Contents: May 2009, Volume 53, Issue 5        Susceptibility        Antiviral Agents        Pharmacology        Clinical Therapeutics        Biologic Response Modifiers        Mechanisms of Resistance        Experimental Therapeutics        Mechanisms of Action        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Susceptibility:

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Novel Inhibitor of Plasmodium Histone Deacetylase That Cures P. berghei-Infected Mice S. Agbor-Enoh, C. Seudieu, E. Davidson, A. Dritschilo, and M. Jung Antimicrob. Agents Chemother. May 2009 53: 1727-1734; published ahead of print February 17, 2009, doi:10.1128/AAC.00729-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibitory and Bactericidal Activities of Daptomycin, Vancomycin, and Teicoplanin against Methicillin-Resistant Staphylococcus aureus Isolates Collected from 1985 to 2007 Maria M. Traczewski, Bradley D. Katz, Judith N. Steenbergen, and Steven D. Brown Antimicrob. Agents Chemother. May 2009 53: 1735-1738; published ahead of print February 17, 2009, doi:10.1128/AAC.01022-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Does the Activity of the Combination of Imipenem and Colistin In Vitro Exceed the Problem of Resistance in Metallo-β-Lactamase-Producing Klebsiella pneumoniae Isolates? Maria Souli, Panagiota Danai Rekatsina, Zoi Chryssouli, Irene Galani, Helen Giamarellou, and Kyriaki Kanellakopoulou Antimicrob. Agents Chemother. May 2009 53: 2133-2135; published ahead of print March 2, 2009, doi:10.1128/AAC.01271-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Terbinafine Combined with Caspofungin and Azoles against Pythium insidiosum Ayrton S. Cavalheiro, Grazieli Maboni, Maria I. de Azevedo, Juliana S. Argenta, Daniela I. B. Pereira, Tatiana B. Spader, Sydney H. Alves, and Janio M. Santurio Antimicrob. Agents Chemother. May 2009 53: 2136-2138; published ahead of print March 16, 2009, doi:10.1128/AAC.01506-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative In Vitro Susceptibilities of Human Mycoplasmas and Ureaplasmas to a New Investigational Ketolide, CEM-101 Ken B. Waites, D. M. Crabb, and Lynn B. Duffy Antimicrob. Agents Chemother. May 2009 53: 2139-2141; published ahead of print March 2, 2009, doi:10.1128/AAC.00090-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo Stefanie C. P. Lopes, Yara C. Blanco, Giselle Z. Justo, Paulo A. Nogueira, Francisco L. S. Rodrigues, Uta Goelnitz, Gerhard Wunderlich, Gustavo Facchini, Marcelo Brocchi, Nelson Duran, and Fabio T. M. Costa Antimicrob. Agents Chemother. May 2009 53: 2149-2152; published ahead of print March 9, 2009, doi:10.1128/AAC.00693-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antianaerobic Activity of Sulopenem Compared to Six Other Agents Lois M. Ednie and Peter C. Appelbaum Antimicrob. Agents Chemother. May 2009 53: 2163-2170; published ahead of print February 17, 2009, doi:10.1128/AAC.01557-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolates Helio S. Sader, Thomas R. Fritsche, and Ronald N. Jones Antimicrob. Agents Chemother. May 2009 53: 2171-2175; published ahead of print March 16, 2009, doi:10.1128/AAC.00129-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Binding of Faropenem and Other β-Lactam Agents to Penicillin-Binding Proteins of Pneumococci with Various β-Lactam Susceptibilities Klaudia Kosowska-Shick, Pamela McGhee, and Peter C. Appelbaum Antimicrob. Agents Chemother. May 2009 53: 2176-2180; published ahead of print February 23, 2009, doi:10.1128/AAC.01566-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fenticonazole Activity Measured by the Methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida Vulvovaginitis Isolates from Two European Regions and Annotations on the Prevalent Genotypes Stavroula Antonopoulou, Michel Aoun, Evangelos C. Alexopoulos, Stavroula Baka, Emanuel Logothetis, Theodoros Kalambokas, Andreas Zannos, Konstantine Papadias, Odysseas Grigoriou, Evangelia Kouskouni, and Aristea Velegraki Antimicrob. Agents Chemother. May 2009 53: 2181-2184; published ahead of print February 17, 2009, doi:10.1128/AAC.01413-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity Profile In Vitro of Micafungin against Spanish Clinical Isolates of Common and Emerging Species of Yeasts and Molds Manuel Cuenca-Estrella, Alicia Gomez-Lopez, Emilia Mellado, Araceli Monzon, Maria J. Buitrago, and Juan L. Rodriguez-Tudela Antimicrob. Agents Chemother. May 2009 53: 2192-2195; published ahead of print February 17, 2009, doi:10.1128/AAC.01543-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Avian Aspergillus fumigatus Strains Resistant to both Itraconazole and Voriconazole L. A. Beernaert, F. Pasmans, L. Van Waeyenberghe, G. M. Dorrestein, F. Verstappen, F. Vercammen, F. Haesebrouck, and A. Martel Antimicrob. Agents Chemother. May 2009 53: 2199-2201; published ahead of print March 2, 2009, doi:10.1128/AAC.01492-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Statins as Potential Antimalarial Drugs: Low Relative Potency and Lack of Synergy with Conventional Antimalarial Drugs Rina P. M. Wong and Timothy M. E. Davis Antimicrob. Agents Chemother. May 2009 53: 2212-2214; published ahead of print March 2, 2009, doi:10.1128/AAC.01469-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibacterial Activity of Ultrashort Cationic Lipo-β-Peptides Griselda N. Serrano, George G. Zhanel, and Frank Schweizer Antimicrob. Agents Chemother. May 2009 53: 2215-2217; published ahead of print February 23, 2009, doi:10.1128/AAC.01100-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Triple Combinations of Lower and Longer Alkyl Gallates and Oxacillin Improve Antibiotic Synergy against Methicillin-Resistant Staphylococcus aureus Hirofumi Shibata, Tatsuro Nakano, M. Anowar Khasru Parvez, Yoshihiro Furukawa, Akio Tomoishi, Shingo Niimi, Naokatu Arakaki, and Tomihiko Higuti Antimicrob. Agents Chemother. May 2009 53: 2218-2220; published ahead of print February 17, 2009, doi:10.1128/AAC.00829-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Single-Dose Escalation and Multiple-Dose Safety, Tolerability, and Pharmacokinetics of IDX899, a Candidate Human Immunodeficiency Virus Type 1 Nonnucleoside Reverse Transcriptase Inhibitor, in Healthy Subjects Xiao-Jian Zhou, Keith Pietropaolo, David Damphousse, Bruce Belanger, Jie Chen, John Sullivan-Bólyai, and Douglas Mayers Antimicrob. Agents Chemother. May 2009 53: 1739-1746; published ahead of print February 17, 2009, doi:10.1128/AAC.01479-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Reverse Transcriptase Inhibitors as Potential Colorectal Microbicides Carolina Herrera, Martin Cranage, Ian McGowan, Peter Anton, and Robin J. Shattock Antimicrob. Agents Chemother. May 2009 53: 1797-1807; published ahead of print March 2, 2009, doi:10.1128/AAC.01096-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

ST-246 Antiviral Efficacy in a Nonhuman Primate Monkeypox Model: Determination of the Minimal Effective Dose and Human Dose Justification Robert Jordan, Arthur Goff, Annie Frimm, Michael L. Corrado, Lisa E. Hensley, Chelsea M. Byrd, Eric Mucker, Josh Shamblin, Tove' C. Bolken, Carly Wlazlowski, Wendy Johnson, Jennifer Chapman, Nancy Twenhafel, Shanthakumar Tyavanagimatt, Adams Amantana, Jarasvech Chinsangaram, Dennis E. Hruby, and John Huggins Antimicrob. Agents Chemother. May 2009 53: 1817-1822; published ahead of print February 17, 2009, doi:10.1128/AAC.01596-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Small-Molecule Dengue Virus Entry Inhibitor Qing-Yin Wang, Sejal J. Patel, Eric Vangrevelinghe, Hao Ying Xu, Ranga Rao, Deana Jaber, Wouter Schul, Feng Gu, Olivier Heudi, Ngai Ling Ma, Mee Kian Poh, Wai Yee Phong, Thomas H. Keller, Edgar Jacoby, and Subhash G. Vasudevan Antimicrob. Agents Chemother. May 2009 53: 1823-1831; published ahead of print February 17, 2009, doi:10.1128/AAC.01148-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Identification and Characterization of Mefloquine Efficacy against JC Virus In Vitro Margot Brickelmaier, Alexey Lugovskoy, Ramya Kartikeyan, Marta M. Reviriego-Mendoza, Norm Allaire, Kenneth Simon, Richard J. Frisque, and Leonid Gorelik Antimicrob. Agents Chemother. May 2009 53: 1840-1849; published ahead of print March 2, 2009, doi:10.1128/AAC.01614-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Mutations in the Nonstructural Protein 3A Confer Resistance to the Novel Enterovirus Replication Inhibitor TTP-8307 Armando M. De Palma, Hendrik Jan Thibaut, Lonneke van der Linden, Kjerstin Lanke, Ward Heggermont, Stephen Ireland, Robert Andrews, Murty Arimilli, Taleb H. Al-Tel, Erik De Clercq, Frank van Kuppeveld, and Johan Neyts Antimicrob. Agents Chemother. May 2009 53: 1850-1857; published ahead of print February 23, 2009, doi:10.1128/AAC.00934-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Safety of Famciclovir in Children with Herpes Simplex or Varicella-Zoster Virus Infection X. Sáez-Llorens, R. Yogev, A. Arguedas, A. Rodriguez, M. G. Spigarelli, T. De León Castrejón, L. Bomgaars, M. Roberts, B. Abrams, W. Zhou, M. Looby, G. Kaiser, and K. Hamed Antimicrob. Agents Chemother. May 2009 53: 1912-1920; published ahead of print March 9, 2009, doi:10.1128/AAC.01054-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chemical Modifications of Antisense Morpholino Oligomers Enhance Their Efficacy against Ebola Virus Infection Dana L. Swenson, Kelly L. Warfield, Travis K. Warren, Candace Lovejoy, Jed N. Hassinger, Gordon Ruthel, Robert E. Blouch, Hong M. Moulton, Dwight D. Weller, Patrick L. Iversen, and Sina Bavari Antimicrob. Agents Chemother. May 2009 53: 2089-2099; published ahead of print February 17, 2009, doi:10.1128/AAC.00936-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Double Combinations of Amantadine, Oseltamivir, and Ribavirin on Influenza A (H5N1) Virus Infections in Cell Culture and in Mice Donald F. Smee, Brett L. Hurst, Min-Hui Wong, Kevin W. Bailey, and John D. Morrey Antimicrob. Agents Chemother. May 2009 53: 2120-2128; published ahead of print March 9, 2009, doi:10.1128/AAC.01012-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

GT-1a or GT-1b Subtype-Specific Resistance Profiles for Hepatitis C Virus Inhibitors Telaprevir and HCV-796 Matthew F. McCown, Sonal Rajyaguru, Simran Kular, Nick Cammack, and Isabel Nájera Antimicrob. Agents Chemother. May 2009 53: 2129-2132; published ahead of print March 9, 2009, doi:10.1128/AAC.01598-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility of Human Immunodeficiency Virus Type 1 to the Maturation Inhibitor Bevirimat Is Modulated by Baseline Polymorphisms in Gag Spacer Peptide 1 Kurt Van Baelen, Karl Salzwedel, Evelien Rondelez, Veerle Van Eygen, Stephanie De Vos, Ann Verheyen, Kim Steegen, Yvan Verlinden, Graham P. Allaway, and Lieven J. Stuyver Antimicrob. Agents Chemother. May 2009 53: 2185-2188; published ahead of print February 17, 2009, doi:10.1128/AAC.01650-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Human Immunodeficiency Virus Type 1 Isolates with the Reverse Transcriptase (RT) Mutation Q145M Retain Nucleoside and Nonnucleoside RT Inhibitor Susceptibility Vici Varghese, Yumi Mitsuya, Rajin Shahriar, Michael H. Bachmann, W. Jeffrey Fessel, Ron M. Kagan, and Robert W. Shafer Antimicrob. Agents Chemother. May 2009 53: 2196-2198; published ahead of print February 17, 2009, doi:10.1128/AAC.01593-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Lack of a Clinically Important Effect of Moderate Hepatic Insufficiency and Severe Renal Insufficiency on Raltegravir Pharmacokinetics Marian Iwamoto, William D. Hanley, Amelia S. Petry, Evan J. Friedman, James T. Kost, Sheila A. Breidinger, Kenneth C. Lasseter, Richard Robson, Norman M. Lunde, Larissa A. Wenning, Julie A. Stone, and John A. Wagner Antimicrob. Agents Chemother. May 2009 53: 1747-1752; published ahead of print February 17, 2009, doi:10.1128/AAC.01194-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Pharmacokinetics of LB80331 and LB80317 following Oral Administration of LB80380, a New Antiviral Agent for Chronic Hepatitis B (CHB), in Healthy Adult Subjects, CHB Patients, and Mice Man-Fung Yuen, Sung-Hack Lee, Hyang-Mi Kang, Chung Ryeol Kim, John Kim, Vincent Ngai, and Ching-Lung Lai Antimicrob. Agents Chemother. May 2009 53: 1779-1785; published ahead of print February 17, 2009, doi:10.1128/AAC.01290-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of EDP-420 after Ascending Single Oral Doses in Healthy Adult Volunteers Li-Juan Jiang, Michelle Wang, and Yat Sun Or Antimicrob. Agents Chemother. May 2009 53: 1786-1792; published ahead of print February 17, 2009, doi:10.1128/AAC.01270-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Serial Plasma Voriconazole Concentrations after Allogeneic Hematopoietic Stem Cell Transplantation Steven M. Trifilio, Paul R. Yarnold, Marc H. Scheetz, Judy Pi, Gennethel Pennick, and Jayesh Mehta Antimicrob. Agents Chemother. May 2009 53: 1793-1796; published ahead of print February 17, 2009, doi:10.1128/AAC.01316-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prospectively Validated Dosing Nomograms for Maximizing the Pharmacodynamics of Vancomycin Administered by Continuous Infusion in Critically Ill Patients Federico Pea, Mario Furlanut, Camilla Negri, Federica Pavan, Massimo Crapis, Francesco Cristini, and Pierluigi Viale Antimicrob. Agents Chemother. May 2009 53: 1863-1867; published ahead of print February 17, 2009, doi:10.1128/AAC.01149-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pilot Pharmacokinetic Study of Human Immunodeficiency Virus-Infected Patients Receiving Tenofovir Disoproxil Fumarate (TDF): Investigation of Systemic and Intracellular Interactions between TDF and Abacavir, Lamivudine, or Lopinavir-Ritonavir Alain Pruvost, Eugènia Negredo, Frédéric Théodoro, Jordi Puig, Mikaël Levi, Rafaela Ayen, Jacques Grassi, and Bonaventura Clotet Antimicrob. Agents Chemother. May 2009 53: 1937-1943; published ahead of print March 9, 2009, doi:10.1128/AAC.01064-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Activity of the Pyrrolopyrazolyl-Substituted Oxazolidinone RWJ-416457 Jamese J. Hilliard, Jeffrey Fernandez, John Melton, Mark J. Macielag, Raul Goldschmidt, Karen Bush, and Darren Abbanat Antimicrob. Agents Chemother. May 2009 53: 2028-2033; published ahead of print March 9, 2009, doi:10.1128/AAC.00833-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Penetration of Moxifloxacin into Bone Evaluated by Monte Carlo Simulation Cornelia B. Landersdorfer, Martina Kinzig, Friedrich F. Hennig, Jürgen B. Bulitta, Ulrike Holzgrabe, George L. Drusano, Fritz Sörgel, and Johannes Gusinde Antimicrob. Agents Chemother. May 2009 53: 2074-2081; published ahead of print February 17, 2009, doi:10.1128/AAC.01056-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bactericidal Activity of the Combination of Levofloxacin with Rifampin in Experimental Prosthetic Knee Infection in Rabbits Due to Methicillin-Susceptible Staphylococcus aureus Claudette Muller-Serieys, Azzam Saleh Mghir, Laurent Massias, and Bruno Fantin Antimicrob. Agents Chemother. May 2009 53: 2145-2148; published ahead of print March 9, 2009, doi:10.1128/AAC.01163-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Intracameral Voriconazole Injection Ying-Cheng Shen, Mei-Yen Wang, Chun-Yuan Wang, Tsun-Chung Tsai, Hin-Yeung Tsai, Hsin-Nung Lee, and Li-Chen Wei Antimicrob. Agents Chemother. May 2009 53: 2156-2157; published ahead of print March 2, 2009, doi:10.1128/AAC.01125-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Early Postpartum Pharmacokinetics of Lopinavir Initiated Intrapartum in Thai Women Tim R. Cressey, Russell Van Dyke, Gonzague Jourdain, Thanyawee Puthanakit, Anuvat Roongpisuthipong, Jullapong Achalapong, Prapap Yuthavisuthi, Sinart Prommas, Nantasak Chotivanich, Robert Maupin, Elizabeth Smith, David E. Shapiro, Mark Mirochnick for the IMPAACT P1032 Team Antimicrob. Agents Chemother. May 2009 53: 2189-2191; published ahead of print February 23, 2009, doi:10.1128/AAC.01091-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Reduced Efficacy of Intermittent Preventive Treatment of Malaria in Malnourished Children Ina Danquah, Ekkehart Dietz, Philipp Zanger, Klaus Reither, Peter Ziniel, Ulrich Bienzle, and Frank P. Mockenhaupt Antimicrob. Agents Chemother. May 2009 53: 1753-1759; published ahead of print February 17, 2009, doi:10.1128/AAC.01723-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prospective Observational Study of the Impact of VIM-1 Metallo-β-Lactamase on the Outcome of Patients with Klebsiella pneumoniae Bloodstream Infections George L. Daikos, Panayiotis Petrikkos, Mina Psichogiou, Chris Kosmidis, Evangelos Vryonis, Athanasios Skoutelis, Kleoniki Georgousi, Leonidas S. Tzouvelekis, Panayotis T. Tassios, Christina Bamia, and George Petrikkos Antimicrob. Agents Chemother. May 2009 53: 1868-1873; published ahead of print February 17, 2009, doi:10.1128/AAC.00782-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Relationship of Carbapenem Restriction in 22 University Teaching Hospitals to Carbapenem Use and Carbapenem-Resistant Pseudomonas aeruginosa Amy L. Pakyz, Michael Oinonen, and Ronald E. Polk Antimicrob. Agents Chemother. May 2009 53: 1983-1986; published ahead of print March 9, 2009, doi:10.1128/AAC.01535-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Continuous versus Intermittent Infusion of Oxacillin for Treatment of Infective Endocarditis Caused by Methicillin-Susceptible Staphylococcus aureus Darrel W. Hughes, Christopher R. Frei, Pamela R. Maxwell, Kay Green, Jan E. Patterson, George E. Crawford, and James S. Lewis, II Antimicrob. Agents Chemother. May 2009 53: 2014-2019; published ahead of print March 2, 2009, doi:10.1128/AAC.01232-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Quasiexperimental Study of the Effects of Antibiotic Use, Gastric Acid-Suppressive Agents, and Infection Control Practices on the Incidence of Clostridium difficile-Associated Diarrhea in Hospitalized Patients Mamoon A. Aldeyab, Stephan Harbarth, Nathalie Vernaz, Mary P. Kearney, Michael G. Scott, Chris Funston, Karen Savage, Denise Kelly, Motasem A. Aldiab, and James C. McElnay Antimicrob. Agents Chemother. May 2009 53: 2082-2088; published ahead of print March 16, 2009, doi:10.1128/AAC.01214-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Tetracyclines Modulate Protease-Activated Receptor 2-Mediated Proinflammatory Reactions in Epidermal Keratinocytes Chika Ishikawa, Tatsuya Tsuda, Hiroe Konishi, Noboru Nakagawa, and Kiyofumi Yamanishi Antimicrob. Agents Chemother. May 2009 53: 1760-1765; published ahead of print March 2, 2009, doi:10.1128/AAC.01540-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Extended-Spectrum Cephalosporinases in Pseudomonas aeruginosa José-Manuel Rodríguez-Martínez, Laurent Poirel, and Patrice Nordmann Antimicrob. Agents Chemother. May 2009 53: 1766-1771; published ahead of print March 2, 2009, doi:10.1128/AAC.01410-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role for Fks1 in the Intrinsic Echinocandin Resistance of Fusarium solani as Evidenced by Hybrid Expression in Saccharomyces cerevisiae Santosh K. Katiyar and Thomas D. Edlind Antimicrob. Agents Chemother. May 2009 53: 1772-1778; published ahead of print March 2, 2009, doi:10.1128/AAC.00020-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chromosomal Integration of the Extended-Spectrum β-Lactamase Gene blaCTX-M-15 in Salmonella enterica Serotype Concord Isolates from Internationally Adopted Children Laëtitia Fabre, Aurélia Delauné, Emmanuelle Espié, Karin Nygard, Maria Pardos, Lucette Polomack, Françoise Guesnier, Marc Galimand, Jørgen Lassen, and François-Xavier Weill Antimicrob. Agents Chemother. May 2009 53: 1808-1816; published ahead of print March 9, 2009, doi:10.1128/AAC.00451-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Functional Characterization of the B-Dependent yabJ-spoVG Operon in Staphylococcus aureus: Role in Methicillin and Glycopeptide Resistance Bettina Schulthess, Stefan Meier, Dagmar Homerova, Christiane Goerke, Christiane Wolz, Jan Kormanec, Brigitte Berger-Bächi, and Markus Bischoff Antimicrob. Agents Chemother. May 2009 53: 1832-1839; published ahead of print February 17, 2009, doi:10.1128/AAC.01255-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Redox Basis for Metronidazole Resistance in Helicobacter pylori N. O. Kaakoush, C. Asencio, F. Mégraud, and G. L. Mendz Antimicrob. Agents Chemother. May 2009 53: 1884-1891; published ahead of print February 17, 2009, doi:10.1128/AAC.01449-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Plasmid-Mediated Quinolone Resistance Gene, qnrC, Found in a Clinical Isolate of Proteus mirabilis Minghua Wang, Qinglan Guo, Xiaogang Xu, Xiaoying Wang, Xinyu Ye, Shi Wu, David C. Hooper, and Minggui Wang Antimicrob. Agents Chemother. May 2009 53: 1892-1897; published ahead of print March 2, 2009, doi:10.1128/AAC.01400-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of Macrolide Efflux Pump mef Subclasses Detected in Clinical Isolates of Streptococcus pyogenes Isolated between 1999 and 2005 J. Blackman Northwood, M. Del Grosso, L. R. Cossins, M. D. Coley, R. Creti, A. Pantosti, and D. J. Farrell Antimicrob. Agents Chemother. May 2009 53: 1921-1925; published ahead of print March 2, 2009, doi:10.1128/AAC.01065-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasmodium falciparum Na+/H+ Exchanger 1 Transporter Is Involved in Reduced Susceptibility to Quinine Maud Henry, Sébastien Briolant, Agnès Zettor, Stéphane Pelleau, Meili Baragatti, Eric Baret, Joel Mosnier, Rémy Amalvict, Thierry Fusai, Christophe Rogier, and Bruno Pradines Antimicrob. Agents Chemother. May 2009 53: 1926-1930; published ahead of print March 9, 2009, doi:10.1128/AAC.01243-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Gene Expression and Evolution of Antifungal Drug Resistance James B. Anderson, Caroline Sirjusingh, Nazia Syed, and Shantelle Lafayette Antimicrob. Agents Chemother. May 2009 53: 1931-1936; published ahead of print March 9, 2009, doi:10.1128/AAC.01315-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Novel Plasmid-Encoded Ceftazidime-Hydrolyzing CTX-M-53 Extended-Spectrum β-Lactamase from Salmonella enterica Serotypes Westhampton and Senftenberg Benoît Doublet, Sophie A. Granier, Frédéric Robin, Richard Bonnet, Laëtitia Fabre, Anne Brisabois, Axel Cloeckaert, and François-Xavier Weill Antimicrob. Agents Chemother. May 2009 53: 1944-1951; published ahead of print March 9, 2009, doi:10.1128/AAC.01581-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Combinations of Mutations in VanD-Type Vancomycin-Resistant Enterococcus faecium, Enterococcus faecalis, and Enterococcus avium Strains F. Depardieu, M.-L. Foucault, J. Bell, A. Dubouix, M. Guibert, J.-P. Lavigne, M. Levast, and P. Courvalin Antimicrob. Agents Chemother. May 2009 53: 1952-1963; published ahead of print March 2, 2009, doi:10.1128/AAC.01348-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Mechanism for Nisin Resistance via Proteolytic Degradation of Nisin by the Nisin Resistance Protein NSR Zhizeng Sun, Jin Zhong, Xiaobo Liang, Jiale Liu, Xiuzhu Chen, and Liandong Huan Antimicrob. Agents Chemother. May 2009 53: 1964-1973; published ahead of print March 9, 2009, doi:10.1128/AAC.01382-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

VanB-Type Enterococcus faecium Clinical Isolate Successively Inducibly Resistant to, Dependent on, and Constitutively Resistant to Vancomycin Alvaro San Millan, Florence Depardieu, Sylvain Godreuil, and Patrice Courvalin Antimicrob. Agents Chemother. May 2009 53: 1974-1982; published ahead of print March 9, 2009, doi:10.1128/AAC.00034-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efflux Unbalance in Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients Lucie Vettoretti, Patrick Plésiat, Cédric Muller, Farid El Garch, Gilles Phan, Inna Attrée, Arnaud Ducruix, and Catherine Llanes Antimicrob. Agents Chemother. May 2009 53: 1987-1997; published ahead of print March 2, 2009, doi:10.1128/AAC.01024-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Organization of Transposase Regions Surrounding blaKPC Carbapenemase Genes on Plasmids from Klebsiella Strains Isolated in a New York City Hospital Thomas D. Gootz, Mary Kay Lescoe, Fadia Dib-Hajj, Brian A. Dougherty, Wen He, Phyllis Della-Latta, and Richard C. Huard Antimicrob. Agents Chemother. May 2009 53: 1998-2004; published ahead of print March 2, 2009, doi:10.1128/AAC.01355-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Concurrent Titration and Determination of Antibiotic Resistance in Ureaplasma Species with Identification of Novel Point Mutations in Genes Associated with Resistance Michael L. Beeton, Victoria J. Chalker, Nicola C. Maxwell, Sailesh Kotecha, and O. Brad Spiller Antimicrob. Agents Chemother. May 2009 53: 2020-2027; published ahead of print March 9, 2009, doi:10.1128/AAC.01349-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Dynamics of Malaria Drug Resistance Patterns in the Amazon Basin Region following Changes in Peruvian National Treatment Policy for Uncomplicated Malaria David J. Bacon, Andrea M. McCollum, Sean M. Griffing, Carola Salas, Valeria Soberon, Meddly Santolalla, Ryan Haley, Pablo Tsukayama, Carmen Lucas, Ananias A. Escalante, and Venkatachalam Udhayakumar Antimicrob. Agents Chemother. May 2009 53: 2042-2051; published ahead of print March 2, 2009, doi:10.1128/AAC.01677-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Genetic Determinants of Resistance to Fusidic Acid among Clinical Bacteremia Isolates of Staphylococcus aureus Jonas Lannergård, Tobias Norström, and Diarmaid Hughes Antimicrob. Agents Chemother. May 2009 53: 2059-2065; published ahead of print March 16, 2009, doi:10.1128/AAC.00871-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Temporal Trends of Antimicrobial Resistance and Clonality of Invasive Streptococcus pneumoniae Isolates in Finland, 2002 to 2006 Lotta Siira, Merja Rantala, Jari Jalava, Antti J. Hakanen, Pentti Huovinen, Tarja Kaijalainen, Outi Lyytikäinen, and Anni Virolainen Antimicrob. Agents Chemother. May 2009 53: 2066-2073; published ahead of print March 9, 2009, doi:10.1128/AAC.01464-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Genetics of para-Aminosalicylic Acid Resistance in Clinical Isolates and Spontaneous Mutants of Mycobacterium tuberculosis Vanessa Mathys, René Wintjens, Philippe Lefevre, Julie Bertout, Amit Singhal, Mehdi Kiass, Natalia Kurepina, Xiao-Ming Wang, Barun Mathema, Alain Baulard, Barry N. Kreiswirth, and Pablo Bifani Antimicrob. Agents Chemother. May 2009 53: 2100-2109; published ahead of print February 23, 2009, doi:10.1128/AAC.01197-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Emergence of Plasmid-Mediated Quinolone Resistance among Non-Typhi Salmonella enterica Isolates from Humans in the United States Maria Sjölund-Karlsson, Jason P. Folster, Gary Pecic, Kevin Joyce, Felicita Medalla, Regan Rickert, and Jean M. Whichard Antimicrob. Agents Chemother. May 2009 53: 2142-2144; published ahead of print February 17, 2009, doi:10.1128/AAC.01288-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Mechanisms of Macrolide Resistance in Clinical Isolates of Mycoplasma pneumoniae from China Deli Xin, Zuhuang Mi, Xu Han, Ling Qin, Jing Li, Tianli Wei, Xiaogeng Chen, Shaojie Ma, Ancun Hou, Gui Li, and Dawei Shi Antimicrob. Agents Chemother. May 2009 53: 2158-2159; published ahead of print March 9, 2009, doi:10.1128/AAC.01563-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibility of Mycoplasma pneumoniae Isolates and Molecular Analysis of Macrolide-Resistant Strains from Shanghai, China Yang Liu, Xinyu Ye, Hong Zhang, Xiaogang Xu, Wanhua Li, Demei Zhu, and Minggui Wang Antimicrob. Agents Chemother. May 2009 53: 2160-2162; published ahead of print March 9, 2009, doi:10.1128/AAC.01684-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Comparative Efficacies of Lipid-Complexed Amphotericin B and Liposomal Amphotericin B against Coccidioidal Meningitis in Rabbits Karl V. Clemons, Javier Capilla, Raymond A. Sobel, Marife Martinez, Ann-Jay Tong, and David A. Stevens Antimicrob. Agents Chemother. May 2009 53: 1858-1862; published ahead of print March 9, 2009, doi:10.1128/AAC.01538-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intracellular Activity of Antibiotics against Staphylococcus aureus in a Mouse Peritonitis Model Anne Sandberg, Jonas H. R. Hessler, Robert L. Skov, Jens Blom, and Niels Frimodt-Møller Antimicrob. Agents Chemother. May 2009 53: 1874-1883; published ahead of print February 17, 2009, doi:10.1128/AAC.01605-07 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Combination Therapy of Advanced Invasive Pulmonary Aspergillosis in Transiently Neutropenic Rats Using Human Pharmacokinetic Equivalent Doses of Voriconazole and Anidulafungin Wendy W. J. van de Sande, Ron A. A. Mathot, Marian T. ten Kate, Wim van Vianen, Mehri Tavakol, Bart J. A. Rijnders, and Irma A. J. M. Bakker-Woudenberg Antimicrob. Agents Chemother. May 2009 53: 2005-2013; published ahead of print February 23, 2009, doi:10.1128/AAC.01556-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel S-Adenosylmethionine Decarboxylase Inhibitors for the Treatment of Human African Trypanosomiasis Robert H. Barker, Jr., Hanlan Liu, Bradford Hirth, Cassandra A. Celatka, Richard Fitzpatrick, Yibin Xiang, Erin K. Willert, Margaret A. Phillips, Marcel Kaiser, Cyrus J. Bacchi, Aixa Rodriguez, Nigel Yarlett, Jeffrey D. Klinger, and Edmund Sybertz Antimicrob. Agents Chemother. May 2009 53: 2052-2058; published ahead of print March 16, 2009, doi:10.1128/AAC.01674-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Effects of Double and Triple Combinations of Antifungal Drugs in a Murine Model of Disseminated Infection by Scedosporium prolificans M. Mar Rodríguez, Enrique Calvo, Carolina Serena, Marçal Mariné, F. Javier Pastor, and Josep Guarro Antimicrob. Agents Chemother. May 2009 53: 2153-2155; published ahead of print February 17, 2009, doi:10.1128/AAC.01477-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tolevamer Is Not Efficacious in the Neutralization of Cytotoxin in a Human Gut Model of Clostridium difficile Infection Simon D. Baines, Jane Freeman, and Mark H. Wilcox Antimicrob. Agents Chemother. May 2009 53: 2202-2204; published ahead of print February 17, 2009, doi:10.1128/AAC.01085-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Experimental Bacteriophage Therapy Increases Survival of Galleria mellonella Larvae Infected with Clinically Relevant Strains of the Burkholderia cepacia Complex Kimberley D. Seed and Jonathan J. Dennis Antimicrob. Agents Chemother. May 2009 53: 2205-2208; published ahead of print February 17, 2009, doi:10.1128/AAC.01166-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Surfactants, Aromatic and Isoprenoid Compounds, and Fatty Acid Biosynthesis Inhibitors Suppress Staphylococcus aureus Production of Toxic Shock Syndrome Toxin 1 Peter J. McNamara, Rae Ellen Syverson, Kathy Milligan-Myhre, Olga Frolova, Sarah Schroeder, Joshua Kidder, Thanh Hoang, and Richard A. Proctor Antimicrob. Agents Chemother. May 2009 53: 1898-1906; published ahead of print February 17, 2009, doi:10.1128/AAC.01293-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Identification of the Bacteriocins Produced by Enterococcus faecium IT62 and Evidence that Bacteriocin 32 Is Identical to Enterocin IT Esther Izquierdo, Yimin Cai, Eric Marchioni, and Saïd Ennahar Antimicrob. Agents Chemother. May 2009 53: 1907-1911; published ahead of print March 9, 2009, doi:10.1128/AAC.00052-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

An ABC Transporter of Streptococcus pneumoniae Involved in Susceptibility to Vancoresmycin and Bacitracin Petra Becker, Regine Hakenbeck, and Bernhard Henrich Antimicrob. Agents Chemother. May 2009 53: 2034-2041; published ahead of print March 9, 2009, doi:10.1128/AAC.01485-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo and In Vitro Patterns of the Activity of Simocyclinone D8, an Angucyclinone Antibiotic from Streptomyces antibioticus Lisa M. Oppegard, Bree L. Hamann, Kathryn R. Streck, Keith C. Ellis, Hans-Peter Fiedler, Arkady B. Khodursky, and Hiroshi Hiasa Antimicrob. Agents Chemother. May 2009 53: 2110-2119; published ahead of print March 9, 2009, doi:10.1128/AAC.01440-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Geraniol Restores Antibiotic Activities against Multidrug-Resistant Isolates from Gram-Negative Species Vannina Lorenzi, Alain Muselli, Antoine François Bernardini, Liliane Berti, Jean-Marie Pagès, Leonard Amaral, and Jean-Michel Bolla Antimicrob. Agents Chemother. May 2009 53: 2209-2211; published ahead of print March 2, 2009, doi:10.1128/AAC.00919-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

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Letters:

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First Organisms with Acquired Metallo-β-Lactamases (IMP-13, IMP-22, and VIM-2) Reported in Austria Wojciech Duljasz, Marek Gniadkowski, Silvia Sitter, Alexandra Wojna, and Crista Jebelean Antimicrob. Agents Chemother. May 2009 53: 2221-2222; published ahead of print February 17, 2009, doi:10.1128/AAC.01573-08 [Full Text] [PDF] [Reprints and Permissions]

Posaconazole Therapeutic Drug Monitoring: a Reference Laboratory Experience George R. Thompson, III, Michael G. Rinaldi, Gennethel Pennick, Sheryl A. Dorsey, Thomas F. Patterson, and James S. Lewis, II Antimicrob. Agents Chemother. May 2009 53: 2223-2224; published ahead of print March 2, 2009, doi:10.1128/AAC.00240-09 [Full Text] [PDF] [Reprints and Permissions]

Further Identification of CTX-M-2 Extended-Spectrum β-Lactamase in Pseudomonas aeruginosa Renata Cristina Picão, Laurent Poirel, Ana C. Gales, and Patrice Nordmann Antimicrob. Agents Chemother. May 2009 53: 2225-2226; published ahead of print February 17, 2009, doi:10.1128/AAC.01602-08 [Full Text] [PDF] [Reprints and Permissions]

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