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Mechanisms of Resistance

Novel OXA-10-Derived Extended-Spectrum β-Lactamases Selected In Vivo or In Vitro

P. Mugnier, I. Casin, A. T. Bouthors, E. Collatz
P. Mugnier
Laboratoire de Recherche Moléculaire sur les Antibiotiques, UFR Broussais-Hôtel Dieu and UFR Pitié-Salpêtrière, Université Paris VI, and
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I. Casin
Laboratoire de Recherche Moléculaire sur les Antibiotiques, UFR Broussais-Hôtel Dieu and UFR Pitié-Salpêtrière, Université Paris VI, and
Laboratoire de Bactériologie, Hôpital Saint-Louis, UniversitéParis VII, Paris, France
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A. T. Bouthors
Laboratoire de Recherche Moléculaire sur les Antibiotiques, UFR Broussais-Hôtel Dieu and UFR Pitié-Salpêtrière, Université Paris VI, and
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E. Collatz
Laboratoire de Recherche Moléculaire sur les Antibiotiques, UFR Broussais-Hôtel Dieu and UFR Pitié-Salpêtrière, Université Paris VI, and
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DOI: 10.1128/AAC.42.12.3113
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ABSTRACT

A clinical isolate of Pseudomonas aeruginosa, PAe191, was found to be highly resistant to all anti-Pseudomonasβ-lactam antibiotics (except imipenem) and resistant also to aminoglycosides. It produced a β-lactamase (with an apparent pI of 7.6) which was not inhibited by clavulanic acid. Cloning and characterization of the β-lactamase gene showed that it coded for a novel extended-spectrum OXA-10 variant, called OXA-19, which differed from OXA-10 by nine amino acids and from OXA-13 by two, i.e., Asn in position 73 (Asn73) instead of Ser and Asp157 instead of Gly. Asparagine in position 157 is implicated in resistance to ceftazidime, while the amino acid in position 73, in this variant, seems to condition the level of resistance to penicillins. The oxa19gene was found to be inserted, in a typical integron structure, immediately downstream from anaac(6′)-Ib gene coding for an aminoglycoside acetyltransferase variant, which was called AAC(6′)-Ib9.

  • Copyright © 1998 American Society for Microbiology
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Novel OXA-10-Derived Extended-Spectrum β-Lactamases Selected In Vivo or In Vitro
P. Mugnier, I. Casin, A. T. Bouthors, E. Collatz
Antimicrobial Agents and Chemotherapy Dec 1998, 42 (12) 3113-3116; DOI: 10.1128/AAC.42.12.3113

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Novel OXA-10-Derived Extended-Spectrum β-Lactamases Selected In Vivo or In Vitro
P. Mugnier, I. Casin, A. T. Bouthors, E. Collatz
Antimicrobial Agents and Chemotherapy Dec 1998, 42 (12) 3113-3116; DOI: 10.1128/AAC.42.12.3113
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KEYWORDS

Pseudomonas aeruginosa
beta-lactamases

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