Hematin Polymerization Assay as a High-Throughput Screen for Identification of New Antimalarial Pharmacophores

Yae Kurosawa; Arnulf Dorn; Michiko Kitsuji-Shirane; Hisao Shimada; Tomoko Satoh; Hugues Matile; Werner Hofheinz; Raffaello Masciadri; Manfred Kansy; Robert G. Ridley

doi:10.1128/AAC.44.10.2638-2644.2000

DOI: 10.1128/AAC.44.10.2638-2644.2000

Article Information

DOI

https://doi.org/10.1128/AAC.44.10.2638-2644.2000

PubMed

10991837

Published By

American Society for Microbiology Journals

History

Received January 24, 2000
Returned for modification April 13, 2000
Accepted June 28, 2000
Published online October 1, 2000.

Author Information

Yae Kurosawa¹,²,
Arnulf Dorn³ *,
Michiko Kitsuji-Shirane¹,⁴,
Hisao Shimada¹,
Tomoko Satoh¹,⁵,
Hugues Matile³,
Werner Hofheinz³,
Raffaello Masciadri³,
Manfred Kansy³ and
Robert G. Ridley³,⁶

Department of Pharmaceutical Screening, Nippon Roche Research Center, 200 Kajiwara, Kamakura, Kanagawa Prefecture 247,¹
New Ceramics Department, Asahi Optical Co., Ltd., Itabashi-ku, Tokyo 174-8639,²
Medical Institute of Bioregulation, Department of Molecular and Cellular Biology, Kyushu University, 3-1-1 Maidaishi, Higashi-ku Fukuoka, Fukuoka 812-8582,⁴ and
Screening Technology, Bayer Yakuhin Research Center Kyoto, 6-5-1-3 Kunimidai, Soraku-gun, Kyoto,⁵ Japan, and
Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd., CH-4070 Basel,³ and
Drug Discovery Research, WHO/TDR, World Health Organization, CH-1211 Geneva 27,⁶ Switzerland

↵* Corresponding author. Mailing address: F. Hoffmann-La Roche Ltd, PRPI-D, Building 70/138, CH-4070 Basel, Switzerland. Phone: (61) 688 84 11. Fax: (61) 688 27 29. E-mail:arnulf.dorn{at}roche.com.

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