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Biosynthesis; Chemistry; Mechanisms of Action and Resistance

Avermectins, New Family of Potent Anthelmintic Agents: Isolation and Chromatographic Properties

Thomas W. Miller, Louis Chaiet, Douglas J. Cole, Lucille J. Cole, James E. Flor, Robert T. Goegelman, Vincent P. Gullo, Henry Joshua, August J. Kempf, Wilson R. Krellwitz, Richard L. Monaghan, Robert E. Ormond, Kenneth E. Wilson, George Albers-Schönberg, Irving Putter
Thomas W. Miller
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065
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Louis Chaiet
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065
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Douglas J. Cole
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065
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Lucille J. Cole
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065
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James E. Flor
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065
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Robert T. Goegelman
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065
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Vincent P. Gullo
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065
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Henry Joshua
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065
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August J. Kempf
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065
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Wilson R. Krellwitz
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065
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Richard L. Monaghan
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065
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Robert E. Ormond
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065
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Kenneth E. Wilson
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065
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George Albers-Schönberg
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065
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Irving Putter
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065
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DOI: 10.1128/AAC.15.3.368
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ABSTRACT

The avermectins, a family of new anthelmintic agents, were isolated from the mycelia of Streptomyces avermitilis. Four closely related major components and four homologous minor components were separated from the complex. Solvent extraction, solvent partition, and adsorption methods were used to isolate and purify the complex; novel partition chromatography systems using Sephadex LH-20 were used to separate the components. A reverse-phase high-pressure liquid chromatography assay for the quantitative determination of all components was used extensively to monitor the purification methods.

  • Copyright © 1979, American Society for Microbiology
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Avermectins, New Family of Potent Anthelmintic Agents: Isolation and Chromatographic Properties
Thomas W. Miller, Louis Chaiet, Douglas J. Cole, Lucille J. Cole, James E. Flor, Robert T. Goegelman, Vincent P. Gullo, Henry Joshua, August J. Kempf, Wilson R. Krellwitz, Richard L. Monaghan, Robert E. Ormond, Kenneth E. Wilson, George Albers-Schönberg, Irving Putter
Antimicrobial Agents and Chemotherapy Mar 1979, 15 (3) 368-371; DOI: 10.1128/AAC.15.3.368

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Avermectins, New Family of Potent Anthelmintic Agents: Isolation and Chromatographic Properties
Thomas W. Miller, Louis Chaiet, Douglas J. Cole, Lucille J. Cole, James E. Flor, Robert T. Goegelman, Vincent P. Gullo, Henry Joshua, August J. Kempf, Wilson R. Krellwitz, Richard L. Monaghan, Robert E. Ormond, Kenneth E. Wilson, George Albers-Schönberg, Irving Putter
Antimicrobial Agents and Chemotherapy Mar 1979, 15 (3) 368-371; DOI: 10.1128/AAC.15.3.368
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