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Research Article

In vitro activity of DU-6859a, a new fluorocyclopropyl quinolone.

S A Marshall, R N Jones
S A Marshall
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
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R N Jones
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
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DOI: 10.1128/AAC.37.12.2747
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ABSTRACT

DU-6859a was tested against 844 recent clinical isolates (most from bacteremias) by using reference MIC determination procedures. The activity of DU-6859a against members of the family Enterobacteriaceae was comparable to that of ciprofloxacin (range of MICs for 90% of isolates [MIC90], < or = 0.015 to 1 microgram/ml), and the highest MICs were observed among Serratia marcescens and Providencia rettgeri isolates. The DU-6859a MIC90 for Pseudomonas aeruginosa and Xanthomonas maltophilia was 0.5 microgram/ml. Pneumococci (MIC90, 0.06 microgram/ml), Haemophilus influenzae (MIC90, < or = 0.004 microgram/ml), Moraxella catarrhalis (MIC90, < or = 0.015 microgram/ml), and pathogenic neisseriae (MIC90, 0.015 to 0.03 microgram/ml) were very susceptible to DU-6859a. All staphylococci had DU-6859a MICs of < or = 1 microgram/ml, including oxacillin- and ciprofloxacin-resistant strains. DU-6859a was very active against isolates resistant to ceftazidime (MIC90, < or = 0.12 microgram/ml), ciprofloxacin (MIC90, < or = 8 micrograms/ml), and gentamicin (MIC90, < or = 1 microgram/ml).

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In vitro activity of DU-6859a, a new fluorocyclopropyl quinolone.
S A Marshall, R N Jones
Antimicrobial Agents and Chemotherapy Dec 1993, 37 (12) 2747-2753; DOI: 10.1128/AAC.37.12.2747

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In vitro activity of DU-6859a, a new fluorocyclopropyl quinolone.
S A Marshall, R N Jones
Antimicrobial Agents and Chemotherapy Dec 1993, 37 (12) 2747-2753; DOI: 10.1128/AAC.37.12.2747
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