DOI: 10.1128/AAC.43.7.1716
Article Figures & Data
Tables
- Table 2.
Survival of mice infected intravenously withH. capsulatuma
Study and inoculum (CFU) Drug or treatment Dose (mg/kg) No. of days of survival No. alive at day 30 Mean SEM Study A (2.0 × 106) Control None 15.2 2.9 2 GM2 20 30b 0 10 10 28.4b 2.6 9 5 29.1b 1.9 9 2 30b 0 10 Amphotericin B 1 30b 0 10 0.5 30b 0 10 Fluconazole 10 23.2 4.0 7 5 20.1 3.7 5 Study B (108) Control None 4.0 0.14 0 GM3 5 6.7b 0.9 0 1.25 4.9 0.4 0 0.3 4.0 0.3 0 0.06 4.1 0.2 0 Amphotericin B 1.25 28.4b 2.6 9 0.3 4.8 0.2 0 Fluconazole 10 13.1b 3.2 2 - Table 3.
Lung and kidney tissue burdensa
Tissue Drug or treatment Dose (mg/kg) Mean burden 95% CI No. of mice with counts of <20 CFU/g Lower Upper Kidney Control None 2.3 × 107 1.2 × 107 5.7 × 107 0 GM3 10 4.8 × 104 b 2.5 × 104 1.2 × 105 0 5 8.0 × 105 b 4.3 × 105 2.0 × 106 0 1.25 1.3 × 108 6.9 × 107 3.2 × 108 0 Amphotericin B 2.5 2.3 × 102 c 1.2 × 102 5.7 × 102 3 Fluconazole 5 3.4 × 106 b 1.8 × 106 8.3 × 106 0 Lung Control None 5.9 × 107 3.1 × 107 1.6 × 108 1 GM3 10 1.1 × 105 b 5.7 × 104 2.6 × 105 0 5 2.9 × 106 b 1.5 × 106 7.8 × 106 1 1.25 1.9 × 108 1.0 × 108 4.8 × 108 0 Amphotericin B 2.5 1.2 × 102 c 6.7 × 101 3.1 × 102 6 Fluconazole 5 1.3 × 107 b 6.8 × 106 3.1 × 107 0 ↵a Values are expressed as CFU per gram of tissue. Each treatment group consisted of seven mice. CI, confidence interval.
b P < 0.05 compared with control group.
c P < 0.01 compared with control group or groups receiving fluconazole or GM3.