Table of Contents

Research Article

• Research Article

  In vitro assays used to measure the activity of topoisomerases.

  J F Barrett, J A Sutcliffe, T D Gootz
• Research Article

  Inhibitory effects of quinolone antibacterial agents on eucaryotic topoisomerases and related test systems.

  T D Gootz, J F Barrett, J A Sutcliffe
• Research Article

  Comparison of fluconazole and SDZ89-485 for therapy of experimental murine coccidioidomycosis.

  J Fierer, T Kirkland, F Finley
• Research Article

  Lomefloxacin pharmacokinetics in subjects with normal and impaired renal function.

  A Leroy, J P Fillastre, G Humbert
• Research Article

  Successful single-dose prophylaxis of Staphylococcus aureus foreign body infections in guinea pigs by fleroxacin.

  N Bouchenaki, P E Vaudaux, E Huggler, F A Waldvogel, D P Lew
• Research Article

  Guinea pig model for antibiotic transport across gastric mucosa: inhibitory tissue concentrations of clindamycin against Helicobacter pylori (Campylobacter pylori) following two separate dose regimens.

  T U Westblom, D E Duriex, E Madan, R B Belshe
• Research Article

  Pharmacokinetics of aerosol amphotericin B in rats.

  Y Niki, E M Bernard, H J Schmitt, W P Tong, F F Edwards, D Armstrong
• Research Article

  Two bactericidal targets for penicillin in pneumococci: autolysis-dependent and autolysis-independent killing mechanisms.

  P Moreillon, Z Markiewicz, S Nachman, A Tomasz
• Research Article

  Oral ciprofloxacin compared with parenteral antibiotics in the treatment of osteomyelitis.

  L O Gentry, G G Rodriguez
• Research Article

  Purification and characterization of inducible beta-lactamases in Aeromonas spp.

  J P Iaconis, C C Sanders
• Research Article

  Outer membrane protein D2 catalyzes facilitated diffusion of carbapenems and penems through the outer membrane of Pseudomonas aeruginosa.

  J Trias, H Nikaido
• Research Article

  Renal handling of fleroxacin in rabbits, dogs, and humans.

  K Shiba, A Saito, J Shimada, S Hori, M Kaji, T Miyahara, H Kusajima, S Kaneko, S Saito, T Ooie
• Research Article

  Activities of ciprofloxacin and ofloxacin against rapidly growing mycobacteria with demonstration of acquired resistance following single-drug therapy.

  R J Wallace, G Bedsole, G Sumter, C V Sanders, L C Steele, B A Brown, J Smith, D R Graham
• Research Article

  Molecular studies on the mechanism of tetracycline resistance mediated by Tet(O).

  E K Manavathu, C L Fernandez, B S Cooperman, D E Taylor
• Research Article

  Multiple-dose pharmacokinetics of ofloxacin in serum, saliva, and skin blister fluid of healthy volunteers.

  R Warlich, H C Korting, M Schäfer-Korting, E Mutschler
• Research Article

  In vitro inhibition of the infectivity and replication of human immunodeficiency virus type 1 by combination of antiretroviral 2',3'-dideoxynucleosides and virus-binding inhibitors.

  S Hayashi, R L Fine, T C Chou, M J Currens, S Broder, H Mitsuya
• Research Article

  Pharmacokinetics of a novel quinolone, AT-4140, in animals.

  S Nakamura, N Kurobe, T Ohue, M Hashimoto, M Shimizu
• Research Article

  Paradoxical activity of beta-lactam antibiotics against Proteus vulgaris in experimental infection in mice.

  Y Ikeda, Y Fukuoka, K Motomura, T Yasuda, T Nishino
• Research Article

  Significance of "extravascular" protein binding for antimicrobial pharmacodynamics in an in vitro capillary model of infection.

  M N Dudley, J Blaser, D Gilbert, S H Zinner
• Research Article

  Postantibiotic effect of beta-lactam antibiotics on Escherichia coli evaluated by bioluminescence assay of bacterial ATP.

  H Hanberger, L E Nilsson, E Kihlström, R Maller
• Research Article

  Topical delivery of liposomally encapsulated interferon evaluated by in vitro diffusion studies.

  K Egbaria, C Ramachandran, D Kittayanond, N Weiner
• Research Article

  Sensitive biological detection method for tetracyclines using a tetA-lacZ fusion system.

  I Chopra, K Hacker, Z Misulovin, D M Rothstein
• Research Article

  Imipenem resistance in Bacteroides distasonis mediated by a novel beta-lactamase.

  S Hurlbut, G J Cuchural, F P Tally
• Research Article

  Production of cyclosporins by Tolypocladium niveum strains.

  C E Isaac, A Jones, M A Pickard
• Research Article

  Effect of concomitant administration of piperacillin on the dispositions of netilmicin and tobramycin in patients with end-stage renal disease.

  C E Halstenson, C A Hirata, K L Heim-Duthoy, P A Abraham, G R Matzke
• Research Article

  Novel sulfated polymers as highly potent and selective inhibitors of human immunodeficiency virus replication and giant cell formation.

  M Baba, D Schols, E De Clercq, R Pauwels, M Nagy, J Györgyi-Edelényi, M Löw, S Görög
• Research Article

  Effects of daptomycin and vancomycin on tobramycin nephrotoxicity in rats.

  D Beauchamp, M Pellerin, P Gourde, M Pettigrew, M G Bergeron
• Research Article

  Comparison of ofloxacin and ceftriaxone in the treatment of uncomplicated gonorrhea caused by penicillinase-producing and non-penicillinase-producing strains.

  J M Covino, M Cummings, B Smith, S Benes, K Draft, W M McCormack
• Research Article

  Pharmacokinetics of lomefloxacin in healthy volunteers: comparison of 400 milligrams once daily and 200 milligrams twice daily given orally for 5 days.

  I Gros, C Carbon
• Research Article

  In vitro susceptibility of mutans streptococci to antimicrobial substances as determined by a membrane transfer assay.

  N K Childers, P W Caufield
• Research Article

  Diverse potential of beta-lactamase inhibitors to induce class I enzymes.

  D A Weber, C C Sanders
• Research Article

  In vitro susceptibilities of Plesiomonas shigelloides to 24 antibiotics and antibiotic-beta-lactamase-inhibitor combinations.

  R B Clark, P D Lister, L Arneson-Rotert, J M Janda
• Research Article

  In vivo selection for transmissible drug resistance in Salmonella typhi during antimicrobial therapy.

  R S Schwalbe, C W Hoge, J G Morris, P N O'Hanlon, R A Crawford, P H Gilligan
• Research Article

  Decay of the ampicillin-induced lysis process in amino acid-deprived Escherichia coli.

  W Kusser, A G Pisabarro, M A De Pedro, E E Ishiguro
• Research Article

  Ciprofloxacin does not inhibit mitochondrial functions but other antibiotics do.

  K Riesbeck, A Bredberg, A Forsgren
• Research Article

  Homology of mecA gene in methicillin-resistant Staphylococcus haemolyticus and Staphylococcus simulans to that of Staphylococcus aureus.

  K Ubukata, R Nonoguchi, M D Song, M Matsuhashi, M Konno
• Research Article

  In vitro emergence of quinolone-resistant mutants of Escherichia coli, Enterobacter cloacae, and Serratia marcescens.

  M Watanabe, Y Kotera, K Yosue, M Inoue, S Mitsuhashi
• Research Article

  Failure of adjunctive cytomegalovirus intravenous immune globulin to improve efficacy of ganciclovir in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: a phase 1 study.

  M A Jacobson, J J O'Donnell, R Rousell, B Dionian, J Mills
• Research Article

  Comparison of in vitro antibiograms of Bacteroides fragilis group isolates: differences in resistance rates in two institutions because of differences in susceptibility testing methodology.

  K E Aldridge, H M Wexler, C V Sanders, S M Finegold