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Journal Article | Research Support, U.S. Gov't, P.H.S.

Hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi as a target for structure-based inhibitor design: crystallization and inhibition studies with purine analogs.

A E Eakin, A Guerra, P J Focia, J Torres-Martinez, S P Craig 3rd
A E Eakin
Division of Medicinal Chemistry, School of Pharmacy, University of North Carolina at Chapel Hill, 27599-7360, USA. eakin@unc.edu
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A Guerra
Division of Medicinal Chemistry, School of Pharmacy, University of North Carolina at Chapel Hill, 27599-7360, USA. eakin@unc.edu
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P J Focia
Division of Medicinal Chemistry, School of Pharmacy, University of North Carolina at Chapel Hill, 27599-7360, USA. eakin@unc.edu
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J Torres-Martinez
Division of Medicinal Chemistry, School of Pharmacy, University of North Carolina at Chapel Hill, 27599-7360, USA. eakin@unc.edu
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S P Craig 3rd
Division of Medicinal Chemistry, School of Pharmacy, University of North Carolina at Chapel Hill, 27599-7360, USA. eakin@unc.edu
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DOI: 10.1128/AAC.41.8.1686
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Article Information

DOI 
https://doi.org/10.1128/AAC.41.8.1686
PubMed 
9257742

Published By 
American Society for Microbiology Journals
History 
  • Published online August 1, 1997.

Author Information

  1. A E Eakin,
  2. A Guerra,
  3. P J Focia,
  4. J Torres-Martinez and
  5. S P Craig 3rd
  1. Division of Medicinal Chemistry, School of Pharmacy, University of North Carolina at Chapel Hill, 27599-7360, USA. eakin@unc.edu

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Hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi as a target for structure-based inhibitor design: crystallization and inhibition studies with purine analogs.
A E Eakin, A Guerra, P J Focia, J Torres-Martinez, S P Craig 3rd
Antimicrobial Agents and Chemotherapy Aug 1997, 41 (8) 1686-1692; DOI: 10.1128/AAC.41.8.1686

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Hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi as a target for structure-based inhibitor design: crystallization and inhibition studies with purine analogs.
A E Eakin, A Guerra, P J Focia, J Torres-Martinez, S P Craig 3rd
Antimicrobial Agents and Chemotherapy Aug 1997, 41 (8) 1686-1692; DOI: 10.1128/AAC.41.8.1686
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