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Journal Article

Effects of 2',3'-dideoxyinosine on Toxoplasma gondii cysts in mice.

M E Sarciron, P Lawton, C Saccharin, A F Petavy, F Peyron
M E Sarciron
Department of Parasitology and Medical Mycology, Claude Bernard University, Lyon, France. sarciron@cismsun.univ-lyon1.fr
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P Lawton
Department of Parasitology and Medical Mycology, Claude Bernard University, Lyon, France. sarciron@cismsun.univ-lyon1.fr
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C Saccharin
Department of Parasitology and Medical Mycology, Claude Bernard University, Lyon, France. sarciron@cismsun.univ-lyon1.fr
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A F Petavy
Department of Parasitology and Medical Mycology, Claude Bernard University, Lyon, France. sarciron@cismsun.univ-lyon1.fr
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F Peyron
Department of Parasitology and Medical Mycology, Claude Bernard University, Lyon, France. sarciron@cismsun.univ-lyon1.fr
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DOI: 10.1128/AAC.41.7.1531
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ABSTRACT

The activity against Toxoplasma gondii of 2',3' dideoxyinosine (ddI), an anti-human immunodeficiency virus drug, was examined in an in vitro and in vivo study. Cell cultures infected with a strain known to cause chronic infections were used to show the dose-dependent effect of this drug compared with spiramycin and sulfadiazine. When a dose of 4 microg/ml was used, no infected THP-1 cells or parasites were found after 60 h of incubation. An electron-microscopic study confirmed that after 12 h at 1 microg/ml, the few parasites observed were severely altered. The treatment of chronically infected mice 3 months postinfection showed that a 30-day treatment with 2 mg of ddI/ml induced a significant reduction in the number of T. gondii cysts in the cerebral tissue. These cysts were not viable, as confirmed by immunofluorescence and reinfection experiments. These experiments suggest a possible role for ddI in the treatment of toxoplasmosis, and this possibility deserves further investigation.

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Effects of 2',3'-dideoxyinosine on Toxoplasma gondii cysts in mice.
M E Sarciron, P Lawton, C Saccharin, A F Petavy, F Peyron
Antimicrobial Agents and Chemotherapy Jul 1997, 41 (7) 1531-1536; DOI: 10.1128/AAC.41.7.1531

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Effects of 2',3'-dideoxyinosine on Toxoplasma gondii cysts in mice.
M E Sarciron, P Lawton, C Saccharin, A F Petavy, F Peyron
Antimicrobial Agents and Chemotherapy Jul 1997, 41 (7) 1531-1536; DOI: 10.1128/AAC.41.7.1531
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