Mutations in 23S rRNA and Ribosomal Protein L4 Account for Resistance in Pneumococcal Strains Selected In Vitro by Macrolide Passage

A. Tait-Kamradt; T. Davies; M. Cronan; M. R. Jacobs; P. C. Appelbaum; J. Sutcliffe

doi:10.1128/AAC.44.8.2118-2125.2000

DOI: 10.1128/AAC.44.8.2118-2125.2000

Article Information

DOI

https://doi.org/10.1128/AAC.44.8.2118-2125.2000

PubMed

10898684

Published By

American Society for Microbiology Journals

History

Received March 7, 2000
Returned for modification April 11, 2000
Accepted May 3, 2000
Published online August 1, 2000.

Author Information

A. Tait-Kamradt¹,
T. Davies²,
M. Cronan³,
M. R. Jacobs⁴,
P. C. Appelbaum² and
J. Sutcliffe¹ *

Department of Infectious Diseases¹ and
Department of Genomic and Proteomic Sciences,³ Pfizer, Inc., Groton, Connecticut;
Hershey Medical Center, Hershey, Pennsylvania;² and
Case Western Reserve University, Cleveland, Ohio⁴

↵* Corresponding author. Mailing address: Pfizer Central Research, Department of Infectious Diseases—RAIIID, Eastern Point Rd., Groton, CT 06340. Phone: (860) 441-4693. Fax: (860) 441-6159. E-mail:joyce_a_sutcliffe{at}groton.pfizer.com.

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