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Experimental Therapeutics

Clavulanate Induces Expression of the Pseudomonas aeruginosa AmpC Cephalosporinase at Physiologically Relevant Concentrations and Antagonizes the Antibacterial Activity of Ticarcillin

Philip D. Lister, Victoria M. Gardner, Christine C. Sanders
Philip D. Lister
Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178
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Victoria M. Gardner
Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178
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Christine C. Sanders
Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178
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DOI: 10.1128/AAC.43.4.882
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Article Information

DOI 
https://doi.org/10.1128/AAC.43.4.882
PubMed 
10103195

Published By 
American Society for Microbiology Journals
History 
  • Received August 10, 1998
  • Returned for modification December 3, 1998
  • Accepted January 31, 1999
  • Published online April 1, 1999.

Copyright & Usage 
Copyright © 1999 American Society for Microbiology

Author Information

  1. Philip D. Lister*,
  2. Victoria M. Gardner and
  3. Christine C. Sanders
  1. Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178
  • ↵* Corresponding author. Mailing address: Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178. Phone: (402) 280-1881. Fax: (402) 280-1225. E-mail: pdlister{at}creighton.edu.

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Clavulanate Induces Expression of the Pseudomonas aeruginosa AmpC Cephalosporinase at Physiologically Relevant Concentrations and Antagonizes the Antibacterial Activity of Ticarcillin
Philip D. Lister, Victoria M. Gardner, Christine C. Sanders
Antimicrobial Agents and Chemotherapy Apr 1999, 43 (4) 882-889; DOI: 10.1128/AAC.43.4.882

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Clavulanate Induces Expression of the Pseudomonas aeruginosa AmpC Cephalosporinase at Physiologically Relevant Concentrations and Antagonizes the Antibacterial Activity of Ticarcillin
Philip D. Lister, Victoria M. Gardner, Christine C. Sanders
Antimicrobial Agents and Chemotherapy Apr 1999, 43 (4) 882-889; DOI: 10.1128/AAC.43.4.882
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KEYWORDS

cephalosporinase
clavulanic acid
penicillins
Pseudomonas aeruginosa
ticarcillin

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