Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About AAC
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • AAC Podcast
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Antimicrobial Agents and Chemotherapy
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About AAC
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • AAC Podcast
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
Susceptibility

Comparative Activities of Ciprofloxacin, Clinafloxacin, Gatifloxacin, Gemifloxacin, Levofloxacin, Moxifloxacin, and Trovafloxacin against Epidemiologically Defined Acinetobacter baumannii Strains

Barbara Heinemann, Hilmar Wisplinghoff, Michael Edmond, Harald Seifert
Barbara Heinemann
Institute of Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hilmar Wisplinghoff
Institute of Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Edmond
Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Harald Seifert
Institute of Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1128/AAC.44.8.2211-2213.2000
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Tables

  • Table 1.

    In vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against 140 A. baumannii isolates

    AntibioticMIC (mg/liter)% of strains fully susceptiblea
    Range50%90%Geometric mean
    Ciprofloxacin≤0.03—>1280.56419.666.4
    Clinafloxacin0.06—320.1241.379.3
    Gatifloxacin≤0.03—1280.1283.771.4
    Gemifloxacin≤0.03—320.12163.272.1
    Levofloxacin≤0.03—320.2583.274.3
    Moxifloxacin≤0.03—640.12164.273.6
    Trovafloxacin≤0.03—320.06163.377.9
    • ↵a MIC breakpoints for susceptibility are those defined by NCCLS for ciprofloxacin (≤1 mg/liter) and levofloxacin (≤2 mg/liter) for susceptibility testing of non-Enterobacteriaceae. For the other fluoroquinolone agents, no breakpoints have been established. For clinafloxacin (≤1 mg/liter), gatifloxacin (≤1 mg/liter), gemifloxacin (≤0.5 mg/liter), moxifloxacin (≤1 mg/liter), and trovafloxacin (≤1 mg/liter), the breakpoints suggested by the manufacturers were applied.

  • Table 2.

    In vitro activities of seven fluoroquinolone agents against sporadic and epidemic A. baumannii isolates

    A. baumannii (no. of strains tested)AntibioticMIC (mg/liter)% of strains fully susceptible
    Range50%90%Geometric mean
    Sporadic isolates (109)Ciprofloxacin≤0.03—>1280.256413.576.1
    Clinafloxacin0.06—160.1220.886.2
    Gatifloxacin≤0.03—640.1282.280.7
    Gemifloxacin≤0.03—320.1281.980.7
    Levofloxacin≤0.03—320.2582.283.5
    Moxifloxacin≤0.03—640.1283.283.5
    Trovafloxacin≤0.03—320.0682.085.3
    Outbreak isolates (31)Ciprofloxacin0.25—>128412841.232.3
    Clinafloxacin0.12—32142.954.8
    Gatifloxacin≤0.03—1282169.138.7
    Gemifloxacin0.06—322327.541.9
    Levofloxacin0.12—324166.641.9
    Moxifloxacin0.06—322328.038.7
    Trovafloxacin≤0.03—321327.651.6
PreviousNext
Back to top
Download PDF
Citation Tools
Comparative Activities of Ciprofloxacin, Clinafloxacin, Gatifloxacin, Gemifloxacin, Levofloxacin, Moxifloxacin, and Trovafloxacin against Epidemiologically Defined Acinetobacter baumannii Strains
Barbara Heinemann, Hilmar Wisplinghoff, Michael Edmond, Harald Seifert
Antimicrobial Agents and Chemotherapy Aug 2000, 44 (8) 2211-2213; DOI: 10.1128/AAC.44.8.2211-2213.2000

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Alerts
Sign In to Email Alerts with your Email Address
Email

Thank you for sharing this Antimicrobial Agents and Chemotherapy article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Comparative Activities of Ciprofloxacin, Clinafloxacin, Gatifloxacin, Gemifloxacin, Levofloxacin, Moxifloxacin, and Trovafloxacin against Epidemiologically Defined Acinetobacter baumannii Strains
(Your Name) has forwarded a page to you from Antimicrobial Agents and Chemotherapy
(Your Name) thought you would be interested in this article in Antimicrobial Agents and Chemotherapy.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Comparative Activities of Ciprofloxacin, Clinafloxacin, Gatifloxacin, Gemifloxacin, Levofloxacin, Moxifloxacin, and Trovafloxacin against Epidemiologically Defined Acinetobacter baumannii Strains
Barbara Heinemann, Hilmar Wisplinghoff, Michael Edmond, Harald Seifert
Antimicrobial Agents and Chemotherapy Aug 2000, 44 (8) 2211-2213; DOI: 10.1128/AAC.44.8.2211-2213.2000
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • ABSTRACT
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

Acinetobacter
anti-infective agents
Aza Compounds
fluoroquinolones
quinolines

Related Articles

Cited By...

About

  • About AAC
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • AAC Podcast
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #AACJournal

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0066-4804; Online ISSN: 1098-6596