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Antiviral Agents

A Double-Blind Placebo-Controlled Crossover Trial of Intravenous Magnesium Sulfate for Foscarnet-Induced Ionized Hypocalcemia and Hypomagnesemia in Patients with AIDS and Cytomegalovirus Infection

Mark M. Huycke, M. Tarek Naguib, Mathias M. Stroemmel, Kenneth Blick, Katherine Monti, Sarah Martin-Munley, Chris Kaufman
Mark M. Huycke
Departments of Medicine and
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M. Tarek Naguib
Departments of Medicine and
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Mathias M. Stroemmel
Departments of Medicine and
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Kenneth Blick
Pathology, University of Oklahoma Health Sciences Center and Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma 73190, and
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Katherine Monti
Astra USA, Inc., Westborough, Massachusetts 01581-4500
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Sarah Martin-Munley
Astra USA, Inc., Westborough, Massachusetts 01581-4500
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Chris Kaufman
Departments of Medicine and
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DOI: 10.1128/AAC.44.8.2143-2148.2000
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    Fig. 1.

    Changes in total serum Mg2+ and plasma iMg2+ concentrations (mean ± standard error of the mean [SEM]) prior to and following morning foscarnet infusion. All MgSO4 doses showed a significant dose response (P = 0.0001 for linear trend). Changes from baseline for iMg2+ concentration at each post-foscarnet infusion assessment also showed a significant dose response (P = 0.0001). Treatment groups were as follows: ■, placebo; ⧫, 1 g of MgSO4; ▴, 2 g of MgSO4; ●, 3 g of MgSO4.

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    Fig. 2.

    Changes in total serum Ca2+ and plasma iCa2+ concentrations (mean ± standard error of the mean [SEM]) prior to and following morning foscarnet infusion. No dose-response trend was noted for the post-foscarnet infusion assessments (P > 0.05 for all tests). Treatment groups are indicated as in Fig. 1.

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    Fig. 3.

    Changes in serum PTH levels (mean ± standard error of the mean [SEM]) prior to and following morning foscarnet infusion. Treatment groups are indicated as in Fig. 1.

Tables

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  • Table 1.

    Sequence across study days of MgSO4 and placebo doses for 12 subjects in a crossover design employing three replicated Latin squares

    Subject no.Dose of MgSO4 (g)
    Day 1Day 2Day 3Day 4
    1123Placebo
    231Placebo2
    3Placebo321
    42Placebo13
    6132Placebo
    7Placebo231
    83Placebo12
    91Placebo32
    1023Placebo1
    11Placebo213
    12312Placebo
    13a21Placebo3
    • ↵a Subject no. 5 was removed from the study due to a protocol violation (dose sequence error) and reenrolled after a 2-day washout as subject no. 13 using the same dose sequence; data for subject no. 5 were excluded except those for adverse events.

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A Double-Blind Placebo-Controlled Crossover Trial of Intravenous Magnesium Sulfate for Foscarnet-Induced Ionized Hypocalcemia and Hypomagnesemia in Patients with AIDS and Cytomegalovirus Infection
Mark M. Huycke, M. Tarek Naguib, Mathias M. Stroemmel, Kenneth Blick, Katherine Monti, Sarah Martin-Munley, Chris Kaufman
Antimicrobial Agents and Chemotherapy Aug 2000, 44 (8) 2143-2148; DOI: 10.1128/AAC.44.8.2143-2148.2000

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A Double-Blind Placebo-Controlled Crossover Trial of Intravenous Magnesium Sulfate for Foscarnet-Induced Ionized Hypocalcemia and Hypomagnesemia in Patients with AIDS and Cytomegalovirus Infection
Mark M. Huycke, M. Tarek Naguib, Mathias M. Stroemmel, Kenneth Blick, Katherine Monti, Sarah Martin-Munley, Chris Kaufman
Antimicrobial Agents and Chemotherapy Aug 2000, 44 (8) 2143-2148; DOI: 10.1128/AAC.44.8.2143-2148.2000
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KEYWORDS

AIDS-Related Opportunistic Infections
Acquired Immunodeficiency Syndrome
Cytomegalovirus Infections
Hypocalcemia
Magnesium
Magnesium Sulfate

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