Kenyan Plasmodium falciparum Field Isolates: Correlation between Pyrimethamine and Chlorcycloguanil Activity In Vitro and Point Mutations in the Dihydrofolate Reductase Domain

A. Nzila-Mounda; E. K. Mberu; C. H. Sibley; C. V. Plowe; P. A. Winstanley; W. M. Watkins

doi:10.1128/AAC.42.1.164

DOI: 10.1128/AAC.42.1.164

Article Information

DOI

https://doi.org/10.1128/AAC.42.1.164

PubMed

9449279

Published By

American Society for Microbiology Journals

History

Received June 11, 1997
Returned for modification August 20, 1997
Accepted October 20, 1997
Published online January 1, 1998.

Author Information

A. Nzila-Mounda¹,²,³ *,
E. K. Mberu¹,⁴,
C. H. Sibley³,
C. V. Plowe⁵,
P. A. Winstanley⁶ and
W. M. Watkins¹,²,⁶

Wellcome Trust Research Laboratories,¹
Kenya Medical Research Institute,² and
Department of Pharmaceutics and Pharmacy Practice, Faculty of Pharmacy, University of Nairobi,⁴ Nairobi, Kenya;
University of Washington Department of Genetics, Seattle, Washington 98195-7360³;
University of Maryland, Division of Geographic Medicine and Entomology, Baltimore, Maryland 21201⁵; and
University of Liverpool, Department of Pharmacology and Therapeutics, Liverpool L69 3BX, United Kingdom⁶

↵* Corresponding author. Mailing address: Wellcome Trust Research Laboratories, P.O. Box 43640, Nairobi, Kenya. Phone: 254 2 725 390 or 254 2 725 398. Fax: 254 2 711 673. E-mail:wellcome{at}users.africaonline.co.ke.

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