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Research Article

Effects of amoxicillin-clavulanate combination on the motility of the small intestine in human beings.

F Caron, P Ducrotte, E Lerebours, R Colin, G Humbert, P Denis
F Caron
Maladies Infectieuses et Tropicales, Hôpital Charles Nicolle, Rouen, France.
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P Ducrotte
Maladies Infectieuses et Tropicales, Hôpital Charles Nicolle, Rouen, France.
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E Lerebours
Maladies Infectieuses et Tropicales, Hôpital Charles Nicolle, Rouen, France.
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R Colin
Maladies Infectieuses et Tropicales, Hôpital Charles Nicolle, Rouen, France.
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G Humbert
Maladies Infectieuses et Tropicales, Hôpital Charles Nicolle, Rouen, France.
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P Denis
Maladies Infectieuses et Tropicales, Hôpital Charles Nicolle, Rouen, France.
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DOI: 10.1128/AAC.35.6.1085
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ABSTRACT

The amoxicillin-clavulanate combination (Augmentin) frequently induces gastric complaints and diarrhea by an unknown mechanism. The aim of this study was to assess the effects of two orally therapeutic regimens of amoxicillin-clavulanate on small bowel motility in human beings. Duodeno-jejunal manometric recordings were performed in six healthy subjects treated in a cross-over double-blind study with placebo; amoxicillin-clavulanate, 1 g plus 250 mg per os every 12 h for 3 days; or amoxicillin-clavulanate, 1 g plus 250 mg per os every 12 h on day 3 only (1-day regimen). Recordings were all performed on day 3 during a diurnal fasting period, a fed state after a standard dinner, and a nocturnal fasting period. Amoxicillin-clavulanate did not affect the motility of the small intestine during the diurnal fast or the fed state. During the nocturnal fast, amoxicillin-clavulanate significantly increased the motility index of the nonpropagated contractions and tended to increase the duration and the amplitude of the propagated contractions. The same digestive motor effect was already observed on the first day of treatment (1-day regimen). This study demonstrates that the oral administration of a therapeutic regimen of amoxicillin-clavulanate is associated, in most cases, with the occurrence of small intestinal motor disturbances.

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Effects of amoxicillin-clavulanate combination on the motility of the small intestine in human beings.
F Caron, P Ducrotte, E Lerebours, R Colin, G Humbert, P Denis
Antimicrobial Agents and Chemotherapy Jun 1991, 35 (6) 1085-1088; DOI: 10.1128/AAC.35.6.1085

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Effects of amoxicillin-clavulanate combination on the motility of the small intestine in human beings.
F Caron, P Ducrotte, E Lerebours, R Colin, G Humbert, P Denis
Antimicrobial Agents and Chemotherapy Jun 1991, 35 (6) 1085-1088; DOI: 10.1128/AAC.35.6.1085
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