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Research Article

Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection.

M Chen, T G Theander, S B Christensen, L Hviid, L Zhai, A Kharazmi
M Chen
Department of Clinical Microbiology, National University Hospital, Copenhagen, Denmark.
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T G Theander
Department of Clinical Microbiology, National University Hospital, Copenhagen, Denmark.
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S B Christensen
Department of Clinical Microbiology, National University Hospital, Copenhagen, Denmark.
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L Hviid
Department of Clinical Microbiology, National University Hospital, Copenhagen, Denmark.
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L Zhai
Department of Clinical Microbiology, National University Hospital, Copenhagen, Denmark.
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A Kharazmi
Department of Clinical Microbiology, National University Hospital, Copenhagen, Denmark.
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DOI: 10.1128/AAC.38.7.1470
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ABSTRACT

Licochalcone A, isolated from Chinese licorice roots, inhibited the in vitro growth of both chloroquine-susceptible (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum strains in a [3H]hypoxanthine uptake assay. The growth inhibition of the chloroquine-resistant strain by licochalcone A was similar to that of the chloroquine-susceptible strain. To examine the activity of licochalcone A on the different asexual blood stages of the parasite, licochalcone A was added to highly synchronized cultures containing rings, trophozoites, and schizonts. The growth of the parasites at all stages was inhibited by licochalcone A. The in vivo activity of licochalcone A was tested in a mouse model of infection with P. yoelii. Licochalcone A administered either intraperitoneally or orally for 3 to 6 days protected the mice from the otherwise lethal P. yoelii infection. These results demonstrate that licochalcone A exhibits potent antimalarial activity and might be developed into a new antimalarial drug.

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Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection.
M Chen, T G Theander, S B Christensen, L Hviid, L Zhai, A Kharazmi
Antimicrobial Agents and Chemotherapy Jul 1994, 38 (7) 1470-1475; DOI: 10.1128/AAC.38.7.1470

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Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection.
M Chen, T G Theander, S B Christensen, L Hviid, L Zhai, A Kharazmi
Antimicrobial Agents and Chemotherapy Jul 1994, 38 (7) 1470-1475; DOI: 10.1128/AAC.38.7.1470
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