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Research Article

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

M Oram, L M Fisher
M Oram
Department of Cellular and Molecular Sciences, St. George's Hospital Medical School, London, United Kingdom.
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L M Fisher
Department of Cellular and Molecular Sciences, St. George's Hospital Medical School, London, United Kingdom.
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DOI: 10.1128/AAC.35.2.387
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ABSTRACT

Seven nalidixic acid-resistant clinical isolates of Escherichia coli were shown to carry resistance mutations in their gyrase A proteins. Six had serine-83 to leucine or tryptophan changes; the seventh had an aspartate-87 to valine substitution. The frequent occurrence of a mutation at serine-83 implies a key role for this residue in quinolone action.

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4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
M Oram, L M Fisher
Antimicrobial Agents and Chemotherapy Feb 1991, 35 (2) 387-389; DOI: 10.1128/AAC.35.2.387

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4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
M Oram, L M Fisher
Antimicrobial Agents and Chemotherapy Feb 1991, 35 (2) 387-389; DOI: 10.1128/AAC.35.2.387
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