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Susceptibility

In Vitro Activities of Antibiotics Alone and in Combination against Brucella melitensis at Neutral and Acidic pHs

Murat Akova, Deniz Gür, David M. Livermore, Tanil Kocagöz, H. Erdal Akalin
Murat Akova
Department of Medicine, Section of Infectious Diseases, Hacettepe University School of Medicine, 06100 Ankara, Turkey
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Deniz Gür
Department of Medicine, Section of Infectious Diseases, Hacettepe University School of Medicine, 06100 Ankara, Turkey
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David M. Livermore
Department of Medicine, Section of Infectious Diseases, Hacettepe University School of Medicine, 06100 Ankara, Turkey
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Tanil Kocagöz
Department of Medicine, Section of Infectious Diseases, Hacettepe University School of Medicine, 06100 Ankara, Turkey
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H. Erdal Akalin
Department of Medicine, Section of Infectious Diseases, Hacettepe University School of Medicine, 06100 Ankara, Turkey
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DOI: 10.1128/AAC.43.5.1298
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    Fig. 1.

    Interactions of different antibiotic combinations at pH 7.0 (A) and at pH 5.0 (B) against 20 B. melitensis isolates. R, rifampin; A, azithromycin; O, ofloxacin; D, doxycycline; S, streptomycin.

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    In vitro activities of antibiotics against B. melitensis isolates (n = 43) in relation to pH

    AntibioticMIC (μg/ml)
    Range50%90%
    pH 7.0pH 5.0pH 7.0pH 5.0pH 7.0pH 5.0
    Erythromycin0.5–25632–>2568>256128>256
    Azithromycin<0.125–416–>25612561>256
    Streptomycin0.25–88–2561162128
    Doxycycline<0.125–8<0.125–8<0.1251<0.1252
    Rifampin1–32<0.125–120.2521
    Ciprofloxacin<0.125–82–>160.50162>16
    Ofloxacin<0.125–44–>161161>16
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In Vitro Activities of Antibiotics Alone and in Combination against Brucella melitensis at Neutral and Acidic pHs
Murat Akova, Deniz Gür, David M. Livermore, Tanil Kocagöz, H. Erdal Akalin
Antimicrobial Agents and Chemotherapy May 1999, 43 (5) 1298-1300; DOI: 10.1128/AAC.43.5.1298

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In Vitro Activities of Antibiotics Alone and in Combination against Brucella melitensis at Neutral and Acidic pHs
Murat Akova, Deniz Gür, David M. Livermore, Tanil Kocagöz, H. Erdal Akalin
Antimicrobial Agents and Chemotherapy May 1999, 43 (5) 1298-1300; DOI: 10.1128/AAC.43.5.1298
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KEYWORDS

azithromycin
Brucella melitensis
doxycycline
Drug Therapy, Combination
quinolones
rifampin
streptomycin

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