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Experimental Therapeutics

Immunization with the Candida albicansMembrane Fraction and in Combination with Fluconazole Protects against Systemic Fungal Infections

Shigetoshi Mizutani, Masahiro Endo, Toshiaki Ino-ue, Masahiro Kurasawa, Yoko Uno, Hideharu Saito, Ikunoshin Kato, Kazutoh Takesako
Shigetoshi Mizutani
Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., 3-4-1 Seta, Otsu, Shiga 520-2193, Japan
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Masahiro Endo
Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., 3-4-1 Seta, Otsu, Shiga 520-2193, Japan
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Toshiaki Ino-ue
Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., 3-4-1 Seta, Otsu, Shiga 520-2193, Japan
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Masahiro Kurasawa
Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., 3-4-1 Seta, Otsu, Shiga 520-2193, Japan
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Yoko Uno
Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., 3-4-1 Seta, Otsu, Shiga 520-2193, Japan
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Hideharu Saito
Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., 3-4-1 Seta, Otsu, Shiga 520-2193, Japan
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Ikunoshin Kato
Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., 3-4-1 Seta, Otsu, Shiga 520-2193, Japan
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Kazutoh Takesako
Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., 3-4-1 Seta, Otsu, Shiga 520-2193, Japan
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DOI: 10.1128/AAC.44.2.243-247.2000
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ABSTRACT

We studied the immunogenicity of a membrane fraction prepared fromCandida albicans cells called C. albicansmembrane antigen (CMA). The present study revealed that CMA immunization has antifungal activity in mouse models of systemic fungal infection. Immunization of mice by subcutaneous injections of CMA with incomplete Freund adjuvant induced resistance to infections caused not only by C. albicans but also by Aspergillus fumigatus. The level of resistance to candidiasis was as high as that induced by whole-cell immunization. The acquired resistance to candidiasis in the mice immunized with CMA was not diminished by immunosuppressive treatment with cyclophosphamide. The level of resistance to fungal infections was superior to that given by fluconazole (FLC) treatment alone and highly enhanced by the combination with FLC. When CD4+ cells in CMA-immunized mice were depleted by a monoclonal antibody, the antifungal activity induced by the combination of CMA and FLC was significantly reduced. These results indicate that immunization with CMA is useful for preventing systemic fungal infections and in combination with FLC for increasing resistance after infection.

  • Copyright © 2000 American Society for Microbiology
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Immunization with the Candida albicansMembrane Fraction and in Combination with Fluconazole Protects against Systemic Fungal Infections
Shigetoshi Mizutani, Masahiro Endo, Toshiaki Ino-ue, Masahiro Kurasawa, Yoko Uno, Hideharu Saito, Ikunoshin Kato, Kazutoh Takesako
Antimicrobial Agents and Chemotherapy Feb 2000, 44 (2) 243-247; DOI: 10.1128/AAC.44.2.243-247.2000

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Immunization with the Candida albicansMembrane Fraction and in Combination with Fluconazole Protects against Systemic Fungal Infections
Shigetoshi Mizutani, Masahiro Endo, Toshiaki Ino-ue, Masahiro Kurasawa, Yoko Uno, Hideharu Saito, Ikunoshin Kato, Kazutoh Takesako
Antimicrobial Agents and Chemotherapy Feb 2000, 44 (2) 243-247; DOI: 10.1128/AAC.44.2.243-247.2000
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KEYWORDS

antifungal agents
Antigens, Fungal
Candida albicans
candidiasis
fluconazole
Fungemia

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