AAC -- Table of Contents (July 1 2009, 53 [7])

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Contents: July 2009, Volume 53, Issue 7

       Experimental Therapeutics

       Clinical Therapeutics

       Pharmacology

       Susceptibility

       Antiviral Agents

       Mechanisms of Resistance

       Mechanisms of Action

       Analytical Procedures

       Chemistry; Biosynthesis

       Letters

       Errata

Other Issues

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Experimental Therapeutics:

Piperaquine Pharmacodynamics and Parasite Viability in a Murine Malaria Model
Brioni R. Moore, Kenneth F. Ilett, Madhu Page-Sharp, Jeffrey D. Jago, and Kevin T. Batty
Antimicrob. Agents Chemother. July 2009 53: 2707-2713; published ahead of print April 20, 2009, doi:10.1128/AAC.00056-09
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Efficacy of Daptomycin in Implant-Associated Infection Due to Methicillin-Resistant Staphylococcus aureus: Importance of Combination with Rifampin
Anne-Kathrin John, Daniela Baldoni, Manuel Haschke, Katharina Rentsch, Patrick Schaerli, Werner Zimmerli, and Andrej Trampuz
Antimicrob. Agents Chemother. July 2009 53: 2719-2724; published ahead of print April 13, 2009, doi:10.1128/AAC.00047-09
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Activity of Telavancin against Staphylococcus aureus Strains with Various Vancomycin Susceptibilities in an In Vitro Pharmacokinetic/Pharmacodynamic Model with Simulated Endocardial Vegetations
Steven N. Leonard, Céline Vidaillac, and Michael J. Rybak
Antimicrob. Agents Chemother. July 2009 53: 2928-2933; published ahead of print May 4, 2009, doi:10.1128/AAC.01544-08
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Impacts of Dosing Frequency of the Combination Rifampin-Streptomycin on Its Bactericidal and Sterilizing Activities against Mycobacterium ulcerans in Mice
Baohong Ji, Aurélie Chauffour, Alexandra Aubry, Jérome Robert, Murad Ibrahim, and Vincent Jarlier
Antimicrob. Agents Chemother. July 2009 53: 2955-2959; published ahead of print April 13, 2009, doi:10.1128/AAC.00011-09
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Combination of Daptomycin plus Ceftriaxone Is More Active than Vancomycin plus Ceftriaxone in Experimental Meningitis after Addition of Dexamethasone
U. Egermann, Z. Stanga, A. Ramin, F. Acosta, A. Stucki, P. Gerber, M. Cottagnoud, and P. Cottagnoud
Antimicrob. Agents Chemother. July 2009 53: 3030-3033; published ahead of print April 13, 2009, doi:10.1128/AAC.00952-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Eradication of Bacteria in Suspension and Biofilms Using Methylene Blue-Loaded Dynamic Nanoplatforms
Jianfeng Wu, Hao Xu, Wei Tang, Raoul Kopelman, Martin A. Philbert, and Chuanwu Xi
Antimicrob. Agents Chemother. July 2009 53: 3042-3048; published ahead of print May 4, 2009, doi:10.1128/AAC.01604-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

An Engineered R-Type Pyocin Is a Highly Specific and Sensitive Bactericidal Agent for the Food-Borne Pathogen Escherichia coli O157:H7
Dean Scholl, Mike Cooley, Steve R. Williams, Dana Gebhart, David Martin, Anna Bates, and Robert Mandrell
Antimicrob. Agents Chemother. July 2009 53: 3074-3080; published ahead of print April 6, 2009, doi:10.1128/AAC.01660-08
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Reduction of Amphotericin B-Induced Renal Tubular Apoptosis by N-Acetylcysteine
Z. Odabasi, A. Karaalp, H. Cermik, J. Mohr, E. T. Tigen, M. Koc, and V. Korten
Antimicrob. Agents Chemother. July 2009 53: 3100-3102; published ahead of print May 4, 2009, doi:10.1128/AAC.00001-09
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Activity of SQ641, a Capuramycin Analog, in a Murine Model of Tuberculosis
Boris V. Nikonenko, Venkata M. Reddy, Marina Protopopova, Elena Bogatcheva, Leo Einck, and Carol A. Nacy
Antimicrob. Agents Chemother. July 2009 53: 3138-3139; published ahead of print May 4, 2009, doi:10.1128/AAC.00366-09
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Comparison of Tigecycline and Vancomycin for Treatment of Experimental Foreign-Body Infection Due to Methicillin-Resistant Staphylococcus aureus
Pierre Vaudaux, Bénédicte Fleury, Asllan Gjinovci, Elzbieta Huggler, Manuela Tangomo-Bento, and Daniel P. Lew
Antimicrob. Agents Chemother. July 2009 53: 3150-3152; published ahead of print April 13, 2009, doi:10.1128/AAC.01612-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clinical Therapeutics:

Early- and Late-Onset Pneumonia: Is This Still a Useful Classification?
Petra Gastmeier, Dorit Sohr, Christine Geffers, Henning Rüden, Ralf-Peter Vonberg, and Tobias Welte
Antimicrob. Agents Chemother. July 2009 53: 2714-2718; published ahead of print April 13, 2009, doi:10.1128/AAC.01070-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multicenter, Randomized Study of the Efficacy and Safety of Intravenous Iclaprim in Complicated Skin and Skin Structure Infections
D. Krievins, R. Brandt, S. Hawser, P. Hadvary, and K. Islam
Antimicrob. Agents Chemother. July 2009 53: 2834-2840; published ahead of print May 4, 2009, doi:10.1128/AAC.01383-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevalence and Risk Factors for Aminoglycoside Nephrotoxicity in Intensive Care Units
João F. P. Oliveira, Carolina A. Silva, Camila D. Barbieri, Giselle M. Oliveira, Dirce M. T. Zanetta, and Emmanuel A. Burdmann
Antimicrob. Agents Chemother. July 2009 53: 2887-2891; published ahead of print April 13, 2009, doi:10.1128/AAC.01430-08
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Safety and Outcomes of Open-Label Deferasirox Iron Chelation Therapy for Mucormycosis
Brad Spellberg, David Andes, Mario Perez, Anne Anglim, Hector Bonilla, Glenn E. Mathisen, Thomas J. Walsh, and Ashraf S. Ibrahim
Antimicrob. Agents Chemother. July 2009 53: 3122-3125; published ahead of print May 11, 2009, doi:10.1128/AAC.00361-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacology:

Effects of Cranberry Juice on Pharmacokinetics of β-Lactam Antibiotics following Oral Administration
Meng Li, Marilee A. Andrew, Joanne Wang, David H. Salinger, Paolo Vicini, Richard W. Grady, Brian Phillips, Danny D. Shen, and Gail D. Anderson
Antimicrob. Agents Chemother. July 2009 53: 2725-2732; published ahead of print April 27, 2009, doi:10.1128/AAC.00774-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Tipranavir-Ritonavir on Pharmacokinetics of Raltegravir
William D. Hanley, Larissa A. Wenning, Allison Moreau, James T. Kost, Eric Mangin, Trisha Shamp, Julie A. Stone, Keith M. Gottesdiener, John A. Wagner, and Marian Iwamoto
Antimicrob. Agents Chemother. July 2009 53: 2752-2755; published ahead of print April 27, 2009, doi:10.1128/AAC.01486-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Pharmacodynamic Profile of Tigecycline against Phenotypically Diverse Escherichia coli and Klebsiella pneumoniae Isolates
Anthony M. Nicasio, Jared L. Crandon, and David P. Nicolau
Antimicrob. Agents Chemother. July 2009 53: 2756-2761; published ahead of print April 13, 2009, doi:10.1128/AAC.01678-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Soft-Tissue Penetration of Ceftobiprole in Healthy Volunteers Determined by In Vivo Microdialysis
April Barbour, Stephan Schmidt, Sreedharan Nair Sabarinath, Maria Grant, Christoph Seubert, Donna Skee, Bindu Murthy, and Hartmut Derendorf
Antimicrob. Agents Chemother. July 2009 53: 2773-2776; published ahead of print April 13, 2009, doi:10.1128/AAC.01409-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Influence of the Cytochrome P450 2B6 Genotype on Population Pharmacokinetics of Efavirenz in Human Immunodeficiency Virus Patients
Salvador E. Cabrera, Dolores Santos, María P. Valverde, Alfonso Domínguez-Gil, Francisco González, Guillermo Luna, and María J. García
Antimicrob. Agents Chemother. July 2009 53: 2791-2798; published ahead of print May 11, 2009, doi:10.1128/AAC.01537-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of the Pharmacodynamics of Biapenem in Bronchial Epithelial Lining Fluid in Healthy Volunteers Given Half-Hour and Three-Hour Intravenous Infusions
Eiki Kikuchi, Junko Kikuchi, Yasuyuki Nasuhara, Satoshi Oizumi, Akitoshi Ishizaka, and Masaharu Nishimura
Antimicrob. Agents Chemother. July 2009 53: 2799-2803; published ahead of print April 20, 2009, doi:10.1128/AAC.01578-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Rifampin, a Potent Inducer of Drug-Metabolizing Enzymes, on the Pharmacokinetics of Raltegravir
Larissa A. Wenning, William D. Hanley, Diana M. Brainard, Amelia S. Petry, Kalyan Ghosh, Bo Jin, Eric Mangin, Thomas C. Marbury, Jolene K. Berg, Jeffrey A. Chodakewitz, Julie A. Stone, Keith M. Gottesdiener, John A. Wagner, and Marian Iwamoto
Antimicrob. Agents Chemother. July 2009 53: 2852-2856; published ahead of print May 11, 2009, doi:10.1128/AAC.01468-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Renal Disposition of Colistin in the Isolated Perfused Rat Kidney
Zheng Ma, Jiping Wang, Roger L. Nation, Jian Li, John D. Turnidge, Kingsley Coulthard, and Robert W. Milne
Antimicrob. Agents Chemother. July 2009 53: 2857-2864; published ahead of print April 20, 2009, doi:10.1128/AAC.00030-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Phase 1/2 Double-Blind, Placebo-Controlled, Dose Escalation, Safety, and Pharmacokinetic Study of Pagibaximab (BSYX-A110), an Antistaphylococcal Monoclonal Antibody for the Prevention of Staphylococcal Bloodstream Infections, in Very-Low-Birth-Weight Neonates
Leonard E. Weisman, Helen M. Thackray, Joseph A. Garcia-Prats, Mirjana Nesin, Joseph H. Schneider, Jennifer Fretz, John F. Kokai-Kun, James J. Mond, William G. Kramer, and Gerald W. Fischer
Antimicrob. Agents Chemother. July 2009 53: 2879-2886; published ahead of print April 20, 2009, doi:10.1128/AAC.01565-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Modeling the Autoinhibition of Clarithromycin Metabolism during Repeated Oral Administration
Khaled Abduljalil, Martina Kinzig, Jürgen Bulitta, Stefan Horkovics-Kovats, Fritz Sörgel, Michael Rodamer, and Uwe Fuhr
Antimicrob. Agents Chemother. July 2009 53: 2892-2901; published ahead of print May 4, 2009, doi:10.1128/AAC.01193-08
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Data Mining Validation of Fluconazole Breakpoints Established by the European Committee on Antimicrobial Susceptibility Testing
Isabel Cuesta, Concha Bielza, Pedro Larrañaga, Manuel Cuenca-Estrella, Fernando Laguna, Dolors Rodriguez-Pardo, Benito Almirante, Albert Pahissa, and Juan L. Rodríguez-Tudela
Antimicrob. Agents Chemother. July 2009 53: 2949-2954; published ahead of print May 11, 2009, doi:10.1128/AAC.00081-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Posaconazole Administered Orally or by Nasogastric Tube in Healthy Volunteers
Elizabeth S. Dodds Ashley, Jay B. Varkey, Gopal Krishna, Donna Vickery, Lei Ma, Xin Yu, Darshana Malavade, Megan Goodwin, John R. Perfect, and Eddie Power
Antimicrob. Agents Chemother. July 2009 53: 2960-2964; published ahead of print May 11, 2009, doi:10.1128/AAC.01178-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Modeling and Monte Carlo Simulation Study of the Pharmacokinetics and Antituberculosis Pharmacodynamics of Rifampin in Lungs
Sylvain Goutelle, Laurent Bourguignon, Pascal H. Maire, Michael Van Guilder, John E. Conte, Jr., and Roger W. Jelliffe
Antimicrob. Agents Chemother. July 2009 53: 2974-2981; published ahead of print April 20, 2009, doi:10.1128/AAC.01520-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacological Exploitation of an Off-Target Antibacterial Effect of the Cyclooxygenase-2 Inhibitor Celecoxib against Francisella tularensis
Hao-Chieh Chiu, Jian Yang, Shilpa Soni, Samuel K. Kulp, John S. Gunn, Larry S. Schlesinger, and Ching-Shih Chen
Antimicrob. Agents Chemother. July 2009 53: 2998-3002; published ahead of print April 27, 2009, doi:10.1128/AAC.00048-09
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In Vivo Pharmacodynamic Characterization of a Novel Plectasin Antibiotic, NZ2114, in a Murine Infection Model
D. Andes, W. Craig, L. A. Nielsen, and H. H. Kristensen
Antimicrob. Agents Chemother. July 2009 53: 3003-3009; published ahead of print May 4, 2009, doi:10.1128/AAC.01584-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Integration of Pharmacokinetic and Pharmacodynamic Indices of Orbifloxacin in Beagle Dogs after a Single Intravenous and Intramuscular Administration
Elias Gebru, Joong-Su Lee, Zhi-Qiang Chang, Mi-Hyun Hwang, Henrique Cheng, and Seung-Chun Park
Antimicrob. Agents Chemother. July 2009 53: 3024-3029; published ahead of print April 27, 2009, doi:10.1128/AAC.01346-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Safety and Pharmacokinetics of Chimeric Anti-Shiga Toxin 1 and Anti-Shiga Toxin 2 Monoclonal Antibodies in Healthy Volunteers
Martin Bitzan, Ruth Poole, Mariam Mehran, Eric Sicard, Catherine Brockus, Claire Thuning-Roberson, and Marc Rivière
Antimicrob. Agents Chemother. July 2009 53: 3081-3087; published ahead of print May 4, 2009, doi:10.1128/AAC.01661-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Elution of Daptomycin by a Synthetic Crystallic Semihydrate Form of Calcium Sulfate, Stimulan
Kyriaki Kanellakopoulou, Periklis Panagopoulos, Efthymia Giannitsioti, Thomas Tsaganos, Dionyssia-Pinelopi Carrer, Nicolas Efstathopoulos, and Evangelos J. Giamarellos-Bourboulis
Antimicrob. Agents Chemother. July 2009 53: 3106-3107; published ahead of print April 27, 2009, doi:10.1128/AAC.01490-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prospective Open-Label Study of the Administration of Two-Percent Voriconazole Eye Drops
Daoud Al-Badriyeh, Lok Leung, Trent Roydhouse, Robert Fullinfaw, Mark Daniell, Geoffrey E. Davies, Kay Stewart, and David C. M. Kong
Antimicrob. Agents Chemother. July 2009 53: 3153-3155; published ahead of print May 11, 2009, doi:10.1128/AAC.01700-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibility:

Epidemic Clonal Groups of Escherichia coli as a Cause of Antimicrobial-Resistant Urinary Tract Infections in Canada, 2002 to 2004
James R. Johnson, Megan Menard, Brian Johnston, Michael A. Kuskowski, Kim Nichol, and George G. Zhanel
Antimicrob. Agents Chemother. July 2009 53: 2733-2739; published ahead of print April 27, 2009, doi:10.1128/AAC.00297-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity
Georgina A. Holloway, William N. Charman, Alan H. Fairlamb, Reto Brun, Marcel Kaiser, Edmund Kostewicz, Patrizia M. Novello, John P. Parisot, John Richardson, Ian P. Street, Keith G. Watson, and Jonathan B. Baell
Antimicrob. Agents Chemother. July 2009 53: 2824-2833; published ahead of print April 13, 2009, doi:10.1128/AAC.01568-08
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Sitafloxacin Activity against Helicobacter pylori Isolates, Including Those with gyrA Mutations
Kazunari Murakami, Tadayoshi Okimoto, Masaaki Kodama, Jin Tanahashi, Toshio Fujioka, Fumiaki Ikeda, Hiroe Muraoka, Motoko Takigawa, Takeshi Saika, Miyuki Hasegawa, and Intetsu Kobayashi
Antimicrob. Agents Chemother. July 2009 53: 3097-3099; published ahead of print April 20, 2009, doi:10.1128/AAC.01552-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Echinocandins against Candida krusei Determined by Three Methods: MIC and Minimal Fungicidal Concentration Measurements and Time-Kill Studies
Emilia Cantón, Javier Pemán, Amparo Valentín, Ana Espinel-Ingroff, and Miguel Gobernado
Antimicrob. Agents Chemother. July 2009 53: 3108-3111; published ahead of print April 20, 2009, doi:10.1128/AAC.00160-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Doripenem against Burkholderia pseudomallei
Visanu Thamlikitkul and Suwanna Trakulsomboon
Antimicrob. Agents Chemother. July 2009 53: 3115-3117; published ahead of print April 13, 2009, doi:10.1128/AAC.00893-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Resistance Selection Studies Comparing the Activity of Razupenem (PTZ601) to Vancomycin and Linezolid against Eight Methicillin-Resistant and Two Methicillin-Susceptible Staphylococcus aureus Strains
Catherine Clark, Klaudia Kosowska-Shick, Pamela McGhee, Bonifacio Dewasse, Linda Beachel, and Peter C. Appelbaum
Antimicrob. Agents Chemother. July 2009 53: 3118-3121; published ahead of print May 11, 2009, doi:10.1128/AAC.00183-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Chemosensitization of Plasmodium falciparum to Antimalarials by Verapamil and Probenecid
Victor Masseno, Steven Muriithi, and Alexis Nzila
Antimicrob. Agents Chemother. July 2009 53: 3131-3134; published ahead of print April 13, 2009, doi:10.1128/AAC.01689-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nine-Hospital Study Comparing Broth Microdilution and Etest Method Results for Vancomycin and Daptomycin against Methicillin-Resistant Staphylococcus aureus
Helio S. Sader, Paul R. Rhomberg, and Ronald N. Jones
Antimicrob. Agents Chemother. July 2009 53: 3162-3165; published ahead of print April 27, 2009, doi:10.1128/AAC.00093-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Telavancin and Vancomycin against Biofilm-Producing Staphylococcus aureus, S. epidermidis, and Enterococcus faecalis Strains
Kerry L. LaPlante and Leonard A. Mermel
Antimicrob. Agents Chemother. July 2009 53: 3166-3169; published ahead of print May 18, 2009, doi:10.1128/AAC.01642-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Agents:

Novel Antiviral Agent DTriP-22 Targets RNA-Dependent RNA Polymerase of Enterovirus 71
Tzu-Chun Chen, Hwan-You Chang, Pei-Fen Lin, Jyh-Haur Chern, John Tsu-An Hsu, Chu-Yi Chang, and Shin-Ru Shih
Antimicrob. Agents Chemother. July 2009 53: 2740-2747; published ahead of print May 4, 2009, doi:10.1128/AAC.00101-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mitochondrial DNA Depletion in Rat Liver Induced by Fosalvudine Tidoxil, a Novel Nucleoside Reverse Transcriptase Inhibitor Prodrug
Ana C. Venhoff, Dirk Lebrecht, Frank U. Reuss, Brigitte Heckl-Östreicher, Roland Wehr, Ulrich A. Walker, and Nils Venhoff
Antimicrob. Agents Chemother. July 2009 53: 2748-2751; published ahead of print May 11, 2009, doi:10.1128/AAC.00364-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ultrasensitive Genotypic Detection of Antiviral Resistance in Hepatitis B Virus Clinical Isolates
Jie Fang, Michael J. Wichroski, Steven M. Levine, Carl J. Baldick, Charles E. Mazzucco, Ann W. Walsh, Bernadette K. Kienzle, Ronald E. Rose, Kevin A. Pokornowski, Richard J. Colonno, and Daniel J. Tenney
Antimicrob. Agents Chemother. July 2009 53: 2762-2772; published ahead of print May 11, 2009, doi:10.1128/AAC.00130-09
[Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

GS-9191 Is a Novel Topical Prodrug of the Nucleotide Analog 9-(2-Phosphonylmethoxyethyl)Guanine with Antiproliferative Activity and Possible Utility in the Treatment of Human Papillomavirus Lesions
Grushenka H. I. Wolfgang, Riri Shibata, Jianying Wang, Adrian S. Ray, Sylvia Wu, Edward Doerrfler, Hans Reiser, William A. Lee, Gabriel Birkus, Neil D. Christensen, Graciela Andrei, and Robert Snoeck
Antimicrob. Agents Chemother. July 2009 53: 2777-2784; published ahead of print April 27, 2009, doi:10.1128/AAC.00103-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Treatment with the Fusion Inhibitor Enfuvirtide Influences the Appearance of Mutations in the Human Immunodeficiency Virus Type 1 Regulatory Protein Rev
Valentina Svicher, Claudia Alteri, Roberta D'Arrigo, Alessandro Laganà, Maria Trignetti, Sergio Lo Caputo, Anna Paola Callegaro, Franco Maggiolo, Francesco Mazzotta, Alfredo Ferro, Salvatore Dimonte, Stefano Aquaro, Giovanni di Perri, Stefano Bonora, Chiara Tommasi, Maria Paola Trotta, Pasquale Narciso, Andrea Antinori, Carlo Federico Perno, and Francesca Ceccherini-Silberstein
Antimicrob. Agents Chemother. July 2009 53: 2816-2823; published ahead of print January 5, 2009, doi:10.1128/AAC.01067-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Alkoxyalkyl Esters of 9-(S)-(3-Hydroxy-2-Phosphonomethoxypropyl) Adenine Are Potent and Selective Inhibitors of Hepatitis B Virus (HBV) Replication In Vitro and in HBV Transgenic Mice In Vivo
John D. Morrey, Brent E. Korba, James R. Beadle, David L. Wyles, and Karl Y. Hostetler
Antimicrob. Agents Chemother. July 2009 53: 2865-2870; published ahead of print April 27, 2009, doi:10.1128/AAC.00114-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetics of Acyclovir in Children and Young People with Malignancy after Administration of Intravenous Acyclovir or Oral Valacyclovir
L. Zeng, C. E. Nath, E. Y. L. Blair, P. J. Shaw, K. Stephen, J. W. Earl, J. C. Coakley, and A. J. McLachlan
Antimicrob. Agents Chemother. July 2009 53: 2918-2927; published ahead of print May 4, 2009, doi:10.1128/AAC.01138-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Protease Inhibitor Resistance Analysis in the MONARK Trial Comparing First-Line Lopinavir-Ritonavir Monotherapy to Lopinavir-Ritonavir plus Zidovudine and Lamivudine Triple Therapy
Constance Delaugerre, Philippe Flandre, Marie Laure Chaix, Jade Ghosn, François Raffi, Pierre Dellamonica, H. Jaeger, D. Shürmann, Isabelle Cohen-Codar, Philippe Ngo Van, Michael Norton, Anne-Marie Taburet, Jean-François Delfraissy, Christine Rouzioux for the MONARK Study Group
Antimicrob. Agents Chemother. July 2009 53: 2934-2939; published ahead of print May 18, 2009, doi:10.1128/AAC.01643-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Novel CXCR4 Antagonist KRH-3955 Is an Orally Bioavailable and Extremely Potent Inhibitor of Human Immunodeficiency Virus Type 1 Infection: Comparative Studies with AMD3100
Tsutomu Murakami, Sei Kumakura, Toru Yamazaki, Reiko Tanaka, Makiko Hamatake, Kazu Okuma, Wei Huang, Jonathan Toma, Jun Komano, Mikiro Yanaka, Yuetsu Tanaka, and Naoki Yamamoto
Antimicrob. Agents Chemother. July 2009 53: 2940-2948; published ahead of print May 18, 2009, doi:10.1128/AAC.01727-08
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Detection and Quantification of Minor Human Immunodeficiency Virus Type 1 Variants Harboring K103N and Y181C Resistance Mutations in Subtype A and D Isolates by Allele-Specific Real-Time PCR
Andrea Hauser, Kizito Mugenyi, Rose Kabasinguzi, Kerstin Bluethgen, Claudia Kuecherer, Gundel Harms, and Andrea Kunz
Antimicrob. Agents Chemother. July 2009 53: 2965-2973; published ahead of print May 11, 2009, doi:10.1128/AAC.01672-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetics of Ganciclovir in Solid-Organ Transplant Recipients Receiving Oral Valganciclovir
N. Perrottet, C. Csajka, M. Pascual, O. Manuel, F. Lamoth, P. Meylan, J. D. Aubert, J. P. Venetz, P. Soccal, L. A. Decosterd, J. Biollaz, and T. Buclin
Antimicrob. Agents Chemother. July 2009 53: 3017-3023; published ahead of print March 23, 2009, doi:10.1128/AAC.00836-08
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cytotoxicological Analysis of a gp120 Binding Aptamer with Cross-Clade Human Immunodeficiency Virus Type 1 Entry Inhibition Properties: Comparison to Conventional Antiretrovirals
Walter Rangel Lopes de Campos, Dayaneethie Coopusamy, Lynn Morris, Bongani M. Mayosi, and Makobetsa Khati
Antimicrob. Agents Chemother. July 2009 53: 3056-3064; published ahead of print April 13, 2009, doi:10.1128/AAC.01502-08
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Susceptibility of Highly Pathogenic H5N1 Influenza Viruses to the Neuraminidase Inhibitor Oseltamivir Differs In Vitro and in a Mouse Model
Elena A. Govorkova, Natalia A. Ilyushina, Jennifer L. McClaren, Tri S. P. Naipospos, Bounlom Douangngeun, and Robert G. Webster
Antimicrob. Agents Chemother. July 2009 53: 3088-3096; published ahead of print April 6, 2009, doi:10.1128/AAC.01667-08
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Antiretroviral Drug Resistance Surveillance among Treatment-Naive Human Immunodeficiency Virus Type 1-Infected Individuals in Angola: Evidence for Low Level of Transmitted Drug Resistance
Inês Bártolo, Cheila Rocha, José Bartolomeu, António Gama, Marlene Fonseca, Ana Mendes, Filipa Cristina, Sven Thamm, Marta Epalanga, Patrícia Cavaco Silva, and Nuno Taveira
Antimicrob. Agents Chemother. July 2009 53: 3156-3158; published ahead of print May 11, 2009, doi:10.1128/AAC.00110-09
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Mechanisms of Resistance:

Effect of MexXY Overexpression on Ceftobiprole Susceptibility in Pseudomonas aeruginosa
Ellen Z. Baum, Steven M. Crespo-Carbone, Brian J. Morrow, Todd A. Davies, Barbara D. Foleno, Wenping He, Anne Marie Queenan, and Karen Bush
Antimicrob. Agents Chemother. July 2009 53: 2785-2790; published ahead of print May 11, 2009, doi:10.1128/AAC.00018-09
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Heteroresistance to Fluconazole in Cryptococcus neoformans Is Intrinsic and Associated with Virulence
Edward Sionov, Yun C. Chang, H. Martin Garraffo, and Kyung J. Kwon-Chung
Antimicrob. Agents Chemother. July 2009 53: 2804-2815; published ahead of print May 4, 2009, doi:10.1128/AAC.00295-09
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Noncanonical Vancomycin Resistance Cluster from Desulfitobacterium hafniense Y51
Lindsay Kalan, Sara Ebert, Tom Kelly, and Gerard D. Wright
Antimicrob. Agents Chemother. July 2009 53: 2841-2845; published ahead of print May 4, 2009, doi:10.1128/AAC.01408-08
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Molecular Characteristics of Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolates Causing Bacteremia in the Calgary Health Region from 2000 to 2007: Emergence of Clone ST131 as a Cause of Community-Acquired Infections
Johann D. D. Pitout, Daniel B. Gregson, Lorraine Campbell, and Kevin B. Laupland
Antimicrob. Agents Chemother. July 2009 53: 2846-2851; published ahead of print April 20, 2009, doi:10.1128/AAC.00247-09
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AmpD_I Is Involved in Expression of the Chromosomal L1 and L2 β-Lactamases of Stenotrophomonas maltophilia
Tsuey-Ching Yang, Yi-Wei Huang, Rouh-Mei Hu, Shao-Cheng Huang, and Yu-Tzu Lin
Antimicrob. Agents Chemother. July 2009 53: 2902-2907; published ahead of print May 4, 2009, doi:10.1128/AAC.01513-08
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Secretion of GOB Metallo-β-Lactamase in Escherichia coli Depends Strictly on the Cooperation between the Cytoplasmic DnaK Chaperone System and the Sec Machinery: Completion of Folding and Zn(II) Ion Acquisition Occur in the Bacterial Periplasm
Jorgelina Morán-Barrio, Adriana S. Limansky, and Alejandro M. Viale
Antimicrob. Agents Chemother. July 2009 53: 2908-2917; published ahead of print May 11, 2009, doi:10.1128/AAC.01637-08
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Nonsense and Missense Mutations in FCY2 and FCY1 Genes Are Responsible for Flucytosine Resistance and Flucytosine-Fluconazole Cross-Resistance in Clinical Isolates of Candida lusitaniae
Martine Florent, Thierry Noël, Gwenaël Ruprich-Robert, Bruno Da Silva, Valérie Fitton-Ouhabi, Christiane Chastin, Nicolas Papon, and Florence Chapeland-Leclerc
Antimicrob. Agents Chemother. July 2009 53: 2982-2990; published ahead of print May 4, 2009, doi:10.1128/AAC.00880-08
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Genetic and Biochemical Characterization of the First Extended-Spectrum CARB-Type ß-Lactamase, RTG-4, from Acinetobacter baumannii
Anaïs Potron, Laurent Poirel, Jacques Croizé, Vanessa Chanteperdrix, and Patrice Nordmann
Antimicrob. Agents Chemother. July 2009 53: 3010-3016; published ahead of print April 20, 2009, doi:10.1128/AAC.01164-08
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Structural Basis of APH(3')-IIIa-Mediated Resistance to N1-Substituted Aminoglycoside Antibiotics
Desiree H. Fong and Albert M. Berghuis
Antimicrob. Agents Chemother. July 2009 53: 3049-3055; published ahead of print May 11, 2009, doi:10.1128/AAC.00062-09
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First Report of Plasmid-Mediated Quinolone Resistance Determinant qnrS1 in an Escherichia coli Strain of Animal Origin in Italy
Marina Cerquetti, Aurora García-Fernández, Maria Giufrè, Daniela Fortini, Marisa Accogli, Caterina Graziani, Ida Luzzi, Alfredo Caprioli, and Alessandra Carattoli
Antimicrob. Agents Chemother. July 2009 53: 3112-3114; published ahead of print May 18, 2009, doi:10.1128/AAC.00239-09
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Characterization of Cefoxitin-Resistant Escherichia coli Isolates from Recreational Beaches and Private Drinking Water in Canada between 2004 and 2006
L. F. Mataseje, N. Neumann, B. Crago, P. Baudry, G. G. Zhanel, M. Louie, M. R. Mulvey and the ARO Water Study Group
Antimicrob. Agents Chemother. July 2009 53: 3126-3130; published ahead of print April 27, 2009, doi:10.1128/AAC.01353-08
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Carriage of CTX-M-15-Producing Escherichia coli Isolates among Children Living in a Remote Village in Senegal
Etienne Ruppé, Paul-Louis Woerther, Abdoulaye Diop, Anne-Marie Sene, Annaelle Da Costa, Guillaume Arlet, Antoine Andremont, and Bernard Rouveix
Antimicrob. Agents Chemother. July 2009 53: 3135-3137; published ahead of print April 13, 2009, doi:10.1128/AAC.00139-09
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First Detection of Plasmid-Encoded bla_OXY β-Lactamase
J. J. González-López, A. Coelho, M. N. Larrosa, S. Lavilla, R. Bartolomé, and G. Prats
Antimicrob. Agents Chemother. July 2009 53: 3143-3146; published ahead of print April 20, 2009, doi:10.1128/AAC.01473-08
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Emergence of Quinolone-Resistant Bordetella pertussis in Japan
Masayuki Ohtsuka, Ken Kikuchi, Kenichiro Shimizu, Namiko Takahashi, Yuka Ono, Takashi Sasaki, and Keiichi Hiramatsu
Antimicrob. Agents Chemother. July 2009 53: 3147-3149; published ahead of print May 4, 2009, doi:10.1128/AAC.00023-09
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Reduced Susceptibility to Cefepime among Escherichia coli Clinical Isolates Producing Novel Variants of CMY-2 β-Lactamase
Yohei Doi, David L. Paterson, Jennifer M. Adams-Haduch, Hanna E. Sidjabat, Alexandra O'Keefe, Andrea Endimiani, and Robert A. Bonomo
Antimicrob. Agents Chemother. July 2009 53: 3159-3161; published ahead of print May 4, 2009, doi:10.1128/AAC.00133-09
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Prevalence of Fluoroquinolone Resistance among Tuberculosis Patients in Shanghai, China
Peng Xu, Xia Li, Ming Zhao, Xiaohong Gui, Kathryn DeRiemer, Sebastien Gagneux, Jian Mei, and Qian Gao
Antimicrob. Agents Chemother. July 2009 53: 3170-3172; published ahead of print April 13, 2009, doi:10.1128/AAC.00177-09
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Mechanisms of Action:

Novel Anion Liposome-Encapsulated Antisense Oligonucleotide Restores Susceptibility of Methicillin-Resistant Staphylococcus aureus and Rescues Mice from Lethal Sepsis by Targeting mecA
Jingru Meng, Hui Wang, Zheng Hou, Tao Chen, Jingguo Fu, Xue Ma, Gonghao He, Xiaoyan Xue, Min Jia, and Xiaoxing Luo
Antimicrob. Agents Chemother. July 2009 53: 2871-2878; published ahead of print May 11, 2009, doi:10.1128/AAC.01542-08
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Substrate-Induced Inactivation of the Escherichia coli AmiD N-Acetylmuramoyl-L-Alanine Amidase Highlights a New Strategy To Inhibit This Class of Enzyme
Anne Pennartz, Catherine Généreux, Claudine Parquet, Dominique Mengin-Lecreulx, and Bernard Joris
Antimicrob. Agents Chemother. July 2009 53: 2991-2997; published ahead of print February 23, 2009, doi:10.1128/AAC.01520-07
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Hypersusceptibility to Azole Antifungals in a Clinical Isolate of Candida glabrata with Reduced Aerobic Growth
Patrick Vandeputte, Guy Tronchin, Françoise Rocher, Gilles Renier, Thierry Bergès, Dominique Chabasse, and Jean-Philippe Bouchara
Antimicrob. Agents Chemother. July 2009 53: 3034-3041; published ahead of print April 20, 2009, doi:10.1128/AAC.01384-08
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Crystal Structure of Bacillus anthracis Dihydrofolate Reductase with the Dihydrophthalazine-Based Trimethoprim Derivative RAB1 Provides a Structural Explanation of Potency and Selectivity
Christina R. Bourne, Richard A. Bunce, Philip C. Bourne, K. Darrell Berlin, Esther W. Barrow, and William W. Barrow
Antimicrob. Agents Chemother. July 2009 53: 3065-3073; published ahead of print April 13, 2009, doi:10.1128/AAC.01666-08
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Lon Protease Is Essential for Paradoxical Survival of Escherichia coli Exposed to High Concentrations of Quinolone
Muhammad Malik, Joseph Capecci, and Karl Drlica
Antimicrob. Agents Chemother. July 2009 53: 3103-3105; published ahead of print May 4, 2009, doi:10.1128/AAC.00019-09
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Analytical Procedures:

Simultaneous Determination of Voriconazole and Posaconazole Concentrations in Human Plasma by High-Performance Liquid Chromatography
Kathrin Kahle, Peter Langmann, Diana Schirmer, Ulrike Lenker, Daniela Keller, Annegret Helle, Hartwig Klinker, and Werner J. Heinz
Antimicrob. Agents Chemother. July 2009 53: 3140-3142; published ahead of print April 20, 2009, doi:10.1128/AAC.00213-09
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Chemistry; Biosynthesis:

Plant Agricultural Streptomycin Formulations Do Not Carry Antibiotic Resistance Genes
Fabio Rezzonico, Virginia O. Stockwell, and Brion Duffy
Antimicrob. Agents Chemother. July 2009 53: 3173-3177; published ahead of print May 4, 2009, doi:10.1128/AAC.00036-09
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Letters:

CMY-29 and CMY-30, Two Novel Plasmid-Mediated AmpC β-Lactamases
Christopher E. Pope, Philip E. Carter, and Helen M. Heffernan
Antimicrob. Agents Chemother. July 2009 53: 3178 published ahead of print May 4, 2009, doi:10.1128/AAC.01586-08
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Errata:

Daptomycin Pharmacokinetics in Adult Oncology Patients with Neutropenic Fever
Joseph S. Bubalo, Myrna Y. Munar, Ganesh Cherala, Brandon Hayes-Lattin, and Richard Maziarz
Antimicrob. Agents Chemother. July 2009 53: 3179
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Early Dissemination of KPC-2-Producing Klebsiella pneumoniae Strains in Brazil
Mónica Pavez, Elsa M. Mamizuka, and Nilton Lincopan
Antimicrob. Agents Chemother. July 2009 53: 3180
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