Article Figures & Data
Figures
- Fig. 1.
Changes in total serum Mg2+ and plasma iMg2+ concentrations (mean ± standard error of the mean [SEM]) prior to and following morning foscarnet infusion. All MgSO4 doses showed a significant dose response (P = 0.0001 for linear trend). Changes from baseline for iMg2+ concentration at each post-foscarnet infusion assessment also showed a significant dose response (P = 0.0001). Treatment groups were as follows: ■, placebo; ⧫, 1 g of MgSO4; ▴, 2 g of MgSO4; ●, 3 g of MgSO4.
- Fig. 2.
Changes in total serum Ca2+ and plasma iCa2+ concentrations (mean ± standard error of the mean [SEM]) prior to and following morning foscarnet infusion. No dose-response trend was noted for the post-foscarnet infusion assessments (P > 0.05 for all tests). Treatment groups are indicated as in Fig. 1.
- Fig. 3.
Changes in serum PTH levels (mean ± standard error of the mean [SEM]) prior to and following morning foscarnet infusion. Treatment groups are indicated as in Fig. 1.
Tables
- Table 1.
Sequence across study days of MgSO4 and placebo doses for 12 subjects in a crossover design employing three replicated Latin squares
Subject no. Dose of MgSO4 (g) Day 1 Day 2 Day 3 Day 4 1 1 2 3 Placebo 2 3 1 Placebo 2 3 Placebo 3 2 1 4 2 Placebo 1 3 6 1 3 2 Placebo 7 Placebo 2 3 1 8 3 Placebo 1 2 9 1 Placebo 3 2 10 2 3 Placebo 1 11 Placebo 2 1 3 12 3 1 2 Placebo 13a 2 1 Placebo 3 ↵a Subject no. 5 was removed from the study due to a protocol violation (dose sequence error) and reenrolled after a 2-day washout as subject no. 13 using the same dose sequence; data for subject no. 5 were excluded except those for adverse events.
