DOI: 10.1128/AAC.43.8.2081
ABSTRACT
A β-lactamase with an Mr of 29,000 and a pI of 7.6 was partially purified from a clinical isolate ofShigella dysenteriae. The bla gene encoded the SHV-11 enzyme carrying the substitution Leu→Gln at position 35 and was linked to a strong promoter. This variant, unlike the prototype SHV-1 enzyme, hydrolyzed oxacillin, cloxacillin, and oxyiminocephalosporins such as cefotaxime.
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