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Chemistry; Biosynthesis

Hematin Polymerization Assay as a High-Throughput Screen for Identification of New Antimalarial Pharmacophores

Yae Kurosawa, Arnulf Dorn, Michiko Kitsuji-Shirane, Hisao Shimada, Tomoko Satoh, Hugues Matile, Werner Hofheinz, Raffaello Masciadri, Manfred Kansy, Robert G. Ridley
Yae Kurosawa
Department of Pharmaceutical Screening, Nippon Roche Research Center, 200 Kajiwara, Kamakura, Kanagawa Prefecture 247,
New Ceramics Department, Asahi Optical Co., Ltd., Itabashi-ku, Tokyo 174-8639,
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Arnulf Dorn
Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd., CH-4070 Basel, and
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Michiko Kitsuji-Shirane
Department of Pharmaceutical Screening, Nippon Roche Research Center, 200 Kajiwara, Kamakura, Kanagawa Prefecture 247,
Medical Institute of Bioregulation, Department of Molecular and Cellular Biology, Kyushu University, 3-1-1 Maidaishi, Higashi-ku Fukuoka, Fukuoka 812-8582, and
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Hisao Shimada
Department of Pharmaceutical Screening, Nippon Roche Research Center, 200 Kajiwara, Kamakura, Kanagawa Prefecture 247,
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Tomoko Satoh
Department of Pharmaceutical Screening, Nippon Roche Research Center, 200 Kajiwara, Kamakura, Kanagawa Prefecture 247,
Screening Technology, Bayer Yakuhin Research Center Kyoto, 6-5-1-3 Kunimidai, Soraku-gun, Kyoto, Japan, and
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Hugues Matile
Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd., CH-4070 Basel, and
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Werner Hofheinz
Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd., CH-4070 Basel, and
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Raffaello Masciadri
Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd., CH-4070 Basel, and
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Manfred Kansy
Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd., CH-4070 Basel, and
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Robert G. Ridley
Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd., CH-4070 Basel, and
Drug Discovery Research, WHO/TDR, World Health Organization, CH-1211 Geneva 27, Switzerland
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DOI: 10.1128/AAC.44.10.2638-2644.2000
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Article Information

DOI 
https://doi.org/10.1128/AAC.44.10.2638-2644.2000
PubMed 
10991837

Published By 
American Society for Microbiology Journals
History 
  • Received January 24, 2000
  • Returned for modification April 13, 2000
  • Accepted June 28, 2000
  • Published online October 1, 2000.

Copyright & Usage 
Copyright © 2000 American Society for Microbiology

Author Information

  1. Yae Kurosawa1,2,
  2. Arnulf Dorn3*,
  3. Michiko Kitsuji-Shirane1,4,
  4. Hisao Shimada1,
  5. Tomoko Satoh1,5,
  6. Hugues Matile3,
  7. Werner Hofheinz3,
  8. Raffaello Masciadri3,
  9. Manfred Kansy3 and
  10. Robert G. Ridley3,6
  1. Department of Pharmaceutical Screening, Nippon Roche Research Center, 200 Kajiwara, Kamakura, Kanagawa Prefecture 247,1
  2. New Ceramics Department, Asahi Optical Co., Ltd., Itabashi-ku, Tokyo 174-8639,2
  3. Medical Institute of Bioregulation, Department of Molecular and Cellular Biology, Kyushu University, 3-1-1 Maidaishi, Higashi-ku Fukuoka, Fukuoka 812-8582,4 and
  4. Screening Technology, Bayer Yakuhin Research Center Kyoto, 6-5-1-3 Kunimidai, Soraku-gun, Kyoto,5 Japan, and
  5. Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd., CH-4070 Basel,3 and
  6. Drug Discovery Research, WHO/TDR, World Health Organization, CH-1211 Geneva 27,6 Switzerland
  • ↵* Corresponding author. Mailing address: F. Hoffmann-La Roche Ltd, PRPI-D, Building 70/138, CH-4070 Basel, Switzerland. Phone: (61) 688 84 11. Fax: (61) 688 27 29. E-mail:arnulf.dorn{at}roche.com.

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Hematin Polymerization Assay as a High-Throughput Screen for Identification of New Antimalarial Pharmacophores
Yae Kurosawa, Arnulf Dorn, Michiko Kitsuji-Shirane, Hisao Shimada, Tomoko Satoh, Hugues Matile, Werner Hofheinz, Raffaello Masciadri, Manfred Kansy, Robert G. Ridley
Antimicrobial Agents and Chemotherapy Oct 2000, 44 (10) 2638-2644; DOI: 10.1128/AAC.44.10.2638-2644.2000

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Hematin Polymerization Assay as a High-Throughput Screen for Identification of New Antimalarial Pharmacophores
Yae Kurosawa, Arnulf Dorn, Michiko Kitsuji-Shirane, Hisao Shimada, Tomoko Satoh, Hugues Matile, Werner Hofheinz, Raffaello Masciadri, Manfred Kansy, Robert G. Ridley
Antimicrobial Agents and Chemotherapy Oct 2000, 44 (10) 2638-2644; DOI: 10.1128/AAC.44.10.2638-2644.2000
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KEYWORDS

antimalarials
Hemin

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