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Susceptibility

Comparison of In Vitro Activity of Liposomal Nystatin againstAspergillus Species with Those of Nystatin, Amphotericin B (AB) Deoxycholate, AB Colloidal Dispersion, Liposomal AB, AB Lipid Complex, and Itraconazole

Karen L. Oakley, Caroline B. Moore, David W. Denning
Karen L. Oakley
Departments of Medicine and
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Caroline B. Moore
Microbiology, Hope Hospital, Salford, and
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David W. Denning
Departments of Medicine and
University of Manchester, and
Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, Manchester M8 6RB, United Kingdom
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DOI: 10.1128/AAC.43.5.1264
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Tables

  • Table 1.

    Summary of MICs for the Aspergillus species tested in this study

    Antimicrobial agentMIC (μg/ml)a
    A. fumigatusA. terreusA. flavusA. nigerTotal
    GM50%90%GM50%90%GM50%90%GM50%90%GM50%90%
    Liposomal nystatin1.92.02.08.7882.4241.4122.328
    Nystatin7.78.016.032.012.316165.7489.58>16
    Liposomal AB1.10.5432.0>16>1616.0>16>160.30.1312.11>16
    AB lipid complex1.61>1632.0>16>1629.3>16>160.10.250.252.52>16
    AB colloidal dispersion0.40.250.520.7>16>165.22>160.20.250.250.90.25>16
    AB0.60.515.716162.6240.30.50.50.90.54
    Itraconazole0.90.25>160.10.130.130.50.2510.50.50.50.60.25>16
    Fluconazoleb2,153>1,280>1,280 NDcNDNDNDNDNDNDNDND2,153>1,280>1,280
    • ↵a 50% and 90%, MICs for 50 and 90% of isolates tested, respectively. In calculating the GM values, a MIC of ≤0.03, >16, or >1,280 is assumed to be 0.03, 32, or 2,560 μg/liter, respectively.

    • ↵b Sixteen isolates were tested against fluconazole.

    • ↵c ND, not done.

  • Table 2.

    Summary of MFCs (99.99% killing) forAspergillus species tested in this study

    Antimicrobial agentMFC (μg/ml)a
    A. fumigatusA. terreusA. flavusA. nigerAll
    GM50%90%GM50%90%GM50%90%GM50%90%GM50%90%
    Liposomal nystatin21.4323232323232323222.63232243232
    Nystatin323232323232323232323232323232
    Liposomal AB31323232323232323211.3323227.53232
    AB lipid complex3232323232323232329.5323227.23232
    AB colloidal dispersion27.432323232323232324.4103222.43232
    AB8.3123232323210.48.0326.26329.81632
    Itraconazole25.4323214.732325.7163217.4323218.43232
    Fluconazoleb2,5602,5602,560 NDcNDNDNDNDNDNDNDND2,5602,5602,560
    • ↵a 50% and 90%, MFCs for 50 and 90% of isolates tested, respectively. In calculating the GM values, an MFC of >16 or >1,280 is assumed to be 32 or 2,560 μg/ml, respectively.

    • ↵b Sixteen isolates were tested against fluconazole.

    • ↵c ND, not done.

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Comparison of In Vitro Activity of Liposomal Nystatin againstAspergillus Species with Those of Nystatin, Amphotericin B (AB) Deoxycholate, AB Colloidal Dispersion, Liposomal AB, AB Lipid Complex, and Itraconazole
Karen L. Oakley, Caroline B. Moore, David W. Denning
Antimicrobial Agents and Chemotherapy May 1999, 43 (5) 1264-1266; DOI: 10.1128/AAC.43.5.1264

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Comparison of In Vitro Activity of Liposomal Nystatin againstAspergillus Species with Those of Nystatin, Amphotericin B (AB) Deoxycholate, AB Colloidal Dispersion, Liposomal AB, AB Lipid Complex, and Itraconazole
Karen L. Oakley, Caroline B. Moore, David W. Denning
Antimicrobial Agents and Chemotherapy May 1999, 43 (5) 1264-1266; DOI: 10.1128/AAC.43.5.1264
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KEYWORDS

amphotericin B
antifungal agents
Aspergillus
Drug Delivery Systems
itraconazole
Nystatin

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