Table of Contents

Research Article

• Research Article

  Molecular biology of penicillin and cephalosporin biosynthesis.

  S W Queener
• Research Article

  Intracellular activity of tosufloxacin (T-3262) against Salmonella enteritidis and ability to penetrate into tissue culture cells of human origin.

  T Noumi, N Nishida, S Minami, Y Watanabe, T Yasuda
• Research Article

  Open trial of cefepime (BMY 28142) for infections in hospitalized patients.

  S Oster, H Edelstein, K Cassano, R McCabe
• Research Article

  Penetration of ampicillin and sulbactam in the lower airways during respiratory infections.

  Y J Valcke, M T Rosseel, R A Pauwels, M G Bogaert, M E Van der Straeten
• Research Article

  Pathogenicity for humans of human rhinovirus type 2 mutants resistant to or dependent on chalcone Ro 09-0410.

  S R Yasin, W al-Nakib, D A Tyrrell
• Research Article

  Liposome-encapsulated-gentamicin therapy of Mycobacterium avium complex infection in beige mice.

  S P Klemens, M H Cynamon, C E Swenson, R S Ginsberg
• Research Article

  In vitro activity of tosufloxacin (A-61827; T-3262) against selected genital pathogens.

  J Segreti, D J Hirsch, A A Harris, K S Kapell, H Orbach, H A Kessler
• Research Article

  Multiple-dose pharmacokinetics and safety of oral amifloxacin in healthy volunteers.

  J A Cook, M H Silverman, D J Schelling, D E Nix, J J Schentag, R R Brown, R M Stroshane
• Research Article

  In vivo efficacy of SM-8668 (Sch 39304), a new oral triazole antifungal agent.

  T Tanio, K Ichise, T Nakajima, T Okuda
• Research Article

  High-level chromosomal gentamicin resistance in Streptococcus agalactiae (group B).

  A Buu-Hoï, C Le Bouguenec, T Horaud
• Research Article

  In vivo effects of fenpropimorph on the yeast Saccharomyces cerevisiae and determination of the molecular basis of the antifungal property.

  C Marcireau, M Guilloton, F Karst
• Research Article

  In vitro activity of LJC10,627, a new carbapenem antibiotic with high stability to dehydropeptidase I.

  K Ubukata, M Hikida, M Yoshida, K Nishiki, Y Furukawa, K Tashiro, M Konno, S Mitsuhashi
• Research Article

  Pharmacokinetics of FCE 22891, a new oral penem.

  A Saathoff, H Lode, B Hampel, K M Deppermann, K Borner, P Koeppe
• Research Article

  Crossover assessment of serum bactericidal activity and pharmacokinetics of five broad-spectrum cephalosporins in the elderly.

  R G Deeter, M P Weinstein, K A Swanson, J S Gross, L C Bailey
• Research Article

  Comparative efficacies of ciprofloxacin, pefloxacin, and vancomycin in combination with rifampin in a rat model of methicillin-resistant Staphylococcus aureus chronic osteomyelitis.

  R Dworkin, G Modin, S Kunz, R Rich, O Zak, M Sande
• Research Article

  Concentrations of oral lomefloxacin in serum and bronchial mucosa.

  D R Baldwin, D Honeybourne, J M Andrews, J P Ashby, R Wise
• Research Article

  Role of sodium in protection by extended-spectrum penicillins against tobramycin-induced nephrotoxicity.

  R Sabra, R A Branch
• Research Article

  Novel pentamidine analogs in the treatment of experimental Pneumocystis carinii pneumonia.

  S K Jones, J E Hall, M A Allen, S D Morrison, K A Ohemeng, V V Reddy, J D Geratz, R R Tidwell
• Research Article

  Effect of renal function on the bioavailability of ciprofloxacin.

  K I Plaisance, G L Drusano, A Forrest, M R Weir, H C Standiford
• Research Article

  Quantification of antibiotic drug potency by a two-compartment radioassay of bacterial growth.

  V Boonkitticharoen, J C Ehrhardt, P T Kirchner
• Research Article

  Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.

  A Verghese, D Roberson, J H Kalbfleisch, F Sarubbi
• Research Article

  Effects of aztreonam on fecal flora and on vitamin K metabolism.

  H Sakata, H Kakehashi, K Fujita, H Yoshioka
• Research Article

  Investigation of potential interaction of ciprofloxacin with cyclosporine in bone marrow transplant recipients.

  H U Krüger, U Schuler, B Proksch, M Göbel, G Ehninger
• Research Article

  Pharmacokinetics and tissue penetration of ceftibuten.

  R Wise, K Nye, P O'Neill, M Wostenholme, J M Andrews
• Research Article

  Intracellular accumulation of azithromycin by cultured human fibroblasts.

  R P Gladue, M E Snider
• Research Article

  Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1.

  R F Schinazi, J P Sommadossi, V Saalmann, D L Cannon, M Y Xie, G C Hart, G A Smith, E F Hahn
• Research Article

  Chemoprophylactic efficacy against experimental endocarditis caused by beta-lactamase-producing, aminoglycoside-resistant enterococci is associated with prolonged serum inhibitory activity.

  A S Bayer, J Tu
• Research Article

  Inhibition of Pneumocystis carinii dihydropteroate synthetase by sulfa drugs.

  S Merali, Y Zhang, D Sloan, S Meshnick
• Research Article

  Ampicillin killing curve patterns for ampicillin-susceptible nontypeable Haemophilus influenzae strains by the agar dilution plate count method.

  B F Woolfrey, M A Enright
• Research Article

  Mechanism of action of lomefloxacin.

  L J Piddock, M C Hall, R Wise
• Research Article

  Pharmacokinetics of cefpodoxime in plasma and skin blister fluid following oral dosing of cefpodoxime proxetil.

  M T Borin, G S Hughes, C R Spillers, R K Patel
• Research Article

  Efficacy, toxicity, and pharmacokinetics of pentoxifylline and its analogs in experimental Staphylococcus aureus infections.

  E G Maderazo, S Breaux, C L Woronick, P J Krause
• Research Article

  Antibacterial activity of lomefloxacin in a pharmacokinetic in vitro model.

  C Rustige, B Wiedemann
• Research Article

  Inhibitory effects of atropine, protamine, and their combination on hepatitis A virus replication in PLC/PRF/5 cells.

  E Biziagos, J M Crance, J Passagot, R Deloince
• Research Article

  Safety, tolerance, and pharmacokinetic evaluation of cefepime after administration of single intravenous doses.

  R H Barbhaiya, S T Forgue, C R Gleason, C A Knupp, K A Pittman, D J Weidler, R R Martin
• Research Article

  In vitro activity of AT-4140 against quinolone- and methicillin-resistant Staphylococcus aureus.

  T Kojima, M Inoue, S Mitsuhashi
• Research Article

  Assessment of cefazolin and cefuroxime tissue penetration by using a continuous intravenous infusion.

  J E Connors, J T DiPiro, R G Hayter, K D Hooker, J A Stanfield, T R Young
• Research Article

  Therapeutic effect of the triazole Bay R 3783 in mouse models of coccidioidomycosis, blastomycosis, and histoplasmosis.

  D Pappagianis, B L Zimmer, G Theodoropoulos, M Plempel, R F Hector
• Research Article

  Interactions of ceftazidime and tobramycin in patients with normal and impaired renal function.

  G R Aronoff, R A Brier, R S Sloan, M E Brier
• Research Article

  Oral temafloxacin versus vancomycin for therapy of experimental endocarditis caused by methicillin-resistant Staphylococcus aureus.

  M T Hessen, P G Pitsakis, D Kaye
• Research Article

  Apparent biliary pseudolithiasis during ceftriaxone therapy.

  K L Heim-Duthoy, E M Caperton, R Pollock, G R Matzke, D Enthoven, P K Peterson
• Research Article

  Pharmacokinetic analysis of cloxacillin loss in children undergoing major surgery with massive bleeding.

  M Levy, P Egersegi, A Strong, A Tessoro, M Spino, R Bannatyne, D Fear, J C Posnick, G Koren
• Research Article

  Comparative in vitro activity of WIN 57273, a new fluoroquinolone antimicrobial agent.

  G M Eliopoulos, K Klimm, L B Rice, M J Ferraro, R C Moellering
• Research Article

  Pharmacokinetics of cephem antibiotics in exudate of pelvic retroperitoneal space after radical hysterectomy and pelvic lymphadenectomy.

  K Ito, M Hayasaki, T Tamaya
• Research Article

  Application of a Bayesian method to monitor and adjust vancomycin dosage regimens.

  A K Hurst, M A Yoshinaga, G H Mitani, K A Foo, R W Jelliffe, E C Harrison
• Research Article

  Clinical pharmacology of imipenem and cilastatin in premature infants during the first week of life.

  M D Reed, R M Kliegman, T S Yamashita, C M Myers, J L Blumer
• Research Article

  Nucleoside metabolism in herpes simplex virus-infected cells following treatment with interferon and acyclovir, a possible mechanism of synergistic antiviral activity.

  W J O'Brien, E C Coe, J L Taylor
• Research Article

  Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense.

  C J Bacchi, H C Nathan, T Livingston, G Valladares, M Saric, P D Sayer, A R Njogu, A B Clarkson
• Research Article

  Uptake of antibiotics by human polymorphonuclear leukocyte cytoplasts.

  W L Hand, N L King-Thompson
• Research Article

  Randomized, double-blind comparison of the efficacies, costs, and vaginal flora alterations with single-dose ceftriaxone and multidose cefazolin prophylaxis in vaginal hysterectomy.

  H G Stiver, B O Binns, R C Brunham, N Cheng, D M Dean, A M Goldring, J B Walker, E Tan, J McLeod
• Research Article

  Phase I study of multiple-dose cefprozil and comparison with cefaclor.

  R H Barbhaiya, U A Shukla, C R Gleason, W C Shyu, R B Wilber, R R Martin, K A Pittman
• Research Article

  Comparison of cefprozil and cefaclor pharmacokinetics and tissue penetration.

  R H Barbhaiya, U A Shukla, C R Gleason, W C Shyu, R B Wilber, K A Pittman
• Research Article

  Comparison of the effects of food on the pharmacokinetics of cefprozil and cefaclor.

  R H Barbhaiya, U A Shukla, C R Gleason, W C Shyu, K A Pittman
• Research Article

  Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rhesus monkeys.

  R F Schinazi, F D Boudinot, K J Doshi, H M McClure
• Research Article

  Lipoteichoic acid as a new target for activity of antibiotics: mode of action of daptomycin (LY146032).

  P Canepari, M Boaretti, M M Lleó, G Satta
• Research Article

  Vancomycin for Staphylococcus aureus endocarditis in intravenous drug users.

  P M Small, H F Chambers
• Research Article

  Eradication of Helicobacter mustelae from the ferret stomach: an animal model of Helicobacter (Campylobacter) pylori chemotherapy.

  G Otto, J G Fox, P Y Wu, N S Taylor
• Research Article

  Induction of the SOS response in Escherichia coli by azidothymidine and dideoxynucleosides.

  S W Mamber, K W Brookshire, S Forenza
• Research Article

  Dissemination of amikacin resistance gene aphA6 in Acinetobacter spp.

  T Lambert, G Gerbaud, P Bouvet, J F Vieu, P Courvalin
• Research Article

  Safety of fleroxacin coadministered with theophylline to young and elderly volunteers.

  M Parent, M St-Laurent, M LeBel
• Research Article

  Influence of lomefloxacin on the pharmacokinetics of theophylline.

  M LeBel, F Vallée, M St-Laurent
• Research Article

  Effects of supraphysiologic temperature and broth dilution on serum protein binding.

  R L White, M B Kays, T A Armstrong, L V Friedrich
• Research Article

  6-(3,4-Dichlorophenoxy)-3-(ethylthio)-2-pyridincarbonitrile inhibits poliovirus uncoating.

  M E González, M J Almela, M Yacout, L Carrasco
• Research Article

  In vitro activities of irloxacin and E-3846, two new quinolones.

  J A García-Rodríguez, J E García Sánchez, J L Muñoz Bellido, I Trujillano
• Research Article

  Influence of temperature on degradation kinetics of ceftriaxone in diluted and undiluted human serum.

  M J Esteban, E Cantón, F Rius
• Research Article

  Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

  H Yoshida, M Bogaki, M Nakamura, S Nakamura
• Research Article

  Proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa.

  H Yoshida, M Nakamura, M Bogaki, S Nakamura
• Research Article

  Influence of plasma exchange pheresis on plasma elimination of ceftriaxone.

  J S Bakken, S J Cavalieri, D Gangeness
• Research Article

  Mobilization of the gentamicin resistance gene in Enterococcus faecalis.

  S L Hodel-Christian, B E Murray
• Research Article

  Penetration of SCH-39304, a new antifungal triazole, into cerebrospinal fluid of primates.

  T J Walsh, C Lester-McCully, M G Rinaldi, J E Wallace, F M Balis, J W Lee, P A Pizzo, D G Poplack
• Research Article

  Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia.

  D A Leib, K L Ruffner, C Hildebrand, P A Schaffer, G E Wright, D M Coen
• Research Article

  Evidence for a staphylococcal-like mercury resistance gene in Enterococcus faecalis.

  K K Zscheck, B E Murray
• Research Article

  Failure of ceftazidime-amikacin therapy for bacteremia and meningitis due to Klebsiella pneumoniae producing an extended-spectrum beta-lactamase.

  C E Smith, B S Tillman, A W Howell, R N Longfield, J H Jorgensen
• Research Article

  Emergence of aminoglycoside resistance genes aadA and aadE in the genus Campylobacter.

  H Pinto-Alphandary, C Mabilat, P Courvalin
• Research Article

  Activities of (-)-carbovir and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro.

  S G Carter, J A Kessler, C D Rankin