Article Figures & Data
Figures
- Fig. 1.
Susceptibility of bloodstream form T. brucei (A), T. cruzi epimastigotes (B), andL. major promastigotes (C) to rimantadine at different pHs. Parasites were cultured as described in the text in the presence or absence of 2 μg of rimantadine ml−1 (A) or 20 μg of rimantadine ml−1 (B, C). In the case of T. brucei, treatment with 20 μg of rimantadine ml−1resulted in total cell death at each pH tested. Values are expressed as a percentage of growth obtained at optimal pH in the absence of drug.
Tables
- Table 1.
Susceptibilities of the cultured bloodstream form ofT. brucei to rimantadine and amantadine
Drug pH of medium IC50 (μg ml−1) IC90 (μg ml−1) Rimantadine 7.4 1.26 ± 0.05 2.50 ± 0.30 7.6 0.98 ± 0.10 1.65 ± 0.19 Amantadine 7.4 >20 >20 7.6 13.8 ± 1.7 19.1 ± 0.5 a IC50 and IC90s were obtained from plots and are expressed relative to the growth of untreated cells at the corresponding pH (Fig. 1). Values shown are the means of three experiments ± standard deviations from the mean.
