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Mechanisms of Action: Physiological Effects

Iron-Chelating Activity of Tetracyclines and Its Impact on the Susceptibility of Actinobacillus actinomycetemcomitansto These Antibiotics

Daniel Grenier, Marie-Pierre Huot, Denis Mayrand
Daniel Grenier
Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, 1
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Marie-Pierre Huot
Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, 1
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Denis Mayrand
and Faculté des Sciences et de Génie, 2 UniversitéLaval, Québec, Canada
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DOI: 10.1128/AAC.44.3.763-766.2000
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ABSTRACT

Three tetracyclines (tetracycline, doxycycline, and minocycline) were found to possess iron-chelating activity in a colorimetric siderophore assay. Determination of MICs indicated that the activity of doxycycline against the periodontopathogen Actinobacillus actinomycetemcomitans was only slightly influenced by the presence of an excess of iron that likely saturates the antibiotic. On the other hand, the MICs of doxycycline and minocycline were significantly lower for A. actinomycetemcomitans cultivated under iron-poor conditions than under iron-rich conditions.

  • Copyright © 2000 American Society for Microbiology
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Iron-Chelating Activity of Tetracyclines and Its Impact on the Susceptibility of Actinobacillus actinomycetemcomitansto These Antibiotics
Daniel Grenier, Marie-Pierre Huot, Denis Mayrand
Antimicrobial Agents and Chemotherapy Mar 2000, 44 (3) 763-766; DOI: 10.1128/AAC.44.3.763-766.2000

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Iron-Chelating Activity of Tetracyclines and Its Impact on the Susceptibility of Actinobacillus actinomycetemcomitansto These Antibiotics
Daniel Grenier, Marie-Pierre Huot, Denis Mayrand
Antimicrobial Agents and Chemotherapy Mar 2000, 44 (3) 763-766; DOI: 10.1128/AAC.44.3.763-766.2000
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