Contents: August 2009, Volume 53, Issue 8        Minireviews        Mechanisms of Resistance        Pharmacology        Experimental Therapeutics        Mechanisms of Action        Antiviral Agents        Susceptibility        Clinical Therapeutics        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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A Balancing Act: Efflux/Influx in Mycobacterial Drug Resistance G. E. Louw, R. M. Warren, N. C. Gey van Pittius, C. R. E. McEvoy, P. D. Van Helden, and T. C. Victor Antimicrob. Agents Chemother. August 2009 53: 3181-3189; published ahead of print May 18, 2009, doi:10.1128/AAC.01577-08 [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Selection of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus by Imipenem Yuki Katayama, Hiroko Murakami-Kuroda, Longzhu Cui, and Keiichi Hiramatsu Antimicrob. Agents Chemother. August 2009 53: 3190-3196; published ahead of print May 18, 2009, doi:10.1128/AAC.00834-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Outer Membrane Protein STM3031 (Ail/OmpX-Like Protein) Plays a Key Role in the Ceftriaxone Resistance of Salmonella enterica Serovar Typhimurium Wensi S. Hu, Jing-Fang Lin, Ying-Hsiu Lin, and Hsin-Yu Chang Antimicrob. Agents Chemother. August 2009 53: 3248-3255; published ahead of print May 26, 2009, doi:10.1128/AAC.00079-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sequence Analyses of Just Four Genes To Detect Extensively Drug-Resistant Mycobacterium tuberculosis Strains in Multidrug-Resistant Tuberculosis Patients Undergoing Treatment Silke Feuerriegel, Helen S. Cox, Nana Zarkua, Hamraev A. Karimovich, Kai Braker, Sabine Rüsch-Gerdes, and Stefan Niemann Antimicrob. Agents Chemother. August 2009 53: 3353-3356; published ahead of print May 26, 2009, doi:10.1128/AAC.00050-09 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

β-Lactamase-Mediated β-Lactam Resistance in Campylobacter Species: Prevalence of Cj0299 (blaOXA-61) and Evidence for a Novel β-Lactamase in C. jejuni Deborah J. Griggs, Leanne Peake, Margaret M. Johnson, Saba Ghori, A. Mott, and Laura J. V. Piddock Antimicrob. Agents Chemother. August 2009 53: 3357-3364; published ahead of print June 8, 2009, doi:10.1128/AAC.01655-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Epidemiology of KPC-Producing Klebsiella pneumoniae Isolates in the United States: Clonal Expansion of Multilocus Sequence Type 258 Brandon Kitchel, J. Kamile Rasheed, Jean B. Patel, Arjun Srinivasan, Shiri Navon-Venezia, Yehuda Carmeli, Alma Brolund, and Christian G. Giske Antimicrob. Agents Chemother. August 2009 53: 3365-3370; published ahead of print June 8, 2009, doi:10.1128/AAC.00126-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multiresistance in Pasteurella multocida Is Mediated by Coexistence of Small Plasmids Alvaro San Millan, Jose Antonio Escudero, Belen Gutierrez, Laura Hidalgo, Nerea Garcia, Montserrat Llagostera, Lucas Dominguez, and Bruno Gonzalez-Zorn Antimicrob. Agents Chemother. August 2009 53: 3399-3404; published ahead of print June 15, 2009, doi:10.1128/AAC.01522-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel pfdhps Haplotypes among Imported Cases of Plasmodium falciparum Malaria in the United Kingdom Colin J. Sutherland, Helen Fifer, Richard J. Pearce, Faisal bin Reza, Meredydd Nicholas, Thomas Haustein, Njah E. Njimgye-Tekumafor, Justin F. Doherty, Philip Gothard, Spencer D. Polley, and Peter L. Chiodini Antimicrob. Agents Chemother. August 2009 53: 3405-3410; published ahead of print May 11, 2009, doi:10.1128/AAC.00024-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inoculum Effect with Cefazolin among Clinical Isolates of Methicillin-Susceptible Staphylococcus aureus: Frequency and Possible Cause of Cefazolin Treatment Failure Esteban C. Nannini, Martin E. Stryjewski, Kavindra V. Singh, Agathe Bourgogne, Tom H. Rude, G. Ralph Corey, Vance G. Fowler, Jr., and Barbara E. Murray Antimicrob. Agents Chemother. August 2009 53: 3437-3441; published ahead of print June 1, 2009, doi:10.1128/AAC.00317-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Protein Kinase G Is Required for Intrinsic Antibiotic Resistance in Mycobacteria Kerstin A. Wolff, Hoa T. Nguyen, Richard H. Cartabuke, Ajay Singh, Sam Ogwang, and Liem Nguyen Antimicrob. Agents Chemother. August 2009 53: 3515-3519; published ahead of print June 15, 2009, doi:10.1128/AAC.00012-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Extended-Spectrum Properties of CMY-30, a Val211Gly Mutant of CMY-2 Cephalosporinase Stathis D. Kotsakis, Costas C. Papagiannitsis, Eva Tzelepi, Leonidas S. Tzouvelekis, and Vivi Miriagou Antimicrob. Agents Chemother. August 2009 53: 3520-3523; published ahead of print May 26, 2009, doi:10.1128/AAC.00219-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of pABVA01, a Plasmid Encoding the OXA-24 Carbapenemase from Italian Isolates of Acinetobacter baumannii Marco Maria D'Andrea, Tommaso Giani, Silvia D'Arezzo, Alessandro Capone, Nicola Petrosillo, Paolo Visca, Francesco Luzzaro, and Gian Maria Rossolini Antimicrob. Agents Chemother. August 2009 53: 3528-3533; published ahead of print June 1, 2009, doi:10.1128/AAC.00178-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

H-NS Modulates Multidrug Resistance of Salmonella enterica Serovar Typhimurium by Repressing Multidrug Efflux Genes acrEF Kunihiko Nishino, Mitsuko Hayashi-Nishino, and Akihito Yamaguchi Antimicrob. Agents Chemother. August 2009 53: 3541-3543; published ahead of print June 8, 2009, doi:10.1128/AAC.00371-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Analysis of Single-Nucleotide Polymorphisms in the crt-o and mdr1 Genes of Plasmodium vivax among Chloroquine-Resistant Isolates from the Brazilian Amazon Region Pamela Orjuela-Sánchez, Franklin Simões de Santana Filho, Ariane Machado-Lima, Yonne Francis Chehuan, Mônica Regina Farias Costa, Maria das Graças Costa Alecrim, and Hernando A. del Portillo Antimicrob. Agents Chemother. August 2009 53: 3561-3564; published ahead of print May 18, 2009, doi:10.1128/AAC.00004-09 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

GES-11, a Novel Integron-Associated GES Variant in Acinetobacter baumannii Carole Moubareck, Sylvie Brémont, Marie-Christine Conroy, Patrice Courvalin, and Thierry Lambert Antimicrob. Agents Chemother. August 2009 53: 3579-3581; published ahead of print May 18, 2009, doi:10.1128/AAC.00072-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

oqxAB Encoding a Multidrug Efflux Pump in Human Clinical Isolates of Enterobacteriaceae Hong Bin Kim, Minghua Wang, Chi Hye Park, Eui-Chong Kim, George A. Jacoby, and David C. Hooper Antimicrob. Agents Chemother. August 2009 53: 3582-3584; published ahead of print June 15, 2009, doi:10.1128/AAC.01574-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel ABC Transporter Gene, vga(C), Located on a Multiresistance Plasmid from a Porcine Methicillin-Resistant Staphylococcus aureus ST398 Strain Kristina Kadlec and Stefan Schwarz Antimicrob. Agents Chemother. August 2009 53: 3589-3591; published ahead of print May 26, 2009, doi:10.1128/AAC.00570-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Pharmacokinetics-Pharmacodynamics of Pyrazinamide in a Novel In Vitro Model of Tuberculosis for Sterilizing Effect: a Paradigm for Faster Assessment of New Antituberculosis Drugs Tawanda Gumbo, Chandima S. W. Siyambalapitiyage Dona, Claudia Meek, and Richard Leff Antimicrob. Agents Chemother. August 2009 53: 3197-3204; published ahead of print May 18, 2009, doi:10.1128/AAC.01681-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of EDP-420 after Multiple Oral Doses in Healthy Adult Volunteers and in a Bioequivalence Study Li-Juan Jiang and Yat Sun Or Antimicrob. Agents Chemother. August 2009 53: 3218-3225; published ahead of print May 18, 2009, doi:10.1128/AAC.00022-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Intravenous Piperacillin Administration in Patients Undergoing On-Line Hemodiafiltration Kook-Hwan Oh, Chiweon Kim, Hankyu Lee, Hajeong Lee, Ji Yong Jung, Nam Joong Kim, Kyung-Sang Yu, Kwang-Hee Shin, In-Jin Jang, and Curie Ahn Antimicrob. Agents Chemother. August 2009 53: 3266-3268; published ahead of print May 18, 2009, doi:10.1128/AAC.01670-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identifying Exposure Targets for Treatment of Staphylococcal Pneumonia with Ceftobiprole Keith A. Rodvold, David P. Nicolau, Thomas P. Lodise, Mohammed Khashab, Gary J. Noel, James B. Kahn, Mark Gotfried, Sara A. Murray, Susan Nicholson, Somvadee Laohavaleeson, Pamela R. Tessier, and G. L. Drusano Antimicrob. Agents Chemother. August 2009 53: 3294-3301; published ahead of print May 18, 2009, doi:10.1128/AAC.00144-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Light-Microscopic Immunocytochemistry for Gentamicin and Its Use for Studying Uptake of the Drug in Kidney Kunio Fujiwara, Masashi Shin, Hayato Matsunaga, Tetsuya Saita, and Lars-Inge Larsson Antimicrob. Agents Chemother. August 2009 53: 3302-3307; published ahead of print May 18, 2009, doi:10.1128/AAC.01627-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamics of Levofloxacin in a Murine Pneumonia Model of Pseudomonas aeruginosa Infection: Determination of Epithelial Lining Fluid Targets Arnold Louie, Christine Fregeau, Weiguo Liu, Robert Kulawy, and G. L. Drusano Antimicrob. Agents Chemother. August 2009 53: 3325-3330; published ahead of print April 13, 2009, doi:10.1128/AAC.00006-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Anidulafungin Is Fungicidal and Exerts a Variety of Postantifungal Effects against Candida albicans, C. glabrata, C. parapsilosis, and C. krusei isolates Katherine T. Nguyen, Philip Ta, Bich Thu Hoang, Shaoji Cheng, Binghua Hao, M. Hong Nguyen, and Cornelius J. Clancy Antimicrob. Agents Chemother. August 2009 53: 3347-3352; published ahead of print April 13, 2009, doi:10.1128/AAC.01480-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamic Profiling of Ceftobiprole for Treatment of Complicated Skin and Skin Structure Infections Holly Kimko, Xu Xu, Partha Nandy, Mahesh N. Samtani, Richard S. Strauss, Partha Bagchi, and Gary J. Noel Antimicrob. Agents Chemother. August 2009 53: 3371-3374; published ahead of print June 15, 2009, doi:10.1128/AAC.01653-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetic/Pharmacodynamic Analysis of the Influence of Inoculum Size on the Selection of Resistance in Escherichia coli by a Quinolone in a Mouse Thigh Bacterial Infection Model Aude A. Ferran, Anne-Sylvie Kesteman, Pierre-Louis Toutain, and Alain Bousquet-Mélou Antimicrob. Agents Chemother. August 2009 53: 3384-3390; published ahead of print June 1, 2009, doi:10.1128/AAC.01347-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamics of SMP-601 (PTZ601) against Vancomycin-Resistant Enterococcus faecium and Methicillin-Resistant Staphylococcus aureus in Neutropenic Murine Thigh Infection Models Ken Eguchi, Katsunori Kanazawa, Yoshiro Eriguchi, and Yutaka Ueda Antimicrob. Agents Chemother. August 2009 53: 3391-3398; published ahead of print June 1, 2009, doi:10.1128/AAC.00972-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetic Analysis of Colistin Methanesulfonate and Colistin after Intravenous Administration in Critically Ill Patients with Infections Caused by Gram-Negative Bacteria D. Plachouras, M. Karvanen, L. E. Friberg, E. Papadomichelakis, A. Antoniadou, I. Tsangaris, I. Karaiskos, G. Poulakou, F. Kontopidou, A. Armaganidis, O. Cars, and H. Giamarellou Antimicrob. Agents Chemother. August 2009 53: 3430-3436; published ahead of print May 11, 2009, doi:10.1128/AAC.01361-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Pharmacokinetics and Safety Profile of the Human Anti-Pseudomonas aeruginosa Serotype O11 Immunoglobulin M Monoclonal Antibody KBPA-101 in Healthy Volunteers Hedvika Lazar, Michael P. Horn, Adrian W. Zuercher, Martin A. Imboden, Peter Durrer, Michael Seiberling, Rolf Pokorny, Christophe Hammer, and Alois B. Lang Antimicrob. Agents Chemother. August 2009 53: 3442-3446; published ahead of print May 18, 2009, doi:10.1128/AAC.01699-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Pharmacodynamics of a Novel Triazole, Isavuconazole: Mathematical Modeling, Importance of Tissue Concentrations, and Impact of Immune Status on Antifungal Effect Peter A. Warn, Andrew Sharp, Arvind Parmar, Jayesh Majithiya, David W. Denning, and William W. Hope Antimicrob. Agents Chemother. August 2009 53: 3453-3461; published ahead of print May 18, 2009, doi:10.1128/AAC.01601-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

New Semiphysiological Absorption Model To Assess the Pharmacodynamic Profile of Cefuroxime Axetil Using Nonparametric and Parametric Population Pharmacokinetics J. B. Bulitta, C. B. Landersdorfer, M. Kinzig, U. Holzgrabe, and F. Sorgel Antimicrob. Agents Chemother. August 2009 53: 3462-3471; published ahead of print June 15, 2009, doi:10.1128/AAC.00054-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Daptomycin Rapidly Penetrates a Staphylococcus epidermidis Biofilm Philip S. Stewart, William M. Davison, and Judith N. Steenbergen Antimicrob. Agents Chemother. August 2009 53: 3505-3507; published ahead of print May 18, 2009, doi:10.1128/AAC.01728-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Pharmacokinetics and Ex Vivo Pharmacodynamic Antimalarial Activity of Dihydroartemisinin-Piperaquine in Patients with Uncomplicated Falciparum Malaria in Vietnam Dao Van Hoang Nguyen, Quoc Phuc Nguyen, Ngoa Dang Nguyen, Thuy Thi Thanh Le, The Duy Nguyen, Duy Ngoc Dinh, Thanh Xuan Nguyen, Dai Bui, Marina Chavchich, and Michael D. Edstein Antimicrob. Agents Chemother. August 2009 53: 3534-3537; published ahead of print June 15, 2009, doi:10.1128/AAC.01717-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Effects of Azithromycin in Combination with Vancomycin, Daptomycin, Fosfomycin, Tigecycline, and Ceftriaxone on Staphylococcus epidermidis Biofilms Elisabeth Presterl, Stefan Hajdu, Andrea M. Lassnigg, Alexander M. Hirschl, Johannes Holinka, and Wolfgang Graninger Antimicrob. Agents Chemother. August 2009 53: 3205-3210; published ahead of print May 18, 2009, doi:10.1128/AAC.01628-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and Murine Efficacy and Toxicity Studies of Nebulized SCC1, a Methylated Caffeine-Silver(I) Complex, for Treatment of Pulmonary Infections Carolyn L. Cannon, Lisa A. Hogue, Ravy K. Vajravelu, George H. Capps, Aida Ibricevic, Khadijah M. Hindi, Aysegul Kascatan-Nebioglu, Michael J. Walter, Steven L. Brody, and Wiley J. Youngs Antimicrob. Agents Chemother. August 2009 53: 3285-3293; published ahead of print May 18, 2009, doi:10.1128/AAC.00314-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification and Biochemical Characterization of Small-Molecule Inhibitors of Clostridium botulinum Neurotoxin Serotype A Virginia Roxas-Duncan, Istvan Enyedy, Vicki A. Montgomery, Vanessa S. Eccard, Marco A. Carrington, Huiguo Lai, Nizamettin Gul, David C. H. Yang, and Leonard A. Smith Antimicrob. Agents Chemother. August 2009 53: 3478-3486; published ahead of print June 15, 2009, doi:10.1128/AAC.00141-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions] OPEN ACCESS

Efficacy of Combination Antifungal Therapy with Intraperitoneally Administered Micafungin and Aerosolized Liposomal Amphotericin B against Murine Invasive Pulmonary Aspergillosis Takahiro Takazono, Koichi Izumikawa, Tomo Mihara, Kosuke Kosai, Tomomi Saijo, Yoshifumi Imamura, Taiga Miyazaki, Masafumi Seki, Hiroshi Kakeya, Yoshihiro Yamamoto, Katsunori Yanagihara, and Shigeru Kohno Antimicrob. Agents Chemother. August 2009 53: 3508-3510; published ahead of print June 15, 2009, doi:10.1128/AAC.00285-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Liposomal Amphotericin B Combined with Gamma Interferon or Granulocyte-Macrophage Colony-Stimulating Factor for Treatment of Systemic Zygomycosis in Mice M. Mar Rodríguez, Enrique Calvo, Marçal Mariné, F. Javier Pastor, Joan Fernandez-Ballart, and Josep Guarro Antimicrob. Agents Chemother. August 2009 53: 3569-3571; published ahead of print May 18, 2009, doi:10.1128/AAC.00456-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Anidulafungin Treatment of Candidal Central Nervous System Infection in a Murine Model Cheol-In Kang, Mark S. Rouse, Jayawant N. Mandrekar, James M. Steckelberg, and Robin Patel Antimicrob. Agents Chemother. August 2009 53: 3576-3578; published ahead of print June 8, 2009, doi:10.1128/AAC.00646-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Triazoles in a Murine Disseminated Infection by Candida krusei Marçal Mariné, F. Javier Pastor, Carolina Serena, and Josep Guarro Antimicrob. Agents Chemother. August 2009 53: 3585-3588; published ahead of print May 26, 2009, doi:10.1128/AAC.00293-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evaluation of Artemisone Combinations in Aotus Monkeys Infected with Plasmodium falciparum Nicanor Obaldia, III, Barbara M. Kotecka, Michael D. Edstein, Richard K. Haynes, Burkhard Fugmann, Dennis E. Kyle, and Karl H. Rieckmann Antimicrob. Agents Chemother. August 2009 53: 3592-3594; published ahead of print June 8, 2009, doi:10.1128/AAC.00471-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Peptide-Lipid Huge Toroidal Pore, a New Antimicrobial Mechanism Mediated by a Lactococcal Bacteriocin, Lacticin Q Fuminori Yoneyama, Yuichi Imura, Kanako Ohno, Takeshi Zendo, Jiro Nakayama, Katsumi Matsuzaki, and Kenji Sonomoto Antimicrob. Agents Chemother. August 2009 53: 3211-3217; published ahead of print May 26, 2009, doi:10.1128/AAC.00209-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

MurF Inhibitors with Antibacterial Activity: Effect on Muropeptide Levels Ellen Z. Baum, Steven M. Crespo-Carbone, Barbara D. Foleno, Lee D. Simon, Jerome Guillemont, Mark Macielag, and Karen Bush Antimicrob. Agents Chemother. August 2009 53: 3240-3247; published ahead of print May 26, 2009, doi:10.1128/AAC.00166-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibitory Effects of Lactoferrin on Growth and Biofilm Formation of Porphyromonas gingivalis and Prevotella intermedia Hiroyuki Wakabayashi, Koji Yamauchi, Tetsuo Kobayashi, Tomoko Yaeshima, Keiji Iwatsuki, and Hiromasa Yoshie Antimicrob. Agents Chemother. August 2009 53: 3308-3316; published ahead of print May 18, 2009, doi:10.1128/AAC.01688-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pyrazolopyrimidinediones Are Selective Agents for Helicobacter pylori That Suppress Growth through Inhibition of Glutamate Racemase (MurI) B. L. M. de Jonge, A. Kutschke, M. Uria-Nickelsen, H. D. Kamp, and S. D. Mills Antimicrob. Agents Chemother. August 2009 53: 3331-3336; published ahead of print May 11, 2009, doi:10.1128/AAC.00226-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antifungal Activity of Tamoxifen: In Vitro and In Vivo Activities and Mechanistic Characterization Kristy Dolan, Sara Montgomery, Bradley Buchheit, Louis DiDone, Melanie Wellington, and Damian J. Krysan Antimicrob. Agents Chemother. August 2009 53: 3337-3346; published ahead of print June 1, 2009, doi:10.1128/AAC.01564-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Telavancin Disrupts the Functional Integrity of the Bacterial Membrane through Targeted Interaction with the Cell Wall Precursor Lipid II Christopher S. Lunde, Stephanie R. Hartouni, James W. Janc, Mathai Mammen, Patrick P. Humphrey, and Bret M. Benton Antimicrob. Agents Chemother. August 2009 53: 3375-3383; published ahead of print May 26, 2009, doi:10.1128/AAC.01710-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions] OPEN ACCESS

Effect of Subinhibitory Concentrations of Antibiotics on Intrachromosomal Homologous Recombination in Escherichia coli Elena López and Jesús Blázquez Antimicrob. Agents Chemother. August 2009 53: 3411-3415; published ahead of print June 1, 2009, doi:10.1128/AAC.00358-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibacterial Properties and Mode of Action of a Short Acyl-Lysyl Oligomer Fadia Zaknoon, Hadar Sarig, Shahar Rotem, Liran Livne, Andrey Ivankin, David Gidalevitz, and Amram Mor Antimicrob. Agents Chemother. August 2009 53: 3422-3429; published ahead of print June 1, 2009, doi:10.1128/AAC.00010-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Three-Dimensional Model of Lanosterol 14-Demethylase from Cryptococcus neoformans: Active-Site Characterization and Insights into Azole Binding Chunquan Sheng, Zhenyuan Miao, Haitao Ji, Jianzhong Yao, Wenya Wang, Xiaoying Che, Guoqiang Dong, Jiaguo Lü, Wei Guo, and Wannian Zhang Antimicrob. Agents Chemother. August 2009 53: 3487-3495; published ahead of print May 26, 2009, doi:10.1128/AAC.01630-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Stability of Peroxide Antimalarials in the Presence of Human Hemoglobin Darren J. Creek, Eileen Ryan, William N. Charman, Francis C. K. Chiu, Richard J. Prankerd, Jonathan L. Vennerstrom, and Susan A. Charman Antimicrob. Agents Chemother. August 2009 53: 3496-3500; published ahead of print June 1, 2009, doi:10.1128/AAC.00363-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapid and Reliable Detection of Antimicrobial Peptide Penetration into Gram-Negative Bacteria Based on Fluorescence Quenching Monica Benincasa, Sabrina Pacor, Renato Gennaro, and Marco Scocchi Antimicrob. Agents Chemother. August 2009 53: 3501-3504; published ahead of print May 26, 2009, doi:10.1128/AAC.01620-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Specific Therapeutic Schemes of Omeprazole Affect the Orientation of Helicobacter pylori Marina Azevedo-Vethacke, Désirée Garten, Claudia Groll, and Sören Schreiber Antimicrob. Agents Chemother. August 2009 53: 3511-3514; published ahead of print June 1, 2009, doi:10.1128/AAC.00158-09 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

Nukacin ISK-1, a Bacteriostatic Lantibiotic Sikder M. Asaduzzaman, Jun-ichi Nagao, Hiroshi Iida, Takeshi Zendo, Jiro Nakayama, and Kenji Sonomoto Antimicrob. Agents Chemother. August 2009 53: 3595-3598; published ahead of print June 8, 2009, doi:10.1128/AAC.01623-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 Protein Min Qing, Feng Yang, Bo Zhang, Gang Zou, John M. Robida, Zhiming Yuan, Hengli Tang, and Pei-Yong Shi Antimicrob. Agents Chemother. August 2009 53: 3226-3235; published ahead of print May 18, 2009, doi:10.1128/AAC.00189-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Retention of Metabolites of 2',3'-Didehydro-3'-Deoxy-4'-Ethynylthymidine, a Novel Anti-Human Immunodeficiency Virus Type 1 Thymidine Analog, in Cells Xin Wang, Hiromichi Tanaka, Masanori Baba, and Yung-chi Cheng Antimicrob. Agents Chemother. August 2009 53: 3317-3324; published ahead of print May 26, 2009, doi:10.1128/AAC.00302-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Activity of Chloroquine against Human Coronavirus OC43 Infection in Newborn Mice Els Keyaerts, Sandra Li, Leen Vijgen, Evelien Rysman, Jannick Verbeeck, Marc Van Ranst, and Piet Maes Antimicrob. Agents Chemother. August 2009 53: 3416-3421; published ahead of print June 8, 2009, doi:10.1128/AAC.01509-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cytochrome P450 3A Inhibition by Atazanavir and Ritonavir, but Not Demography or Drug Formulation, Influences Saquinavir Population Pharmacokinetics in Human Immunodeficiency Virus Type 1-Infected Adults Nils von Hentig and Jörn Lötsch Antimicrob. Agents Chemother. August 2009 53: 3524-3527; published ahead of print June 15, 2009, doi:10.1128/AAC.00025-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Enhancement of Human Immunodeficiency Virus Type 1 Replication Is Not Intrinsic to All Polyanion-Based Microbicides Secondo Sonza, Adam Johnson, David Tyssen, Tim Spelman, Gareth R. Lewis, Jeremy R. A. Paull, and Gilda Tachedjian Antimicrob. Agents Chemother. August 2009 53: 3565-3568; published ahead of print June 15, 2009, doi:10.1128/AAC.00102-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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In Vitro Activity of TR-700, the Active Ingredient of the Antibacterial Prodrug TR-701, a Novel Oxazolidinone Antibacterial Agent Ronda Schaadt, Debora Sweeney, Dean Shinabarger, and Gary Zurenko Antimicrob. Agents Chemother. August 2009 53: 3236-3239; published ahead of print June 15, 2009, doi:10.1128/AAC.00228-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Curcumin Modulates Efflux Mediated by Yeast ABC Multidrug Transporters and Is Synergistic with Antifungals Monika Sharma, Raman Manoharlal, Suneet Shukla, Nidhi Puri, Tulika Prasad, Suresh V. Ambudkar, and Rajendra Prasad Antimicrob. Agents Chemother. August 2009 53: 3256-3265; published ahead of print May 26, 2009, doi:10.1128/AAC.01497-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Trypanocidal Activity of 8-Methyl-5'-{[(Z)-4-Aminobut-2-enyl]-(Methylamino)}Adenosine (Genz-644131), an Adenosylmethionine Decarboxylase Inhibitor Cyrus J. Bacchi, Robert H. Barker, Jr., Aixa Rodriguez, Bradford Hirth, Donna Rattendi, Nigel Yarlett, Clifford L. Hendrick, and Edmund Sybertz Antimicrob. Agents Chemother. August 2009 53: 3269-3272; published ahead of print May 18, 2009, doi:10.1128/AAC.00076-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

NB-002, a Novel Nanoemulsion with Broad Antifungal Activity against Dermatophytes, Other Filamentous Fungi, and Candida albicans J. Pannu, A. McCarthy, A. Martin, T. Hamouda, S. Ciotti, A. Fothergill, and J. Sutcliffe Antimicrob. Agents Chemother. August 2009 53: 3273-3279; published ahead of print May 11, 2009, doi:10.1128/AAC.00218-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of High Levels of Extended-Spectrum-β-Lactamase-Producing Gram-Negative Bacilli in the Asia-Pacific Region: Data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) Program, 2007 Stephen P. Hawser, Samuel K. Bouchillon, Daryl J. Hoban, Robert E. Badal, Po-Ren Hsueh, and David L. Paterson Antimicrob. Agents Chemother. August 2009 53: 3280-3284; published ahead of print June 8, 2009, doi:10.1128/AAC.00426-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Imcroporin, a New Cationic Antimicrobial Peptide from the Venom of the Scorpion Isometrus maculates Zhenhuan Zhao, Yibao Ma, Chao Dai, Ruiming Zhao, SongRyong Li, Yingliang Wu, Zhijian Cao, and Wenxin Li Antimicrob. Agents Chemother. August 2009 53: 3472-3477; published ahead of print May 18, 2009, doi:10.1128/AAC.01436-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synergistic Interaction between Silver Nanoparticles and Membrane-Permeabilizing Antimicrobial Peptides Serge Ruden, Kai Hilpert, Marina Berditsch, Parvesh Wadhwani, and Anne S. Ulrich Antimicrob. Agents Chemother. August 2009 53: 3538-3540; published ahead of print June 15, 2009, doi:10.1128/AAC.01106-08 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

AFN-1252, a FabI Inhibitor, Demonstrates a Staphylococcus-Specific Spectrum of Activity James A. Karlowsky, Nachum Kaplan, Barry Hafkin, Daryl J. Hoban, and George G. Zhanel Antimicrob. Agents Chemother. August 2009 53: 3544-3548; published ahead of print June 1, 2009, doi:10.1128/AAC.00400-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes Eric Dannaoui, Patrick Schwarz, and Olivier Lortholary Antimicrob. Agents Chemother. August 2009 53: 3549-3551; published ahead of print May 18, 2009, doi:10.1128/AAC.00184-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Besifloxacin, a Novel Fluoroquinolone, Has Broad-Spectrum In Vitro Activity against Aerobic and Anaerobic Bacteria Wolfgang Haas, Chris M. Pillar, Gary E. Zurenko, Jacqueline C. Lee, Lynne S. Brunner, and Timothy W. Morris Antimicrob. Agents Chemother. August 2009 53: 3552-3560; published ahead of print June 8, 2009, doi:10.1128/AAC.00418-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Garenoxacin against Streptococcus pneumoniae Mutants with Characterized Resistance Mechanisms Kazuko Yamamoto, Katsunori Yanagihara, Kazuyuki Sugahara, Yoshifumi Imamura, Masafumi Seki, Koichi Izumikawa, Hiroshi Kakeya, Yoshihiro Yamamoto, Yoichi Hirakata, Shimeru Kamihira, and Shigeru Kohno Antimicrob. Agents Chemother. August 2009 53: 3572-3575; published ahead of print May 18, 2009, doi:10.1128/AAC.00176-09 [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Prospective Comparison of the Clinical Impacts of Heterogeneous Vancomycin-Intermediate Methicillin-Resistant Staphylococcus aureus (MRSA) and Vancomycin-Susceptible MRSA K. C. Horne, B. P. Howden, E. A. Grabsch, M. Graham, P. B. Ward, S. Xie, B. C. Mayall, P. D. R. Johnson, and M. L. Grayson Antimicrob. Agents Chemother. August 2009 53: 3447-3452; published ahead of print June 8, 2009, doi:10.1128/AAC.01365-08 [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]

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Letters:

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In Vitro Activity of NXL104 in Combination with β-Lactams against Klebsiella pneumoniae Isolates Producing KPC Carbapenemases Andrea Endimiani, Yuvraj Choudhary, and Robert A. Bonomo Antimicrob. Agents Chemother. August 2009 53: 3599-3601; published ahead of print June 15, 2009, doi:10.1128/AAC.00641-09 [Full Text] [PDF] [Reprints and Permissions]

Characterization of ermA in Macrolide-Susceptible Strains of Methicillin-Resistant Staphylococcus aureus Henry Wong, Lisa Louie, Christine Watt, Eric Sy, Reggie Y. C. Lo, Michael R. Mulvey, and Andrew E. Simor Antimicrob. Agents Chemother. August 2009 53: 3602-3603; published ahead of print June 1, 2009, doi:10.1128/AAC.00313-09 [Full Text] [PDF] [Reprints and Permissions]

Streptococcus pyogenes YtgP (Spy_0390) Complements Escherichia coli Strains Depleted of the Putative Peptidoglycan Flippase MurJ Natividad Ruiz Antimicrob. Agents Chemother. August 2009 53: 3604-3605; published ahead of print June 15, 2009, doi:10.1128/AAC.00578-09 [Full Text] [PDF] [Reprints and Permissions]

Lack of Antimicrobial Activity by the Antiretroviral Drug Nevirapine against Common Bacterial Pathogens J. Brooks Jackson, James Dick, Tsigereda Tekle, Antoine Simmons, and Karen C. Carroll Antimicrob. Agents Chemother. August 2009 53: 3606-3607; published ahead of print June 1, 2009, doi:10.1128/AAC.01583-08 [Full Text] [PDF] [Reprints and Permissions]

What Should Be the First-Choice Strategy To Maximize Posaconazole Exposure in Daily Clinical Practice? Federico Pea, Mario Furlanut, Pierluigi Viale, Gopal Krishna, Allen Moton, Lei Ma, James McLeod, and Matthew M. Medlock Antimicrob. Agents Chemother. August 2009 53: 3608-3610; [Full Text] [PDF] [Reprints and Permissions]

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