Contents: June 2009, Volume 53, Issue 6        Minireviews        Susceptibility        Mechanisms of Resistance        Experimental Therapeutics        Mechanisms of Action        Analytical Procedures        Antiviral Agents        Pharmacology        Clinical Therapeutics        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Resistance Plasmid Families in Enterobacteriaceae Alessandra Carattoli Antimicrob. Agents Chemother. June 2009 53: 2227-2238; published ahead of print March 23, 2009, doi:10.1128/AAC.01707-08 [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Comparative Antipneumococcal Activities of Sulopenem and Other Drugs Klaudia Kosowska-Shick, Lois M. Ednie, Pamela McGhee, and Peter C. Appelbaum Antimicrob. Agents Chemother. June 2009 53: 2239-2247; published ahead of print March 23, 2009, doi:10.1128/AAC.01531-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Atorvastatin Is a Promising Partner for Antimalarial Drugs in Treatment of Plasmodium falciparum Malaria Véronique Parquet, Sébastien Briolant, Marylin Torrentino-Madamet, Maud Henry, Lionel Almeras, Rémy Amalvict, Eric Baret, Thierry Fusaï, Christophe Rogier, and Bruno Pradines Antimicrob. Agents Chemother. June 2009 53: 2248-2252; published ahead of print March 23, 2009, doi:10.1128/AAC.01462-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Ceftaroline Alone and in Combination against Clinical Isolates of Resistant Gram-Negative Pathogens, Including β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa Céline Vidaillac, Steve N. Leonard, Helio S. Sader, Ronald N. Jones, and Michael J. Rybak Antimicrob. Agents Chemother. June 2009 53: 2360-2366; published ahead of print April 6, 2009, doi:10.1128/AAC.01452-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of sarA on Antibiotic Susceptibility of Staphylococcus aureus in a Catheter-Associated In Vitro Model of Biofilm Formation Elizabeth C. Weiss, Horace J. Spencer, Sonja J. Daily, Brian D. Weiss, and Mark S. Smeltzer Antimicrob. Agents Chemother. June 2009 53: 2475-2482; published ahead of print March 16, 2009, doi:10.1128/AAC.01432-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Micafungin against Planktonic and Sessile Candida albicans Isolates Melissa J. Jacobson, Kathryn E. Steckelberg, Kerryl E. Piper, James M. Steckelberg, and Robin Patel Antimicrob. Agents Chemother. June 2009 53: 2638-2639; published ahead of print March 23, 2009, doi:10.1128/AAC.01724-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antifungal Activities of Natural and Synthetic Iron Chelators Alone and in Combination with Azole and Polyene Antibiotics against Aspergillus fumigatus Kol A. Zarember, Anna R. Cruz, Chiung-Yu Huang, and John I. Gallin Antimicrob. Agents Chemother. June 2009 53: 2654-2656; published ahead of print March 23, 2009, doi:10.1128/AAC.01547-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibiotic Susceptibility of Waddlia chondrophila in Acanthamoeba castellanii Amoebae Geneviève Goy and Gilbert Greub Antimicrob. Agents Chemother. June 2009 53: 2663-2666; published ahead of print March 30, 2009, doi:10.1128/AAC.00046-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of Human Serum Albumin on Oritavancin In Vitro Activity against Enterococci Geoffrey A. McKay, Sylvain Beaulieu, Ingrid Sarmiento, Francis F. Arhin, Thomas R. Parr, Jr., and Gregory Moeck Antimicrob. Agents Chemother. June 2009 53: 2687-2689; published ahead of print April 6, 2009, doi:10.1128/AAC.00197-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bacteriostatic and Bactericidal Activities of Tigecycline against Coxiella burnetii and Comparison with Those of Six Other Antibiotics Ioanna Spyridaki, Anna Psaroulaki, Iosif Vranakis, Yannis Tselentis, and Achilleas Gikas Antimicrob. Agents Chemother. June 2009 53: 2690-2692; published ahead of print March 30, 2009, doi:10.1128/AAC.01424-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tetracycline Susceptibility Testing and Resistance Genes in Isolates of Acinetobacter baumannii-Acinetobacter calcoaceticus Complex from a U.S. Military Hospital Kevin S. Akers, Katrin Mende, Heather C. Yun, Duane R. Hospenthal, Miriam L. Beckius, Xin Yu, and Clinton K. Murray Antimicrob. Agents Chemother. June 2009 53: 2693-2695; published ahead of print March 23, 2009, doi:10.1128/AAC.01405-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High Rate of Reduced Susceptibility to Ciprofloxacin and Ceftriaxone among Nontyphoid Salmonella Clinical Isolates in Asia Hao-Yuan Lee, Lin-Hui Su, Ming-Han Tsai, Shin-Woo Kim, Hyun-Ha Chang, Sook-In Jung, Kyung-Hwa Park, Jennifer Perera, Celia Carlos, Ban Hock Tan, Gamini Kumarasinghe, Thomas So, Anan Chongthaleong, Po-Ren Hsueh, Jien-Wei Liu, Jae-Hoon Song, and Cheng-Hsun Chiu Antimicrob. Agents Chemother. June 2009 53: 2696-2699; published ahead of print March 30, 2009, doi:10.1128/AAC.01297-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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The Chromosomal Toxin Gene yafQ Is a Determinant of Multidrug Tolerance for Escherichia coli Growing in a Biofilm Joe J. Harrison, William D. Wade, Sarah Akierman, Caterina Vacchi-Suzzi, Carol A. Stremick, Raymond J. Turner, and Howard Ceri Antimicrob. Agents Chemother. June 2009 53: 2253-2258; published ahead of print March 23, 2009, doi:10.1128/AAC.00043-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inactivation of the Glycoside Hydrolase NagZ Attenuates Antipseudomonal β-Lactam Resistance in Pseudomonas aeruginosa Azizah Asgarali, Keith A. Stubbs, Antonio Oliver, David J. Vocadlo, and Brian L. Mark Antimicrob. Agents Chemother. June 2009 53: 2274-2282; published ahead of print March 9, 2009, doi:10.1128/AAC.01617-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Module Located at a Chromosomal Integration Hot Spot Is Responsible for the Multidrug Resistance of a Reference Strain from Escherichia coli Clonal Group A Mathilde Lescat, Alexandra Calteau, Claire Hoede, Valérie Barbe, Marie Touchon, Eduardo Rocha, Olivier Tenaillon, Claudine Médigue, James R. Johnson, and Erick Denamur Antimicrob. Agents Chemother. June 2009 53: 2283-2288; published ahead of print April 13, 2009, doi:10.1128/AAC.00123-09 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Genetic Analysis of Colistin Resistance in Salmonella enterica Serovar Typhimurium Song Sun, Aurel Negrea, Mikael Rhen, and Dan I. Andersson Antimicrob. Agents Chemother. June 2009 53: 2298-2305; published ahead of print March 30, 2009, doi:10.1128/AAC.01016-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Analysis of Cell Membrane Characteristics of In Vitro-Selected Daptomycin-Resistant Strains of Methicillin-Resistant Staphylococcus aureus Nagendra N. Mishra, Soo-Jin Yang, Ayumi Sawa, Aileen Rubio, Cynthia C. Nast, Michael R. Yeaman, and Arnold S. Bayer Antimicrob. Agents Chemother. June 2009 53: 2312-2318; published ahead of print March 30, 2009, doi:10.1128/AAC.01682-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence and Evolution of Multiply Antibiotic-Resistant Salmonella enterica Serovar Paratyphi B D-Tartrate-Utilizing Strains Containing SGI1 Steven P. Djordjevic, Amy K. Cain, Nick J. Evershed, Linda Falconer, Renee S. Levings, Diane Lightfoot, and Ruth M. Hall Antimicrob. Agents Chemother. June 2009 53: 2319-2326; published ahead of print March 30, 2009, doi:10.1128/AAC.01532-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

AAC(6')-Iaf, a Novel Aminoglycoside 6'-N-Acetyltransferase from Multidrug-Resistant Pseudomonas aeruginosa Clinical Isolates Tomoe Kitao, Tohru Miyoshi-Akiyama, and Teruo Kirikae Antimicrob. Agents Chemother. June 2009 53: 2327-2334; published ahead of print April 6, 2009, doi:10.1128/AAC.01360-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fitness Cost of VanA-Type Vancomycin Resistance in Methicillin-Resistant Staphylococcus aureus Marie-Laure Foucault, Patrice Courvalin, and Catherine Grillot-Courvalin Antimicrob. Agents Chemother. June 2009 53: 2354-2359; published ahead of print March 30, 2009, doi:10.1128/AAC.01702-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibility and Mechanisms of Resistance in Shigella and Salmonella Isolates from Children under Five Years of Age with Diarrhea in Rural Mozambique Inácio Mandomando, Dinis Jaintilal, Maria J. Pons, Xavier Vallès, Mateu Espasa, Laura Mensa, Betuel Sigaúque, Sergi Sanz, Jahit Sacarlal, Eusébio Macete, Fátima Abacassamo, Pedro L. Alonso, and Joaquim Ruiz Antimicrob. Agents Chemother. June 2009 53: 2450-2454; published ahead of print March 30, 2009, doi:10.1128/AAC.01282-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Analysis of the gyrA and gyrB Quinolone Resistance-Determining Regions of Fluoroquinolone-Resistant Clostridium difficile Mutants Selected In Vitro Patrizia Spigaglia, Fabrizio Barbanti, Thomas Louie, Frédéric Barbut, and Paola Mastrantonio Antimicrob. Agents Chemother. June 2009 53: 2463-2468; published ahead of print April 13, 2009, doi:10.1128/AAC.01252-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibiotic Resistance in Pseudomonas aeruginosa Strains with Increased Mutation Frequency Due to Inactivation of the DNA Oxidative Repair System L. F. Mandsberg, O. Ciofu, N. Kirkby, L. E. Christiansen, H. E. Poulsen, and N. Høiby Antimicrob. Agents Chemother. June 2009 53: 2483-2491; published ahead of print March 30, 2009, doi:10.1128/AAC.00428-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Integron Mobilization Unit as a Source of Mobility of Antibiotic Resistance Genes Laurent Poirel, Amélie Carrër, Johann D. Pitout, and Patrice Nordmann Antimicrob. Agents Chemother. June 2009 53: 2492-2498; published ahead of print March 30, 2009, doi:10.1128/AAC.00033-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genomewide Identification of Genetic Determinants of Antimicrobial Drug Resistance in Pseudomonas aeruginosa Andreas Dötsch, Tanja Becker, Claudia Pommerenke, Zofia Magnowska, Lothar Jänsch, and Susanne Häussler Antimicrob. Agents Chemother. June 2009 53: 2522-2531; published ahead of print March 30, 2009, doi:10.1128/AAC.00035-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characteristics of Travel-Related Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolates from the Calgary Health Region Johann D. D. Pitout, Lorraine Campbell, Deirdre L. Church, Daniel B. Gregson, and Kevin B. Laupland Antimicrob. Agents Chemother. June 2009 53: 2539-2543; published ahead of print April 13, 2009, doi:10.1128/AAC.00061-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Polymorphism in PfMRP1 (Plasmodium falciparum Multidrug Resistance Protein 1) Amino Acid 1466 Associated with Resistance to Sulfadoxine-Pyrimethamine Treatment Sabina Dahlström, M. Isabel Veiga, Andreas Mårtensson, Anders Björkman, and J. Pedro Gil Antimicrob. Agents Chemother. June 2009 53: 2553-2556; published ahead of print April 13, 2009, doi:10.1128/AAC.00091-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Topoisomerase I Gene Mutations at F270 in the Large Subunit and N184 in the Small Subunit Contribute to the Resistance Mechanism of the Unicellular Parasite Leishmania donovani towards 3,3'-Diindolylmethane Amit Roy, Somdeb BoseDasgupta, Agneyo Ganguly, Parasuraman Jaisankar, and Hemanta K. Majumder Antimicrob. Agents Chemother. June 2009 53: 2589-2598; published ahead of print March 30, 2009, doi:10.1128/AAC.01648-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Identification of a Novel Variant of Staphylococcal Cassette Chromosome mec, Type II.5, and Its Truncated Form by Insertion of Putative Conjugative Transposon Tn6012 Xiao Han, Teruyo Ito, Fumihiko Takeuchi, Xiao Xue Ma, Michihiko Takasu, Yoshio Uehara, Duarte C. Oliveira, Hermínia de Lencastre, and Keiichi Hiramatsu Antimicrob. Agents Chemother. June 2009 53: 2616-2619; published ahead of print April 13, 2009, doi:10.1128/AAC.00772-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

High Prevalence of qnr Genes in Commensal Enterobacteria from Healthy Children in Peru and Bolivia Lucia Pallecchi, Eleonora Riccobono, Antonia Mantella, Filippo Bartalesi, Samanta Sennati, Herlan Gamboa, Eduardo Gotuzzo, Alessandro Bartoloni, and Gian Maria Rossolini Antimicrob. Agents Chemother. June 2009 53: 2632-2635; published ahead of print April 13, 2009, doi:10.1128/AAC.01722-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Regulation of mprF in Daptomycin-Nonsusceptible Staphylococcus aureus Strains Soo-Jin Yang, Yan Q. Xiong, Paul M. Dunman, Jacques Schrenzel, Patrice François, Andreas Peschel, and Arnold S. Bayer Antimicrob. Agents Chemother. June 2009 53: 2636-2637; published ahead of print March 16, 2009, doi:10.1128/AAC.01415-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Unusual Class 1 Integron-Associated Gene Cassette Configuration Found in IncA/C Plasmids from Salmonella enterica Nick J. Evershed, Renee S. Levings, Neil L. Wilson, Steven P. Djordjevic, and Ruth M. Hall Antimicrob. Agents Chemother. June 2009 53: 2640-2642; published ahead of print March 23, 2009, doi:10.1128/AAC.00233-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevalence of aac(6')-Ib-cr Encoding a Ciprofloxacin-Modifying Enzyme among Enterobacteriaceae Blood Isolates in Korea Eun Sil Kim, Jin-Yong Jeong, Jae-Bum Jun, Sang-Ho Choi, Sang-Oh Lee, Mi-Na Kim, Jun Hee Woo, and Yang Soo Kim Antimicrob. Agents Chemother. June 2009 53: 2643-2645; published ahead of print March 16, 2009, doi:10.1128/AAC.01534-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intracellular Localization of the ABCC Proteins of Leishmania and Their Role in Resistance to Antimonials Philippe Leprohon, Danielle Légaré, and Marc Ouellette Antimicrob. Agents Chemother. June 2009 53: 2646-2649; published ahead of print March 23, 2009, doi:10.1128/AAC.01474-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Capsular Type and Antibiotic Resistance in Streptococcus agalactiae Isolates from Patients, Ranging from Newborns to the Elderly, with Invasive Infections Somay Yamagata Murayama, Chizuko Seki, Hiroshi Sakata, Katsuhiko Sunaoshi, Eiichi Nakayama, Satoshi Iwata, Keisuke Sunakawa, Kimiko Ubukata and the Invasive Streptococcal Disease Working Group Antimicrob. Agents Chemother. June 2009 53: 2650-2653; published ahead of print March 30, 2009, doi:10.1128/AAC.01716-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Selection of Reduced Susceptibility to Carbapenems in Acinetobacter baumannii Related to ISAba1-Mediated Overexpression of the Natural blaOXA-66 Oxacillinase Gene Samy Figueiredo, Laurent Poirel, Jacques Croize, Christine Recule, and Patrice Nordmann Antimicrob. Agents Chemother. June 2009 53: 2657-2659; published ahead of print March 23, 2009, doi:10.1128/AAC.01663-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

AbaR5, a Large Multiple-Antibiotic Resistance Region Found in Acinetobacter baumannii Virginia Post and Ruth M. Hall Antimicrob. Agents Chemother. June 2009 53: 2667-2671; published ahead of print April 13, 2009, doi:10.1128/AAC.01407-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Gene Context and DNA Rearrangements in the Carbapenemase Locus of Division II Strains of Bacteroides fragilis Nuria García, Gloria Gutiérrez, María Lorenzo, Santiago Vadillo, Segundo Píriz, and Alberto Quesada Antimicrob. Agents Chemother. June 2009 53: 2677-2678; published ahead of print April 13, 2009, doi:10.1128/AAC.01514-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Effect of Topical Liposomes Containing Paromomycin Sulfate in the Course of Leishmania major Infection in Susceptible BALB/c Mice Mahmoud R. Jaafari, Neda Bavarsad, Bibi Sedigheh Fazly Bazzaz, Afshin Samiei, Dina Soroush, Serajodin Ghorbani, Mohammad M. Lotfi Heravi, and Ali Khamesipour Antimicrob. Agents Chemother. June 2009 53: 2259-2265; published ahead of print February 17, 2009, doi:10.1128/AAC.01319-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Combination Therapy in Treatment of Experimental Pulmonary Aspergillosis: In Vitro and In Vivo Correlations of the Concentration- and Dose- Dependent Interactions between Anidulafungin and Voriconazole by Bliss Independence Drug Interaction Analysis Vidmantas Petraitis, Ruta Petraitiene, William W. Hope, Joseph Meletiadis, Diana Mickiene, Johanna E. Hughes, Margaret P. Cotton, Theodouli Stergiopoulou, Miki Kasai, Andrea Francesconi, Robert L. Schaufele, Tin Sein, Nilo A. Avila, John Bacher, and Thomas J. Walsh Antimicrob. Agents Chemother. June 2009 53: 2382-2391; published ahead of print March 23, 2009, doi:10.1128/AAC.00329-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Therapeutic Evaluation of Polyamine Analogue Drug Candidates against Enterocytozoon bieneusi in a SCID Mouse Model Xiaochuan Feng, Venudhar K. Reddy, Harriet Mayanja-Kizza, Louis M. Weiss, Laurence J. Marton, and Saul Tzipori Antimicrob. Agents Chemother. June 2009 53: 2417-2423; published ahead of print March 16, 2009, doi:10.1128/AAC.01113-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevention of Death in Bacterium-Infected Mice by a Synthetic Antimicrobial Peptide, L5, through Activation of Host Immunity Yukiko Okuyama-Nishida, Nobuko Akiyama, Giichi Sugimori, Kazuhide Nomura, Kenji Ogawa, Koichi J. Homma, Kazuhisa Sekimizu, Masafumi Tsujimoto, and Shunji Natori Antimicrob. Agents Chemother. June 2009 53: 2510-2516; published ahead of print March 16, 2009, doi:10.1128/AAC.00863-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Galleria mellonella as a Model System To Study Acinetobacter baumannii Pathogenesis and Therapeutics Anton Y. Peleg, Sebastian Jara, Divya Monga, George M. Eliopoulos, Robert C. Moellering, Jr., and Eleftherios Mylonakis Antimicrob. Agents Chemother. June 2009 53: 2605-2609; published ahead of print March 30, 2009, doi:10.1128/AAC.01533-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhaled Voriconazole for Prevention of Invasive Pulmonary Aspergillosis Justin A. Tolman, Nathan P. Wiederhold, Jason T. McConville, Laura K. Najvar, Rosie Bocanegra, Jay I. Peters, Jacqueline J. Coalson, John R. Graybill, Thomas F. Patterson, and Robert O. Williams, III Antimicrob. Agents Chemother. June 2009 53: 2613-2615; published ahead of print March 16, 2009, doi:10.1128/AAC.01657-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Efficacies of Telavancin and Vancomycin in Preventing Device-Associated Colonization and Infection by Staphylococcus aureus in Rabbits Rabih O. Darouiche, Mohammad D. Mansouri, and Marlowe J. Schneidkraut Antimicrob. Agents Chemother. June 2009 53: 2626-2628; published ahead of print April 13, 2009, doi:10.1128/AAC.01101-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antifungal Combinations against Simulated Candida albicans Endocardial Vegetations Manjunath P. Pai Antimicrob. Agents Chemother. June 2009 53: 2629-2631; published ahead of print March 23, 2009, doi:10.1128/AAC.01026-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Differing Effects of Combination Chemotherapy with Meropenem and Tobramycin on Cell Kill and Suppression of Resistance of Wild-Type Pseudomonas aeruginosa PAO1 and Its Isogenic MexAB Efflux Pump-Overexpressed Mutant G. L. Drusano, Weiguo Liu, Christine Fregeau, Robert Kulawy, and Arnold Louie Antimicrob. Agents Chemother. June 2009 53: 2266-2273; published ahead of print March 16, 2009, doi:10.1128/AAC.01680-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Ceftobiprole and Other Cephalosporins against Extracellular and Intracellular (THP-1 Macrophages and Keratinocytes) Forms of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus Sandrine Lemaire, Youri Glupczynski, Valérie Duval, Bernard Joris, Paul M. Tulkens, and Françoise Van Bambeke Antimicrob. Agents Chemother. June 2009 53: 2289-2297; published ahead of print March 16, 2009, doi:10.1128/AAC.01135-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Farnesol-Induced Apoptosis in Candida albicans Mark E. Shirtliff, Bastiaan P. Krom, Roelien A. M. Meijering, Brian M. Peters, Jingsong Zhu, Mark A. Scheper, Megan L. Harris, and Mary Ann Jabra-Rizk Antimicrob. Agents Chemother. June 2009 53: 2392-2401; published ahead of print April 13, 2009, doi:10.1128/AAC.01551-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Omeprazole Antagonizes Virulence and Inflammation in Salmonella enterica-Infected RAW264.7 Cells Speranta Puiac, Aurel Negrea, Agneta Richter-Dahlfors, Laura Plant, and Mikael Rhen Antimicrob. Agents Chemother. June 2009 53: 2402-2409; published ahead of print March 23, 2009, doi:10.1128/AAC.01483-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Computer-Aided Identification of Recognized Drugs as Pseudomonas aeruginosa Quorum-Sensing Inhibitors Liang Yang, Morten Theil Rybtke, Tim Holm Jakobsen, Morten Hentzer, Thomas Bjarnsholt, Michael Givskov, and Tim Tolker-Nielsen Antimicrob. Agents Chemother. June 2009 53: 2432-2443; published ahead of print April 13, 2009, doi:10.1128/AAC.01283-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

P1A Recombinant β-Lactamase Prevents Emergence of Antimicrobial Resistance in Gut Microflora of Healthy Subjects during Intravenous Administration of Ampicillin Ann-Mari Tarkkanen, Tuula Heinonen, Rain Jõgi, Silja Mentula, Michel E. van der Rest, Curtis J. Donskey, Tuomas Kemppainen, Konstantin Gurbanov, and Carl Erik Nord Antimicrob. Agents Chemother. June 2009 53: 2455-2462; published ahead of print March 23, 2009, doi:10.1128/AAC.00853-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dermcidin-Derived Peptides Show a Different Mode of Action than the Cathelicidin LL-37 against Staphylococcus aureus Ilknur Senyürek, Maren Paulmann, Tobias Sinnberg, Hubert Kalbacher, Martin Deeg, Thomas Gutsmann, Marina Hermes, Thomas Kohler, Fritz Götz, Christiane Wolz, Andreas Peschel, and Birgit Schittek Antimicrob. Agents Chemother. June 2009 53: 2499-2509; published ahead of print April 13, 2009, doi:10.1128/AAC.01679-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Metabolism of an Alkyl Polyamine Analog by a Polyamine Oxidase from the Microsporidian Encephalitozoon cuniculi Cyrus J. Bacchi, Nigel Yarlett, Evangeline Faciane, Xiangdong Bi, Donna Rattendi, Louis M. Weiss, and Patrick M. Woster Antimicrob. Agents Chemother. June 2009 53: 2599-2604; published ahead of print February 17, 2009, doi:10.1128/AAC.00267-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Analytical Procedures:

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High-Throughput Screening Identifies Novel Inhibitors of the Acetyltransferase Activity of Escherichia coli GlmU Mark P. Pereira, Jan E. Blanchard, Cecilia Murphy, Steven L. Roderick, and Eric D. Brown Antimicrob. Agents Chemother. June 2009 53: 2306-2311; published ahead of print April 6, 2009, doi:10.1128/AAC.01572-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Assessment of Malaria In Vitro Drug Combination Screening and Mixed-Strain Infections Using the Malaria Sybr Green I-Based Fluorescence Assay Edgie-Mark A. Co, Richard A. Dennull, Drew D. Reinbold, Norman C. Waters, and Jacob D. Johnson Antimicrob. Agents Chemother. June 2009 53: 2557-2563; published ahead of print April 6, 2009, doi:10.1128/AAC.01370-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Colorimetric High-Throughput Screen for Detection of Heme Crystallization Inhibitors Margaret A. Rush, Mary Lynn Baniecki, Ralph Mazitschek, Joseph F. Cortese, Roger Wiegand, Jon Clardy, and Dyann F. Wirth Antimicrob. Agents Chemother. June 2009 53: 2564-2568; published ahead of print March 23, 2009, doi:10.1128/AAC.01466-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Analysis of blaSHV Codon 238 and 240 Allele Mixtures Using Sybr Green High-Resolution Melting Analysis Patiyan Andersson, Tegan Harris, Steven Y. C. Tong, and Philip M. Giffard Antimicrob. Agents Chemother. June 2009 53: 2679-2683; published ahead of print April 6, 2009, doi:10.1128/AAC.00063-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Predictive Value of Pharmacokinetics-Adjusted Phenotypic Susceptibility on Response to Ritonavir-Enhanced Protease Inhibitors (PIs) in Human Immunodeficiency Virus-Infected Subjects Failing Prior PI Therapy Joseph J. Eron, Jr., Jeong-Gun Park, Richard Haubrich, Francesca Aweeka, Barbara Bastow, Gary E. Pakes, Song Yu, Hulin Wu, Douglas D. Richman for the ACTG5126 Study Team Antimicrob. Agents Chemother. June 2009 53: 2335-2341; published ahead of print March 23, 2009, doi:10.1128/AAC.01387-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genital Tract, Cord Blood, and Amniotic Fluid Exposures of Seven Antiretroviral Drugs during and after Pregnancy in Human Immunodeficiency Virus Type 1-Infected Women Rosa F. Yeh, Naser L. Rezk, Angela D. M. Kashuba, Julie B. Dumond, Hiba L. Tappouni, Hsiao-Chuan Tien, Ya-Chi Chen, Manoli Vourvahis, Amanda L. Horton, Susan A. Fiscus, and Kristine B. Patterson Antimicrob. Agents Chemother. June 2009 53: 2367-2374; published ahead of print March 23, 2009, doi:10.1128/AAC.01523-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prediction of the Pharmacodynamically Linked Variable of Oseltamivir Carboxylate for Influenza A Virus Using an In Vitro Hollow-Fiber Infection Model System James J. McSharry, Qingmei Weng, Ashley Brown, Robert Kulawy, and George L. Drusano Antimicrob. Agents Chemother. June 2009 53: 2375-2381; published ahead of print April 13, 2009, doi:10.1128/AAC.00167-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions] FREE

Antiviral Activity of MK-4965, a Novel Nonnucleoside Reverse Transcriptase Inhibitor Ming-Tain Lai, Vandna Munshi, Sinoeun Touch, Robert M. Tynebor, Thomas J. Tucker, Philip M. McKenna, Theresa M. Williams, Daniel J. DiStefano, Daria J. Hazuda, and Michael D. Miller Antimicrob. Agents Chemother. June 2009 53: 2424-2431; published ahead of print March 16, 2009, doi:10.1128/AAC.01559-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Stable Extended Human Immunodeficiency Virus Type 1 gp41 Coiled Coil as an Effective Target in an Assay for High-Affinity Fusion Inhibitors Lifeng Cai, Edina Balogh, and Miriam Gochin Antimicrob. Agents Chemother. June 2009 53: 2444-2449; published ahead of print April 13, 2009, doi:10.1128/AAC.00150-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase Stephanie T. Shi, Koleen J. Herlihy, Joanne P. Graham, Jim Nonomiya, Sadayappan V. Rahavendran, Heather Skor, Rebecca Irvine, Susan Binford, John Tatlock, Hui Li, Javier Gonzalez, Angelica Linton, Amy K. Patick, and Cristina Lewis Antimicrob. Agents Chemother. June 2009 53: 2544-2552; published ahead of print March 23, 2009, doi:10.1128/AAC.01599-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Inhibition of Vaccinia Virus Replication by Two Small Interfering RNAs Targeting B1R and G7L Genes and Their Synergistic Combination with Cidofovir Solenne Vigne, Sophie Duraffour, Graciela Andrei, Robert Snoeck, Daniel Garin, and Jean-Marc Crance Antimicrob. Agents Chemother. June 2009 53: 2579-2588; published ahead of print March 23, 2009, doi:10.1128/AAC.01626-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

R964C Mutation of DNA Polymerase Imparts Increased Stavudine Toxicity by Decreasing Nucleoside Analog Discrimination and Impairing Polymerase Activity Christopher M. Bailey, Rajesh Kasiviswanathan, William C. Copeland, and Karen S. Anderson Antimicrob. Agents Chemother. June 2009 53: 2610-2612; published ahead of print April 13, 2009, doi:10.1128/AAC.01659-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nonhuman Primates Are Protected from Smallpox Virus or Monkeypox Virus Challenges by the Antiviral Drug ST-246 John Huggins, Arthur Goff, Lisa Hensley, Eric Mucker, Josh Shamblin, Carly Wlazlowski, Wendy Johnson, Jennifer Chapman, Tom Larsen, Nancy Twenhafel, Kevin Karem, Inger K. Damon, Chelsea M. Byrd, Tove' C. Bolken, Robert Jordan, and Dennis Hruby Antimicrob. Agents Chemother. June 2009 53: 2620-2625; published ahead of print April 6, 2009, doi:10.1128/AAC.00021-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Octadecyloxyethyl Ester of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy) Propyl]Adenine Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication in Genotype 1A, 1B, and 2A Replicons David L. Wyles, Kelly A. Kaihara, Brent E. Korba, Robert T. Schooley, James R. Beadle, and Karl Y. Hostetler Antimicrob. Agents Chemother. June 2009 53: 2660-2662; published ahead of print March 16, 2009, doi:10.1128/AAC.01546-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Evaluation of Cefotaxime and Desacetylcefotaxime Concentrations in Cord Blood after Intrapartum Prophylaxis with Cefotaxime Jacques Lepercq, Jean Marc Treluyer, Christelle Auger, Josette Raymond, Elisabeth Rey, Thomas Schmitz, and Vincent Jullien Antimicrob. Agents Chemother. June 2009 53: 2342-2345; published ahead of print March 23, 2009, doi:10.1128/AAC.01429-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Model-Based Approach To Characterize Efavirenz Autoinduction and Concurrent Enzyme Induction with Carbamazepine Min Zhu, Sanjeev Kaul, Partha Nandy, Dennis M. Grasela, and Marc Pfister Antimicrob. Agents Chemother. June 2009 53: 2346-2353; published ahead of print February 17, 2009, doi:10.1128/AAC.01120-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification of the Efflux Transporter of the Fluoroquinolone Antibiotic Ciprofloxacin in Murine Macrophages: Studies with Ciprofloxacin-Resistant Cells Béatrice Marquez, Nancy E. Caceres, Marie-Paule Mingeot-Leclercq, Paul M. Tulkens, and Françoise Van Bambeke Antimicrob. Agents Chemother. June 2009 53: 2410-2416; published ahead of print March 23, 2009, doi:10.1128/AAC.01428-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibacterial Efficacy of Phages against Pseudomonas aeruginosa Infections in Mice and Drosophila melanogaster Yun-Jeong Heo, Yu-Rim Lee, Hyun-Hee Jung, JungEun Lee, GwangPyo Ko, and You-Hee Cho Antimicrob. Agents Chemother. June 2009 53: 2469-2474; published ahead of print April 13, 2009, doi:10.1128/AAC.01646-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Nikkomycin Z after Single Rising Oral Doses David E. Nix, Robert R. Swezey, Richard Hector, and John N. Galgiani Antimicrob. Agents Chemother. June 2009 53: 2517-2521; published ahead of print April 6, 2009, doi:10.1128/AAC.01609-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetics of Lopinavir Predict Suboptimal Therapeutic Concentrations in Treatment-Experienced Human Immunodeficiency Virus-Infected Children Natella Rakhmanina, John van den Anker, Aline Baghdassarian, Steven Soldin, Keetra Williams, and Michael N. Neely Antimicrob. Agents Chemother. June 2009 53: 2532-2538; published ahead of print March 2, 2009, doi:10.1128/AAC.01374-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bone Penetration of Amoxicillin and Clavulanic Acid Evaluated by Population Pharmacokinetics and Monte Carlo Simulation Cornelia B. Landersdorfer, Martina Kinzig, Jürgen B. Bulitta, Friedrich F. Hennig, Ulrike Holzgrabe, Fritz Sörgel, and Johannes Gusinde Antimicrob. Agents Chemother. June 2009 53: 2569-2578; published ahead of print March 23, 2009, doi:10.1128/AAC.01119-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Concentrations of Voriconazole in Healthy and Inflamed Lung in Rats Christian Joukhadar, Christiane Thallinger, Wolfgang Pöppl, Florian Kovar, Karl H. Konz, Samir M. Joukhadar, and Friederike Traunmüller Antimicrob. Agents Chemother. June 2009 53: 2684-2686; published ahead of print March 30, 2009, doi:10.1128/AAC.00885-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Long-Term Follow-Up Trial of Oral Rifampin-Cotrimoxazole Combination versus Intravenous Cloxacillin in Treatment of Chronic Staphylococcal Osteomyelitis G. Euba, O. Murillo, N. Fernández-Sabé, J. Mascaró, J. Cabo, A. Pérez, F. Tubau, R. Verdaguer, F. Gudiol, and J. Ariza Antimicrob. Agents Chemother. June 2009 53: 2672-2676; published ahead of print March 23, 2009, doi:10.1128/AAC.01504-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Activity of Temocillin against KPC-Producing Klebsiella pneumoniae and Escherichia coli Jennifer M. Adams-Haduch, Brian A. Potoski, Hanna E. Sidjabat, David L. Paterson, and Yohei Doi Antimicrob. Agents Chemother. June 2009 53: 2700-2701; published ahead of print March 30, 2009, doi:10.1128/AAC.00290-09 [Full Text] [PDF] [Reprints and Permissions]

Early Dissemination of KPC-2-Producing Klebsiella pneumoniae Strains in Brazil Mónica Pavez, Elsa M. Mamizuka, and Nilton Lincopan Antimicrob. Agents Chemother. June 2009 53: 2702 published ahead of print March 30, 2009, doi:10.1128/AAC.00089-09 [Full Text] [PDF] [Reprints and Permissions]

Thermosensitive Nature of IncHI1 Plasmid Transfer Diane E. Taylor Antimicrob. Agents Chemother. June 2009 53: 2703 [Full Text] [PDF] [Reprints and Permissions]

Association of Fluconazole Pharmacodynamics with Mortality in Patients with Candidemia Maiken C. Arendrup, Manuel Cuenca-Estrella, J. Peter Donnelly, Cornelia Lass-Flörl, Juan L. Rodriguez-Tudela, John W. Baddley, Luis Ostrosky-Zeichner, Sujata M. Bhavnani, and David R. Andes Antimicrob. Agents Chemother. June 2009 53: 2704-2706; [Full Text] [PDF] [Reprints and Permissions]

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