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Pharmacology

Single-Dose Pharmacokinetics of Meropenem during Continuous Venovenous Hemofiltration

Florian Thalhammer, Peter Schenk, Heinz Burgmann, Ibrahim El Menyawi, Ursula M. Hollenstein, Alexander R. Rosenkranz, Gere Sunder-Plassmann, Stefan Breyer, Klaus Ratheiser
Florian Thalhammer
Department of Internal Medicine I, Division of Infectious Diseases,
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Peter Schenk
Department of Internal Medicine IV, Intensive Care Unit,and
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Heinz Burgmann
Department of Internal Medicine I, Division of Infectious Diseases,
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Ibrahim El Menyawi
Department of Internal Medicine I, Division of Infectious Diseases,
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Ursula M. Hollenstein
Department of Internal Medicine I, Division of Infectious Diseases,
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Alexander R. Rosenkranz
Department of Internal Medicine III, Division of Nephrology and Dialysis, University of Vienna, A-1090 Vienna, Austria
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Gere Sunder-Plassmann
Department of Internal Medicine III, Division of Nephrology and Dialysis, University of Vienna, A-1090 Vienna, Austria
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Stefan Breyer
Department of Internal Medicine I, Division of Infectious Diseases,
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Klaus Ratheiser
Department of Internal Medicine IV, Intensive Care Unit,and
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DOI: 10.1128/AAC.42.9.2417
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ABSTRACT

The pharmacokinetic properties of meropenem were investigated in nine critically ill patients treated by continuous venovenous hemofiltration (CVVH). All patients received one dose of 1 g of meropenem intravenously. High-flux polysulfone membranes were used as dialyzers. Meropenem levels were measured in plasma and ultrafiltrate by high-performance liquid chromatography. The total body clearance and elimination half-life were 143.7 ± 18.6 ml/min and 2.46 ± 0.41 h, respectively. The post- to prehemofiltration ratio of meropenem was 0.24 ± 0.06. Peak plasma drug concentrations measured 60 min postinfusion were 28.1 ± 2.7 μg/ml, and trough levels after 6 h of CVVH were 6.6 ± 1.5 μg/ml. The calculated total daily meropenem requirement in these patients with acute renal failure and undergoing CVVH was 2,482 ± 321 mg. Based on these data, we conclude that patients with severe infections who are undergoing CVVH can be treated effectively with 1 g of meropenem every 8 h.

  • Copyright © 1998 American Society for Microbiology
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Single-Dose Pharmacokinetics of Meropenem during Continuous Venovenous Hemofiltration
Florian Thalhammer, Peter Schenk, Heinz Burgmann, Ibrahim El Menyawi, Ursula M. Hollenstein, Alexander R. Rosenkranz, Gere Sunder-Plassmann, Stefan Breyer, Klaus Ratheiser
Antimicrobial Agents and Chemotherapy Sep 1998, 42 (9) 2417-2420; DOI: 10.1128/AAC.42.9.2417

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Single-Dose Pharmacokinetics of Meropenem during Continuous Venovenous Hemofiltration
Florian Thalhammer, Peter Schenk, Heinz Burgmann, Ibrahim El Menyawi, Ursula M. Hollenstein, Alexander R. Rosenkranz, Gere Sunder-Plassmann, Stefan Breyer, Klaus Ratheiser
Antimicrobial Agents and Chemotherapy Sep 1998, 42 (9) 2417-2420; DOI: 10.1128/AAC.42.9.2417
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KEYWORDS

hemofiltration
Thienamycins

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