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Mechanisms of Resistance

Prevalence of β-Lactamases among 1,072 Clinical Strains of Proteus mirabilis: a 2-Year Survey in a French Hospital

C. Chanal, R. Bonnet, C. De Champs, D. Sirot, R. Labia, J. Sirot
C. Chanal
Laboratoire de Bactériologie, Faculté de Médecine, 63001 Clermont-Ferrand Cedex, and
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R. Bonnet
Laboratoire de Bactériologie, Faculté de Médecine, 63001 Clermont-Ferrand Cedex, and
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C. De Champs
Laboratoire de Bactériologie, Faculté de Médecine, 63001 Clermont-Ferrand Cedex, and
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D. Sirot
Laboratoire de Bactériologie, Faculté de Médecine, 63001 Clermont-Ferrand Cedex, and
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R. Labia
UMR 175, CNRS-MNHN, 29000 Quimper, France
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J. Sirot
Laboratoire de Bactériologie, Faculté de Médecine, 63001 Clermont-Ferrand Cedex, and
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DOI: 10.1128/AAC.44.7.1930-1935.2000
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ABSTRACT

β-Lactam resistance was studied in 1,072 consecutive P. mirabilis clinical strains isolated at the Clermont-Ferrand teaching hospital between April 1996 and March 1998. The frequency of amoxicillin resistance was 48.5%. Among the 520 amoxicillin-resistant isolates, three resistance phenotypes were detected: penicillinase (407 strains [78.3%]), extended-spectrum β-lactamase (74 strains [14.2%]), and inhibitor resistance (39 strains [7.5%]). The penicillinase phenotype isolates were divided into three groups according to the level of resistance to β-lactams, which was shown to be related to the strength of the promoter. The characterization of the different β-lactamases showed that amoxicillin resistance in P. mirabilis was almost always (97%) associated with TEM or TEM-derived β-lactamases, most of which evolved via TEM-2.

  • Copyright © 2000 American Society for Microbiology
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Prevalence of β-Lactamases among 1,072 Clinical Strains of Proteus mirabilis: a 2-Year Survey in a French Hospital
C. Chanal, R. Bonnet, C. De Champs, D. Sirot, R. Labia, J. Sirot
Antimicrobial Agents and Chemotherapy Jul 2000, 44 (7) 1930-1935; DOI: 10.1128/AAC.44.7.1930-1935.2000

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Prevalence of β-Lactamases among 1,072 Clinical Strains of Proteus mirabilis: a 2-Year Survey in a French Hospital
C. Chanal, R. Bonnet, C. De Champs, D. Sirot, R. Labia, J. Sirot
Antimicrobial Agents and Chemotherapy Jul 2000, 44 (7) 1930-1935; DOI: 10.1128/AAC.44.7.1930-1935.2000
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KEYWORDS

Proteus mirabilis
beta-lactamases

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