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Susceptibility

Comparative In Vitro Activities of GAR-936 against Aerobic and Anaerobic Animal and Human Bite Wound Pathogens

Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Yumi Warren, Kerin Tyrrell
Ellie J. C. Goldstein
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, and
UCLA School of Medicine, Los Angeles, California 90073
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Diane M. Citron
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, and
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C. Vreni Merriam
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, and
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Yumi Warren
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, and
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Kerin Tyrrell
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, and
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DOI: 10.1128/AAC.44.10.2747-2751.2000
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ABSTRACT

GAR-936 is a new semisynthetic glycylcycline with a broad antibacterial spectrum, including tetracycline-resistant strains. The in vitro activities of GAR-936, minocycline, doxycycline, tetracycline, moxifloxacin, penicillin G, and erythromycin were determined by agar dilution methods against 268 aerobic and 148 anaerobic strains of bacteria (including Pasteurella, Eikenella,Moraxella, Bergeyella, Neisseria, EF-4, Bacteroides, Prevotella,Porphyromonas, Fusobacterium,Staphylococcus, Streptococcus,Enterococcus, Corynebacterium,Propionibacterium, Peptostreptococcus, andActinomyces) isolated from infected human and animal bite wounds in humans, including strains resistant to commonly used antimicrobials. GAR-936 was very active, with an MIC at which 90% of the strains are inhibited (MIC90) of ≤0.25 μg/ml, against all aerobic gram-positive and -negative strains, including tetracycline-resistant strains of Enterococcus,Streptococcus, and coagulase-negative staphylococci, except for Eikenella corrodens (MIC90, ≤4 μg/ml). GAR-936 was also very active against all anaerobic species, including tetracycline-, doxycycline-, and minocycline-resistant strains ofPrevotella spp., Porphyromonas spp.,Bacteroides tectum, and Peptostreptococcusspp., with an MIC90 of ≤0.25 μg/ml. Erythromycin- and moxifloxacin-resistant fusobacteria were susceptible to GAR-936, with an MIC90 of 0.06 μg/ml.

  • Copyright © 2000 American Society for Microbiology
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Comparative In Vitro Activities of GAR-936 against Aerobic and Anaerobic Animal and Human Bite Wound Pathogens
Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Yumi Warren, Kerin Tyrrell
Antimicrobial Agents and Chemotherapy Oct 2000, 44 (10) 2747-2751; DOI: 10.1128/AAC.44.10.2747-2751.2000

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Comparative In Vitro Activities of GAR-936 against Aerobic and Anaerobic Animal and Human Bite Wound Pathogens
Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Yumi Warren, Kerin Tyrrell
Antimicrobial Agents and Chemotherapy Oct 2000, 44 (10) 2747-2751; DOI: 10.1128/AAC.44.10.2747-2751.2000
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KEYWORDS

Anti-Bacterial Agents
Bacteria, Aerobic
Bacteria, Anaerobic
Bites and Stings
minocycline

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