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Mechanisms of Action: Physiological Effects

Identification of Elongation Factor 2 as the Essential Protein Targeted by Sordarins in Candida albicans

Juan Manuel Domínguez, J. Julio Martín
Juan Manuel Domínguez
Departamento de Investigación, Glaxo Wellcome S.A. 28760-Tres Cantos, Madrid, Spain
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J. Julio Martín
Departamento de Investigación, Glaxo Wellcome S.A. 28760-Tres Cantos, Madrid, Spain
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DOI: 10.1128/AAC.42.9.2279
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ABSTRACT

The target for sordarins in Candida albicans has been elucidated. Kinetic experiments of sordarin inhibition as well as displacement experiments showed that the formation of a sordarin-target complex follows a reversible mechanism. Binding of tritiated drug to the target is enhanced in the presence of ribosomes. Isolation of the target by classical protein purification methods has allowed us to identify it as elongation factor 2. This is in agreement with the nature of sordarin derivatives as specific inhibitors of the elongation cycle within protein synthesis in yeasts.

  • Copyright © 1998 American Society for Microbiology
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Identification of Elongation Factor 2 as the Essential Protein Targeted by Sordarins in Candida albicans
Juan Manuel Domínguez, J. Julio Martín
Antimicrobial Agents and Chemotherapy Sep 1998, 42 (9) 2279-2283; DOI: 10.1128/AAC.42.9.2279

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Identification of Elongation Factor 2 as the Essential Protein Targeted by Sordarins in Candida albicans
Juan Manuel Domínguez, J. Julio Martín
Antimicrobial Agents and Chemotherapy Sep 1998, 42 (9) 2279-2283; DOI: 10.1128/AAC.42.9.2279
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KEYWORDS

antifungal agents
Candida albicans
Peptide Elongation Factors
Protein Synthesis Inhibitors

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