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Biosynthesis; Chemistry; Mechanisms of Action and Resistance

Inhibition of Escherichia coli K-12 by β-Lactam Antibiotics With Poor Antibacterial Activity: Interaction of Permeability And Intrinsic Activity Against Penicillin-Binding Proteins

Nigel A. C. Curtis, Carol Brown, Mike Boxall, Michael G. Boulton
Nigel A. C. Curtis
Microbial Biochemistry Department, Glaxo-Allenburys Research Ltd., Greenford, Middlesex, England
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Carol Brown
Microbial Biochemistry Department, Glaxo-Allenburys Research Ltd., Greenford, Middlesex, England
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Mike Boxall
Microbial Biochemistry Department, Glaxo-Allenburys Research Ltd., Greenford, Middlesex, England
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Michael G. Boulton
Microbial Biochemistry Department, Glaxo-Allenburys Research Ltd., Greenford, Middlesex, England
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DOI: 10.1128/AAC.15.3.332
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ABSTRACT

The effect of methicillin, cloxacillin, 1078/1/1, penicillin G, and cephaloridine upon the penicillin-binding proteins of a permeability mutant of Escherichia coli K-12 and its isogenic wild type have been investigated. Comparison of the 50% inhibition values for the antibiotics against the penicillin-binding proteins of the two strains with the minimal inhibitory concentrations for the same compounds indicates that methicillin, cloxacillin, 1078/1/1, and to a lesser extent penicillin G, owe their poor antibacterial activity to exclusion from the bacterial cell, whereas cephaloridine is not excluded and is equally active against both the mutant and its wild type. The results further suggest that the lesion in the permeability mutant E. coli DC2 allows free access of all the compounds tested to the inner membrane target proteins.

  • Copyright © 1979, American Society for Microbiology
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Inhibition of Escherichia coli K-12 by β-Lactam Antibiotics With Poor Antibacterial Activity: Interaction of Permeability And Intrinsic Activity Against Penicillin-Binding Proteins
Nigel A. C. Curtis, Carol Brown, Mike Boxall, Michael G. Boulton
Antimicrobial Agents and Chemotherapy Mar 1979, 15 (3) 332-336; DOI: 10.1128/AAC.15.3.332

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Inhibition of Escherichia coli K-12 by β-Lactam Antibiotics With Poor Antibacterial Activity: Interaction of Permeability And Intrinsic Activity Against Penicillin-Binding Proteins
Nigel A. C. Curtis, Carol Brown, Mike Boxall, Michael G. Boulton
Antimicrobial Agents and Chemotherapy Mar 1979, 15 (3) 332-336; DOI: 10.1128/AAC.15.3.332
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