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Susceptibility

Comparative In Vitro Activities of GAR-936 against Aerobic and Anaerobic Animal and Human Bite Wound Pathogens

Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Yumi Warren, Kerin Tyrrell
Ellie J. C. Goldstein
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, and
UCLA School of Medicine, Los Angeles, California 90073
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Diane M. Citron
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, and
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C. Vreni Merriam
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, and
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Yumi Warren
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, and
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Kerin Tyrrell
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, and
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DOI: 10.1128/AAC.44.10.2747-2751.2000
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ABSTRACT

GAR-936 is a new semisynthetic glycylcycline with a broad antibacterial spectrum, including tetracycline-resistant strains. The in vitro activities of GAR-936, minocycline, doxycycline, tetracycline, moxifloxacin, penicillin G, and erythromycin were determined by agar dilution methods against 268 aerobic and 148 anaerobic strains of bacteria (including Pasteurella, Eikenella,Moraxella, Bergeyella, Neisseria, EF-4, Bacteroides, Prevotella,Porphyromonas, Fusobacterium,Staphylococcus, Streptococcus,Enterococcus, Corynebacterium,Propionibacterium, Peptostreptococcus, andActinomyces) isolated from infected human and animal bite wounds in humans, including strains resistant to commonly used antimicrobials. GAR-936 was very active, with an MIC at which 90% of the strains are inhibited (MIC90) of ≤0.25 μg/ml, against all aerobic gram-positive and -negative strains, including tetracycline-resistant strains of Enterococcus,Streptococcus, and coagulase-negative staphylococci, except for Eikenella corrodens (MIC90, ≤4 μg/ml). GAR-936 was also very active against all anaerobic species, including tetracycline-, doxycycline-, and minocycline-resistant strains ofPrevotella spp., Porphyromonas spp.,Bacteroides tectum, and Peptostreptococcusspp., with an MIC90 of ≤0.25 μg/ml. Erythromycin- and moxifloxacin-resistant fusobacteria were susceptible to GAR-936, with an MIC90 of 0.06 μg/ml.

Approximately 20% of the 5 million people bitten by animals each year in the United States are allergic to penicillin or beta-lactam agents (5, 20, 22). The selection of an alternative antimicrobial can be problematic. In the past, doxycycline and minocycline have shown in vitro activity against common animal and human bite pathogens, including Pasteurella multocida and Eikenella corrodens (6, 7), and have shown clinical utility (5, 22). However, tetracycline resistance among both aerobic and anaerobic bacteria has increased, and consequently, tetracycline and its derivatives have been relegated to second- and third-line therapies by many clinicians.

GAR-936 is a synthetic analogue of minocycline that has activity against tetracycline-resistant strains that possess either ribosomal protection, such as tet(M), or active efflux mechanisms, such as tet(A), tet(B), etc. (1, 17, 18). Preliminary studies have shown GAR-936 to be active against a broad range of aerobic and anaerobic bacteria, including staphylococci, streptococci, Prevotella spp., and peptostreptococci (2, 3, 9, 17). In addition, GAR-936 is undergoing clinical trials for safety and efficacy in the treatment of complicated skin and soft-tissue infections. In order to determine the potential efficacy of GAR-936 in the treatment of skin and soft-tissue infections associated with human and animal bites, we studied its comparative in vitro activity against 416 clinical isolates.

MATERIALS AND METHODS

The strains used in this study were recent isolates from infected skin and soft-tissue bite wounds in humans. All isolates were identified by standard criteria (8, 12, 13, 19). The specific sources were dog bites (184), cat bites (191), human bites (18), and other animal bites (23). The numbers and species of isolates tested are given in Table 1.

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Table 1.

Comparative in vitro activity of GAR-936 and other tetracycline derivatives, selected macrolides, fluoroquinolones, penicillin, and vancomycin against 416 aerobic and anaerobic animal and human bite wound pathogens

Standard laboratory powders were supplied as follows: GAR-936 and minocycline, Wyeth-Ayerst Research, Pearl River, N.Y.; azithromycin and doxycycline, Pfizer Inc., New York, N.Y.; erythromycin and vancomycin, Eli Lilly & Co., Indianapolis, Ind.; levofloxacin, Ortho McNiel Pharmaceuticals, Raritan, N.J.; moxifloxacin, Bayer Corp., West Haven, Conn.; and penicillin G and tetracycline, Sigma Chemical Co., St. Louis, Mo.

Antimicrobial agents were reconstituted according to the manufacturers' instructions. Serial twofold dilutions of antimicrobial agents were prepared on the day of the test and added to the media in various concentrations.

Frozen cultures were transferred twice on tryptic soy agar supplemented with 5% sheep blood or chocolate agar (Hardy Diagnostics, Santa Maria, Calif.) for the aerobes and brucella agar supplemented with hemin, vitamin K1, and 5% sheep blood (Anaerobe Systems, Morgan Hill, Calif.) for the anaerobes to ensure purity and good growth. Susceptibility testing was performed according to NCCLS standards (14, 15). Brucella agar supplemented with hemin, vitamin K1, and 5% laked sheep blood was the basal medium used for anaerobic species and for E. corrodens, Bergeyella zoohelcum, and Capnocytophaga spp. Mueller-Hinton agar was used for staphylococci, and Mueller-Hinton agar supplemented with 5% sheep blood was used for the remainder of the organisms.

The agar plates were inoculated with a Steers replicator (Craft Machine Inc., Chester, Pa.). The inoculum used for aerobic bacteria was 104 CFU per spot, and the inoculum used for E. corrodens and anaerobic bacteria was 105 CFU per spot. Control plates without antimicrobial agents were inoculated before and after each set of drug-containing plates. Plates with aerobic isolates were incubated at 35°C in an aerobic environment for 18 to 20 h and then examined. E. corrodens, B. zoohelcum,Capnocytophaga spp., and streptococci were incubated in 5% CO2 for 42 to 44 h and were then examined. Plates with anaerobes were incubated in an anaerobic chamber (Anaerobe Systems) at 35°C for 48 h and then examined.

The control strains tested included Staphylococcus aureusATCC 29213, Enterococcus faecalis ATCC 29212,Escherichia coli ATCC 25922, Bacteroides fragilisATCC 25285, and Bacteroides thetaiotaomicron ATCC 29741. These strains were tested simultaneously with the appropriate plates and environments. The MIC was defined as the lowest concentration of an agent that yielded no growth or a marked change in the appearance of growth compared to the growth control plate.

RESULTS

The results of our study are shown in Table 1. GAR 936 was very active, with an MIC at which 90% of the strains were inhibited (MIC90) of ≤0.25 μg/ml, against all aerobic gram-positive strains, including tetracycline-resistant strains ofEnterococcus, Streptococcus, coagulase-negative staphylococci, and Corynebacterium spp. GAR 936 was also very active against all aerobic gram-negative strains, with an MIC90 of ≤0.25 μg/ml for all isolates with the exception of E. corrodens (MIC90, 4 μg/ml), of which 3 of 18 strains required 2 to 4 μg/ml for inhibition while the other 15 strains were susceptible to ≤0.5 μg of GAR-936/ml. Sixty of the 62Pasteurellaceae isolates tested, including Pasteurella multocida subsp. multocida, Pasteurella multocida subsp. septica, Pasteurella canis,Pasteurella dagmatis, and Pasteurella stomatis, were susceptible to ≤0.06 μg of GAR-936/ml; two isolates of P. stomatis required 0.125 μg of GAR-936/ml for inhibition. GAR-936 was also very active against all anaerobic species, including tetracycline-, doxycycline-, and minocycline-resistant strains ofPrevotella spp. (such as Prevotella heparinolytica, Prevotella melaninogenica,Prevotella bivia, and Prevotella loeschii,Porphyromonas spp. (such as Porphyromonas levii),Bacteroides tectum, and Peptostreptococcus spp. and had an MIC90 of ≤0.25 μg/ml. Macrolide (erythromycin and azithromycin)- and fluoroquinolone (levofloxacin and moxifloxacin)-resistant Fusobacterium nucleatum and otherFusobacterium spp. were susceptible to GAR-936 (MIC90, 0.06 μg/ml).

DISCUSSION

Selection of an inappropriate antimicrobial agent for the therapy of infected bite wounds can lead to therapeutic failure and long-term sequelae (5, 10, 11). While beta-lactams have been the traditional drugs of choice, many patients report a history of penicillin allergy or side effects and require the selection of an alternative agent. This choice has been somewhat problematic in the past, since erythromycin MICs against bite pathogens have been inconsistent (4) and clinical failures of erythromycin therapy have been reported (10, 11, 16). Other agents, such as the fluoroquinolones, were also attractive, but some relatively common bite isolate species, such as the fusobacteria, were often resistant (6, 7). Our prior clinical experience had suggested that tetracyclines were attractive alternative agents, but tetracycline resistance evolved, both because of efflux-based and ribosomal protection mechanisms, and some bite isolates were resistant (1, 5, 17).

GAR-936 is a derivative of minocycline that has activity against tetracycline-resistant strains that possess either ribosomal protection or active efflux mechanisms (17, 18). In vitro data has shown GAR-936 to be active against a broad range of gram-positive and gram-negative pathogens (1, 3, 17, 18, 21). van Ogtrop et al. (21) have shown GAR-936 to be active in an experimental in vivo murine thigh infection model and to have good activity againstS. aureus and other gram-positive and gram-negative aerobic bacteria. They stated that GAR-936 would be a “promising drug(s) for the treatment of staphylococcal infections” and suggested that, based on their model, “the theoretical breakpoint MIC” would be about 0.5 μg/ml.

In our study, GAR-936 showed excellent activity against the full spectrum of 268 aerobic and 148 anaerobic clinical bite wound isolates. Many of our isolates were resistant to tetracycline and tetracycline analogues, such as doxycycline and minocycline, yet, of all the aerobic and anaerobic bacteria studied, the GAR-936 MICs for only 3 of 18E. corrodens isolates were >0.5 μg/ml. GAR-936 was active against typical primary animal bite pathogens, such as P. multocida subspecies (all 30 strains were susceptible to ≤0.06 μg/ml), and secondary invaders, such as S. aureus (all 15 isolates were susceptible to ≤0.125 μg/ml). In addition, GAR-936 was active against macrolide-resistant aerobic isolates, such asCorynebacterium aquaticum, Corynebacterium spp.,E. corrodens, enterococci, coagulase-negative staphylococci, and levofloxacin-resistant corynebacteria. Gales and Jones (3) studied the activities of GAR-936 against 1,203 recent clinical isolates and noted its improved activity compared to older tetracyclines as well as its broad spectrum of activity. While most of the isolates in our study are not represented in their data, their GAR-936 MIC90 of 0.25 μg/ml against both oxacillin-susceptible and -resistant S. aureus was one dilution higher than that found for our S. aureus isolates. In our study, moxifloxacin exhibited good in vitro activity against all aerobic bite isolates.

Among anaerobic bacteria, GAR-936 also exhibited excellent activity against isolates, including macrolide-, levofloxacin-, and moxifloxacin-resistant F. nucleatum and otherFusobacterium spp. and tetracycline-, minocycline-, and doxycycline-resistant isolates of B. tectum, P. heparinolytica, Prevotella spp., Porphyromonas macaccae, Porphyromonas spp. (P. levii), and peptostreptococci. Of note, the GAR-936-susceptible peptostreptococci showed resistance to erythromycin, azithromycin, levofloxacin, tetracycline, doxycycline, and minocycline. Edlund and Nord (2) studied the activity of GAR-936 against 327 anaerobes, using PDM-ASM media supplemented with 5% horse blood. The species they studied differed from the species of our bite isolates in most instances. In general, our results were similar for peptostreptococci, and both studies showed GAR-936 MIC90 of 0.06 μg/ml against F. nucleatum isolates.

Overall, GAR-936 exhibited the best activity of the agents tested against the full spectrum of aerobic and anaerobic bite isolates, including multidrug-resistant strains. This excellent in vitro activity warrants its further investigation for clinical use in skin and soft-tissue infections, including those due to human and animal bites.

ACKNOWLEDGMENTS

This study was supported in part by a grant from Wyeth-Ayerst Laboratories.

We thank Judee H. Knight and Alice E. Goldstein for assistance.

FOOTNOTES

    • Received 12 May 2000.
    • Accepted 11 July 2000.
  • Copyright © 2000 American Society for Microbiology

REFERENCES

  1. 1.↵
    1. Bryskier A.
    Novelties in the field of anti-infectives in 1998. Clin. Infect. Dis. 29 1999 632 658
    OpenUrlCrossRefPubMedWeb of Science
  2. 2.↵
    1. Edlund C.,
    2. Nord C. E.
    In vitro susceptibility of anaerobic bacteria to GAR-936, a new glycylcycline. Clin. Microbiol. Infect. 6 2000 158 163
    OpenUrl
  3. 3.↵
    1. Gales A. C.,
    2. Jones R. N.
    Antimicrobial activity and spectrum of the new glycylcycline, GAR-936 tested against 1,203 recent clinical bacterial isolates. Diagn. Microbiol. Infect. Dis. 36 2000 19 36
    OpenUrlCrossRefPubMedWeb of Science
  4. 4.↵
    1. Goldstein E. J. C.,
    2. Citron D. M.,
    3. Richwald G. A.
    Lack of in vitro efficacy of oral forms of certain cephalosporins, erythromycin, and oxacillin against Pasteurella multocida. Antimicrob. Agents Chemother. 32 1988 213 215
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. Goldstein E. J. C.
    Bite wounds and infection. Clin. Infect. Dis. 14 1992 633 640
    OpenUrlCrossRefPubMedWeb of Science
  6. 6.↵
    1. Goldstein E. J. C.,
    2. Nesbit C. A.,
    3. Citron D. M.
    In vitro activity of azithromycin, Bay y 3118, levofloxacin, sparfloxacin, and 11 other oral antimicrobial agents against 194 aerobic and anaerobic bite wound isolates. Antimicrob. Agents Chemother. 39 1995 1097 1100
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Goldstein E. J. C.,
    2. Citron D. M.,
    3. Hudspeth M.,
    4. Gerardo S. H.,
    5. Merriam C. V.
    In vitro activity of Bay 12-8039, a new 8-methoxy quinolone, compared to 11 other oral antimicrobial agents against 390 aerobic and anaerobic bacteria isolated from human and animal bite wound skin and soft tissue infections in humans. Antimicrob. Agents Chemother. 41 1997 1552 1557
    OpenUrlAbstract/FREE Full Text
  8. 8.↵
    1. Holdeman L. V.,
    2. Moore W. E. C.
    Anaerobic laboratory manual 4th ed. 1977 Virginia Polytechnic Institute and State University Blacksburg
  9. 9.↵
    1. Jones R. N.
    Disk diffusion susceptibility test development for the new glycylcycline, GAR-936. Diagn. Microbiol. Infect. Dis. 35 1999 249 252
    OpenUrlCrossRefPubMed
  10. 10.↵
    1. Kumar A.,
    2. Devlin H. R.,
    3. Velland H.
    Pasteurella multocida meningitis in an adult: case report and review. Rev. Infect. Dis. 12 1990 440 448
    OpenUrlPubMedWeb of Science
  11. 11.↵
    1. Levin J. M.,
    2. Talan D. A.
    Erythromycin failure with subsequent Pasteurella multocida meningitis and septic arthritis in a cat bite victim. Ann. Emerg. Med. 19 1990 1458 1461
    OpenUrlCrossRefPubMedWeb of Science
  12. 12.↵
    1. Murray P. R.,
    2. Baron E. J.,
    3. Pfaller M. A.,
    4. Tenover F. C.,
    5. Yolken R. H.
    Manual of clinical microbiology 6th ed. 1995 American Society for Microbiology Washington, D.C.
  13. 13.↵
    1. Mutters R.,
    2. Ihm P.,
    3. Pohl S.,
    4. Frederiksen W.,
    5. Mannheim W.
    Reclassification of the genus Pasteurella Trevisan 1887 on the basis of deoxyribonucleic acid homology, with proposals for the new species Pasteurella dagmatis,Pasteurella canis,Pasteurella stomatis,Pasteurella anatis, and Pasteurella langaa. Int. J. Syst. Bacteriol. 35 1985 309 322
    OpenUrlCrossRef
  14. 14.↵
    National Committee for Clinical Laboratory Standards Methods for antimicrobial susceptibility testing of anaerobic bacteria, 4th ed. Approved standard. NCCLS publication no. M11-A4. 1998 National Committee for Clinical Laboratory Standards Wayne, Pa
  15. 15.↵
    National Committee for Clinical Laboratory Standards Method for dilution antimicrobial susceptibility testing for bacteria that grow aerobically, 4th ed. Approved standard. NCCLS publication no. M7-A4. 1998 National Committee for Clinical Laboratory Standards Wayne, Pa
  16. 16.↵
    1. Orton D. W.
    Pasteurella multocida: bilateral septic knee joint prosthesis from a distant cat bite. Ann. Emerg. Med. 13 1984 1065 1067
    OpenUrlCrossRefPubMed
  17. 17.↵
    1. Petersen P. J.,
    2. Jacobus N. V.,
    3. Weiss W. J.,
    4. Sum P. E.,
    5. Testa R. T.
    In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamino derivative of minocycline (GAR-936). Antimicrob. Agents Chemother. 43 1999 738 744
    OpenUrlAbstract/FREE Full Text
  18. 18.↵
    1. Sum P. E.,
    2. Petersen P.
    Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936. Bioorg. Med. Chem. Lett. 17 1999 1459 1462
    OpenUrl
  19. 19.↵
    1. Summanen P.,
    2. Baron E. J.,
    3. Citron D. M.,
    4. Strong C. A.,
    5. Wexler H. M.,
    6. Finegold S. M.
    Wadsworth anaerobic bacteriology manual 5th ed. 1993 Star Publishing Co. Belmont, Calif
  20. 20.↵
    1. Talan D. A.,
    2. Citron D. M.,
    3. Abrahamian F. A.,
    4. Moran G. J.,
    5. Goldstein E. J. C.,
    6. the Emergency Medicine Animal Bite Infection Study Group
    The bacteriology and management of dog and cat bite wound infections presenting to Emergency Departments. N. Engl. J. Med. 340 1999 85 92
    OpenUrlCrossRefPubMedWeb of Science
  21. 21.↵
    1. van Ogtrop M. L.,
    2. Andes D.,
    3. Stamstad T. J.,
    4. Conklin B.,
    5. Weiss W. J.,
    6. Craig W. A.,
    7. Vesga O.
    In vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 162,288) against various gram-positive and gram-negative bacteria. Antimicrob. Agents Chemother. 44 2000 943 949
    OpenUrlAbstract/FREE Full Text
  22. 22.↵
    1. Weber D. J.,
    2. Wolfson J. S.,
    3. Swartz M. N.,
    4. Hooper D. C.
    Pasteurella multocida infections: report of 34 cases and review of the literature. Medicine 63 1984 133 154
    OpenUrlCrossRefPubMedWeb of Science
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Comparative In Vitro Activities of GAR-936 against Aerobic and Anaerobic Animal and Human Bite Wound Pathogens
Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Yumi Warren, Kerin Tyrrell
Antimicrobial Agents and Chemotherapy Oct 2000, 44 (10) 2747-2751; DOI: 10.1128/AAC.44.10.2747-2751.2000

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Comparative In Vitro Activities of GAR-936 against Aerobic and Anaerobic Animal and Human Bite Wound Pathogens
Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Yumi Warren, Kerin Tyrrell
Antimicrobial Agents and Chemotherapy Oct 2000, 44 (10) 2747-2751; DOI: 10.1128/AAC.44.10.2747-2751.2000
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  • Top
  • Article
    • ABSTRACT
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
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  • Info & Metrics
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KEYWORDS

Anti-Bacterial Agents
Bacteria, Aerobic
Bacteria, Anaerobic
Bites and Stings
minocycline

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