Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About AAC
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • AAC Podcast
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Antimicrobial Agents and Chemotherapy
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About AAC
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • AAC Podcast
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
Susceptibility

Kenyan Plasmodium falciparum Field Isolates: Correlation between Pyrimethamine and Chlorcycloguanil Activity In Vitro and Point Mutations in the Dihydrofolate Reductase Domain

A. Nzila-Mounda, E. K. Mberu, C. H. Sibley, C. V. Plowe, P. A. Winstanley, W. M. Watkins
A. Nzila-Mounda
Wellcome Trust Research Laboratories,
Kenya Medical Research Institute, and
University of Washington Department of Genetics, Seattle, Washington 98195-7360;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
E. K. Mberu
Wellcome Trust Research Laboratories,
Department of Pharmaceutics and Pharmacy Practice, Faculty of Pharmacy, University of Nairobi, Nairobi, Kenya;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. H. Sibley
University of Washington Department of Genetics, Seattle, Washington 98195-7360;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. V. Plowe
University of Maryland, Division of Geographic Medicine and Entomology, Baltimore, Maryland 21201; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P. A. Winstanley
University of Liverpool, Department of Pharmacology and Therapeutics, Liverpool L69 3BX, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
W. M. Watkins
Wellcome Trust Research Laboratories,
Kenya Medical Research Institute, and
University of Liverpool, Department of Pharmacology and Therapeutics, Liverpool L69 3BX, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1128/AAC.42.1.164
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1128/AAC.42.1.164
PubMed 
9449279

Published By 
American Society for Microbiology Journals
History 
  • Received June 11, 1997
  • Returned for modification August 20, 1997
  • Accepted October 20, 1997
  • Published online January 1, 1998.

Copyright & Usage 
Copyright © 1998 American Society for Microbiology

Author Information

  1. A. Nzila-Mounda1,2,3*,
  2. E. K. Mberu1,4,
  3. C. H. Sibley3,
  4. C. V. Plowe5,
  5. P. A. Winstanley6 and
  6. W. M. Watkins1,2,6
  1. Wellcome Trust Research Laboratories,1
  2. Kenya Medical Research Institute,2 and
  3. Department of Pharmaceutics and Pharmacy Practice, Faculty of Pharmacy, University of Nairobi,4 Nairobi, Kenya;
  4. University of Washington Department of Genetics, Seattle, Washington 98195-73603;
  5. University of Maryland, Division of Geographic Medicine and Entomology, Baltimore, Maryland 212015; and
  6. University of Liverpool, Department of Pharmacology and Therapeutics, Liverpool L69 3BX, United Kingdom6
  • ↵* Corresponding author. Mailing address: Wellcome Trust Research Laboratories, P.O. Box 43640, Nairobi, Kenya. Phone: 254 2 725 390 or 254 2 725 398. Fax: 254 2 711 673. E-mail:wellcome{at}users.africaonline.co.ke.

View Abstract

Article usage

Article usage: January 1999 to January 2021

Rendering graph...
AbstractFullPdf
Jan 1999260
Feb 1999281
Mar 1999637
Apr 1999332
May 1999105
Jun 1999303
Jul 1999221
Aug 1999212
Sep 1999212
Oct 1999212
Nov 19994106
Dec 1999266
Jan 2000115
Feb 2000135
Mar 2000253
Apr 2000002
May 2000035
Jun 20003145
Jul 20003143
Aug 2000385
Sep 2000210
Oct 200011910
Nov 2000262
Dec 2000623
Jan 2001314
Feb 200110715
Mar 2001130
Apr 20014103
May 2001113
Jun 2001547
Jul 2001152
Aug 20010102
Sep 2001223
Oct 2001261
Nov 20014114
Dec 2001332
Jan 2002023
Feb 2002492
Mar 2002023
Apr 2002345
May 20021811
Jun 2002064
Jul 2002155
Aug 200211313
Sep 2002234
Oct 2002069
Nov 2002244
Dec 2002320
Jan 2003125
Feb 2003035
Mar 20033711
Apr 20031139
May 2003186
Jun 2003026
Jul 2003453
Aug 20038114
Sep 200372912
Oct 200371517
Nov 200314275
Dec 20037124
Jan 200410248
Feb 20049132
Mar 200410286
Apr 200410145
May 200412151
Jun 200412286
Jul 200410245
Aug 200410328
Sep 200462516
Oct 20045155
Nov 20045194
Dec 200482710
Jan 20050205
Feb 20053132
Mar 20053106
Apr 20052119
May 2005384
Jun 2005182
Jul 2005684
Aug 200562213
Sep 2005294
Oct 20054103
Nov 20055145
Dec 20055142
Jan 20067226
Feb 20062142
Mar 20066225
Apr 20066105
May 20063208
Jun 2006450
Jul 2006294
Aug 2006291
Sep 2006341
Oct 20065127
Nov 2006992
Dec 2006954
Jan 2007873
Feb 2007653
Mar 2007692
Apr 2007760
May 20077111
Jun 2007394
Jul 20071356
Aug 2007474
Sep 20076102
Oct 20071066
Nov 2007473
Dec 2007152
Jan 20081176
Feb 20081152
Mar 2008939
Apr 200841220
May 20081682
Jun 20081181
Jul 20081283
Aug 20081450
Sep 2008464
Oct 2008678
Nov 2008554
Dec 2008355
Jan 20091143
Feb 20091344
Mar 2009444
Apr 2009682
May 2009473
Jun 2009552
Jul 20091024
Aug 2009421
Sep 2009244
Oct 2009661
Nov 2009260
Dec 2009011
Jan 20101154
Feb 2010634
Mar 2010453
Apr 2010431
May 20109108
Jun 2010320
Jul 2010241
Aug 2010713
Sep 2010302
Oct 2010425
Nov 2010553
Dec 2010643
Jan 2011423
Feb 20111081
Mar 201112136
Apr 20116115
May 2011621
Jun 2011767
Jul 2011443
Aug 2011554
Sep 20115110
Oct 2011965
Nov 20111443
Dec 2011860
Jan 20121122
Feb 2012144
Mar 20121033
Apr 2012512
May 20129135
Jun 2012631
Jul 2012323
Aug 2012974
Sep 2012951
Oct 2012432
Nov 2012756
Dec 2012451
Jan 2013751
Feb 2013832
Mar 2013423
Apr 20139122
May 2013743
Jun 2013235
Jul 2013681
Aug 2013421
Sep 2013383
Oct 2013512
Nov 2013883
Dec 2013251
Jan 20144183
Feb 2014461
Mar 201410102
Apr 20147143
May 20141155
Jun 20141105
Jul 2014640
Aug 2014540
Sep 2014181
Oct 2014101
Nov 2014311
Dec 20141330
Jan 2015970
Feb 2015483
Mar 2015671
Apr 2015200
May 20151443
Jun 20151131
Jul 2015532
Aug 2015741
Sep 2015734
Oct 2015130
Nov 2015451
Dec 2015910
Jan 20161228
Feb 2016635
Mar 20165311
Apr 2016301
May 2016420
Jun 20161221
Jul 2016103
Aug 2016121
Sep 2016323
Oct 2016301
Nov 20161224
Dec 2016111
Jan 2017230
Feb 20171222
Mar 2017100
Apr 2017110
May 2017210
Jun 2017700
Jul 20171103
Aug 2017400
Sep 2017201
Oct 2017523
Nov 2017131
Dec 2017101
Jan 2018400
Feb 2018121
Mar 2018412
Apr 2018210
May 2018402
Jun 2018220
Jul 2018112
Aug 2018461
Sep 20180111
Oct 2018373
Nov 2018072
Dec 2018286
Jan 2019162
Feb 2019122
Mar 2019195
Apr 2019051
May 2019073
Jun 2019158
Jul 2019142
Aug 2019386
Sep 2019145
Oct 2019271
Nov 2019014
Dec 2019033
Jan 2020367
Feb 2020031
Mar 2020345
Apr 20200142
May 2020053
Jun 2020444
Jul 20201165
Aug 2020061
Sep 20200225
Oct 20200185
Nov 20201123
Dec 2020173
Jan 2021174
PreviousNext
Back to top
Download PDF
Citation Tools
Kenyan Plasmodium falciparum Field Isolates: Correlation between Pyrimethamine and Chlorcycloguanil Activity In Vitro and Point Mutations in the Dihydrofolate Reductase Domain
A. Nzila-Mounda, E. K. Mberu, C. H. Sibley, C. V. Plowe, P. A. Winstanley, W. M. Watkins
Antimicrobial Agents and Chemotherapy Jan 1998, 42 (1) 164-169; DOI: 10.1128/AAC.42.1.164

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Alerts
Sign In to Email Alerts with your Email Address
Email

Thank you for sharing this Antimicrobial Agents and Chemotherapy article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Kenyan Plasmodium falciparum Field Isolates: Correlation between Pyrimethamine and Chlorcycloguanil Activity In Vitro and Point Mutations in the Dihydrofolate Reductase Domain
(Your Name) has forwarded a page to you from Antimicrobial Agents and Chemotherapy
(Your Name) thought you would be interested in this article in Antimicrobial Agents and Chemotherapy.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Kenyan Plasmodium falciparum Field Isolates: Correlation between Pyrimethamine and Chlorcycloguanil Activity In Vitro and Point Mutations in the Dihydrofolate Reductase Domain
A. Nzila-Mounda, E. K. Mberu, C. H. Sibley, C. V. Plowe, P. A. Winstanley, W. M. Watkins
Antimicrobial Agents and Chemotherapy Jan 1998, 42 (1) 164-169; DOI: 10.1128/AAC.42.1.164
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • ABSTRACT
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

antimalarials
Plasmodium falciparum
Point Mutation
proguanil
Protozoan Proteins
pyrimethamine
Tetrahydrofolate Dehydrogenase
Triazines

Related Articles

Cited By...

About

  • About AAC
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • AAC Podcast
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #AACJournal

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0066-4804; Online ISSN: 1098-6596