DOI: 10.1128/AAC.44.8.2211-2213.2000
Article Figures & Data
Tables
- Table 1.
In vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against 140 A. baumannii isolates
Antibiotic MIC (mg/liter) % of strains fully susceptiblea Range 50% 90% Geometric mean Ciprofloxacin ≤0.03—>128 0.5 64 19.6 66.4 Clinafloxacin 0.06—32 0.12 4 1.3 79.3 Gatifloxacin ≤0.03—128 0.12 8 3.7 71.4 Gemifloxacin ≤0.03—32 0.12 16 3.2 72.1 Levofloxacin ≤0.03—32 0.25 8 3.2 74.3 Moxifloxacin ≤0.03—64 0.12 16 4.2 73.6 Trovafloxacin ≤0.03—32 0.06 16 3.3 77.9 ↵a MIC breakpoints for susceptibility are those defined by NCCLS for ciprofloxacin (≤1 mg/liter) and levofloxacin (≤2 mg/liter) for susceptibility testing of non-Enterobacteriaceae. For the other fluoroquinolone agents, no breakpoints have been established. For clinafloxacin (≤1 mg/liter), gatifloxacin (≤1 mg/liter), gemifloxacin (≤0.5 mg/liter), moxifloxacin (≤1 mg/liter), and trovafloxacin (≤1 mg/liter), the breakpoints suggested by the manufacturers were applied.
- Table 2.
In vitro activities of seven fluoroquinolone agents against sporadic and epidemic A. baumannii isolates
A. baumannii (no. of strains tested) Antibiotic MIC (mg/liter) % of strains fully susceptible Range 50% 90% Geometric mean Sporadic isolates (109) Ciprofloxacin ≤0.03—>128 0.25 64 13.5 76.1 Clinafloxacin 0.06—16 0.12 2 0.8 86.2 Gatifloxacin ≤0.03—64 0.12 8 2.2 80.7 Gemifloxacin ≤0.03—32 0.12 8 1.9 80.7 Levofloxacin ≤0.03—32 0.25 8 2.2 83.5 Moxifloxacin ≤0.03—64 0.12 8 3.2 83.5 Trovafloxacin ≤0.03—32 0.06 8 2.0 85.3 Outbreak isolates (31) Ciprofloxacin 0.25—>128 4 128 41.2 32.3 Clinafloxacin 0.12—32 1 4 2.9 54.8 Gatifloxacin ≤0.03—128 2 16 9.1 38.7 Gemifloxacin 0.06—32 2 32 7.5 41.9 Levofloxacin 0.12—32 4 16 6.6 41.9 Moxifloxacin 0.06—32 2 32 8.0 38.7 Trovafloxacin ≤0.03—32 1 32 7.6 51.6
