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Mechanisms of Resistance

Characterization of Fluoroquinolone Resistance among Veterinary Isolates of Avian Escherichia coli

David G. White, Laura J. V. Piddock, John J. Maurer, Shaohua Zhao, Vito Ricci, Stephan G. Thayer
David G. White
Department of Veterinary and Microbiological Sciences, North Dakota State University, Fargo, North Dakota;
Division of Animal and Food Microbiology, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland
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Laura J. V. Piddock
Division of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom;
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John J. Maurer
Department of Avian Medicine, University of Georgia, Athens, Georgia; and
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Shaohua Zhao
Division of Animal and Food Microbiology, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland
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Vito Ricci
Division of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom;
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Stephan G. Thayer
Department of Avian Medicine, University of Georgia, Athens, Georgia; and
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DOI: 10.1128/AAC.44.10.2897-2899.2000
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ABSTRACT

Fluoroquinolone-resistant avian Escherichia coliisolates from northern Georgia were investigated for gyrAand parC mutations. All isolates contained a mutation in GyrA replacing Ser83 with Leu; seven isolates also contained mutations replacing Asp87 with either Gly or Tyr. Random amplified polymorphic DNA analysis revealed that quinolone-resistant E. coliisolates were genetically diverse.

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Characterization of Fluoroquinolone Resistance among Veterinary Isolates of Avian Escherichia coli
David G. White, Laura J. V. Piddock, John J. Maurer, Shaohua Zhao, Vito Ricci, Stephan G. Thayer
Antimicrobial Agents and Chemotherapy Oct 2000, 44 (10) 2897-2899; DOI: 10.1128/AAC.44.10.2897-2899.2000

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Characterization of Fluoroquinolone Resistance among Veterinary Isolates of Avian Escherichia coli
David G. White, Laura J. V. Piddock, John J. Maurer, Shaohua Zhao, Vito Ricci, Stephan G. Thayer
Antimicrobial Agents and Chemotherapy Oct 2000, 44 (10) 2897-2899; DOI: 10.1128/AAC.44.10.2897-2899.2000
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KEYWORDS

anti-infective agents
Escherichia coli
Escherichia coli Infections
poultry
Poultry Diseases

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