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Research Article

Tet determinants provide poor protection against some tetracyclines: further evidence for division of tetracyclines into two classes.

B Oliva, I Chopra
B Oliva
Department of Microbial Biochemistry and Genetics, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965.
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I Chopra
Department of Microbial Biochemistry and Genetics, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965.
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DOI: 10.1128/AAC.36.4.876
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ABSTRACT

Atypical tetracyclines were active against Escherichia coli and Staphylococcus aureus strains containing determinants that mediate resistance to typical tetracyclines by efflux (Tet B and Tet K) or ribosomal protection (Tet M) mechanisms. The results support recently published data that tetracyclines are divisible into at least two classes on the basis of their modes of action.

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Tet determinants provide poor protection against some tetracyclines: further evidence for division of tetracyclines into two classes.
B Oliva, I Chopra
Antimicrobial Agents and Chemotherapy Apr 1992, 36 (4) 876-878; DOI: 10.1128/AAC.36.4.876

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Tet determinants provide poor protection against some tetracyclines: further evidence for division of tetracyclines into two classes.
B Oliva, I Chopra
Antimicrobial Agents and Chemotherapy Apr 1992, 36 (4) 876-878; DOI: 10.1128/AAC.36.4.876
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