Comparison of In Vitro Activity of Liposomal Nystatin againstAspergillus Species with Those of Nystatin, Amphotericin B (AB) Deoxycholate, AB Colloidal Dispersion, Liposomal AB, AB Lipid Complex, and Itraconazole | Antimicrobial Agents and Chemotherapy

DOI: 10.1128/AAC.43.5.1264

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Table 1.

Summary of MICs for the Aspergillus species tested in this study

Antimicrobial agent	MIC (μg/ml)^a
	A. fumigatus			A. terreus			A. flavus			A. niger			Total
	GM	50%	90%	GM	50%	90%	GM	50%	90%	GM	50%	90%	GM	50%	90%
Liposomal nystatin	1.9	2.0	2.0	8.7	8	8	2.4	2	4	1.4	1	2	2.3	2	8
Nystatin	7.7	8.0	16.0	32.0			12.3	16	16	5.7	4	8	9.5	8	>16
Liposomal AB	1.1	0.5	4	32.0	>16	>16	16.0	>16	>16	0.3	0.13	1	2.1	1	>16
AB lipid complex	1.6	1	>16	32.0	>16	>16	29.3	>16	>16	0.1	0.25	0.25	2.5	2	>16
AB colloidal dispersion	0.4	0.25	0.5	20.7	>16	>16	5.2	2	>16	0.2	0.25	0.25	0.9	0.25	>16
AB	0.6	0.5	1	5.7	16	16	2.6	2	4	0.3	0.5	0.5	0.9	0.5	4
Itraconazole	0.9	0.25	>16	0.1	0.13	0.13	0.5	0.25	1	0.5	0.5	0.5	0.6	0.25	>16
Fluconazole^b	2,153	>1,280	>1,280	ND^c	ND	ND	ND	ND	ND	ND	ND	ND	2,153	>1,280	>1,280

↵a 50% and 90%, MICs for 50 and 90% of isolates tested, respectively. In calculating the GM values, a MIC of ≤0.03, >16, or >1,280 is assumed to be 0.03, 32, or 2,560 μg/liter, respectively.
↵b Sixteen isolates were tested against fluconazole.
↵c ND, not done.

Table 2.

Summary of MFCs (99.99% killing) forAspergillus species tested in this study

Antimicrobial agent	MFC (μg/ml)^a
	A. fumigatus			A. terreus			A. flavus			A. niger			All
	GM	50%	90%	GM	50%	90%	GM	50%	90%	GM	50%	90%	GM	50%	90%
Liposomal nystatin	21.4	32	32	32	32	32	32	32	32	22.6	32	32	24	32	32
Nystatin	32	32	32	32	32	32	32	32	32	32	32	32	32	32	32
Liposomal AB	31	32	32	32	32	32	32	32	32	11.3	32	32	27.5	32	32
AB lipid complex	32	32	32	32	32	32	32	32	32	9.5	32	32	27.2	32	32
AB colloidal dispersion	27.4	32	32	32	32	32	32	32	32	4.4	10	32	22.4	32	32
AB	8.3	12	32	32	32	32	10.4	8.0	32	6.2	6	32	9.8	16	32
Itraconazole	25.4	32	32	14.7	32	32	5.7	16	32	17.4	32	32	18.4	32	32
Fluconazole^b	2,560	2,560	2,560	ND^c	ND	ND	ND	ND	ND	ND	ND	ND	2,560	2,560	2,560

↵a 50% and 90%, MFCs for 50 and 90% of isolates tested, respectively. In calculating the GM values, an MFC of >16 or >1,280 is assumed to be 32 or 2,560 μg/ml, respectively.
↵b Sixteen isolates were tested against fluconazole.
↵c ND, not done.

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