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Mechanisms of Action: Physiological Effects

Inhibition of RNA Synthesis as a Therapeutic Strategy against Aspergillus and Fusarium: Demonstration of In Vitro Synergy between Rifabutin and Amphotericin B

Cornelius J. Clancy, Yue C. Yu, Alfred Lewin, M. Hong Nguyen
Cornelius J. Clancy
Division of Infectious Disease, Department of Medicine, and
Veterans Affairs Medical Center, Gainesville, Florida
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Yue C. Yu
Division of Infectious Disease, Department of Medicine, and
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Alfred Lewin
Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, and the
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M. Hong Nguyen
Division of Infectious Disease, Department of Medicine, and
Veterans Affairs Medical Center, Gainesville, Florida
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DOI: 10.1128/AAC.42.3.509
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Article Information

DOI 
https://doi.org/10.1128/AAC.42.3.509
PubMed 
9517924

Published By 
American Society for Microbiology Journals
History 
  • Received May 19, 1997
  • Returned for modification August 15, 1997
  • Accepted December 8, 1997
  • Published online March 1, 1998.

Copyright & Usage 
Copyright © 1998 American Society for Microbiology

Author Information

  1. Cornelius J. Clancy1,3,
  2. Yue C. Yu1,
  3. Alfred Lewin2 and
  4. M. Hong Nguyen1,3*
  1. Division of Infectious Disease, Department of Medicine,1 and
  2. Department of Molecular Genetics and Microbiology,2 University of Florida College of Medicine, and the
  3. Veterans Affairs Medical Center,3 Gainesville, Florida
  • ↵* Corresponding author. Mailing address: Department of Medicine, University of Florida College of Medicine, P.O. Box 100277, JHMHC, Gainesville, FL 32610. Phone: (352) 392-4058. Fax: (352) 392-6481. E-mail: nguyemt{at}medicine.ufl.edu.

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Inhibition of RNA Synthesis as a Therapeutic Strategy against Aspergillus and Fusarium: Demonstration of In Vitro Synergy between Rifabutin and Amphotericin B
Cornelius J. Clancy, Yue C. Yu, Alfred Lewin, M. Hong Nguyen
Antimicrobial Agents and Chemotherapy Mar 1998, 42 (3) 509-513; DOI: 10.1128/AAC.42.3.509

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Inhibition of RNA Synthesis as a Therapeutic Strategy against Aspergillus and Fusarium: Demonstration of In Vitro Synergy between Rifabutin and Amphotericin B
Cornelius J. Clancy, Yue C. Yu, Alfred Lewin, M. Hong Nguyen
Antimicrobial Agents and Chemotherapy Mar 1998, 42 (3) 509-513; DOI: 10.1128/AAC.42.3.509
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KEYWORDS

amphotericin B
Aspergillus
Drug Therapy, Combination
Fusarium
RNA, Fungal
rifabutin

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