Efavirenz: In Vitro Modulation of ABC Transporter and Intracellular Drug Accumulation Laurence Bousquet, Alain Pruvost, Anne-Cécile Guyot, Robert Farinotti, and Aloïse Mabondzo Antimicrob. Agents Chemother. March 2009 53: 896-902; published ahead of print December 15, 2008, doi:10.1128/AAC.00733-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees Steven S. Carroll, Steven Ludmerer, Larry Handt, Kenneth Koeplinger, Nanyan Rena Zhang, Donald Graham, Mary-Ellen Davies, Malcolm MacCoss, Daria Hazuda, and David B. Olsen Antimicrob. Agents Chemother. March 2009 53: 926-934; published ahead of print December 15, 2008, doi:10.1128/AAC.01032-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Debio 025, a Cyclophilin Binding Molecule, Is Highly Efficient in Clearing Hepatitis C Virus (HCV) Replicon-Containing Cells When Used Alone or in Combination with Specifically Targeted Antiviral Therapy for HCV (STAT-C) Inhibitors Lotte Coelmont, Suzanne Kaptein, Jan Paeshuyse, Inge Vliegen, Jean-Maurice Dumont, Grégoire Vuagniaux, and Johan Neyts Antimicrob. Agents Chemother. March 2009 53: 967-976; published ahead of print December 22, 2008, doi:10.1128/AAC.00939-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multiple Peptides Homologous to Herpes Simplex Virus Type 1 Glycoprotein B Inhibit Viral Infection Radeekorn Akkarawongsa, Nina E. Pocaro, Gary Case, Aaron W. Kolb, and Curtis R. Brandt Antimicrob. Agents Chemother. March 2009 53: 987-996; published ahead of print December 22, 2008, doi:10.1128/AAC.00793-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

GRL-02031, a Novel Nonpeptidic Protease Inhibitor (PI) Containing a Stereochemically Defined Fused Cyclopentanyltetrahydrofuran Potent against Multi-PI-Resistant Human Immunodeficiency Virus Type 1 In Vitro Yasuhiro Koh, Debananda Das, Sofiya Leschenko, Hirotomo Nakata, Hiromi Ogata-Aoki, Masayuki Amano, Maki Nakayama, Arun K. Ghosh, and Hiroaki Mitsuya Antimicrob. Agents Chemother. March 2009 53: 997-1006; published ahead of print October 27, 2008, doi:10.1128/AAC.00689-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Efficacy of ST246 against Smallpox and Monkeypox Scott K. Smith, Victoria A. Olson, Kevin L. Karem, Robert Jordan, Dennis E. Hruby, and Inger K. Damon Antimicrob. Agents Chemother. March 2009 53: 1007-1012; published ahead of print December 15, 2008, doi:10.1128/AAC.01044-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

SC29EK, a Peptide Fusion Inhibitor with Enhanced -Helicity, Inhibits Replication of Human Immunodeficiency Virus Type 1 Mutants Resistant to Enfuvirtide Takeshi Naito, Kazuki Izumi, Eiichi Kodama, Yasuko Sakagami, Keiko Kajiwara, Hiroki Nishikawa, Kentaro Watanabe, Stefan G. Sarafianos, Shinya Oishi, Nobutaka Fujii, and Masao Matsuoka Antimicrob. Agents Chemother. March 2009 53: 1013-1018; published ahead of print December 29, 2008, doi:10.1128/AAC.01211-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Detection of Molecular Markers of Antiviral Resistance in Influenza A (H5N1) Viruses Using a Pyrosequencing Method Varough M. Deyde, Tung Nguyen, Rick A. Bright, Amanda Balish, Bo Shu, Stephen Lindstrom, Alexander I. Klimov, and Larisa V. Gubareva Antimicrob. Agents Chemother. March 2009 53: 1039-1047; published ahead of print January 5, 2009, doi:10.1128/AAC.01446-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Virologic Failure in First-Line Human Immunodeficiency Virus Therapy with a CCR5 Entry Inhibitor, Aplaviroc, plus a Fixed-Dose Combination of Lamivudine-Zidovudine: Nucleoside Reverse Transcriptase Inhibitor Resistance Regardless of Envelope Tropism James F. Demarest, Heather Amrine-Madsen, David M. Irlbeck, Kathryn M. Kitrinos on behalf of the CCR102881 Clinical Study Team Antimicrob. Agents Chemother. March 2009 53: 1116-1123; published ahead of print December 15, 2008, doi:10.1128/AAC.01055-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Virologic Failure in Therapy-Naïve Subjects on Aplaviroc plus Lopinavir-Ritonavir: Detection of Aplaviroc Resistance Requires Clonal Analysis of Envelope Kathryn M. Kitrinos, Heather Amrine-Madsen, David M. Irlbeck, J. Michael Word, James F. Demarest on behalf of the CCR100136 Study Team Antimicrob. Agents Chemother. March 2009 53: 1124-1131; published ahead of print December 15, 2008, doi:10.1128/AAC.01057-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Preclinical Evaluation of GS-9160, a Novel Inhibitor of Human Immunodeficiency Virus Type 1 Integrase Gregg S. Jones, Fang Yu, Ameneh Zeynalzadegan, Joseph Hesselgesser, Xiaowu Chen, James Chen, Haolun Jin, Choung U. Kim, Matthew Wright, Romas Geleziunas, and Manuel Tsiang Antimicrob. Agents Chemother. March 2009 53: 1194-1203; published ahead of print December 22, 2008, doi:10.1128/AAC.00984-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Effects of Zidovudine and Stavudine on Mitochondrial DNA of Differentiating 3T3-F442a Cells Are Not Associated with Imbalanced Deoxynucleotide Pools Matthew D. Lynx, Darcy D. LaClair, and Edward E. McKee Antimicrob. Agents Chemother. March 2009 53: 1252-1255; published ahead of print December 22, 2008, doi:10.1128/AAC.01115-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Susceptibility:

---

Association between Antimicrobial Consumption and Resistance in Escherichia coli Miika Bergman, Solja T. Nyberg, Pentti Huovinen, Pirkko Paakkari, Antti J. Hakanen and the Finnish Study Group for Antimicrobial Resistance Antimicrob. Agents Chemother. March 2009 53: 912-917; published ahead of print December 22, 2008, doi:10.1128/AAC.00856-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Breakthrough Aspergillus fumigatus and Candida albicans Double Infection during Caspofungin Treatment: Laboratory Characteristics and Implication for Susceptibility Testing Maiken Cavling Arendrup, Guillermo Garcia-Effron, Walter Buzina, Klaus Leth Mortensen, Nanna Reiter, Christian Lundin, Henrik Elvang Jensen, Cornelia Lass-Flörl, David S. Perlin, and Brita Bruun Antimicrob. Agents Chemother. March 2009 53: 1185-1193; published ahead of print December 22, 2008, doi:10.1128/AAC.01292-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Theileria Apicoplast as a Target for Chemotherapy Regina Lizundia, Dirk Werling, Gordon Langsley, and Stuart A. Ralph Antimicrob. Agents Chemother. March 2009 53: 1213-1217; published ahead of print December 15, 2008, doi:10.1128/AAC.00126-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Antimicrobial Activity of Prulifloxacin Tested against a Worldwide Collection of Gastroenteritis-Producing Pathogens, Including Those Causing Traveler's Diarrhea Thomas R. Fritsche, Douglas J. Biedenbach, and Ronald N. Jones Antimicrob. Agents Chemother. March 2009 53: 1221-1224; published ahead of print December 29, 2008, doi:10.1128/AAC.01260-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A 10-Year Survey of Antifungal Susceptibility of Candidemia Isolates from Intensive Care Unit Patients in Greece George Dimopoulos, Aristea Velegraki, and Matthew E. Falagas Antimicrob. Agents Chemother. March 2009 53: 1242-1244; published ahead of print December 29, 2008, doi:10.1128/AAC.01368-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Activities of Jadomycin B and Structurally Related Analogues David L. Jakeman, Srinivasulu Bandi, Cathy L. Graham, Taryn R. Reid, Jason R. Wentzell, and Susan E. Douglas Antimicrob. Agents Chemother. March 2009 53: 1245-1247; published ahead of print December 15, 2008, doi:10.1128/AAC.00801-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Dalbavancin against a Worldwide Collection of 81,673 Gram-Positive Bacterial Isolates Douglas J. Biedenbach, Jan M. Bell, Helio S. Sader, John D. Turnidge, and Ronald N. Jones Antimicrob. Agents Chemother. March 2009 53: 1260-1263; published ahead of print January 5, 2009, doi:10.1128/AAC.01453-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antimicrobial Activity of a New Cephalosporin, Ceftaroline, and Determination of Quality Control Ranges for MIC Testing Steven D. Brown and Maria M. Traczewski Antimicrob. Agents Chemother. March 2009 53: 1271-1274; published ahead of print December 29, 2008, doi:10.1128/AAC.01021-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Postantibiotic Effects of Telavancin against 16 Gram-Positive Organisms G. A. Pankuch and P. C. Appelbaum Antimicrob. Agents Chemother. March 2009 53: 1275-1277; published ahead of print January 5, 2009, doi:10.1128/AAC.01244-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Oral and Parenteral Therapeutic Options for Outpatient Urinary Infections Caused by Enterobacteriaceae Producing CTX-M Extended-Spectrum β-Lactamases Vidhya Prakash, James S. Lewis, II, Monica L. Herrera, Brian L. Wickes, and James H. Jorgensen Antimicrob. Agents Chemother. March 2009 53: 1278-1280; published ahead of print January 5, 2009, doi:10.1128/AAC.01519-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibility of Borrelia spielmanii to Antimicrobial Agents Commonly Used for Treatment of Lyme Disease Kristina Morgenstern, Georg Baljer, Douglas E. Norris, Peter Kraiczy, Christa Hanssen-Hübner, and Klaus-Peter Hunfeld Antimicrob. Agents Chemother. March 2009 53: 1281-1284; published ahead of print December 15, 2008, doi:10.1128/AAC.01247-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibiotic Resistance in Urinary Isolates of Escherichia coli from College Women with Urinary Tract Infections Ronald P. Olson, Lizzie J. Harrell, and Keith S. Kaye Antimicrob. Agents Chemother. March 2009 53: 1285-1286; published ahead of print December 22, 2008, doi:10.1128/AAC.01188-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Mechanisms of Action:

---

Oritavancin Kills Stationary-Phase and Biofilm Staphylococcus aureus Cells In Vitro Adam Belley, Eve Neesham-Grenon, Geoffrey McKay, Francis F. Arhin, Robert Harris, Terry Beveridge, Thomas R. Parr, Jr., and Gregory Moeck Antimicrob. Agents Chemother. March 2009 53: 918-925; published ahead of print December 22, 2008, doi:10.1128/AAC.00766-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Host Defense Peptide LL-37 Selectively Permeabilizes Apoptotic Leukocytes Åse Björstad, Galia Askarieh, Kelly L. Brown, Karin Christenson, Huamei Forsman, Karin Önnheim, Hsin-Ni Li, Susann Teneberg, Olaf Maier, Dick Hoekstra, Claes Dahlgren, Donald J. Davidson, and Johan Bylund Antimicrob. Agents Chemother. March 2009 53: 1027-1038; published ahead of print December 15, 2008, doi:10.1128/AAC.01310-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Praziquantel Affects the Regulatory Myosin Light Chain of Schistosoma mansoni Munirathinam Gnanasekar, Ashok M. Salunkhe, A. Krishna Mallia, Yi Xun He, and Ramaswamy Kalyanasundaram Antimicrob. Agents Chemother. March 2009 53: 1054-1060; published ahead of print December 22, 2008, doi:10.1128/AAC.01222-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Immobilization Reduces the Activity of Surface-Bound Cationic Antimicrobial Peptides with No Influence upon the Activity Spectrum Mojtaba Bagheri, Michael Beyermann, and Margitta Dathe Antimicrob. Agents Chemother. March 2009 53: 1132-1141; published ahead of print December 22, 2008, doi:10.1128/AAC.01254-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification, Characterization, and Azole-Binding Properties of Mycobacterium smegmatis CYP164A2, a Homolog of ML2088, the Sole Cytochrome P450 Gene of Mycobacterium leprae Andrew G. S. Warrilow, Colin J. Jackson, Josie E. Parker, Timothy H. Marczylo, Diane E. Kelly, David C. Lamb, and Steven L. Kelly Antimicrob. Agents Chemother. March 2009 53: 1157-1164; published ahead of print December 15, 2008, doi:10.1128/AAC.01237-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of DNase and Antibiotics on Biofilm Characteristics George V. Tetz, Natalia K. Artemenko, and Victor V. Tetz Antimicrob. Agents Chemother. March 2009 53: 1204-1209; published ahead of print December 8, 2008, doi:10.1128/AAC.00471-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Affinity of Tomopenem (CS-023) for Penicillin-Binding Proteins in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa Tetsufumi Koga, Chika Sugihara, Masayo Kakuta, Nobuhisa Masuda, Eiko Namba, and Takashi Fukuoka Antimicrob. Agents Chemother. March 2009 53: 1238-1241; published ahead of print December 22, 2008, doi:10.1128/AAC.01433-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Selectivity of TMC207 towards Mycobacterial ATP Synthase Compared with That towards the Eukaryotic Homologue Anna C. Haagsma, Rooda Abdillahi-Ibrahim, Marijke J. Wagner, Klaas Krab, Karen Vergauwen, Jerome Guillemont, Koen Andries, Holger Lill, Anil Koul, and Dirk Bald Antimicrob. Agents Chemother. March 2009 53: 1290-1292; published ahead of print December 15, 2008, doi:10.1128/AAC.01393-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Experimental Therapeutics:

---

Efficacy of the Novel Diamidine Compound 2,5-Bis(4-Amidinophenyl)- Furan-Bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense Infection in Vervet Monkeys after Oral Administration R. E. Mdachi, J. K. Thuita, J. M. Kagira, J. M. Ngotho, G. A. Murilla, J. M. Ndung'u, R. R. Tidwell, J. E. Hall, and R. Brun Antimicrob. Agents Chemother. March 2009 53: 953-957; published ahead of print December 8, 2008, doi:10.1128/AAC.00831-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Properties of Ellagic Acid in Malaria Treatment Patrice Njomnang Soh, Benoît Witkowski, David Olagnier, Marie-Laure Nicolau, Maria-Concepcion Garcia-Alvarez, Antoine Berry, and Françoise Benoit-Vical Antimicrob. Agents Chemother. March 2009 53: 1100-1106; published ahead of print November 17, 2008, doi:10.1128/AAC.01175-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Linezolid Alone or Combined with Rifampin against Methicillin-Resistant Staphylococcus aureus in Experimental Foreign-Body Infection Daniela Baldoni, Manuel Haschke, Zarko Rajacic, Werner Zimmerli, and Andrej Trampuz Antimicrob. Agents Chemother. March 2009 53: 1142-1148; published ahead of print December 15, 2008, doi:10.1128/AAC.00775-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamics of Tigecycline against Phenotypically Diverse Staphylococcus aureus Isolates in a Murine Thigh Model Jared L. Crandon, Mary Anne Banevicius, and David P. Nicolau Antimicrob. Agents Chemother. March 2009 53: 1165-1169; published ahead of print December 29, 2008, doi:10.1128/AAC.00647-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficient Neutralization of Antibody-Resistant Forms of Anthrax Toxin by a Soluble Receptor Decoy Inhibitor Shilpi Sharma, Diane Thomas, John Marlett, Marianne Manchester, and John A. T. Young Antimicrob. Agents Chemother. March 2009 53: 1210-1212; published ahead of print December 15, 2008, doi:10.1128/AAC.01294-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Chemistry; Biosynthesis:

---

A Novel Insertion Mutation in Streptomyces coelicolor Ribosomal S12 Protein Results in Paromomycin Resistance and Antibiotic Overproduction Guojun Wang, Takashi Inaoka, Susumu Okamoto, and Kozo Ochi Antimicrob. Agents Chemother. March 2009 53: 1019-1026; published ahead of print December 22, 2008, doi:10.1128/AAC.00388-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Letters:

---

New Composite Genetic Element of the Tn916 Family with Dual Macrolide Resistance Genes in a Streptococcus pneumoniae Isolate Belonging to Clonal Complex 271 Maria Del Grosso, Romina Camilli, Balazs Libisch, Miklos Füzi, and Annalisa Pantosti Antimicrob. Agents Chemother. March 2009 53: 1293-1294; published ahead of print December 22, 2008, doi:10.1128/AAC.01066-08 [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Tigecycline, Minocycline, and Colistin-Tigecycline Combination against Multi- and Pandrug-Resistant Clinical Isolates of Acinetobacter baumannii Group Luis A. Arroyo, Ingeborg Mateos, Verónica González, and Javier Aznar Antimicrob. Agents Chemother. March 2009 53: 1295-1296; published ahead of print December 15, 2008, doi:10.1128/AAC.01097-08 [Full Text] [PDF] [Reprints and Permissions]

Sialidase Fusion Protein as Inhibitor of Infection by Influenza Virus Hong Zhang Antimicrob. Agents Chemother. March 2009 53: 1297 [Full Text] [PDF] [Reprints and Permissions]

---

Errata:

---

In Vitro Activity of the Quinolone WCK 771 against Recent U.S. Hospital and Community-Acquired Staphylococcus aureus Pathogens with Various Resistance Types Sachin S. Bhagwat, Pamela McGhee, Klaudia Kosowska-Shick, Mahesh V. Patel, and Peter C. Appelbaum Antimicrob. Agents Chemother. March 2009 53: 1298 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.