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Comparative Study | Journal Article | Research Support, Non-U.S. Gov't

In vitro activities of the oxazolidinone antibiotics U-100592 and U-100766 against Staphylococcus aureus and coagulase-negative Staphylococcus species.

J H Jorgensen, M L McElmeel, C W Trippy
J H Jorgensen
Department of Pathology, University of Texas Health Science Center, San Antonio 78284-7750, USA.
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M L McElmeel
Department of Pathology, University of Texas Health Science Center, San Antonio 78284-7750, USA.
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C W Trippy
Department of Pathology, University of Texas Health Science Center, San Antonio 78284-7750, USA.
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DOI: 10.1128/AAC.41.2.465
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ABSTRACT

U-100592 and U-100766 are closely related antibiotics of the oxazolidinone class. Their in vitro activities were determined against 100 isolates of Staphylococcus aureus and 100 isolates of coagulase-negative Staphylococcus species by broth and agar dilution test methods. The MICs of both compounds by either test method at which 50 and 90% of isolates are inhibited were 2 and 4 micrograms/ml, respectively, for S. aureus and 1 to 2 micrograms/ml for coagulase-negative staphylococci. Time-kill assay with selected strains indicated a primarily bacteriostatic effect against staphylococci.

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In vitro activities of the oxazolidinone antibiotics U-100592 and U-100766 against Staphylococcus aureus and coagulase-negative Staphylococcus species.
J H Jorgensen, M L McElmeel, C W Trippy
Antimicrobial Agents and Chemotherapy Feb 1997, 41 (2) 465-467; DOI: 10.1128/AAC.41.2.465

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In vitro activities of the oxazolidinone antibiotics U-100592 and U-100766 against Staphylococcus aureus and coagulase-negative Staphylococcus species.
J H Jorgensen, M L McElmeel, C W Trippy
Antimicrobial Agents and Chemotherapy Feb 1997, 41 (2) 465-467; DOI: 10.1128/AAC.41.2.465
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