Contents: April 2009, Volume 53, Issue 4        Chemistry; Biosynthesis        Mechanisms of Resistance        Experimental Therapeutics        Pharmacology        Susceptibility        Antiviral Agents        Clinical Therapeutics        Mechanisms of Action        Analytical Procedures        Biologic Response Modifiers        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

---

Chemistry; Biosynthesis:

---

Engineered Streptomyces platensis Strains That Overproduce Antibiotics Platensimycin and Platencin Michael J. Smanski, Ryan M. Peterson, Scott R. Rajski, and Ben Shen Antimicrob. Agents Chemother. April 2009 53: 1299-1304; published ahead of print January 21, 2009, doi:10.1128/AAC.01358-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Mechanisms of Resistance:

---

Low Plasma Membrane Expression of the Miltefosine Transport Complex Renders Leishmania braziliensis Refractory to the Drug María P. Sánchez-Cañete, Luís Carvalho, F. Javier Pérez-Victoria, Francisco Gamarro, and Santiago Castanys Antimicrob. Agents Chemother. April 2009 53: 1305-1313; published ahead of print February 2, 2009, doi:10.1128/AAC.01694-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Epidemiology of Outbreak-Related Pseudomonas aeruginosa Strains Carrying the Novel Variant blaVIM-17 Metallo-β-Lactamase Gene Victoria I. Siarkou, Danai Vitti, Efthimia Protonotariou, Alexandros Ikonomidis, and Danai Sofianou Antimicrob. Agents Chemother. April 2009 53: 1325-1330; published ahead of print January 21, 2009, doi:10.1128/AAC.01230-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Relative Contributions of the Candida albicans ABC Transporters Cdr1p and Cdr2p to Clinical Azole Resistance Sarah Tsao, Fariba Rahkhoodaee, and Martine Raymond Antimicrob. Agents Chemother. April 2009 53: 1344-1352; published ahead of print February 17, 2009, doi:10.1128/AAC.00926-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Role of Known Molecular Markers of Resistance in the Antimalarial Potency of Piperaquine and Dihydroartemisinin In Vitro Sant Muangnoicharoen, David J. Johnson, Sornchai Looareesuwan, Srivicha Krudsood, and Stephen A. Ward Antimicrob. Agents Chemother. April 2009 53: 1362-1366; published ahead of print February 2, 2009, doi:10.1128/AAC.01656-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Novel Gene, erm(41), Confers Inducible Macrolide Resistance to Clinical Isolates of Mycobacterium abscessus but Is Absent from Mycobacterium chelonae Kevin A. Nash, Barbara A. Brown-Elliott, and Richard J. Wallace, Jr. Antimicrob. Agents Chemother. April 2009 53: 1367-1376; published ahead of print January 26, 2009, doi:10.1128/AAC.01275-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasmodium falciparum pfmdr1 Amplification, Mefloquine Resistance, and Parasite Fitness Piyanuch Preechapornkul, Mallika Imwong, Kesinee Chotivanich, Wirichada Pongtavornpinyo, Arjen M. Dondorp, Nicholas P. J. Day, Nicholas J. White, and Sasithon Pukrittayakamee Antimicrob. Agents Chemother. April 2009 53: 1509-1515; published ahead of print January 21, 2009, doi:10.1128/AAC.00241-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Azithromycin in Pseudomonas aeruginosa Biofilms: Bactericidal Activity and Selection of nfxB Mutants Xavier Mulet, María D. Maciá, Ana Mena, Carlos Juan, José L. Pérez, and Antonio Oliver Antimicrob. Agents Chemother. April 2009 53: 1552-1560; published ahead of print February 2, 2009, doi:10.1128/AAC.01264-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

blaCTX-M Genes in Escherichia coli Strains from Croatian Hospitals Are Located in New (blaCTX-M-3a) and Widely Spread (blaCTX-M-3a and blaCTX-M-15) Genetic Structures Elzbieta Literacka, Branka Bedenic, Anna Baraniak, Janusz Fiett, Marija Tonkic, Ines Jajic-Bencic, and Marek Gniadkowski Antimicrob. Agents Chemother. April 2009 53: 1630-1635; published ahead of print February 2, 2009, doi:10.1128/AAC.01431-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Two Clinical Strains of Klebsiella pneumoniae Carrying Plasmid-Borne blaIMP-4, blaSHV-12, and armA Isolated at a Pediatric Center in Shanghai, China Ying Liu, Bei Zhang, Qing Cao, Weichun Huang, Lisong Shen, and Xuan Qin Antimicrob. Agents Chemother. April 2009 53: 1642-1644; published ahead of print January 21, 2009, doi:10.1128/AAC.01325-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Occurrence of Efflux Mechanism and Cephalosporinase Variant in a Population of Enterobacter aerogenes and Klebsiella pneumoniae Isolates Producing Extended-Spectrum β-Lactamases Que-Tien Tran, Myrielle Dupont, Jean-Philippe Lavigne, Jacqueline Chevalier, Jean-Marie Pagès, Albert Sotto, and Anne Davin-Regli Antimicrob. Agents Chemother. April 2009 53: 1652-1656; published ahead of print January 21, 2009, doi:10.1128/AAC.00822-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Surveillance of Carbapenem-Resistant Pseudomonas aeruginosa Isolates from Puerto Rican Medical Center Hospitals: Dissemination of KPC and IMP-18 β-Lactamases Daniel J. Wolter, Noha Khalaf, Iraida E. Robledo, Guillermo J. Vázquez, Maria I. Santé, Edna E. Aquino, Richard V. Goering, and Nancy D. Hanson Antimicrob. Agents Chemother. April 2009 53: 1660-1664; published ahead of print February 2, 2009, doi:10.1128/AAC.01172-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Temporal Appearance of Plasmid-Mediated Quinolone Resistance Genes George A. Jacoby, Nancy Gacharna, Todd A. Black, George H. Miller, and David C. Hooper Antimicrob. Agents Chemother. April 2009 53: 1665-1666; published ahead of print January 21, 2009, doi:10.1128/AAC.01447-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations in Three Distinct Loci Cause Resistance to Peptide Deformylase Inhibitors in Bacillus subtilis Yann Duroc, Carmela Giglione, and Thierry Meinnel Antimicrob. Agents Chemother. April 2009 53: 1673-1678; published ahead of print January 26, 2009, doi:10.1128/AAC.01340-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A blaVEB-1 Variant, blaVEB-6, Associated with Repeated Elements in a Complex Genetic Structure Zhiyong Zong, Sally R. Partridge, and Jonathan R. Iredell Antimicrob. Agents Chemother. April 2009 53: 1693-1697; published ahead of print January 12, 2009, doi:10.1128/AAC.01313-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Transmission of IncN Plasmids Carrying blaCTX-M-1 between Commensal Escherichia coli in Pigs and Farm Workers Arshnee Moodley and Luca Guardabassi Antimicrob. Agents Chemother. April 2009 53: 1709-1711; published ahead of print February 2, 2009, doi:10.1128/AAC.01014-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

---

Experimental Therapeutics:

---

Promising Antituberculosis Activity of the Oxazolidinone PNU-100480 Relative to That of Linezolid in a Murine Model K. N. Williams, C. K. Stover, T. Zhu, R. Tasneen, S. Tyagi, J. H. Grosset, and E. Nuermberger Antimicrob. Agents Chemother. April 2009 53: 1314-1319; published ahead of print December 15, 2008, doi:10.1128/AAC.01182-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synthesis and Antimalarial Activities of Cyclen 4-Aminoquinoline Analogs M. O. Faruk Khan, Mark S. Levi, Babu L. Tekwani, Shabana I. Khan, Eiichi Kimura, and Ronald F. Borne Antimicrob. Agents Chemother. April 2009 53: 1320-1324; published ahead of print January 26, 2009, doi:10.1128/AAC.01304-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Gallium Maltolate Treatment Eradicates Pseudomonas aeruginosa Infection in Thermally Injured Mice Katrina DeLeon, Fredrik Balldin, Chase Watters, Abdul Hamood, John Griswold, Sunil Sreedharan, and Kendra P. Rumbaugh Antimicrob. Agents Chemother. April 2009 53: 1331-1337; published ahead of print February 2, 2009, doi:10.1128/AAC.01330-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tigecycline Therapy Significantly Reduces the Concentrations of Inflammatory Pulmonary Cytokines and Chemokines in a Murine Model of Mycoplasma pneumoniae Pneumonia C. M. Salvatore, C. Techasaensiri, C. Tagliabue, K. Katz, N. Leos, A. M. Gomez, G. H. McCracken, and R. D. Hardy Antimicrob. Agents Chemother. April 2009 53: 1546-1551; published ahead of print January 12, 2009, doi:10.1128/AAC.00979-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Activity of Curcumin against Helicobacter pylori Isolates from India and during Infections in Mice Ronita De, Parag Kundu, Snehasikta Swarnakar, T. Ramamurthy, Abhijit Chowdhury, G. Balakrish Nair, and Asish K. Mukhopadhyay Antimicrob. Agents Chemother. April 2009 53: 1592-1597; published ahead of print February 9, 2009, doi:10.1128/AAC.01242-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Ciprofloxacin in an Experimental Model of Escherichia coli Chorioamnionitis in Rabbits Elise Launay, Nicolas Joram, Cédric Jacqueline, Anne Francoise Miegeville, Jocelyne Caillon, Gilles Potel, Jean Christophe Roze, and Christèle Gras-Le Guen Antimicrob. Agents Chemother. April 2009 53: 1624-1627; published ahead of print January 21, 2009, doi:10.1128/AAC.00186-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Radioimmunotherapy Is Effective against High-Inoculum Cryptococcus neoformans Infection in Mice and Does Not Select for Radiation-Resistant Cryptococcal Cells Ruth A. Bryan, Zewei Jiang, Xianchun Huang, Alfred Morgenstern, Frank Bruchertseifer, Rani Sellers, Arturo Casadevall, and Ekaterina Dadachova Antimicrob. Agents Chemother. April 2009 53: 1679-1682; published ahead of print January 12, 2009, doi:10.1128/AAC.01334-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interactions between Triazoles and Amphotericin B in Treatment of Disseminated Murine Infection by Fusarium oxysporum Mery Ruíz-Cendoya, Marçal Mariné, M. M. Rodríguez, and Josep Guarro Antimicrob. Agents Chemother. April 2009 53: 1705-1708; published ahead of print February 2, 2009, doi:10.1128/AAC.01606-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Pharmacology:

---

Dry Powder Nitroimidazopyran Antibiotic PA-824 Aerosol for Inhalation Jean C. Sung, Lucila Garcia-Contreras, Jarod L. VerBerkmoes, Charles A. Peloquin, Katharina J. Elbert, Anthony J. Hickey, and David A. Edwards Antimicrob. Agents Chemother. April 2009 53: 1338-1343; published ahead of print January 12, 2009, doi:10.1128/AAC.01389-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mode of Action of Ranbezolid against Staphylococci and Structural Modeling Studies of Its Interaction with Ribosomes Vandana Kalia, Rajni Miglani, Kedar P. Purnapatre, Tarun Mathur, Smita Singhal, Seema Khan, Sreedhara R. Voleti, Dilip J. Upadhyay, Kulvinder Singh Saini, Ashok Rattan, and V. Samuel Raj Antimicrob. Agents Chemother. April 2009 53: 1427-1433; published ahead of print December 15, 2008, doi:10.1128/AAC.00887-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intracellular Activity of Antibiotics in a Model of Human THP-1 Macrophages Infected by a Staphylococcus aureus Small-Colony Variant Strain Isolated from a Cystic Fibrosis Patient: Pharmacodynamic Evaluation and Comparison with Isogenic Normal-Phenotype and Revertant Strains Hoang Anh Nguyen, Olivier Denis, Anne Vergison, Anne Theunis, Paul M. Tulkens, Marc J. Struelens, and Françoise Van Bambeke Antimicrob. Agents Chemother. April 2009 53: 1434-1442; published ahead of print February 2, 2009, doi:10.1128/AAC.01145-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Intracellular Activity of Antibiotics in a Model of Human THP-1 Macrophages Infected by a Staphylococcus aureus Small-Colony Variant Strain Isolated from a Cystic Fibrosis Patient: Study of Antibiotic Combinations Hoang Anh Nguyen, Olivier Denis, Anne Vergison, Paul M. Tulkens, Marc J. Struelens, and Françoise Van Bambeke Antimicrob. Agents Chemother. April 2009 53: 1443-1449; published ahead of print February 2, 2009, doi:10.1128/AAC.01146-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Pharmacokinetics and Safety of Caspofungin in Older Infants and Toddlers Michael Neely, Hasan S. Jafri, Nita Seibel, Katherine Knapp, Peter C. Adamson, Susan K. Bradshaw, Kim M. Strohmaier, Peng Sun, Sheng Bi, Marissa Fallon Dockendorf, Julie A. Stone, and Nicholas A. Kartsonis Antimicrob. Agents Chemother. April 2009 53: 1450-1456; published ahead of print December 29, 2008, doi:10.1128/AAC.01027-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

P-Glycoprotein-Mediated Transport of Moxifloxacin in a Calu-3 Lung Epithelial Cell Model Julien Brillault, Whocely Victor De Castro, Thomas Harnois, Alain Kitzis, Jean-Christophe Olivier, and William Couet Antimicrob. Agents Chemother. April 2009 53: 1457-1462; published ahead of print February 2, 2009, doi:10.1128/AAC.01253-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Hydroxychloroquine and Its Clinical Implications in Chemoprophylaxis against Malaria Caused by Plasmodium vivax Hyeong-Seok Lim, Jeong-Soo Im, Joo-Youn Cho, Kyun-Seop Bae, Terry A. Klein, Joon-Sup Yeom, Tae-Seon Kim, Jae-Seon Choi, In-Jin Jang, and Jae-Won Park Antimicrob. Agents Chemother. April 2009 53: 1468-1475; published ahead of print February 2, 2009, doi:10.1128/AAC.00339-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetics of High-Dose, Prolonged-Infusion Cefepime in Adult Critically Ill Patients with Ventilator-Associated Pneumonia Anthony M. Nicasio, Robert E. Ariano, Sheryl A. Zelenitsky, Aryun Kim, Jared L. Crandon, Joseph L. Kuti, and David P. Nicolau Antimicrob. Agents Chemother. April 2009 53: 1476-1481; published ahead of print February 2, 2009, doi:10.1128/AAC.01141-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Steady-State Pharmacokinetics of Abacavir in Plasma and Intracellular Carbovir Triphosphate following Administration of Abacavir at 600 Milligrams Once Daily and 300 Milligrams Twice Daily in Human Immunodeficiency Virus-Infected Subjects Graeme Moyle, Marta Boffito, Carl Fletcher, Chris Higgs, Phillip E. Hay, Ivy H. Song, Yu Lou, Geoffrey J. Yuen, Sherene S. Min, and Elena M. Guerini Antimicrob. Agents Chemother. April 2009 53: 1532-1538; published ahead of print February 2, 2009, doi:10.1128/AAC.01000-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Urinary Bactericidal Activity of Doripenem versus That of Levofloxacin in Patients with Complicated Urinary Tract Infections or Pyelonephritis Florian M. E. Wagenlehner, Christine Wagenlehner, Rebecca Redman, Wolfgang Weidner, and Kurt G. Naber Antimicrob. Agents Chemother. April 2009 53: 1567-1573; published ahead of print February 2, 2009, doi:10.1128/AAC.01133-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Amoxicillin in Maternal, Umbilical Cord, and Neonatal Sera Anouk E. Muller, Paul M. Oostvogel, Joost DeJongh, Johan W. Mouton, Eric A. P. Steegers, P. Joep Dörr, Meindert Danhof, and Rob A. Voskuyl Antimicrob. Agents Chemother. April 2009 53: 1574-1580; published ahead of print January 21, 2009, doi:10.1128/AAC.00119-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High Cerebrospinal Fluid (CSF) Penetration and Potent Bactericidal Activity in CSF of NZ2114, a Novel Plectasin Variant, during Experimental Pneumococcal Meningitis Christian Østergaard, Dorthe Sandvang, Niels Frimodt-Møller, and Hans-Henrik Kristensen Antimicrob. Agents Chemother. April 2009 53: 1581-1585; published ahead of print February 2, 2009, doi:10.1128/AAC.01202-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Anidulafungin in a Murine Model of Candida krusei Infection: Evaluation of Mortality and Disease Burden by Quantitative Tissue Cultures and Measurement of Serum (1,3)-β-D-Glucan Levels Luis Ostrosky-Zeichner, Victor L. Paetznick, Jose Rodriguez, Enuo Chen, and Daniel J. Sheehan Antimicrob. Agents Chemother. April 2009 53: 1639-1641; published ahead of print January 12, 2009, doi:10.1128/AAC.00955-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Accelerated Metabolism of Voriconazole and Its Partial Reversal by Cimetidine Brad Moriyama, Jason Elinoff, Robert L. Danner, Juan Gea-Banacloche, Gennethel Pennick, Michael G. Rinaldi, and Thomas J. Walsh Antimicrob. Agents Chemother. April 2009 53: 1712-1714; published ahead of print January 26, 2009, doi:10.1128/AAC.01221-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Susceptibility:

---

Antistaphylococcal Activity of Dihydrophthalazine Antifolates, a Family of Novel Antibacterial Drugs Catherine Clark, Lois M. Ednie, Gengrong Lin, Kathy Smith, Klaudia Kosowska-Shick, Pamela McGhee, Bonifacio Dewasse, Linda Beachel, Patrick Caspers, Bérangère Gaucher, Gürkan Mert, Stuart Shapiro, and Peter C. Appelbaum Antimicrob. Agents Chemother. April 2009 53: 1353-1361; published ahead of print February 2, 2009, doi:10.1128/AAC.01619-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Relationship between Susceptibility to Daptomycin In Vitro and Activity In Vivo in a Rabbit Model of Aortic Valve Endocarditis H. F. Chambers, L. Basuino, B. A. Diep, J. Steenbergen, S. Zhang, P. Tattevin, and J. Alder Antimicrob. Agents Chemother. April 2009 53: 1463-1467; published ahead of print January 26, 2009, doi:10.1128/AAC.01307-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chlamydia trachomatis Laboratory Strains versus Recent Clinical Isolates: Implications for Routine Microbicide Testing M. C. Skinner, W. E. Stamm, and M. L. Lampe Antimicrob. Agents Chemother. April 2009 53: 1482-1489; published ahead of print February 2, 2009, doi:10.1128/AAC.01179-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibiotic Susceptibility and Characteristics of Neisseria meningitidis Isolates from the African Meningitis Belt, 2000 to 2006: Phenotypic and Genotypic Perspectives Sara Thulin Hedberg, Hans Fredlund, Pierre Nicolas, Dominique A. Caugant, Per Olcén, and Magnus Unemo Antimicrob. Agents Chemother. April 2009 53: 1561-1566; published ahead of print February 2, 2009, doi:10.1128/AAC.00994-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Retigeric Acid B Alone and in Combination with Azole Antifungal Agents against Candida albicans Lingmei Sun, Shujuan Sun, Aixia Cheng, Xiuzhen Wu, Yu Zhang, and Hongxiang Lou Antimicrob. Agents Chemother. April 2009 53: 1586-1591; published ahead of print January 26, 2009, doi:10.1128/AAC.00940-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Breakpoints for Susceptibility Testing Should Not Divide Wild-Type Distributions of Important Target Species Maiken Cavling Arendrup, Gunnar Kahlmeter, Juan Luis Rodriguez-Tudela, and J. Peter Donnelly Antimicrob. Agents Chemother. April 2009 53: 1628-1629; published ahead of print February 2, 2009, doi:10.1128/AAC.01624-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Comparison of the Efficacies of Natamycin and Silver Nitrate against Ocular Fungi Yan Xu, Guangren Pang, Chuanwen Gao, Dongqing Zhao, Lutan Zhou, Shengtao Sun, and Bingliang Wang Antimicrob. Agents Chemother. April 2009 53: 1636-1638; published ahead of print January 12, 2009, doi:10.1128/AAC.00697-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Isavuconazole against Aspergillus Species and Zygomycetes According to the Methodology of the European Committee on Antimicrobial Susceptibility Testing Susanne Perkhofer, Veronika Lechner, and Cornelia Lass-Flörl Antimicrob. Agents Chemother. April 2009 53: 1645-1647; published ahead of print January 21, 2009, doi:10.1128/AAC.01530-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Fluconazole and Voriconazole against Clinical Isolates of Candida spp. Determined by Disk Diffusion Testing in Turin, Italy Narcisa Mandras, Vivian Tullio, Valeria Allizond, Daniela Scalas, Giuliana Banche, Janira Roana, Francesca Robbiano, Giacomo Fucale, Aurelio Malabaila, Anna Maria Cuffini, and Nicola Carlone Antimicrob. Agents Chemother. April 2009 53: 1657-1659; published ahead of print February 2, 2009, doi:10.1128/AAC.00998-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Posaconazole and Other Antifungal Agents against Mucorales Strains Identified by Sequencing of Internal Transcribed Spacers Ana Alastruey-Izquierdo, Maria Victoria Castelli, Isabel Cuesta, Araceli Monzon, Manuel Cuenca-Estrella, and Juan Luis Rodriguez-Tudela Antimicrob. Agents Chemother. April 2009 53: 1686-1689; published ahead of print January 26, 2009, doi:10.1128/AAC.01467-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Iclaprim against Respiratory and Bacteremic Isolates of Streptococcus pneumoniae George G. Zhanel and James A. Karlowsky Antimicrob. Agents Chemother. April 2009 53: 1690-1692; published ahead of print January 12, 2009, doi:10.1128/AAC.01388-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Piperacillin Combined with the Penem β-Lactamase Inhibitor BLI-489 in Murine Models of Systemic Infection Peter J. Petersen, C. Hal Jones, Aranapakam M. Venkatesan, and Patricia A. Bradford Antimicrob. Agents Chemother. April 2009 53: 1698-1700; published ahead of print February 2, 2009, doi:10.1128/AAC.01549-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Antiviral Agents:

---

In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor Tse-I Lin, Oliver Lenz, Gregory Fanning, Thierry Verbinnen, Frédéric Delouvroy, Annick Scholliers, Katrien Vermeiren, Åsa Rosenquist, Michael Edlund, Bertil Samuelsson, Lotta Vrang, Herman de Kock, Piet Wigerinck, Pierre Raboisson, and Kenneth Simmen Antimicrob. Agents Chemother. April 2009 53: 1377-1385; published ahead of print January 26, 2009, doi:10.1128/AAC.01058-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Polyanionic Microbicides Modify Toll-Like Receptor-Mediated Cervicovaginal Immune Responses R. T. Trifonova, G. F. Doncel, and R. N. Fichorova Antimicrob. Agents Chemother. April 2009 53: 1490-1500; published ahead of print January 12, 2009, doi:10.1128/AAC.01152-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Imino Sugar Derivatives Demonstrate Potent Antiviral Activity against Flaviviruses Jinhong Chang, Lijuan Wang, Dongling Ma, Xiaowang Qu, Haitao Guo, Xiaodong Xu, Peter M. Mason, Nigel Bourne, Robert Moriarty, Baohua Gu, Ju-Tao Guo, and Timothy M. Block Antimicrob. Agents Chemother. April 2009 53: 1501-1508; published ahead of print February 17, 2009, doi:10.1128/AAC.01457-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Detection of Human Immunodeficiency Virus (HIV) Type 1 M184V and K103N Minority Variants in Patients with Primary HIV Infection Thomas A. Toni, Eugene L. Asahchop, Daniela Moisi, Michel Ntemgwa, Maureen Oliveira, Bernard Masquelier, Bluma G. Brenner, and Mark A. Wainberg Antimicrob. Agents Chemother. April 2009 53: 1670-1672; published ahead of print January 26, 2009, doi:10.1128/AAC.01494-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Apricitabine Does Not Select Additional Drug Resistance Mutations in Tissue Culture in Human Immunodeficiency Virus Type 1 Variants Containing K65R, M184V, or M184V plus Thymidine Analogue Mutations Maureen Oliveira, Daniela Moisi, Bonnie Spira, Susan Cox, Bluma G. Brenner, and Mark A. Wainberg Antimicrob. Agents Chemother. April 2009 53: 1683-1685; published ahead of print February 17, 2009, doi:10.1128/AAC.01168-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Clinical Therapeutics:

---

β-Lactam and Fluoroquinolone Combination Antibiotic Therapy for Bacteremia Caused by Gram-Negative Bacilli Majdi N. Al-Hasan, John W. Wilson, Brian D. Lahr, Kristine M. Thomsen, Jeanette E. Eckel-Passow, Emily A. Vetter, Imad M. Tleyjeh, and Larry M. Baddour Antimicrob. Agents Chemother. April 2009 53: 1386-1394; published ahead of print January 21, 2009, doi:10.1128/AAC.01231-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Voriconazole Use for Endemic Fungal Infections Alison Freifeld, Laurie Proia, David Andes, Larry M. Baddour, Janis Blair, Brad Spellberg, Sandra Arnold, Arnold Lentnek, and L. Joseph Wheat Antimicrob. Agents Chemother. April 2009 53: 1648-1651; published ahead of print January 12, 2009, doi:10.1128/AAC.01148-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Mechanisms of Action:

---

Contribution of Oxidative Damage to Antimicrobial Lethality Xiuhong Wang and Xilin Zhao Antimicrob. Agents Chemother. April 2009 53: 1395-1402; published ahead of print February 17, 2009, doi:10.1128/AAC.01087-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Amiodarone Destabilizes Intracellular Ca2+ Homeostasis and Biosynthesis of Sterols in Leishmania mexicana Xenón Serrano-Martín, Yael García-Marchan, Alexis Fernandez, Noris Rodriguez, Hector Rojas, Gonzalo Visbal, and Gustavo Benaim Antimicrob. Agents Chemother. April 2009 53: 1403-1410; published ahead of print January 21, 2009, doi:10.1128/AAC.01215-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Distinct Mode of Interaction of a Novel Ketolide Antibiotic That Displays Enhanced Antimicrobial Activity Ekaterini C. Kouvela, Dimitrios L. Kalpaxis, Daniel N. Wilson, and George P. Dinos Antimicrob. Agents Chemother. April 2009 53: 1411-1419; published ahead of print January 21, 2009, doi:10.1128/AAC.01425-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Amphotericin B-Induced Renal Tubular Cell Injury Is Mediated by Na+ Influx through Ion-Permeable Pores and Subsequent Activation of Mitogen-Activated Protein Kinases and Elevation of Intracellular Ca2+ Concentration Takahisa Yano, Yoshinori Itoh, Eiko Kawamura, Asuka Maeda, Nobuaki Egashira, Motohiro Nishida, Hitoshi Kurose, and Ryozo Oishi Antimicrob. Agents Chemother. April 2009 53: 1420-1426; published ahead of print January 12, 2009, doi:10.1128/AAC.01137-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

New High-Throughput Screening Assay To Reveal Similarities and Differences in Inhibitory Sensitivities of Multidrug ATP-Binding Cassette Transporters Marcin Kolaczkowski, Anna Kolaczkowska, Noboru Motohashi, and Krystyna Michalak Antimicrob. Agents Chemother. April 2009 53: 1516-1527; published ahead of print February 2, 2009, doi:10.1128/AAC.00956-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Analysis of Factors Affecting Susceptibility of Bacillus subtilis to Daptomycin Anna-Barbara Hachmann, Esther R. Angert, and John D. Helmann Antimicrob. Agents Chemother. April 2009 53: 1598-1609; published ahead of print January 21, 2009, doi:10.1128/AAC.01329-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

The Lipopeptide Antibiotic Friulimicin B Inhibits Cell Wall Biosynthesis through Complex Formation with Bactoprenol Phosphate T. Schneider, K. Gries, M. Josten, I. Wiedemann, S. Pelzer, H. Labischinski, and H.-G. Sahl Antimicrob. Agents Chemother. April 2009 53: 1610-1618; published ahead of print January 21, 2009, doi:10.1128/AAC.01040-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Daptomycin versus Friulimicin B: In-Depth Profiling of Bacillus subtilis Cell Envelope Stress Responses Tina Wecke, Daniela Zühlke, Ulrike Mäder, Sina Jordan, Birgit Voigt, Stefan Pelzer, Harald Labischinski, Georg Homuth, Michael Hecker, and Thorsten Mascher Antimicrob. Agents Chemother. April 2009 53: 1619-1623; published ahead of print January 21, 2009, doi:10.1128/AAC.01046-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Contribution of the Autolysin AtlA to the Bactericidal Activity of Amoxicillin against Enterococcus faecalis JH2-2 Anne-Lise Bravetti, Stéphane Mesnage, Agnès Lefort, Françoise Chau, Catherine Eckert, Louis Garry, Michel Arthur, and Bruno Fantin Antimicrob. Agents Chemother. April 2009 53: 1667-1669; published ahead of print February 2, 2009, doi:10.1128/AAC.00692-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Transcriptional Signature following Inhibition of Early-Stage Cell Wall Biosynthesis in Staphylococcus aureus A. J. O'Neill, J. A. Lindsay, K. Gould, J. Hinds, and I. Chopra Antimicrob. Agents Chemother. April 2009 53: 1701-1704; published ahead of print January 21, 2009, doi:10.1128/AAC.01309-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Analytical Procedures:

---

Use of a Surface Plasmon Resonance Method To Investigate Antibiotic and Plasma Protein Interactions Françoise Banères-Roquet, Maxime Gualtieri, Philippe Villain-Guillot, Martine Pugnière, and Jean-Paul Leonetti Antimicrob. Agents Chemother. April 2009 53: 1528-1531; published ahead of print January 21, 2009, doi:10.1128/AAC.00971-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Biologic Response Modifiers:

---

Roles of NF-B Activation and Peroxisome Proliferator-Activated Receptor Gamma Inhibition in the Effect of Rifampin on Inducible Nitric Oxide Synthase Transcription in Human Lung Epithelial Cells Yael Yuhas, Eva Berent, Regev Cohen, and Shai Ashkenazi Antimicrob. Agents Chemother. April 2009 53: 1539-1545; published ahead of print December 29, 2008, doi:10.1128/AAC.00961-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Letters:

---

Lack of Allergic Cross-Reactivity between Fluconazole and Voriconazole Angie Pinto and Raymond C. Chan Antimicrob. Agents Chemother. April 2009 53: 1715-1716; published ahead of print January 21, 2009, doi:10.1128/AAC.01500-08 [Full Text] [PDF] [Reprints and Permissions]

Permeation of Chlorhexidine from Alcoholic and Aqueous Solutions within Excised Human Skin T. J. Karpanen, T. Worthington, B. R. Conway, A. C. Hilton, T. S. J. Elliott, and P. A. Lambert Antimicrob. Agents Chemother. April 2009 53: 1717-1719; published ahead of print January 21, 2009, doi:10.1128/AAC.01289-08 [Full Text] [PDF] [Reprints and Permissions]

Sitafloxacin and Garenoxacin May Overcome the Antibiotic Resistance of Helicobacter pylori with gyrA Mutation Hidekazu Suzuki, Toshihiro Nishizawa, Hiroe Muraoka, and Toshifumi Hibi Antimicrob. Agents Chemother. April 2009 53: 1720-1721; published ahead of print February 2, 2009, doi:10.1128/AAC.00049-09 [Full Text] [PDF] [Reprints and Permissions]

Plasmodium falciparum and Dihydrofolate Reductase I164L Mutations in Africa Alisa P. Alker, Jonathan J. Juliano, Steven R. Meshnick, Andrew Owen, Edwin Ochong, David J. Bell, David J. Johnson, Umberto d'Alessandro, Modest Mulenga, Sant Muangnoicharoen, J. P. Van Geertruyden, Peter A. Winstanley, Patrick G. Bray, and Stephen A. Ward Antimicrob. Agents Chemother. April 2009 53: 1722-1723; [Full Text] [PDF] [Reprints and Permissions]

Both a Protective and a Deleterious Role for the L76V Mutation Alessandra Tartaglia, Annalisa Saracino, Laura Monno, Carmine Tinelli, and Gioacchino Angarano Antimicrob. Agents Chemother. April 2009 53: 1724-1725; [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.