Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About AAC
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • AAC Podcast
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Antimicrobial Agents and Chemotherapy
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About AAC
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • AAC Podcast
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
Susceptibility

In Vitro Activities of Voriconazole, Fluconazole, and Itraconazole against 566 Clinical Isolates of Cryptococcus neoformans from the United States and Africa

M. A. Pfaller, J. Zhang, S. A. Messer, M. E. Brandt, R. A. Hajjeh, C. J. Jessup, M. Tumberland, E. K. Mbidde, M. A. Ghannoum
M. A. Pfaller
Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Zhang
Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. A. Messer
Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. E. Brandt
Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. A. Hajjeh
Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. J. Jessup
Mycology Reference Laboratory, Center for Medical Mycology, Department of Dermatology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Tumberland
University of California San Francisco, San Francisco, California; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
E. K. Mbidde
Uganda Cancer Institute, Kampala, Uganda
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. A. Ghannoum
Mycology Reference Laboratory, Center for Medical Mycology, Department of Dermatology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1128/AAC.43.1.169
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Tables

  • Table 1.

    In vitro susceptibilities of 566 clinical isolates ofC. neoformans to voriconazole and itraconazole stratified by fluconazole susceptibility category

    Fluconazole susceptibility category (μg/ml)aIsolate sourceNo. of isolates testedMIC (μg/ml)
    ItraconazoleVoriconazole
    RangeMIC50MIC90RangeMIC50MIC90
    ≤8.0Africa1540.06–0.50.250.50.015–0.250.120.12
    United States321≤0.007–0.50.250.5≤0.007–0.120.060.06
    All475≤0.007–0.50.250.5≤0.007–0.250.060.12
    16–32Africa100.25–1.00.51.00.25–0.50.250.25
    United States780.25–1.00.51.00.03–0.50.120.25
    All880.25–1.00.51.00.03–0.50.120.25
    ≥64Africa
    United States30.5–1.00.50.25–2.01.0
    All30.5–1.00.50.25–2.01.0
     TotalAfrica1640.06–1.00.250.50.015–0.50.120.25
    United States402≤0.007–1.00.250.5≤0.007–2.00.060.12
    All566≤0.007–1.00.250.5≤0.007–2.00.060.12
    • ↵a Fluconazole MICs ranged from 0.12 to >128 μg/ml with a MIC50 of 8.0 μg/ml (both United States and Africa) and a MIC90 of 16 μg/ml (United States, 16 μg/ml; Africa, 8.0 μg/ml).

PreviousNext
Back to top
Download PDF
Citation Tools
In Vitro Activities of Voriconazole, Fluconazole, and Itraconazole against 566 Clinical Isolates of Cryptococcus neoformans from the United States and Africa
M. A. Pfaller, J. Zhang, S. A. Messer, M. E. Brandt, R. A. Hajjeh, C. J. Jessup, M. Tumberland, E. K. Mbidde, M. A. Ghannoum
Antimicrobial Agents and Chemotherapy Jan 1999, 43 (1) 169-171; DOI: 10.1128/AAC.43.1.169

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Alerts
Sign In to Email Alerts with your Email Address
Email

Thank you for sharing this Antimicrobial Agents and Chemotherapy article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
In Vitro Activities of Voriconazole, Fluconazole, and Itraconazole against 566 Clinical Isolates of Cryptococcus neoformans from the United States and Africa
(Your Name) has forwarded a page to you from Antimicrobial Agents and Chemotherapy
(Your Name) thought you would be interested in this article in Antimicrobial Agents and Chemotherapy.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
In Vitro Activities of Voriconazole, Fluconazole, and Itraconazole against 566 Clinical Isolates of Cryptococcus neoformans from the United States and Africa
M. A. Pfaller, J. Zhang, S. A. Messer, M. E. Brandt, R. A. Hajjeh, C. J. Jessup, M. Tumberland, E. K. Mbidde, M. A. Ghannoum
Antimicrobial Agents and Chemotherapy Jan 1999, 43 (1) 169-171; DOI: 10.1128/AAC.43.1.169
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • ABSTRACT
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

antifungal agents
Cryptococcus neoformans
fluconazole
itraconazole
Pyrimidines
triazoles

Related Articles

Cited By...

About

  • About AAC
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • AAC Podcast
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #AACJournal

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0066-4804; Online ISSN: 1098-6596