In Vitro and In Vivo Experimental Activities of Antifungal Agents against Fusarium solani

DOI: 10.1128/AAC.43.5.1256

Article Figures & Data

Table 1.

MICs of amphotericin B, rifampin, and flucytosine alone and in combination^a

↵a Tests were performed with fungal inocula of 10³ conidia/ml at 30°C and 48 h of incubation. FIC, fractional inhibitory concentration; AMB, amphotericin B; RIF, rifampin; 5FC, flucytosine.

Table 2.

Survival of mice infected with F. solaniand treated with amphotericin B alone or combined with rifampin or flucytosine

Strain	Treatment group^a	No. of ani-mals that died/ no. tested	Survival time (days)
Strain	Treatment group^a	No. of ani-mals that died/ no. tested	Median (SE)	Range
FMR 5207	Control 1	10/10	2 (0.5)	1–14
	Control 2	10/10	2 (0.7)	1–22
	AMB 1.5 ip	10/10	3 (1.0)	1–8
	AMB 1.5 ip + RIF 20 or	10/10	2 (3.6)	1–27
	AMB 1.5 ip + 5FC 150 or	10/10	4 (1.1)	0–13
FMR 4391	Control 1	10/10	9 (2.1)	1–16
	Control 2	10/10	9 (2.1)	1–13
	AMB 1.5 ip	9/10	13 (2.6)	7–>30
	AMB 1.5 ip + RIF 20 or	9/10	13 (2.0)	4–>30
	AMB 1.5 ip + 5FC 150 or	10/10	10 (1.5)	1–22
FMR 4928	Control 1	9/10	13 (3.1)	2–>30
	Control 2	10/10	2	2–16
	AMB 1.5 ip	10/10	6^b (2.6)	2–13
	AMB 1.5 ip + RIF 20 or	10/10	3 (0.5)	2–14
	AMB 1.5 ip + 5FC 150 or	10/10	3 (0.7)	2–16
FMR 4927	Control 1	9/9	7 (4.4)	2–15
	Control 2	8/8	7 (4.9)	2–19
	AMB 1.5 ip	10/10	3 (1.1)	2–19
	AMB 1.5 ip + RIF 20 or	9/10	3 (0.3)	2–>30
	AMB 1.5 ip + 5FC 150 or	10/10	6 (1.5)	3–14
FMR 4931	Control 1	8/8	14 (0.4)	11–19
	Control 2	8/8	14 (0.9)	11–18
	AMB 1.5 ip	9/10	14 (3.3)	3–>30
	AMB 1.5 ip + RIF 20 or	10/10	14 (2.1)	2–26
	AMB 1.5 ip + 5FC 150 or	9/10	14 (4.6)	2–>30

↵a Control 1, saline solution; control 2, saline solution plus sterile distilled water; AMB 1.5 ip, amphotericin B at 1.5 mg/kg/day intraperitoneally; RIF 20 or, rifampin at 20 mg/kg/day orally; 5FC 150 or, flucytosine at 150 mg/kg/day orally.
↵b P < 0.5 versus control value (Wilcoxon rank sum).