AAC -- Table of Contents (September 1 2009, 53 [9])

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Contents: September 2009, Volume 53, Issue 9

       Minireviews

       Mechanisms of Action

       Mechanisms of Resistance

       Susceptibility

       Clinical Therapeutics

       Pharmacology

       Chemistry; Biosynthesis

       Antiviral Agents

       Experimental Therapeutics

       Analytical Procedures

       Letters

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Table of Contents

[Index by Author]

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Minireviews:

Antiretroviral Drug Resistance in Human Immunodeficiency Virus Type 2
Michel L. Ntemgwa, Thomas d'Aquin Toni, Bluma G. Brenner, Ricardo J. Camacho, and Mark A. Wainberg
Antimicrob. Agents Chemother. September 2009 53: 3611-3619; published ahead of print May 26, 2009, doi:10.1128/AAC.00154-09
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Mechanisms of Action:

In Vitro and In Vivo Properties of Dihydrophthalazine Antifolates, a Novel Family of Antibacterial Drugs
Patrick Caspers, Luc Bury, Bérangère Gaucher, Jutta Heim, Stuart Shapiro, Sibylle Siegrist, Anne Schmitt-Hoffmann, Laure Thenoz, and Heinrich Urwyler
Antimicrob. Agents Chemother. September 2009 53: 3620-3627; published ahead of print June 22, 2009, doi:10.1128/AAC.00377-09
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Novel Expression Vector for Secretion of Cecropin AD in Bacillus subtilis with Enhanced Antimicrobial Activity
Xiang Chen, Faming Zhu, Yunhe Cao, and Shiyan Qiao
Antimicrob. Agents Chemother. September 2009 53: 3683-3689; published ahead of print June 22, 2009, doi:10.1128/AAC.00251-09
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Lipid Segregation Explains Selective Toxicity of a Series of Fragments Derived from the Human Cathelicidin LL-37
Raquel F. Epand, Guangshun Wang, Bob Berno, and Richard M. Epand
Antimicrob. Agents Chemother. September 2009 53: 3705-3714; published ahead of print July 6, 2009, doi:10.1128/AAC.00321-09
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Probing the Differential Interactions of Quinazolinedione PD 0305970 and Quinolones with Gyrase and Topoisomerase IV
Xiao-Su Pan, Katherine A. Gould, and L. Mark Fisher
Antimicrob. Agents Chemother. September 2009 53: 3822-3831; published ahead of print June 29, 2009, doi:10.1128/AAC.00113-09
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Effect of β-1,6-Glucan Inhibitors on the Invasion Process of Candida albicans: Potential Mechanism of Their In Vivo Efficacy
Akihiro Kitamura, Saito Higuchi, Masato Hata, Katsuhiro Kawakami, Kumi Yoshida, Kenji Namba, and Ryohei Nakajima
Antimicrob. Agents Chemother. September 2009 53: 3963-3971; published ahead of print July 13, 2009, doi:10.1128/AAC.00435-09
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In Vitro Trafficking and Efficacy of Core-Shell Nanostructures for Treating Intracellular Salmonella Infections
A. Ranjan, N. Pothayee, M. N. Seleem, N. Sriranganathan, R. Kasimanickam, M. Makris, and J. S. Riffle
Antimicrob. Agents Chemother. September 2009 53: 3985-3988; published ahead of print July 13, 2009, doi:10.1128/AAC.00009-09
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Mechanisms of Resistance:

Resistance to Colistin in Acinetobacter baumannii Associated with Mutations in the PmrAB Two-Component System
Mark D. Adams, Gabrielle C. Nickel, Saralee Bajaksouzian, Heather Lavender, A. Rekha Murthy, Michael R. Jacobs, and Robert A. Bonomo
Antimicrob. Agents Chemother. September 2009 53: 3628-3634; published ahead of print June 15, 2009, doi:10.1128/AAC.00284-09
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Prevalence and Characterization of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Isolates from 14 Cities in China
Wenjia Sun, Hongbin Chen, Yudong Liu, Chunjiang Zhao, Wright W. Nichols, Minjun Chen, Jianzhong Zhang, Yue Ma, and Hui Wang
Antimicrob. Agents Chemother. September 2009 53: 3642-3649; published ahead of print June 22, 2009, doi:10.1128/AAC.00206-09
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VanA-Type Staphylococcus aureus Strain VRSA-7 Is Partially Dependent on Vancomycin for Growth
Carole Moubareck, Djalal Meziane-Cherif, Patrice Courvalin, and Bruno Périchon
Antimicrob. Agents Chemother. September 2009 53: 3657-3663; published ahead of print June 15, 2009, doi:10.1128/AAC.00338-09
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Role of the Mycobacterium tuberculosis P55 Efflux Pump in Intrinsic Drug Resistance, Oxidative Stress Responses, and Growth
Santiago Ramón-García, Carlos Martín, Charles J. Thompson, and José A. Aínsa
Antimicrob. Agents Chemother. September 2009 53: 3675-3682; published ahead of print June 29, 2009, doi:10.1128/AAC.00550-09
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Effect of Candida glabrata FKS1 and FKS2 Mutations on Echinocandin Sensitivity and Kinetics of 1,3-β-D-Glucan Synthase: Implication for the Existing Susceptibility Breakpoint
Guillermo Garcia-Effron, Samuel Lee, Steven Park, John D. Cleary, and David S. Perlin
Antimicrob. Agents Chemother. September 2009 53: 3690-3699; published ahead of print June 22, 2009, doi:10.1128/AAC.00443-09
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Genetics of Chromosomally Mediated Intermediate Resistance to Ceftriaxone and Cefixime in Neisseria gonorrhoeae
Shuqing Zhao, Margaret Duncan, Joshua Tomberg, Christopher Davies, Magnus Unemo, and Robert A. Nicholas
Antimicrob. Agents Chemother. September 2009 53: 3744-3751; published ahead of print June 15, 2009, doi:10.1128/AAC.00304-09
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Exploring the Mode of Action of Antimicrobial Peptide MUC7 12-Mer by Fitness Profiling of Saccharomyces cerevisiae Genomewide Mutant Collection
Maciej Lis, Jason R. Fuss, and Libuse A. Bobek
Antimicrob. Agents Chemother. September 2009 53: 3762-3769; published ahead of print July 13, 2009, doi:10.1128/AAC.00668-09
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In Vitro Activity of Antifolate and Polymorphism in Dihydrofolate Reductase of Plasmodium falciparum Isolates from the Kenyan Coast: Emergence of Parasites with Ile-164-Leu Mutation
Steven M. Kiara, John Okombo, Victor Masseno, Leah Mwai, Isabella Ochola, Steffen Borrmann, and Alexis Nzila
Antimicrob. Agents Chemother. September 2009 53: 3793-3798; published ahead of print June 15, 2009, doi:10.1128/AAC.00308-09
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Lipoprotein Processing Is Essential for Resistance of Mycobacterium tuberculosis to Malachite Green
Niaz Banaei, Eleanor Z. Kincaid, S.-Y. Grace Lin, Edward Desmond, William R. Jacobs, Jr., and Joel D. Ernst
Antimicrob. Agents Chemother. September 2009 53: 3799-3802; published ahead of print July 13, 2009, doi:10.1128/AAC.00647-09
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Mechanisms of Resistance in Nontyphoidal Salmonella enterica Strains Exhibiting a Nonclassical Quinolone Resistance Phenotype
Marianne Gunell, Mark A. Webber, Pirkko Kotilainen, Andrew J. Lilly, Jonathan M. Caddick, Jari Jalava, Pentti Huovinen, Anja Siitonen, Antti J. Hakanen, and Laura J. V. Piddock
Antimicrob. Agents Chemother. September 2009 53: 3832-3836; published ahead of print July 13, 2009, doi:10.1128/AAC.00121-09
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Diversity of β-Lactamases Produced by Ceftazidime-Resistant Pseudomonas aeruginosa Isolates Causing Bloodstream Infections in Brazil
Renata C. Picão, Laurent Poirel, Ana C. Gales, and Patrice Nordmann
Antimicrob. Agents Chemother. September 2009 53: 3908-3913; published ahead of print July 13, 2009, doi:10.1128/AAC.00453-09
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Candida albicans and Staphylococcus aureus Form Polymicrobial Biofilms: Effects on Antimicrobial Resistance
Melphine M. Harriott and Mairi C. Noverr
Antimicrob. Agents Chemother. September 2009 53: 3914-3922; published ahead of print June 29, 2009, doi:10.1128/AAC.00657-09
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A Novel Tryptophanyl-tRNA Synthetase Gene Confers High-Level Resistance to Indolmycin
James J. Vecchione and Jason K. Sello
Antimicrob. Agents Chemother. September 2009 53: 3972-3980; published ahead of print June 22, 2009, doi:10.1128/AAC.00723-09
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Genetic Context of Plasmid-Carried bla_CMY-2-Like Genes in Enterobacteriaceae
C. Verdet, V. Gautier, E. Chachaty, E. Ronco, N. Hidri, D. Decré, and G. Arlet
Antimicrob. Agents Chemother. September 2009 53: 4002-4006; published ahead of print July 13, 2009, doi:10.1128/AAC.00753-08
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Influence of Recombination on Development of Mutational Resistance to Linezolid in Enterococcus faecalis JH2-2
Leyla Boumghar-Bourtchaï, Anne Dhalluin, Brigitte Malbruny, Sébastien Galopin, and Roland Leclercq
Antimicrob. Agents Chemother. September 2009 53: 4007-4009; published ahead of print June 22, 2009, doi:10.1128/AAC.01633-08
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Contribution of dfrA and inhA Mutations to the Detection of Isoniazid-Resistant Mycobacterium tuberculosis Isolates
Yu Min Ho, Yong-Jiang Sun, Sin-Yew Wong, and Ann S. G. Lee
Antimicrob. Agents Chemother. September 2009 53: 4010-4012; published ahead of print July 6, 2009, doi:10.1128/AAC.00433-09
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CraA, a Major Facilitator Superfamily Efflux Pump Associated with Chloramphenicol Resistance in Acinetobacter baumannii
I. Roca, S. Marti, P. Espinal, P. Martínez, I. Gibert, and J. Vila
Antimicrob. Agents Chemother. September 2009 53: 4013-4014; published ahead of print July 6, 2009, doi:10.1128/AAC.00584-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of Porins in the Susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to Aldehyde-Based Disinfectants and Drugs
Zuzana Svetlíková, Henrieta Skovierová, Michael Niederweis, Jean-Louis Gaillard, Gerald McDonnell, and Mary Jackson
Antimicrob. Agents Chemother. September 2009 53: 4015-4018; published ahead of print July 6, 2009, doi:10.1128/AAC.00590-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of the Plasmid-Borne Quinolone Resistance Gene qnrB19 in Salmonella enterica Serovar Typhimurium
Anna Maria Dionisi, Claudia Lucarelli, Slawomir Owczarek, Ida Luzzi, and Laura Villa
Antimicrob. Agents Chemother. September 2009 53: 4019-4021; published ahead of print June 15, 2009, doi:10.1128/AAC.00294-09
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Mosaic Penicillin-Binding Protein 2 in Neisseria gonorrhoeae Isolates Collected in 2008 in San Francisco, California
Mark Pandori, Pennan M. Barry, Abel Wu, Alyssa Ren, William L. H. Whittington, Sally Liska, and Jeffrey D. Klausner
Antimicrob. Agents Chemother. September 2009 53: 4032-4034; published ahead of print June 22, 2009, doi:10.1128/AAC.00406-09
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Susceptibility:

Efficacy of Iclaprim against Wild-Type and Thymidine Kinase-Deficient Methicillin-Resistant Staphylococcus aureus Isolates in an In Vitro Fibrin Clot Model
José M. Entenza, Andreas Haldimann, Marlyse Giddey, Sergio Lociuro, Stephen Hawser, and Philippe Moreillon
Antimicrob. Agents Chemother. September 2009 53: 3635-3641; published ahead of print June 29, 2009, doi:10.1128/AAC.00325-09
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Combination Chemotherapy against Clonorchis sinensis: Experiments with Artemether, Artesunate, OZ78, Praziquantel, and Tribendimidine in a Rat Model
Jennifer Keiser, Shu-Hua Xiao, Thomas A. Smith, and Jürg Utzinger
Antimicrob. Agents Chemother. September 2009 53: 3770-3776; published ahead of print July 6, 2009, doi:10.1128/AAC.00452-09
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Antiprotozoal Activity of 1-Phenethyl-4-Aminopiperidine Derivatives
Christophe Dardonville, Cristina Fernández-Fernández, Sarah-Louise Gibbons, Nadine Jagerovic, Lidia Nieto, Gary Ryan, Marcel Kaiser, and Reto Brun
Antimicrob. Agents Chemother. September 2009 53: 3815-3821; published ahead of print June 29, 2009, doi:10.1128/AAC.00124-09
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In Vitro Susceptibilities of Leishmania donovani Promastigote and Amastigote Stages to Antileishmanial Reference Drugs: Practical Relevance of Stage-Specific Differences
Marieke Vermeersch, Raquel Inocêncio da Luz, Kim Toté, Jean-Pierre Timmermans, Paul Cos, and Louis Maes
Antimicrob. Agents Chemother. September 2009 53: 3855-3859; published ahead of print June 22, 2009, doi:10.1128/AAC.00548-09
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In Vitro Activities of Telavancin and Six Comparator Agents against Anaerobic Bacterial Isolates
Sydney M. Finegold, Mauricio Bolanos, Paula H. Sumannen, and Denise R. Molitoris
Antimicrob. Agents Chemother. September 2009 53: 3996-4001; published ahead of print July 6, 2009, doi:10.1128/AAC.00908-08
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Antimicrobial Susceptibility and Mutations Involved in Clarithromycin Resistance in Helicobacter pylori Isolates from Patients in the Western Central Region of Colombia
Adalucy Álvarez, José Ignacio Moncayo, Jorge Javier Santacruz, Mario Santacoloma, Luisa Fernanda Corredor, and Elizabeth Reinosa
Antimicrob. Agents Chemother. September 2009 53: 4022-4024; published ahead of print June 22, 2009, doi:10.1128/AAC.00145-09
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Evaluation of Analogs of Reutericyclin as Prospective Candidates for Treatment of Staphylococcal Skin Infections
Julian G. Hurdle, Raghunandan Yendapally, Dianqing Sun, and Richard E. Lee
Antimicrob. Agents Chemother. September 2009 53: 4028-4031; published ahead of print July 6, 2009, doi:10.1128/AAC.00457-09
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Antimalarial Activity of Tigecycline, a Novel Glycylcycline Antibiotic
P. Starzengruber, K. Thriemer, R. Haque, W. A. Khan, H. P. Fuehrer, A. Siedl, V. Hofecker, B. Ley, W. H. Wernsdorfer, and H. Noedl
Antimicrob. Agents Chemother. September 2009 53: 4040-4042; published ahead of print July 13, 2009, doi:10.1128/AAC.00312-09
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Clinical Therapeutics:

Continuous versus Intermittent Infusions of Ceftazidime for Treating Exacerbation of Cystic Fibrosis
Dominique Hubert, Evelyne Le Roux, Thibaud Lavrut, Benoit Wallaert, Philippe Scheid, Dominique Manach, Dominique Grenet, Isabelle Sermet-Gaudelus, Sophie Ramel, Claire Cracowski, Anne Sardet, Nathalie Wizla, Eric Deneuville, and Rodolphe Garraffo
Antimicrob. Agents Chemother. September 2009 53: 3650-3656; published ahead of print June 15, 2009, doi:10.1128/AAC.00174-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intravenous Doripenem at 500 Milligrams versus Levofloxacin at 250 Milligrams, with an Option To Switch to Oral Therapy, for Treatment of Complicated Lower Urinary Tract Infection and Pyelonephritis
K. G. Naber, L. Llorens, K. Kaniga, P. Kotey, D. Hedrich, and R. Redman
Antimicrob. Agents Chemother. September 2009 53: 3782-3792; published ahead of print July 6, 2009, doi:10.1128/AAC.00837-08
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Pharmacology:

Pharmacokinetics and Buccal Mucosal Concentrations of a 15 Milligram per Kilogram of Body Weight Total Dose of Liposomal Amphotericin B Administered as a Single Dose (15 mg/kg), Weekly Dose (7.5 mg/kg), or Daily Dose (1 mg/kg) in Peripheral Stem Cell Transplant Patients
Paul O. Gubbins, Jarrett R. Amsden, Scott A. McConnell, and Elias J. Anaissie
Antimicrob. Agents Chemother. September 2009 53: 3664-3674; published ahead of print June 22, 2009, doi:10.1128/AAC.01448-08
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Safety, Tolerability, and Pharmacokinetics of PA-824 in Healthy Subjects
Ann M. Ginsberg, Martino W. Laurenzi, Doris J. Rouse, Karl D. Whitney, and Melvin K. Spigelman
Antimicrob. Agents Chemother. September 2009 53: 3720-3725; published ahead of print June 15, 2009, doi:10.1128/AAC.00106-09
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Assessment of the Effects of the Nitroimidazo-Oxazine PA-824 on Renal Function in Healthy Subjects
Ann M. Ginsberg, Martino W. Laurenzi, Doris J. Rouse, Karl D. Whitney, and Mel K. Spigelman
Antimicrob. Agents Chemother. September 2009 53: 3726-3733; published ahead of print June 15, 2009, doi:10.1128/AAC.00112-09
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Population Pharmacokinetics of Lumefantrine in Pregnant Women Treated with Artemether-Lumefantrine for Uncomplicated Plasmodium falciparum Malaria
Joel Tarning, Rose McGready, Niklas Lindegardh, Elizabeth A. Ashley, Mupawjay Pimanpanarak, Benjamas Kamanikom, Anna Annerberg, Nicholas P. J. Day, Kasia Stepniewska, Pratap Singhasivanon, Nicholas J. White, and François Nosten
Antimicrob. Agents Chemother. September 2009 53: 3837-3846; published ahead of print June 29, 2009, doi:10.1128/AAC.00195-09
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Pharmacokinetic and Pharmacodynamic Evaluation of Liposomal Amikacin for Inhalation in Cystic Fibrosis Patients with Chronic Pseudomonal Infection
Ólanrewaju O. Okusanya, Sujata M. Bhavnani, Jeffrey Hammel, Predrag Minic, Lieven J. Dupont, Alan Forrest, Geert-Jan Mulder, Constance Mackinson, Paul G. Ambrose, and Renu Gupta
Antimicrob. Agents Chemother. September 2009 53: 3847-3854; published ahead of print May 18, 2009, doi:10.1128/AAC.00872-08
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Meropenem Pharmacokinetics in the Newborn
John N. van den Anker, Pavla Pokorna, Martina Kinzig-Schippers, Jirina Martinkova, Ronald de Groot, G. L. Drusano, and Fritz Sorgel
Antimicrob. Agents Chemother. September 2009 53: 3871-3879; published ahead of print July 6, 2009, doi:10.1128/AAC.00351-09
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Activities of Daptomycin and Vancomycin Alone and in Combination with Rifampin and Gentamicin against Biofilm-Forming Methicillin-Resistant Staphylococcus aureus Isolates in an Experimental Model of Endocarditis
Kerry L. LaPlante and Suzanne Woodmansee
Antimicrob. Agents Chemother. September 2009 53: 3880-3886; published ahead of print June 29, 2009, doi:10.1128/AAC.00134-09
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Pharmacodynamics of Vancomycin at Simulated Epithelial Lining Fluid Concentrations against Methicillin-Resistant Staphylococcus aureus (MRSA): Implications for Dosing in MRSA Pneumonia
Yoriko Harigaya, Jürgen B. Bulitta, Alan Forrest, George Sakoulas, Alan J. Lesse, Joseph M. Mylotte, and Brian T. Tsuji
Antimicrob. Agents Chemother. September 2009 53: 3894-3901; published ahead of print July 13, 2009, doi:10.1128/AAC.01585-08
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Competitive Inhibition of Renal Tubular Secretion of Gemifloxacin by Probenecid
Cornelia B. Landersdorfer, Carl M. J. Kirkpatrick, Martina Kinzig, Jürgen B. Bulitta, Ulrike Holzgrabe, George L. Drusano, and Fritz Sörgel
Antimicrob. Agents Chemother. September 2009 53: 3902-3907; published ahead of print June 29, 2009, doi:10.1128/AAC.01200-08
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Population Pharmacokinetics of Linezolid in Adults with Pulmonary Tuberculosis
Bryan McGee, Reynaldo Dietze, David Jamil Hadad, Lucilia Pereira Dutra Molino, Ethel Leonor Noia Maciel, W. Henry Boom, Moises Palaci, John L. Johnson, and Charles A. Peloquin
Antimicrob. Agents Chemother. September 2009 53: 3981-3984; published ahead of print June 29, 2009, doi:10.1128/AAC.01378-08
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Vancomycin and Daptomycin Pharmacodynamics Differ against a Site-Directed Staphylococcus epidermidis Mutant Displaying the Small-Colony-Variant Phenotype
Marina Wu, Christof von Eiff, Nahed Al Laham, and Brian T. Tsuji
Antimicrob. Agents Chemother. September 2009 53: 3992-3995; published ahead of print June 29, 2009, doi:10.1128/AAC.01597-08
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Chemistry; Biosynthesis:

Inhibition of Intracellular Growth of Salmonella enterica Serovar Typhimurium in Tissue Culture by Antisense Peptide-Phosphorodiamidate Morpholino Oligomer
Georgi M. Mitev, Brett L. Mellbye, Patrick L. Iversen, and Bruce L. Geller
Antimicrob. Agents Chemother. September 2009 53: 3700-3704; published ahead of print July 6, 2009, doi:10.1128/AAC.00099-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Agents:

Anti-Human Immunodeficiency Virus Activity, Cross-Resistance, Cytotoxicity, and Intracellular Pharmacology of the 3'-Azido-2',3'-Dideoxypurine Nucleosides
Nicolas Sluis-Cremer, Dianna Koontz, Leda Bassit, Brenda I. Hernandez-Santiago, Mervi Detorio, Kim L. Rapp, Franck Amblard, Lavanya Bondada, Jason Grier, Steven J. Coats, Raymond F. Schinazi, and John W. Mellors
Antimicrob. Agents Chemother. September 2009 53: 3715-3719; published ahead of print July 13, 2009, doi:10.1128/AAC.00392-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fluorescence-Based Assay for Phenotypic Characterization of Human Cytomegalovirus Polymerase Mutations Regarding Drug Susceptibility and Viral Replicative Fitness
Meike Chevillotte, Axel Schubert, Thomas Mertens, and Jens von Einem
Antimicrob. Agents Chemother. September 2009 53: 3752-3761; published ahead of print June 22, 2009, doi:10.1128/AAC.00165-09
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Profound Antiviral Effect of Oral Administration of MIV-210 on Chronic Hepadnaviral Infection in a Woodchuck Model of Hepatitis B
Tomasz I. Michalak, Hong Zhang, Norma D. Churchill, Torbjörn Larsson, Nils-Gunnar Johansson, and Bo Öberg
Antimicrob. Agents Chemother. September 2009 53: 3803-3814; published ahead of print June 29, 2009, doi:10.1128/AAC.00263-09
[Abstract] [Full Text] [PDF] [Reprints and Permissions]

Target Analysis of the Experimental Measles Therapeutic AS-136A
Jeong-Joong Yoon, Stefanie A. Krumm, J. Maina Ndungu, Vanessa Hoffman, Bettina Bankamp, Paul A. Rota, Aiming Sun, James P. Snyder, and Richard K. Plemper
Antimicrob. Agents Chemother. September 2009 53: 3860-3870; published ahead of print June 15, 2009, doi:10.1128/AAC.00503-09
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Potent Activity of a Nucleoside Reverse Transcriptase Inhibitor, 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine, against Human Immunodeficiency Virus Type 1 Infection in a Model Using Human Peripheral Blood Mononuclear Cell-Transplanted NOD/SCID Janus Kinase 3 Knockout Mice
Shinichiro Hattori, Kazuhiko Ide, Hirotomo Nakata, Hideki Harada, Shinya Suzu, Noriyuki Ashida, Satoru Kohgo, Hiroyuki Hayakawa, Hiroaki Mitsuya, and Seiji Okada
Antimicrob. Agents Chemother. September 2009 53: 3887-3893; published ahead of print June 22, 2009, doi:10.1128/AAC.00270-09
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DAS181 Inhibits H5N1 Influenza Virus Infection of Human Lung Tissues
Renee W. Y. Chan, Michael C. W. Chan, Adam C. N. Wong, Rositsa Karamanska, Anne Dell, Stuart M. Haslam, Alan D. L. Sihoe, W. H. Chui, Gallen Triana-Baltzer, Qixiang Li, J. S. Malik Peiris, Fang Fang, and John M. Nicholls
Antimicrob. Agents Chemother. September 2009 53: 3935-3941; published ahead of print July 13, 2009, doi:10.1128/AAC.00389-09
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Effect of Hemagglutinin-Neuraminidase Inhibitors BCX 2798 and BCX 2855 on Growth and Pathogenicity of Sendai/Human Parainfluenza Type 3 Chimera Virus in Mice
Makiko Watanabe, Vasiliy P. Mishin, Scott A. Brown, Charles J. Russell, Kelli Boyd, Y. Sudhakara Babu, Garry Taylor, Xiaoping Xiong, Xiaowei Yan, Allen Portner, and Irina V. Alymova
Antimicrob. Agents Chemother. September 2009 53: 3942-3951; published ahead of print June 29, 2009, doi:10.1128/AAC.00220-09
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RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy
Rene Alvarez, Sayda Elbashir, Todd Borland, Ivanka Toudjarska, Philipp Hadwiger, Mathias John, Ingo Roehl, Svetlana Shulga Morskaya, Rick Martinello, Jeffrey Kahn, Mark Van Ranst, Ralph A. Tripp, John P. DeVincenzo, Rajendra Pandey, Martin Maier, Lubomir Nechev, Muthiah Manoharan, Victor Kotelianski, and Rachel Meyers
Antimicrob. Agents Chemother. September 2009 53: 3952-3962; published ahead of print June 8, 2009, doi:10.1128/AAC.00014-09
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Experimental Therapeutics:

Cellular Accumulation and Pharmacodynamic Evaluation of the Intracellular Activity of CEM-101, a Novel Fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in Human THP-1 Macrophages
Sandrine Lemaire, Françoise Van Bambeke, and Paul M. Tulkens
Antimicrob. Agents Chemother. September 2009 53: 3734-3743; published ahead of print June 29, 2009, doi:10.1128/AAC.00203-09
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In Vivo Characterization of the Peptide Deformylase Inhibitor LBM415 in Murine Infection Models
Colin S. Osborne, Georg Neckermann, Evelin Fischer, Robert Pecanka, Donghui Yu, Kari Manni, Julie Goldovitz, Kerri Amaral, JoAnn Dzink-Fox, and Neil S. Ryder
Antimicrob. Agents Chemother. September 2009 53: 3777-3781; published ahead of print July 13, 2009, doi:10.1128/AAC.00026-09
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Efficacy of Aerosol MP-376, a Levofloxacin Inhalation Solution, in Models of Mouse Lung Infection Due to Pseudomonas aeruginosa
Mojgan Sabet, Courtney E. Miller, Thomas G. Nolan, Kathy Senekeo-Effenberger, Michael N. Dudley, and David C. Griffith
Antimicrob. Agents Chemother. September 2009 53: 3923-3928; published ahead of print June 15, 2009, doi:10.1128/AAC.00268-09
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Photodynamic Therapy for Acinetobacter baumannii Burn Infections in Mice
Tianhong Dai, George P. Tegos, Zongshun Lu, Liyi Huang, Timur Zhiyentayev, Michael J. Franklin, David G. Baer, and Michael R. Hamblin
Antimicrob. Agents Chemother. September 2009 53: 3929-3934; published ahead of print June 29, 2009, doi:10.1128/AAC.00027-09
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The Diarylquinoline R207910 Is Bactericidal against Mycobacterium leprae in Mice at Low Dose and Administered Intermittently
Robert Gelber, Koen Andries, Rose Maria D. Paredes, Cora Evelyn S. Andaya, and Jasmin Burgos
Antimicrob. Agents Chemother. September 2009 53: 3989-3991; published ahead of print July 13, 2009, doi:10.1128/AAC.00722-09
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Anidulafungin in Combination with Amphotericin B against Aspergillus fumigatus
Elisabetta Spreghini, Fiorenza Orlando, Alfredo Santinelli, Eleonora Pisa, Cristian Loretelli, Esther Manso, Maria Eleonara Milici, Giorgio Scalise, and Francesco Barchiesi
Antimicrob. Agents Chemother. September 2009 53: 4035-4039; published ahead of print July 13, 2009, doi:10.1128/AAC.00659-09
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Analytical Procedures:

Evaluation of Target Specificity of Antibacterial Agents Using Staphylococcus aureus ddlA Mutants and D-Cycloserine in a Silkworm Infection Model
Kenji Kurokawa, Hiroshi Hamamoto, Miki Matsuo, Satoshi Nishida, Noriko Yamane, Bok Luel Lee, Kazuhisa Murakami, Hideki Maki, and Kazuhisa Sekimizu
Antimicrob. Agents Chemother. September 2009 53: 4025-4027; published ahead of print June 22, 2009, doi:10.1128/AAC.00200-09
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Letters:

Emergence of Extended-Spectrum β-Lactamase PER-1 in Proteus vulgaris and Providencia stuartii Isolates from Algiers, Algeria
Hassen Iabadene, Caroline Dallenne, Yamina Messai, Delphine Geneste, Rabah Bakour, and Guillaume Arlet
Antimicrob. Agents Chemother. September 2009 53: 4043-4044; published ahead of print June 22, 2009, doi:10.1128/AAC.00274-09
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Overexpression of the Naturally Occurring bla_OXA-51 Gene in Acinetobacter baumannii Mediated by Novel Insertion Sequence ISAba9
Samy Figueiredo, Laurent Poirel, Anna Papa, Vassiliki Koulourida, and Patrice Nordmann
Antimicrob. Agents Chemother. September 2009 53: 4045-4047; published ahead of print June 29, 2009, doi:10.1128/AAC.00292-09
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Emerging Klebsiella pneumoniae Isolates Coproducing KPC-2 and VIM-1 Carbapenemases
Panagiota Giakkoupi, Olga Pappa, Michalis Polemis, Alkiviadis C. Vatopoulos, Vivi Miriagou, Anastasia Zioga, Costas C. Papagiannitsis, and Leonidas S. Tzouvelekis
Antimicrob. Agents Chemother. September 2009 53: 4048-4050; published ahead of print July 6, 2009, doi:10.1128/AAC.00690-09
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