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Research Article

Efficacy of cefuroxime axetil suspension compared with that of penicillin V suspension in children with group A streptococcal pharyngitis.

W M Gooch 3rd, S E McLinn, G H Aronovitz, M E Pichichero, A Kumar, E L Kaplan, M J Ossi
W M Gooch 3rd
Primary Children's Medical Center, Salt Lake City, Utah 84113-1100.
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S E McLinn
Primary Children's Medical Center, Salt Lake City, Utah 84113-1100.
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G H Aronovitz
Primary Children's Medical Center, Salt Lake City, Utah 84113-1100.
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M E Pichichero
Primary Children's Medical Center, Salt Lake City, Utah 84113-1100.
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A Kumar
Primary Children's Medical Center, Salt Lake City, Utah 84113-1100.
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E L Kaplan
Primary Children's Medical Center, Salt Lake City, Utah 84113-1100.
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M J Ossi
Primary Children's Medical Center, Salt Lake City, Utah 84113-1100.
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DOI: 10.1128/AAC.37.2.159
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ABSTRACT

The bacteriological and clinical efficacies of cefuroxime axetil suspension (20 mg/kg of body weight per day in two divided doses) were compared with those of penicillin V suspension (50 mg/kg/day in three divided doses) in a multicenter, randomized, evaluator-blinded study. Children aged 2 to 13 years with clinical signs and symptoms of acute pharyngitis and a positive throat culture for group A beta-hemolytic streptococci (GABHS) were eligible. Patients were assessed and samples from the throat for culture were obtained at the time of diagnosis, 3 to 7 days after the initiation of treatment, and 4 to 8 days and 19 to 25 days after the completion of 10 days of therapy. Of the 385 evaluable patients, GABHS were eradicated from 244 of 259 (94.2%) cefuroxime-treated patients and 106 of 126 (84.1%) penicillin-treated patients (P = 0.001). Complete resolution of the signs and symptoms present at the time of diagnosis was achieved in 238 of 259 (91.9%) cefuroxime-treated patients and 102 of 126 (81.0%) penicillin-treated patients (P = 0.001). Potential drug-related adverse events were reported in 7.0 and 3.2% of the cefuroxime- and penicillin-treated patients, respectively (P = 0.078). In the present study, cefuroxime axetil suspension given twice daily resulted in significantly greater bacteriological and clinical efficacies than those of penicillin V suspension given three times daily to pediatric patients with acute pharyngitis and a positive throat culture for GABHS.

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Efficacy of cefuroxime axetil suspension compared with that of penicillin V suspension in children with group A streptococcal pharyngitis.
W M Gooch 3rd, S E McLinn, G H Aronovitz, M E Pichichero, A Kumar, E L Kaplan, M J Ossi
Antimicrobial Agents and Chemotherapy Feb 1993, 37 (2) 159-163; DOI: 10.1128/AAC.37.2.159

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Efficacy of cefuroxime axetil suspension compared with that of penicillin V suspension in children with group A streptococcal pharyngitis.
W M Gooch 3rd, S E McLinn, G H Aronovitz, M E Pichichero, A Kumar, E L Kaplan, M J Ossi
Antimicrobial Agents and Chemotherapy Feb 1993, 37 (2) 159-163; DOI: 10.1128/AAC.37.2.159
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