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Mechanisms of Resistance

The R467K Amino Acid Substitution in Candida albicans Sterol 14α-Demethylase Causes Drug Resistance through Reduced Affinity

David C. Lamb, Diane E. Kelly, Theodore C. White, Steven L. Kelly
David C. Lamb
Institute of Biological Sciences, University of Wales Aberystwyth, Aberystwyth SY23 3DA, United Kingdom, and
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Diane E. Kelly
Institute of Biological Sciences, University of Wales Aberystwyth, Aberystwyth SY23 3DA, United Kingdom, and
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Theodore C. White
Department of Pathobiology, School of Public Health and Community Medicine, University of Washington and Seattle Biomedical Research Institute, Seattle, Washington 98109
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Steven L. Kelly
Institute of Biological Sciences, University of Wales Aberystwyth, Aberystwyth SY23 3DA, United Kingdom, and
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DOI: 10.1128/AAC.44.1.63-67.2000
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Article Information

DOI 
https://doi.org/10.1128/AAC.44.1.63-67.2000
PubMed 
10602724

Published By 
American Society for Microbiology Journals
History 
  • Received March 19, 1999
  • Returned for modification August 5, 1999
  • Accepted October 14, 1999
  • Published online January 1, 2000.

Copyright & Usage 
Copyright © 2000 American Society for Microbiology

Author Information

  1. David C. Lamb1,
  2. Diane E. Kelly1,
  3. Theodore C. White2 and
  4. Steven L. Kelly1*
  1. Institute of Biological Sciences, University of Wales Aberystwyth, Aberystwyth SY23 3DA, United Kingdom,1 and
  2. Department of Pathobiology, School of Public Health and Community Medicine, University of Washington and Seattle Biomedical Research Institute, Seattle, Washington 981092
  • ↵* Corresponding author. Mailing address: Institute of Biological Sciences, Edward Llwyd Bldg., University of Wales Aberystwyth, Aberystwyth SY23 3DA, United Kingdom. Phone: 01970 621515. Fax: 01970 622350. E-mail: Steven.Kelly{at}aber.ac.uk.

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The R467K Amino Acid Substitution in Candida albicans Sterol 14α-Demethylase Causes Drug Resistance through Reduced Affinity
David C. Lamb, Diane E. Kelly, Theodore C. White, Steven L. Kelly
Antimicrobial Agents and Chemotherapy Jan 2000, 44 (1) 63-67; DOI: 10.1128/AAC.44.1.63-67.2000

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The R467K Amino Acid Substitution in Candida albicans Sterol 14α-Demethylase Causes Drug Resistance through Reduced Affinity
David C. Lamb, Diane E. Kelly, Theodore C. White, Steven L. Kelly
Antimicrobial Agents and Chemotherapy Jan 2000, 44 (1) 63-67; DOI: 10.1128/AAC.44.1.63-67.2000
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KEYWORDS

antifungal agents
Candida albicans
Cytochrome P-450 Enzyme System
fluconazole
Oxidoreductases

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